Effect of telmisartan on the expression of adiponectin ... - Springer Link
Recommend Documents
Feb 1, 2011 - ... Economopoulos2, Dimitrios T Kremastinos3, George Dimitriadis2, ...... Bunn RC, Cockrell GE, Ou Y, Thrailkill KM, Lumpkin CK Jr, Fowlkes JL:.
exercise training affects plasma adiponectin concentrations. 643. Journal of Endocrinology (2006) ... Online version via
addition, activation of PPAR gamma results in the modulation of Wnt signaling ..... http://www.iiste.org/conference/upcoming-conferences-call-for-paper/.
Effect of DHEA-sulfate on adiponectin gene expression in adipose ... estrone, and 17b-estradiol (1, 2). .... 17b-Estradiol and testosterone were determined by.
The root of Lithospermum erythrorhizon Sieb. et. Zucc. (Boraginaceae), a medicinal plant, produces red naphthoquinone compounds, shikonin and its.
Savontaus E, Conwell IM, Wardlaw SL. Effects of adrenalectomy on ... Goldstone AP, Russell SH, Stanley SA, Smith DM, Yagaloff K, Ghatei MA,. Bloom SR.
Apr 27, 2013 - ORIGINAL PAPER. Telmisartan Ameliorates Neurotrophic Support and Oxidative. Stress in the Retina of Streptozotocin-Induced Diabetic Rats.
Jul 1, 2005 - abundantly expressed in the liver. Thiazolidinedione treatment increases plasma concen- trations of adiponectin [4]. In adipocytes, thiazolidine-.
Nov 24, 2005 - Department of Internal Medicine and Therapeutics, Clinica Medica II, IRCCS Policlinico S. Matteo,. University of Pavia .... labs Inc., Bellevue, CA, USA), validated against .... o10 mmHg) and three did not return for clinic visit.
Effect of telmisartan on the expression of adiponectin ... - Springer Link
Guo et al. Cardiovascular Diabetology 2012, 11:94 http://www.cardiab.com/content/11/1/94
ORIGINAL INVESTIGATION
Open Access
Effect of telmisartan on the expression of adiponectin receptors and nicotinamide adenine dinucleotide phosphate oxidase in the heart and aorta in type 2 diabetic rats Zhixin Guo*, Rong Zhang, Jiawei Li and Guojun Xu
Abstract Background: Diabetic cardiovascular disease is associated with decreased adiponectin and increased oxidative stress. This study investigated the effect of telmisartan on the expression of adiponectin receptor 2 (adipoR2) and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase subunits in the heart and the expression of adiponectin receptor 1 (adipoR1) in aorta in type 2 diabetic rats. Methods: Type 2 diabetes was induced by high-fat and high-sugar diet and intraperitoneal injection of a low dose of streptozotocin (STZ). Heart function, adipoR2, p22phox, NOX4, glucose transporter 4(GLUT4), monocyte chemoattractant protein-1(MCP-1) and connective tissue growth factor (CTGF)in the heart, and adipoR1, MCP-1 and nuclear factor kappa B (NF-κB) in aorta were analyzed in controls and diabetic rats treated with or without telmisartan (5mg/kg/d) by gavage for 12 weeks. Results: Heart function, plasma and myocardial adiponectin levels, the expression of myocardial adipoR2 and GLUT4 were significantly decreased in diabetic rats (P
