Hormone (GH) Therapy on Cardiac Mass and Function in Children with Classical ... GH APPEARS TO BE a determinant of cardiac growth, but the confounding ...
Effects of One Year of Recombinant Human Growth Hormone (GH) Therapy on Cardiac Mass and Function in Children with Classical GH Deficiency DOROTHY I. SHULMAN, ALLEN W. ROOT, FRANK B. DIAMOND, BARRY B. BERCU, RICHARD MARTINEZ, AND ROBERT J. BOUCEK, JR. Department of Pediatrics, Divisions of Endocrinology and Cardiology, University of South Florida College of Medicine, Tampa 33612; and All Children’s Hospital, St. Petersburg, Florida 33701 Cardiac mass and function were evaluated in 10 children with classical GH deficiency. Echocardiograms were performed at baseline, 3, 6, and 12 months after initiation of recombinant human (rh) GH therapy (0.3 mg/kg䡠wk). Before treatment, left ventricular (LV) mass indexed to body surface area (BSA) was low or low normal (
