Aug 5, 2016 - Raoul V. Kuiper, Leander Blaas, Mattheus C.B. Wielenga, Sven Almer, Anja A. Kühl, Erik Fredlund,. Gijs R. van den Brink & Rune Toftgård.
DOI: 10.1038/ncomms12936
OPEN
Erratum: Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth Marco Gerling, Nike` V.J.A. Bu¨ller, Leonard M. Kirn, Simon Joost, Oliver Frings, Benjamin Englert, Åsa Bergstro¨m, Raoul V. Kuiper, Leander Blaas, Mattheus C.B. Wielenga, Sven Almer, Anja A. Ku¨hl, Erik Fredlund, Gijs R. van den Brink & Rune Toftgård Nature Communications 7:12321 doi: 10.1038/ncomms12321 (2016); Published 5 Aug 2016; Updated 13 Sep 2016 In Fig. 6f of this Article, the labelling of the two immunohistochemistry images was inadvertently changed from ‘Haematoxylin, ki67’ to ‘Haematoxylin, Casp-3’ during the production process. The correct version of Fig. 6 appears below as Fig. 1.
NATURE COMMUNICATIONS | 7:12936 | DOI: 10.1038/ncomms12936 | www.nature.com/naturecommunications
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ERRATUM
NATURE COMMUNICATIONS | DOI: 10.1038/ncomms12936
Ptch1ΔCol1
c
Tumour vaw
AOM
US US US ... lu
DSS DSS DSS Week 0
ub
ca 10 +1 +2 +...
TAM 1x luminal
DAPI, beta-catenin
d
Tumour volume after Tam
* *
150
Tumour Tumour volume in mm3
b
Col1a2CreER; tdTomato
a
*
100
* 50
0 0
Cleaved caspase-3
Haematoxylin, Casp-3
Haematoxylin, Casp-3
**
100
Control
Signals per HPF
150
1 2 3 4 5 6 Weeks after Tam administration
Ptch1ΔCol1
e
Controls Ptch1ΔCol1
50 0 Controls Ptch1ΔCol1
f 100
Haematoxylin, ki67
Proliferative index
Haematoxylin, ki67
* Ptch1ΔCol1
60
Control
% of nuclei
80
40 20 0 Controls Ptch1ΔCol1
g
TOPRO-3, Grem1
TOPRO-3, Grem1
p-smad1/5
Haematoxylin, p-smad1/5
Haematoxylin, p-smad1/5
**
80 60
Ptch1ΔCol1
100
Ptch1ΔCol1
7
Controls Ptch1ΔCol1
Control
DAB intensity(bit), epithelium
5
3 2 1 0
Control
50
0
h
**
100
ISH grading
% of tumours
Grem1 mRNA
40 ΔCol1 Controls Ptch1
Figure 1
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NATURE COMMUNICATIONS | 7:12936 | DOI: 10.1038/ncomms12936 | www.nature.com/naturecommunications
