Figure S2. - Plos

Klac_RPS9 Scer_RPS9A Egos_RPS9 Kthe_RPS9 Lwal_RPS9 Cgla_RPS9A Cgla_RPS9B Vpol_RPS9A Vpol_RPS9B Zrou_RPS9 Lklu_RPS9 Ncas_RPS9A Ncas_RPS9B Sbay_RPS9A Sbay_RPS9B Scer_RPS9B

1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

ATGCCAAGTATGTGGTATCACATTCCAGATATGCTTCATTGATACACTCTGTTACATTTCAAGTCTTTCCTTTGGATTGTCTAGAGATGGGGAAGATAATGCCAGCATCA ATGCCAAGTACGTCGTTAATC-------------------------------------------------TTCTCCTTTTAAGGGGTTGAGAATATTTTTATTAAAA--ATGCCAAGTACGTA--------------------------------------------------------TATGACATGCGCAGCGAGCGCAGAGCGGCCGGG------ATGCCAAGTACGTATTAACATC---------------------ACAACAGATGCCATGCATCCTAACGGATGCAGGGCGTCGGAAGAACGAGTTGCACTTGTGC-----ATGCCAAGTACGTATCAGCATTATGCACAGGTGTCATATCGTTCCATTGGGC------------------GATAAGATGCCGGGAGATGTGGTTACTGTTTAGCTTCTGA ATGCCAAGTATGTGCTAATATGGACA-----------------CCACTCTAA------------------AGTGGAATAACTGAAAATGAGAATTGCACTTATATGAGGA ATGCCAAGTACGTTACACTAATTTATGATAATAGATAAGCAACACCTGCTTT------------------CTAATAATTTCTAAGCATGATAGTTATCTATCTTTTGCTC ATGCCAAGTACGTAT----------------------ATCAAGTTATTCCACTTCA--------------TTCTATATCATACAGATTGATAGTTATGTTTGGTTTTTAATGCCAAGTATGTTATAATTATTAATT-------------------------------------------TTTCAAAGTATATATATATAAATTGGTATATTTATTATCA ATGCCAAGTACGTTACAAATATG--------------------------------------------------------------------------------------ATGCCAAGTACGTATTAACAATAACCACAGACTTACCTTTCCCATGCTCACT------------------TGTGAATTTGGGAAAGGTGGAGATGAGGTCATATCAAT-ATGCCAAGTACGTTAT---------------------------CCAATTAAC----------------------------AAACAAAGAAGGATACTATA---------ATGCCAAGTACGT------------------------------------------------------------------------------------------------ATGCCAAGTACGTTATTCATC-------------------------------------------------TTATCCTTTTAAAAGGAAAAAGATAAATTTTACGCAATAA ATGCCAAGTACGTATTA-----------------------------------------------------CACCCCATCGGGAAAATGAAAGATAGTTCAATCTCTC--ATGCCAAGTACGTATTA-----------------------------------------------------GACTATATCGAAGAGGAGGGAAATTCTTC----------Met 5’ss


111 59 48 84 93 76 93 74 68 24 91 46 14 62 55 47

GCT----------------AGCTTAAATCTTC-----------------CTTCGAGGA--TCGGGTC---CTCATGATTCAAT-----------TAAAT-----------------------------AATCATACTTGCT-------------ATGATTTTGAGGA--TCGGGTC---CTCA--------------------TAAAT----------A -------------------AAACCGGCGCTAG------------------CCTTAGGT--TCGGGTCCTTCGCG------------------------------------------------------AATACTCTTCTTT------------------TTCGAGGA--TCGGGTC---CTCA--------------------TGAAT----------ACAA---------------AACTCATCTCTTT-------------------TCGAGGA--TCGGGTC---CTCA--------------------TGAAT----------AATGAATTGAGAAATTGAAAAATTGAATAAATGAGAAATTGAAATGAAATATAGAGGTGCTCGGGTCCCTCTCATGAAACGATTTGATTTGATATGAAT-------ACCA TACAATTGTAGGGCATTGGACAGGTTATCTTT-------------GAATGCTAGAGGT--TCGGGTC---CTCATTTACAAACTAGATGATACGTTATTTGTTCATCTCA -------------------AATAAAAACCTTT--TACATACCTAGTGTATATAGAGGT-TTCGGGTC---CTCATGATCAT-------------TGAAT----------AATCAAATTGGAAATTCTCATTACGATTATCT----------------CCAATGAGGT--TCGGGTCCTCCTTT--------------------TCATT-----------------------------AATCAAGACCATT-----------TATGGTCTTAGAGGT--TCGGGTC---CTCA--------------------TAAAT-----------------------------GACTCTTTTCTCT------------------TTTGAGGT--TCGGGTC---CTCA--------------------TGAAT-----------------------------AATTGTATTCCTT--------------------CGAGGT--TCGGGTC---CTCA--------------------TAAAT-----------------------------ACCCCAAATCAAG-----------GAATGATTCAGAGGT--TCGGGTC---CTCA--------------------TAAATGATTAATGAGT A------------------AGTCATATACACT-----------ATATGACTTTGAGGA--TCGGGTC---CTCA--------------------TAAAT----------A -------------------AATCCAATTTCTT---------------TAAGAAGAGGT--TCGGGTC---CTCA--------------------TAAAA----------T -------------------ACTCTGACTCGTT-----------GATTTTGAAAGAGGT--TCGGGTC---CTCA--------------------TAAAT----------A Conserved stem-loop 2 ((((( ]]]]]))...)))


