in a single comprehensive haemophilia centre over three decades is reported. ..... Hay, C.R.M., Ludlam, C.A., Colvin, B.T., Hill, F.G.H., Preston, F.E.,. Waseem, N.
British Journal of Haematology, 1999, 104, 909–914
Factor VIII inhibitors in haemophiliacs: a single-centre experience over 34 years, 1964–97 T. T. Y EE , K. J. PASI , P. A. L ILL EY AN D C. A. L E E Katharine Dormandy Haemophilia Centre and Haemostasis Unit, Department of Haematology, Royal Free Hospital, London Received 27 April 1998; accepted for publication 11 December 1998
Summary. A retrospective study of the natural history of factor VIII inhibitors in haemophilia A patients experienced in a single comprehensive haemophilia centre over three decades is reported. 431 haemophilia A patients of all severities have been followed-up for a total of 5626 patientyears. The frequency of inhibitors was 10% in the severe haemophilia A patients and 37% occurred in children 5 BU) or low responder (200
