Nogo isoforms belong to the superfamily of proteins called reticulons (RTN), which exert various biological functions strongly dependent on their localization (4, ...
ANTICANCER RESEARCH 34: 4059-4068 (2014)
Expression of Nogo Isoforms and Nogo-B Receptor (NgBR) in Non-small Cell Lung Carcinomas BARTOSZ PULA1, BOZENA WERYNSKA2, MATEUSZ OLBROMSKI1, BEATA MUSZCZYNSKA-BERNHARD3, MARIUSZ CHABOWSKI4, DARIUSZ JANCZAK4,5, MACIEJ ZABEL1,6, MARZENA PODHORSKA-OKOLOW1 and PIOTR DZIEGIEL1,7*
Departments of 1Histology and Embryology, 2Pulmonology and Pulmonary Tumors, 5Clinical Proceedings, Medical University, Wroclaw, Poland; 3Laboratory of Histopathology, Lower Silesia Centre of Pulmonary Diseases, Wroclaw, Poland; 4Surgery Department, 4th Military Teaching Hospital, Wroclaw, Poland; 6Department of Histology and Embryology, Medical University, Poznan, Poland; 7Department of Physiotherapy, Wroclaw University School of Physical Education, Wroclaw, Poland
Abstract. Background: Nogo-B was recently shown to be involved in proliferation, apoptosis and invasiveness of cancer cells, whereas its specific receptor (NgBR) was found to be up-regulated in estrogen receptor-α positive breast cancer. No data are currently available concerning their expression in non-small cell lung carcinomas (NSCLC). Materials and Methods: Expression of Nogo isoforms and NgBR was studied in 191 NSCLC. Results: Higher Nogo-A/B immunoreactivity was noted in cancer cells of squamous cell carcinomas (SQC) compared to adenocarcinomas (p
