Expression levels of the long noncoding RNA steroid receptor
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Expression levels of the long noncoding RNA steroid receptor
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ONCOLOGY LETTERS 16: 5410-5418, 2018
5410
Expression levels of the long noncoding RNA steroid receptor activator promote cell proliferation and invasion and predict patient prognosis in human cervical cancer HEE JUNG KIM1*, LEE KYUNG KIM1*, SAN‑HUI LEE1,2*, SUN AE PARK1, KYUNG JIN EOH1 and YOUNG TAE KIM1 1
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Institute of Women's Life Medical Science, Yonsei University College of Medicine, Seoul 03722; 2Department of Obstetrics and Gynecology, Yonsei University Wonju College of Medicine, Weonju, Gangwon-do 26493, Republic of Korea Received February 7, 2018; Accepted July 26, 2018 DOI: 10.3892/ol.2018.9265
Abstract. Long noncoding RNAs (lncRNAs) are involved in developmental processes and diseases and function as critical regulators of a number of different cancer types. Previous research has revealed that lncRNAs affect cervical cancer development. Steroid receptor activator (SRA), an lncRNA, serves as a critical regulator of gynecologic cancer. However, the association between SRA expression and cervical cancer remains unclear. In the present study, the SRA expression levels in patients with cervical cancer were examined and the association between SRA expression and clinicopathological factors was determined. SRA expression was observed in cervical cancer tissues (n=100) and corresponding normal tissues (n=22) using reverse transcription‑quantitative polymerase chain reaction, and its associations with clinical parameters and prognosis were analyzed. SRA expression was significantly greater in tissues from patients with cervical cancer compared with in control patients (P
