Epitopes in α8β1 and other RGD-binding integrins ... - Semantic Scholar
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Epitopes in α8β1 and other RGD-binding integrins ... - Semantic Scholar
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received: 23 June 2015 accepted: 04 August 2015 Published: 09 September 2015
Epitopes in α8β1 and other RGDbinding integrins delineate classes of integrin-blocking antibodies and major binding loops in α subunits Norihisa Nishimichi1, Nagako Kawashima1 & Yasuyuki Yokosaki1,2 Identification of epitopes for integrin-blocking monoclonal antibodies (mAbs) has aided our understanding of structure-function relationship of integrins. We mapped epitopes of chicken antiintegrin-α8-subunit-blocking mAbs by mutational analyses, examining regions that harboured all mapped epitopes recognized by mAbs against other α-subunits in the RGD-binding-integrin subfamily. Six mAbs exhibited blocking function, and these mAbs recognized residues on the same W2:41-loop on the top-face of the β-propeller. Loop-tips sufficiently close to W2:41 (
