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Electronic Supplementary Material (ESI) for Journal of Materials Chemistry B This journal is © The Royal Society of Chemistry 2012

Electronic Supplemental Information (ESI)

Title Biologically Responsive, Sustainable Release from Metallo-Drug Coordinated 1D Nanostructures

Authors Naohiro Kameta,* Soo Jin Lee, Mitsutoshi Masuda and Toshimi Shimizu


KOH 1.2 g (21 mmol)

Conc. HCl

EtOH / Water 2.3 g (12 mmol, 59%)

4.7 g (21 mmol)

NEt3

0.9 g (12 mmol)

DMF

3.2 g (9.1 mmol, 76%)

5.0 g (12 mmol)

Pd/C, H2 MeOH

DMT‐MM (1.5 eq.)

(1.0 eq.) MeOH

KOH 1.2 g (21 mmol)

Conc. HCl

EtOH / Water

2.1 g (5.5 mmol, 61%)

Figure S1. Synthetic scheme of the ligand.

(a)

(b)

100 nm

100 nm

Figure S2. TEM images of the (a) 1-nanotubes and (b) 2-nanotubes, which were negatively stained with phosphotungstate. The nanochannel of the nanotubes is visible and is characterized by a relatively darker contrast to the background. 2


(a)

(b)

400 nm

100 nm

Figure S3. TEM images of the (a) 1L3-nanotapes and (b) 2L3-nanotubes, which were negatively stained with phosphotungstate. The nanochannel of the 2L3-nanotubes is visible and is characterized by a relatively darker contrast to the background.

+

673.21

Figure S4. ESI-MS spectrum of the Pt-2L3-nanotube.

2L3-nanotube + Aqueous DACH-Pt



Pt-2L3-nanotube

A = [Pt-2L3-nanotube] + tube[2L3-nanotube]   C   C  1  1 Pt   1 tube  

1C tube  1CPt  12  412C tubeCPt     tube    tubeC tube  21



: Molar absorptivity of Pt-2L3-nanotube

Ctube : Total concentration of 2L3-nanotube

tube : Molar absorptivity of 2L3-nanotube

CPt : Total concentration of aqueous DACH-Pt

Figure S5. The general equation of the stability constant (1) derived from the apparent absorbance (A) and total concentrations (Ctube and CPt) of the 2L3-nanotube and aqueous DACH-Pt. 3


(a)

(b)

400 nm

100 nm

Figure S6. TEM images of the (a) nanotapes and (b) nanotubes after release of the DACH-Pt, which were negatively stained with phosphotungstate. The nanochannel of the nanotubes is visible and is characterized by a relatively darker contrast to the background.

Absorbance

(a)

300 310 320 330 340 350 360 370 380 Wavelength / nm

(b)

⊿ Absorbance

Pt-1L3-nanotube

Pt-1L3-nanotape

0

10

20

30

40

Time / h

Figure S7. (a) The absorption spectral change of the Pt-2L3-nanotube and in the phosphate buffer saline from 0 (black line) to 40 h (red line). (b) Time dependence of the variation of the absorbance at 343 nm. 4