Jan 3, 2015 - Doxorubicin (Dox) is one of the most potent broad-spectrum antitumor anthracycline antibiotics, but its use is limited by the development of ...
Effect of ferulic acid and syringic acid on Doxorubicin induced cardiotoxicity ajbm.net/effect-ferulic-acid-syringic-acid-doxorubicin-induced-cardiotoxicity-2/
1/3/2015 American Journal of BioMedicine Volume 3, Issue 13, January 2015 Bassim I Mohammad; Nada Al-Haris; Najah Hadi; Maitham G. Yousif; Zainab Alkefaee Abstract Doxorubicin (Dox) is one of the most potent broad-spectrum antitumor anthracycline antibiotics, but its use is limited by the development of life-threatening cardiomyopathy. This study was undertaken to investigate the cardioprotective effect of ferulic acid and syringic acid on Doxorubicin induced cardiotoxicity. The rats were randomized into 4 equal groups, group 1 sham group, which received no treatment, group 2, received Doxorubicin at a dose 3mg/Kg IP every other 2 days plus normal saline as vehicle orally and considered as Cardiotoxic group, group 3 received Doxorubicin plus ferulic acid 10mg/kg/day p.o for 2 weeks. Group 4 received Doxorubicin plus syringic acid 100mg/kg/day p.o for 2 weeks. Compared with the sham group, levels of myocardial TNF-α, IL-1βand IL-10; plasma cTn-I were increased (P