161 102 83 121 133 179 185 135 129 68 128 81 69 108 96 92

---------------------------------TATTGACTCAAAGTATTTCAAGTACTGA---TATTCGATTTGC-AATCTAAACTGTTTCAT-------TTGTTCCTTTTTGAAGAGCCTTTGTTGAATTTTT--------TTCTTTTCGTTTTGTTCAATAATGGAC---GGTTCTT--------CATAGAATACTTTTT-------TTTTCGGAG -----------------------------------------------GTTCGCCG----------------------CACTCTGCCCCCACGCC--------------------------------------------------------------ATTT----------------------------CTATACCTTCTCAAT-------GTCAAGCCG -----------------------------------------------ATTT----------------------------CTTCAAACTATCTCT-------GTCAAGCCG TTGAGGAATA-------TGAATATACTATCCGCAATATAGCTTACACCTTCACTAAGAGAC---TTGTTTCT-----AGAAGAATGTTTCTGAT-------TACACACTA TTTGAGATATCAAATTTTCATCA---------------ATCCTTTTCGTTTGTACA--------ACTTTTTTCTCCTCAGTAAGGATACTCATT-------TATATTTCA -------------------------------------TATTCAATACCTTTAAAGATTTTT---TGTTATTTTATCAGATTTGAAACTTGTTTT-------TATGTGTTC -----------------------------------------------CTTCATTAAAGAGCAACTT-----------CATTTCAAATTATTTATGATATTGTTGAAATTA ------------------------------------------------GTTAGAGAATCAA----------------CAATTAAAGCAAGAAAC-------TGGACACAA -----------------------------------------------ATTCAAAGAA---------TCTGAGAAGAGAATTTCAAATCTTCAAT-------CCAAATTGA ------------------------AATAAATTGACAACAAGTCATTTCTTCCATGAGTCAA---TTTCTAAA-----AACTAAAAATACAATCT-------AGAATTTTA TTTGAAATGAGAAAAGTAGAGAAGAA-----------------------TCACAGACCTACGCATGATTAAAGCGGACATTTAAAACACATTAT-------TTCAAATTG TTTGAAAGAGCTTTCGTTGAAATTAA----------------ATCATTTTCAAATAATGAA---CGATTCTT-----CGCCTGATACTTTTATT-------TTGGAAATA TATGAGAATATGAAATTAAAACACAC------------ATTCAAAACCTCCACCGAC--------------------AGACTGAAATACTTTCT-------ACCTTAACT TTTGAGAATATGAAATTCCATAATAG----------------TATACCTTCATTGAGTAGC---ACGACAAC-----AGCCTGAATTACTATCC-------ATATTATGA


