Effects of iron supplementation on red blood cell hemoglobin content
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Effects of iron supplementation on red blood cell hemoglobin content
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Effects of iron supplementation on red blood cell hemoglobin content in pregnancy Margreet Schoorl, Marianne Schoorl, Derek van der Gaag, Piet C. M. Bartels Department of Clinical Chemistry, Haematology and Immunology, Medical Center Alkmaar, The Netherlands
Abstract Although a mild degree of anemia is common in the third trimester of pregnancy, it remains a challenge to establish whether a decrease in hemoglobin (Hb) concentration is physiological or pathological. The World Health Organization suggested a Hb concentration of 110 g/L to discriminate anemia. Several European investigators recommended Hb cut-off values of between 101-110 g/L. The aim of this study was to establish short-term effects of iron supplementation on the hemoglobin content of reticulocytes (Ret-He) and red blood cells (RBC-He) in case of suspected iron deficient erythropoiesis (IDE) in the third trimester of pregnancy. Twenty-five subjects with suspected IDE during pregnancy (Hb ≤110g/L, Ret-He 75 mol/mol hem) participated in the study. After iron supplementation, reticulocyte counts increased from 0.061±0.015¥1012/L to 0.079±0.026¥1012/L and Ret-He increased from 23.6±2.8 pg to 28.3±2.6 pg (P=
