Effects of high-intensity aerobic interval training versus moderate exercise on hemodynamic, metabolic, and neuro-humoral abnormalities of young normotensive women at high familial risk for hypertension (Pre-print version)
Emmanuel G. Ciolac, PhD;1,2,3 Edimar A. Bocchi, MD, PhD;1 Luiz A. Bortolotto, MD, PhD;1 Vitor O. Carvalho, PhD;1,3 Julia M. D. Greve, MD, PhD;2 Guilherme V. Guimarães, PhD1,3
1. Heart Institute do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil. 2. Institute of Orthopedics and Traumatology do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Laboratory of Kinesiology, São Paulo, Brazil. 3. Centro de Práticas Esportivas da Universidade de São Paulo, Laboratory of Physical Activity and Health, São Paulo, Brazil.
Publishers’ version at Hypertension Research (2010) 33, 836–843; published online 7 May 2010; http://dx.doi.org/10.1038/hr.2010.72
Please cite this article as: Ciolac EG, et al. Effects of high-intensity aerobic interval training versus moderate exercise on hemodynamic, metabolic, and neuro-humoral abnormalities of young normotensive women at high familial risk for hypertension. Hypertension Research 2010; 33: 836–843.
Correspondence to: Dr. Emmanuel G Ciolac, Instituto de Ortopedia e Traumatologia do HCFMUSP, Laboratório de Estudos do Movimento, Rua Dr. Ovídio Pires de Campos, 333, Segundo Andar, Ala C, Sao Paulo 05403-010, Brazil. E-mail:
[email protected]
Ciolac EG, et al. – Exercise and Familial Hypertension (Pre-print version)
ABSTRACT Background: Exercise training has an important role in the prevention and treatment of hypertension, but its effects on the early metabolic and hemodynamic abnormalities observed in normotensive subjects offspring of hypertensive parents (FH+) has not been studied. We compared high-intensity interval (AIT) and moderate-intensity continuous exercise training (CMT) with regard hemodynamic, metabolic and hormonal variables in FH+. Methods and Results: Forty-four healthy women FH+ (25.0±4.4 years), randomized to control (ConFH+) or to a 3 times-a-week equal volume AIT (80-90% of VO2MAX) or CMT (50-60% of VO2MAX), and 15 healthy women with normotensive parents (ConFH−; 25.3±3.1 years) had their hemodynamic, metabolic and hormonal variables analyzed before and after 16 weeks of follow-up. Ambulatorial blood pressure (ABP), glucose and cholesterol levels were similar among all groups, but FH+ groups displayed higher insulin, insulin sensitivity, carotid-femoral pulse wave velocity (PWV), norepinephrine and endothelin-1 (ET-1), and lower nitrite/nitrate (NOx) levels than ConFH−. AIT and CMT were equally effective in improving ABP (P
