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R Mandela School of Medicine, University of KwaZulu-Natal, ... The carefully and thoroughly updated 9th edition of the South African Medicines Formulary ...
FORUM CLINICAL IMAGES

The progression of a J wave during induction of hypothermia Reitze Nils Rodseth

J waves can commonly be seen in patients with severe hypothermia. Fig. 1 shows an ECG recording of a patient undergoing coronary artery revascularisation with the use of cardiopulmonary bypass. The purple recording shows the ECG with a small, existing J wave early during the initiation of cooling. The green overlay demonstrates the accentuation of the J wave as the patient was further cooled to 29°C. The J wave (also known as the Osborn wave) is often seen in hypothermia and in hypercalcaemia. It has been described in patients with early repolarisation syndrome, Chagas’ disease and Brugada syndrome. The proposed mechanism for J wave development is cold-induced accentuation of the action potential of M and epicardial cells, creating the J wave. Additional conduction delay from endocardium to epicardium then moves the J wave out of the QRS complex.1 J waves in

Dr Rodseth is an anaesthetic specialist in the Department of Anaesthetics at Inkosi Albert Luthuli Central Hospital, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban.

Musculoskeletal System Central Nervous System Antiparasitic Products Respiratory System Sensory Organs

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The South Africa Health and Medicn Medical Assoc iation al Private Bag X1, Publishing Group , Pinelands , 7430 ISBN 978-1 -875098-43 -9

SAMF S o u th

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Published by the African Sout Med formulary ical Associatio h pharmac is aimed at doctn, the ors, and othe ists, nurses, dent rs conc erned with ists safe and prescribin cost-effective the g of med icines. The Sout Formularyh African Med icines written is researched by mem and bers of Divis the Pharmac ion of Clini cal ology of of Cape the Univ Town, ersity in colla with heal boration th care profession als.

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South African Medicines Formulary

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The South African Medicines Formulary is researched and written by members of the Division of Clinical Pharmacology of the University of Cape Town, in collaboration with health care professionals.

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SAMF

The ESSENTIAL REFERENCE for every healthcare professional! The carefully and thoroughly updated 9th edition of the South African Medicines Formulary (SAMF) can now be ordered. It is your essential reference to rational, safe and cost-efficient use of medicines. That is why you should not prescribe without it. The newly published SAMF provides easy access to the latest, most scientifically accurate information – including full drug profiles, clinical notes and special prescriberʼs points. The convenient pocket-size design enables you to fit it comfortably into your bag or hospital coat pocket – always at hand for ready reference.

SAMF

Blood and Blood-forming Organs

SAMF

Alimentary Tract and Metabolism

Published by the South African Medical Association, the formulary is aimed at doctors, pharmacists, nurses, dentists and others concerned with the safe and cost-effective prescribing of medicines.

most cases of hypothermia resolve on return to normothermia, but may persist in some patients. Other ECG changes that may be seen in hypothermia include flattening of the p wave and QT prolongation.

1. Y  an GX, Antzelevitch C. Cellular basis for the electrocardiographic J wave. Circulation 1996; 93(2): 372-379.

Corresponding author: R Rodseth ([email protected])

Guidance on Prescribing

Fig. 1. ECG recording of a patient undergoing coronary artery revascularisation. The purple recording shows the ECG with a small existing J wave during initiation of cooling. The green overlay demonstrates accentuation of the J wave as the patient was further cooled to 29°C.

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Ninth Edition

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Produced EDITI by the Faculty Divis ON Publishe of Health Scie ion of Clin d by the nces, Univ ical Phar mac Health and Med ersity of Cap ology, of the e Town. ical Pub South African lishing Medical Grou Associati p on.

The new 9th edition of SAMF provides expanded information on key issues facing South African healthcare professionals today, including antiretrovirals, TB treatment guidelines, management guidelines for asthma and chronic heart failure, other common chronic conditions and prescribing in sport. • It presents practical, new approaches to the management of venomous bites and stings. • It outlines extensively the acute adverse reactions to drugs of abuse, and their management. • It features new as well as existing drugs, indexed by both trade and generic names. • It offers fresh insights into informed prescribing and carries cautionary guidelines on drug interactions and a range of special risk patients and conditions. And, as always, you can rely on... • the professional compilation and editing by a team from the Division of Clinical Pharmacology, UCT • an independent and unbiased guide on prescribing in South Africa today • the indication of agents included in the SA and WHO essential drug lists • support of the SA national drug policy • guidance for prescribing during pregnancy and lactation, and in patients with porphyria, liver disease and renal impairment (including tables with drug dosage adjustments); and • indexed and page tabs for quick and easy access to each section.

Medicines Formulary

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June 2010, Vol. 100, No. 6 SAMJ

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