1Department of Pharmacology & Toxicology, University of Benin, Nigeria ... pyramidal side effects (Rang et al., 2007; Meltzer,. 2009). ..... Rang and Dale's.
Nigerian Journal of Pharmaceutical and Applied Science Research, 4(3):19-25, December 2015 Evaluation of Antipsychotic Properties of Aqueous Extract of Lophira alata (Ochnaceae) and Afzelia africana (Leguminosae) Stem Barks in Rats Loretta O. Iniaghe1*, Mohammed G. Magaji2, Ogbonnaya Nmeka1 Department of Pharmacology & Toxicology, University of Benin, Nigeria 2 Department of Pharmacology & Therapeutics, Ahmadu Bello University, Zaria Nigeria 1
ABSTRACT Stem barks of Lophira alata (family: Ochnaceae) and Afzelia africana (family: Leguminosae) are used in ethnomedicine for the management of psychosis. Since no existing data was found on their anti-psychotic properties, this study was carried out to evaluate their ability to reduce amphetamine induced stereotypy in rats. The oral mean lethal dose (LD50) of both extracts was estimated and preliminary phytochemical screening was conducted. Lophira alata and Afzelia africana extract (6.25, 12.5 and 25 mg/kg po) was investigated for antipsychotic potential on amphetamine induced stereotypy model in rats. The LD50 of each of the plants was estimated to be greater than 5000 mg/kg. Oral administration of Lophira alata and Afzelia africana extract produced a significant reduction (p
