Jul 5, 1991 - Thus, L . acidophilus given together with fried meat lowered ... Heterocyclic aromatic amines are a group of compounds that are formed.
MICROBIAL ECOLOGY IN HEALTH AND DISEASE
VOL.
5: 59-67 ( 1992)
Effect of Lactobacillus acidophilus Supplements on Mutagen Excretion in Faeces and Urine in Humans A. LIDBECK?, E. OVERVIKf, J. RAFTER$, C. E. NORD*llt and J-A. GUSTAFSSONf Departments of Microbiology and t Medical Nutrition. Huddinge Universirj' Hospital, Karolinska Institute and 1 1 National Bacteriological Laboratory. Stockholm. Swclen Received 5 July 1991; revised 13 September 1991
Lactic acid bacteria have been reported to have antimutagenic properties in ,+fro.In order to investigate whether Lactobacillus acidophilus supplements have antimutagenic effects in humans, 1 1 healthy subjects on a standardised diet consumed fried beef patties twice daily for 3 d. The diets were supplemented with ordinary Lmtococcus fermented milk (phase 1) and thereafter with L . ucidophilus fermented milk (phase 2), whereby the excretion of mutagenic activity was determined in urine and faeces. In both faeces and urine high levels of mutagenicity were detected during phase 1. There was an increase in lactobacilli in the intestinal microflora in seven of I 1 subjects by the L. ucidophilus supplement (phase 2), and the mutagenic activity in urine was 72 per cent lower on day 2 ( P
