RESEARCH ARTICLE
Factors Associated with Streptococcal Bacteremia in Diarrheal Children under Five Years of Age and Their Outcome in an Urban Hospital in Bangladesh Abu Sadat Mohammad Sayeem Bin Shahid1, Tahmeed Ahmed2, K. M. Shahunja2, Senjuti Kabir1, Fahmida Chowdhury1, Abu Syeed Golam Faruque2, Sumon Kumar Das2, Mohammad Habibur Rahman Sarker2, Pradip Kumar Bardhan2, Mohammod Jobayer Chisti2*
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1 Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh, 2 Nutrition & Clinical Services Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh *
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OPEN ACCESS Citation: Shahid ASMSB, Ahmed T, Shahunja KM, Kabir S, Chowdhury F, Faruque ASG, et al. (2016) Factors Associated with Streptococcal Bacteremia in Diarrheal Children under Five Years of Age and Their Outcome in an Urban Hospital in Bangladesh. PLoS ONE 11(5): e0154777. doi:10.1371/journal. pone.0154777 Editor: MD A Motaleb, East Carolina University Brody School of Medicine, UNITED STATES Received: July 25, 2015 Accepted: April 19, 2016 Published: May 2, 2016 Copyright: © 2016 Shahid et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: Institutional Review Board (IRB) of the International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) has restrictions to disclose any personal information of the patients, and on the basis of this recommendation by the IRB, the Research & Clinical Administration and Strategy (RCAS) of icddr,b has imposed these restrictions. However, it is confirmed that the part of data set related to this manuscript is available upon request and readers may contact to Armana Ahmed
Abstract Background Although Streptococcal bacteremia is common in diarrheal children with high morbidity and mortality, no systematic data are available on Streptococcal bacteremia in diarrheal children. We sought to evaluate the factors associated with Streptococcal bacteremia in diarrheal children under five years of age and their outcome.
Methods We used an unmatched case-control design to investigate the associated factors with Streptococcal bacteremia in all the diarrheal children under five years of age through electronic medical record system of Dhaka hospital of International Centre for Diarrhoeal Disease Research, Bangladesh. We had simultaneously used a retrospective cohort design to further evaluate the outcome of our study children. All the enrolled children had their blood culture done between January 2010 and December 2012. Comparison was made among the children with (cases = 26) and without Streptococcal bacteremia (controls = 78). Controls were selected randomly from hospitalized diarrheal children under five years of age.
Results Cases had proportionately higher deaths compared to controls, but it was statistically insignificant (15% vs. 10%, p = 0.49). The cases more often presented with severe dehydration, fever, respiratory distress, severe sepsis, and abnormal mental status compared to the controls (for all p
