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8.02 Evolution and the Enzyme. Shelley D. Copley, University of Colorado at Boulder, Boulder, CO, USA. ª 2010 Elsevier
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enzyme. Remarkably, compared to the zymogen, the peptide-bound complex showed no radical changes in active site conformation. Nevertheless, mutations.
Mar 13, 2009 - arXiv:0711.3960v4 [cond-mat.stat-mech] 13 Mar 2009. The iTEBD algorithm beyond unitary evolution. R. Orús and G. Vidal. School of Physical ...
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Evolution of Enzyme Kinetic Mechanisms - CORE › publication › fulltext › Evolution... › publication › fulltext › Evolution...by NN Ulusu · 2015 · Cited by 23 — Uni Ping Pong. Branched mechanism. Theorell. Chance. Irreversible single substrate kinetic
DPP4 in anti-tumor immunity: going beyond the enzyme. Kei Ohnuma, Ryo Hatano & Chikao Morimoto. Effective anti-tumor immune therapy in solid tumors ...
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Jun 16, 2011 - Maynard-Smith J, Szathmáry E (1995) The major transitions of evolution. ... Joyce GF (2002) The antiquity of RNA-based evolution. Nature 418: ...
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Trees with Profiles instead of a Distance Matrix by Morgan N. Price, Paramvir S. Dehal, and Adam P. Arkin. Supplementary Table 1 - Topological accuracy of ...
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Code 210-41, California. Institute of Technology. Pasadena, CA 91125, USA. Sets of genes improved by directed evolution can be recombined in vitro.
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Supplementary Table S1. An update of the original 1998 listing of 105 EC nodes with predicted analogous enzymes (online) Supplementary Table S2. New listing of confirmed and predicted analogous enzymes (online) Supplementary Table S3. Statistics of analogous enzyme searches in the ENZYME and KEGG databases
Four-digit EC nodes EC nodes with at least one assigned sequence Without proteases sequences Without remaining single sequences Multisubunit enzyme EC nodes to be excluded EC nodes selected for clustering
ENZYME database 4890 2487
KEGG database – 2256
ENZYME & KEGG combined set – –
2187 1893 4
2041 1934 4
2637 2181 4
1889
1930
2177
Supplementary Table S4. Combined results of clustering sequences from the ENZYME and KEGG databases Number of clusters per EC node
Each cell shows the number of EC nodes whose sequences clustered into the specified number of clusters (1 – 5 or more than 5) in KEGG and ENZYME databases. Only about half of EC nodes (yellow highlighting) had the same numbers of clusters in the two databases.
1
Supplementary Table S5. Distribution of analogous enzymes among enzyme classes Enzyme class 1 2 3 4 5 6
Oxidoreductase Transferase Hydrolase Lyase Isomerase Ligase Total
Supplementary Table S6. Distribution of analogous enzymes by COG category COG Analogs All EC category analyzed B N V K J O ox stress H T L M P Q F R C E I G
