Jul 10, 2018 - balance, Huntington's disease, manual dexterity, mobility, muscle strength ... therapy have reported positive effects on physical function, mood and quality of ... (within ±2 hours) at all assessment time points, (c) patients were.
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Received: 26 March 2018 Revised: 29 June 2018 Accepted: 10 July 2018 DOI: 10.1111/ane.13002
ORIGINAL ARTICLE
Effects of multidisciplinary therapy on physical function in Huntington’s disease Travis M. Cruickshank1,2
| Alvaro P. Reyes3 | Luis E. Penailillo4 | Tim Pulverenti1 |
Danielle M. Bartlett1 | Pauline Zaenker1 | Anthony J. Blazevich1,5 | Robert U. Newton1,6 | Jennifer A. Thompson1 | Johnny Lo1 | Mel R. Ziman1,7 1 School of Medical and Health Sciences, Edith Cowan University, Perth, Western Australia, Australia
Objective: The primary objective of this trial was to evaluate the effects of outpatient multidisciplinary therapy, compared to usual care, on measures of physical func-
2
Perron Institute for Neurological and Translational Science, Perth, Western Australia, Australia
tion and muscle strength in patients with manifest Huntington’s disease (HD).
3
36 weeks of outpatient multidisciplinary therapy or usual care. Outpatient multidisci-
Facultad de Ciencias de la Rehabilitacion, Universidad Andres Bello, Santiago, Chile 4 Exercise Physiology Laboratory, School of Kinesiology, Faculty of Medicine, Universidad Finis Terrae, Santiago, Chile 5
Centre of Exercise and Sports Science, Edith Cowan University, Perth, Western Australia, Australia
6
UQ Centre for Clinical Research, University of Queensland, Brisbane, Queensland, Australia 7
School of Pathology and Laboratory Medicine, University Western Australia, Perth, Western Australia, Australia
Correspondence: Travis M. Cruickshank, School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA, Australia (t.cruickshank@ ecu.edu.au). Funding information This work was supported by Lotterywest (grant number 107/20090827). J. A. T. salary was supported by the Lotterywest grant.
Methods: Twenty-two patients with clinically verified HD were randomized to receive plinary therapy comprised 9 months of supervised exercise, cognitive therapy and self-directed home-based exercise. Usual care consisted of standard medical care. Patients were assessed at 0 and 36 weeks by blinded assessors. The primary outcome was changed in mobility as measured by the 10-m Timed Walk Test. Secondary outcome measures included changes in manual dexterity (Timed Nut and Bolt Test), balance (Berg Balance Scale), cardiorespiratory endurance (6-Minute Walk Test) and upper and lower extremity muscle strength (isokinetic and isometric muscle strength and 10 Repetition Sit-to-Stand Tests). Results: Patients receiving outpatient multidisciplinary therapy demonstrated significantly enhanced manual dexterity (P
