Feb 19, 2016 - Quail eggs contain lots of vitamins and minerals that help fight some diseases in the body. Overdose of paracetamol® (acetaminophen) is ...
Journal of Applied Biology & Biotechnology Vol. 4 (01), pp. 034-038, Jan-Feb, 2016 Available online at http://www.jabonline.in DOI: 10.7324/JABB.2016.40106
Effect of Quail Egg Pretreatment on the Lipid Profile and Histomorphology of the Liver of Acetaminophen-Induced Hepatotoxicity in Rats Patrick Emeka Aba1, Chiamaka Pearl Eneasato2, Jonas Anayo Onah3 1
Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Nigeria. Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Nsukka, Nigeria. 3 Department of Veterinary Surgery, University of Abuja, Nigeria. 2
ARTICLE INFO
ABSTRACT
Article history: Received on: 13/11/2015 Revised on: 22/12/2015 Accepted on: 16/01/2016 Available online: 19/02/2016
Quail eggs contain lots of vitamins and minerals that help fight some diseases in the body. Overdose of paracetamol® (acetaminophen) is considered one of the major causes of damages to liver cells. This study was conducted to assess the effect of graded doses of quail egg pretreatment on lipid profile and liver histomorphology of acetaminophen-induced hepatotoxicity in rats. Thirty (30) albino rats were assigned into 5 groups of 6 rats per group. Rats in groups 2-4 were pretreated with 30 mg/kg, 15 mg/kg, 7.5 mg/kg respectively of quail egg solution for 7 days before intoxication with 2000 mg/kg paracetamol® orally. Rats in group 5 were intoxicated but pretreated with distilled water (DW) at 10 ml/kg to serve as negative control while rats in group 1 were not intoxicated but pretreated with DW (10 ml/kg) (positive control). Fourty eight (48 h) hours post intoxication, blood was collected for lipid profile analysis. Thereafter, 2 rats per group were humanely sacrificed and the liver collected for histomorphological examination. The results obtained showed that 30 mg/kg quail eggpretreated rats (Group 2 rats) had significantly (P0.05) in HDL level among all the groups. They were all statistically comparable (P>0.05). Table 2: Effects of the graded doses of quail egg on low-density-lipoprotein level of acetaminophen-induced hepatotoxicity in rats Group LDL (mg/dl) 1 39.37 ± 4.27ab 2 14.47 ± 1.81a 3 31.78 ±0.67a 4 62.69 ± 6.77b 5 107.38 ± 15.55c
The result showed that LDL levels of groups 1-3 rats were statistically comparable (P>0.05). The LDL level of rats in groups 1and 4 were also comparable while that of the group 5 rats were statistically higher (p
