Chun TW, Murray D, Justement JS, Hallahan CW, Moir S, Kovacs C, Fauci AS. Relationship between ... Bregigeon S, Dignat-George F, et al. Lack of correlation ...
Falasca et al. BMC Infectious Diseases (2017) 17:581 DOI 10.1186/s12879-017-2676-2
RESEARCH ARTICLE
Open Access
Evaluation of HIV-DNA and inflammatory markers in HIV-infected individuals with different viral load patterns Francesca Falasca1, Daniele Di Carlo1, Corrado De Vito2, Isabella Bon3, Gabriella d’Ettorre2, Alessandra Fantauzzi4, Ivano Mezzaroma4, Caterina Fimiani5, Maria Carla Re3, Vincenzo Vullo2, Guido Antonelli1 and Ombretta Turriziani1*
Abstract Background: Persistent residual viremia (RV) and low grade inflammation and immune activation have been associated with non-AIDS defining events. The impact of persistent RV and HIV-DNA load on immune activation/ inflammation remains unclear. The purpose of this study was to gain new insights into the relation between viremia, markers of inflammation and HIV-DNA levels. Methods: Three hundred and twenty-one HIV-infected patients were studied. A retrospective analysis of viremia values, prospectively collected for 48 months, was performed. Patients were separated into three groups: 113 TND (Target Not Detected, patients with sustained undetectable viremia); 113 RV (Residual Viremia, patients who had at least three detectable viral load (VL) values 37 but
