Mar 15, 2016 - findings show that women with PCOS have multiple transcriptional and ... Polycystic ovary syndrome (PCOS) is the most common endocrine ...
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OPEN
received: 15 September 2015 accepted: 23 February 2016 Published: 15 March 2016
Epigenetic and Transcriptional Alterations in Human Adipose Tissue of Polycystic Ovary Syndrome Milana Kokosar1, Anna Benrick1, Alexander Perfilyev2, Romina Fornes3, Emma Nilsson2, Manuel Maliqueo3,4, Carl Johan Behre5, Antonina Sazonova6, Claes Ohlsson7, Charlotte Ling2 & Elisabet Stener-Victorin3 Genetic and epigenetic factors may predispose women to polycystic ovary syndrome (PCOS), a common heritable disorder of unclear etiology. Here we investigated differences in genome-wide gene expression and DNA methylation in adipose tissue from 64 women with PCOS and 30 controls. In total, 1720 unique genes were differentially expressed (Q
