Open Journal of Radiology, 2014, 4, 53-59 Published Online March 2014 in SciRes. http://www.scirp.org/journal/ojrad http://dx.doi.org/10.4236/ojrad.2014.41007
Effect of Slice Thickness Reconstruction on Quantitative Vascular Parameters in Perfusion CT Anxo Martínez-de-Alegría1*, Roberto García-Figueiras1, Sandra Baleato-González1, María José Rodriguez-Alvarez2, Iago Martínez-Souto3, Carmen Villalba-Martín1 1
Departments of Radiology, Hospital Clínico Universitario, Santiago de Compostela, Spain Statistics, Hospital Clínico Universitario, Santiago de Compostela, Spain 3 General Electric, Santiago de Compostela, Spain Email: *
[email protected] 2
Received 18 November 2013; revised 18 December 2013; accepted 26 December 2013 Copyright © 2014 by authors and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY). http://creativecommons.org/licenses/by/4.0/
Abstract Objective: The purpose of this study was to determine how the slice thickness reconstruction influences quantitative perfusion CT parameters. Materials and Methods: Eighteen patients with cancer (15 non-small-cell lung cancer, 2 rectal cancer and 1 renal cancer) were examined prospectively with multidetector row CT. A 90-second perfusion study was performed after intravenous bolus injection of contrast material. Blood flow, blood volume, mean transit time and permeability-surface area product were determined at three different slice thickness reconstruction (1.25, 2.5 and 5 mms) both in tumors and in paraspinal muscle. Mean values, limits of agreement between measurements and within-subject coefficient of correlation were obtained for these thicknesses. Results: Mean ± standard deviation BF, BV, MTT and PS in lesions were 118.7 ± 117.9 mL/min/100g tissue, 8.2 ± 8.2 mL/100g tissue, 7.5 ± 5.4 seconds and 10.3 ± 7.2 mL/min/100g tissue respectively at 1.25 mm slice thickness; 116.1 ± 115.7 mL/min/100g tissue, 7.8 ± 8.7 mL/100g tissue, 7 ± 4.5 seconds and 10.4 ± 7.5 mL/min/100g tissue at 2.5 mms; and 119.6 ± 115.7 mL/min/100g tissue, 7.8 ± 8.8 mL/100g tissue, 5.4 ± 3.4 seconds and 9.6 ± 7.5 mL/min/100g tissue at 5 mms. Differences between means for different slice thickness where relatively small in all parameters (
