Epidemiology and management of patients with acute coronary syndromes in contemporary real-world practice: evolving trends from the EYESHOT study to the START-ANTIPLATELET registry
Paolo Calabrò, MD, PhD1, Felice Gragnano, MD1, Marco di Maio, MD1, Giuseppe Patti, MD2, Emilia Antonucci3, Plinio Cirillo, MD, PhD4, Paolo Gresele, MD, PhD5, Gualtiero Palareti, MD3, Vittorio Pengo, MD6, Pasquale Pignatelli, MD7, Mauro Pennacchi, MD8, Antonino Granatelli, MD8, Stefano De Servi, MD9, Leonardo De Luca, MD, PhD8, Rossella Marcucci, MD10
1
Division of Cardiology, Department of Cardiothoracic and Respiratory Sciences, University of
Campania "Luigi Vanvitelli", A.O. dei Colli Monaldi Hospital, Naples, Italy 2
Department of Cardiovascular Sciences, Campus Bio-Medico University of Rome, Rome, Italy
3
Arianna Anticoagulazione Foundation, Bologna, Italy
4
Department of Advanced Biomedical Sciences, School of Medicine, "Federico II" University,
Naples, Italy 5
Department of Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia,
Perugia, Italy 6
Department of Cardiac, Thoracic, and Vascular Sciences, Padua University Hospital, Padua, Italy
7
Department of Internal Medicine and Medical Specialties, University of Rome “La Sapienza”,
Rome, Italy 8
Division of Cardiology, San Giovanni Evangelista Hospital, Tivoli, Rome, Italy
9
Division of Cardiology, IRCCS Multimedica, Sesto San Giovanni, Milan, Italy
10
Department of Experimental and Clinical Medicine, Center for Atherothrombotic diseases,
University of Florence, Florence, Italy.
List of Collaborators: Francesco Elia1, Veronica Amato1, Elisabetta Ricottini2, Ilaria Cavallari2, Mario Crisci4, Francesco Natale4, Maurizio del Pinto5, Tiziana Fierro5, Gentian Denas6, Alessia Bracco6, Daniele Pastori7, Tommasa Vicario7, Serafina Valente8, Anna Maria Gori8. 1: Department of Advanced Biomedical Sciences, Division of Cardiology, School of Medicine, "Federico II" University, Naples, Italy; 2: Department of Cardiovascular Sciences, Campus BioMedico University of Rome, Italy; 3: Arianna Anticoagulazione Foundation-Bologna (Gualtiero Palareti, coordinator of START Register); 4: Department of Cardio-Thoracic and Respiratory Sciences, Università degli Studi della Campania "Luigi Vanvitelli", Italy; 5: Department of Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia, Perugia, Italy; 6: Department of Cardiac, Thoracic, and Vascular Sciences, Padua University Hospital, Padua, Italy; 7: Department of Internal Medicine and Medical Specialities University of Rome “La Sapienza”; 8: Center for atherothrombotic disease Dpt. of Experimental and Clinical Medicine University of Florence.
Corresponding author: Prof. Paolo Calabrò Division of Cardiology, University of Campania "Luigi Vanvitelli" A.O. dei Colli Monaldi Hospital, Naples, Italy Email:
[email protected] Tel: +39-081-706-5289
Fax: +39-081-706-4285
Email addresses: Felice Gragnano:
[email protected] ;
[email protected]
Abstract The epidemiology and management of patients with acute coronary syndromes (ACS) have evolved. We aimed to describe recent demographics and therapeutic changes in the Italian ACS population. We analyzed data from two multicenter consecutive Italian registries (the EYESHOT and START-ANTIPLATELET registries) enrolling ACS patients between December 2013-June 2016. An overall population of 3756 patients with ACS was enrolled: 2585 in the EYESHOT and 1171 in the START-ANTIPLATELET. Compared with the EYESHOT, patients in the STARTANTIPLATELET registry presented more frequently with STEMI and were more often smokers and dyslipidemic (all p
