Annals of Medicine
ISSN: 0785-3890 (Print) 1365-2060 (Online) Journal homepage: http://www.tandfonline.com/loi/iann20
PLASMA ENDOTHELIN-1 LEVELS IN PATIENTS WITH RESISTANT HYPERTENSION: EFFECTS OF RENAL SYMPATHETIC DENERVATION Luigi Petramala, Federica Olmati, Massimo Mancone, Antonio Concistré, Matteo Galassi, Cristiano Marinelli, Gianfranco Tonnarini, Piernatale Lucia, Umberto Costi, Gino Iannucci, Gennaro Sardella & Claudio Letizia To cite this article: Luigi Petramala, Federica Olmati, Massimo Mancone, Antonio Concistré, Matteo Galassi, Cristiano Marinelli, Gianfranco Tonnarini, Piernatale Lucia, Umberto Costi, Gino Iannucci, Gennaro Sardella & Claudio Letizia (2017): PLASMA ENDOTHELIN-1 LEVELS IN PATIENTS WITH RESISTANT HYPERTENSION: EFFECTS OF RENAL SYMPATHETIC DENERVATION, Annals of Medicine, DOI: 10.1080/07853890.2017.1282623 To link to this article: http://dx.doi.org/10.1080/07853890.2017.1282623
Accepted author version posted online: 13 Jan 2017.
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Date: 14 January 2017, At: 14:13
PLASMA
ENDOTHELIN-1
LEVELS
IN
PATIENTS
WITH
RESISTANT
HYPERTENSION: EFFECTS OF RENAL SYMPATHETIC DENERVATION
Running title: renal sympathetic denervation and endothelin-1
Luigi Petramala*, Federica Olmati*, Massimo Mancone**, Antonio Concistré*, Matteo Galassi *, Cristiano Marinelli*, Gianfranco Tonnarini*, Piernatale Lucia*, Umberto Costi***, Gino Iannucci*,
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Gennaro Sardella** and Claudio Letizia*.
*
TE
Specialized Center of Secondary Hypertension, Department of Internal Medicine and Medical
Specialties, and **Department of Cardiovascular, Respiratory, Nephrology, Anestesiology and
EP
Geriatric Sciences, ***Department of Surgery “P. Valdoni”, Policlinico “Umberto I”, University of
ST
Correspondence to:
AC
C
Rome “Sapienza”, Rome, Italy
Prof. Claudio Letizia, M.D.
JU
Department of Internal Medicine and Medical Specialties Policlinico “Umberto I”, University “La Sapienza”, Rome, 00155 Rome, Italy E-mail:
[email protected]
ABSTRACT Introduction: Resistant arterial hypertension (RHT) is defined as poor controlled blood pressure (BP) despite optimal doses of 3 or more antihypertensive agents, including a diuretic. In the development of RHT, hyperactivity of sympathetic (SNS) and renin-angiotensin-aldosterone (SRAA) systems are involved, and SNS is a potent stimulator of vasoactive endothelin-1 (ET1) peptide. Renal sympathetic denervation (RSD) through disrupting renal afferent and efferent nerves attenuates SNS activity. Material and Methods: We carried out pilot study investigating the effect of RSD on BP and plasma ET-1 levels in consecutive 9 RHT patients (7 male and 2 female, mean age of 56 ± 13.3).
D
Results: After 12 months of the RSD, we observed a significant reduction of BP office, 24-hr
TE
ambulatory BP monitoring (ABPM) (p