Jun 9, 2011 - Treatment of toothace, fungoid dermatitis on the feet, coughing asthma and pleurisy; lowering blood glucose level. (Rukachaisirikul et al., 2004).
Journal of Medicinal Plants Research Vol. 5(23), pp. 5555-5563, 23 October, 2011 Available online at http://www.academicjournals.org/JMPR ISSN 1996-0875 ©2011 Academic Journals
Full Length Research Paper
Evaluation of anti-inflammatory, antioxidant and antinociceptive activities of six Malaysian medicinal plants K. H. Lee1, A. M. Padzil1,2, A. Syahida1,3*, N. Abdullah1,3, S. W. Zuhainis1,3, M. Maziah1,3, M. R. Sulaiman2,3, D. A. Israf2,3, K. Shaari3,4 and N. H. Lajis3,4 1
Faculty of Biotechnology and Biomolecular Sciences, 43400 UPM Serdang, Selangor, Malaysia. 2 Faculty of Medicine and Health Sciences, 43400 UPM Serdang, Selangor, Malaysia. 3 Institute of Bioscience, 43400 UPM Serdang, Selangor, Malaysia. 4 Faculty of Science, 43400 UPM Serdang, Selangor, Malaysia. Accepted 9 June, 2011
The anti-inflammatory, antioxidant and anti-nociceptive properties of six Malaysian medicinal plants, including Carica papaya, Musa acuminata, Oenanthe javanica, Piper sarmentosum, Psophocarpus tetragonolobus and Sauropus androgynus were investigated. The anti-inflammatory effects of the methanolic plant extracts were evaluated by using Griess assay on nitric oxide inhibitory activity upon IFN-γγ/LPS stimulated RAW 264.7 cells. The antioxidant property and total phenolic content of the plant extracts were determined by using DPPH radical scavenging assay and Folin-Ciocalteu’s assay, respectively. Anti-nociceptive activity of the plant extracts were evaluated by measuring the number of writhing response of mice upon acetic acid induction. All plant species showed significant nitric oxide (NO) inhibitory activity (IC50