226 186 108 149 161 267 265 198 181 107 175 152 149 187 167 171

--------------------------------TGTCGTTGAAAACCCGACACTTCAGCTCAAGGATAGAAACATTTTAATGCAAATCAATAAGAGCGAGAGCTCTTATTT AAAACCT-------------------------TTACACTGAACTCCCGACACTTCAGGT--------AAAGCGTTCCGAAGTAATTCAACATTAGAAGAGGAACATTTCC ----------------------------------GCACTGGAAACCCGACACTCCAGTG--------------------------------------------------ACACCTTGCTGGATACGCTT------------TTACTCTGAAAACCCGACACTTCAGGT--------AAAAGTACCA--GCTACACTGGTGCCTGCCGAGCTTGCTCTTACATATCTC-----------TGGCCTTACTTTTTGCACTGAACACCCGACACTTCATGC--------AAATAGTGCCAGTATTTCATTAGGACTGTCTG------TTTCA CTGTACACA-----------------------GTACGCTAAATTCCCGACACTTTAGTC--------GTACTATCAT--CTT--AATAGCATGGGCCTA------TTTTT ATCGGAATGTAAGAAGTATCTTCTCTTTGGTTTGGCACTGAATTCCCGACACTTCAGGT--------CAAACATT-------------ATAACTACAGTATCTGTTTTTG ATCTTTA-------------------------TTGAATTGAACTCCCGACACTACAATT--------------------------------------------------CTATATGCAT----------------------TTGCACTGAACTCCCGACACTACAGGT--------AAATGTTGTA---------------------ATTTCACTTTCT AAAGAT--------------------------TTCGTTTGAAAACCCGACACTTCAAAC--------GAAATTGTCC--------------------------------TTGTACC-------------GTGGAATTATTTCTGCACTGAACTCCCGACACTTCAGGC--------AGAAACTCCA--------------------------------TC------------------------------TTTTACTGAATTCCCGACACTTCAGAT--------AAAGATATTC--TAGAGCTGACTTTATGTCAAATTGTATTTTT AATAGTTTTG----------------------TTTCACTGAATCCCCGACACTTCAGTAAAT-----GAAACTTTTC--GTTCTATGAATTTGAAATGTGTTGACTTTTC TAATCT--------------------------TTGCACTGAATTCCCGACACTTCAGGT-------AAAGTTTTTCCAAATCCTTCCAACATTTGTAGCATTCACCCCCT ACATCTTTAT----------------------TTACACTGAACTCCCGACACTTCAGTTAAA----AGAAAGATGTAGCAAACAATTAAGGTGATTCATGCGGACTTTCC ATATCTTTAT----------------------TTACACTGAACTCCCGACACTTCAGTT--------AAACA-------------------------------------Conserved stem-loop 4 ((((((..[[[[[..))))))


304 263 133 236 246 336 354 232 240 150 231 222 230 264 251 213

AGTAC----TGTATGAATTAACACCTCATTCTGTTGTCAATTGACCCACAGAATGGACTTCGTTTTTTTCAGTTATACTTCTTTTTTGTTCATGTGTTTTCATGTTCTTA CCAGT------------------TCTGATTATGTCTGTTGAAGATAACTCAAGTATTCTAGGCTTAA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CAGGCCCGGTTATTGTCATCTGGACTGCAATT------------------------------------------CAGGCACTTCTGTTGAAATTTGAAAGTCAAAGCCGAAAGGTTGCGTTTTCAAGTCGTGCTTATTGTG------------------------------------------CTTCT----CGGGAGAATTGAGGTTCTTTTAGCTTCCAAGATGACTATGGTAGTGTAATCTGCCTCTGTATGTTACCACTTTTGGTTATGTACATAGTACTGAATGTTCA CTACTGCAGTGAGAGGTTTTGAGGATTTCTTAATACAGGATGTGTTAATGTCACTAGGTTGCTTTAG--------CTATTCCGTTTTTAAGATAGAAAGTTAATGAACGA --------------------------CAATTATTTTAAGAAATATTTATGTCACACTCCCCCCTGTC------------------------------------------CTAGT--------------------TTATTAAATATGAGCTAGAGACGTATCATGTTGAAAATTTTT-------------------------------------------------------AGTAATTGTGATACTGTTACTTTAA---TGGTTATCATGATGTCTTGTGCTAAT------------------------------------------------CAGCTTTAATCATGAGACTTCTTGTTTTGTGATGCTGCTCAAAAGAAACTTTCTTTTTTTT------------------------------------------ATCAT-----TTTAGTGATTACATACTCATTTTGTTCATATCTTTTGACAATTTGTAATAAACCAAT------------------------------------------CCGTT---------------------TTTCAAAGTTGAGGCTGGATTTTCAAGCATTTTTCTTCTTT------------------------------------------TCTAG---------GGGGTTGTCCTTTTACATTGTTGGTTGGAAGTATTTGAGCTTGATACAATTAT------------------------------------------AAAGA----------------------CGTCTCTTTGGAGAGAATGAAAAGAGTATTTCATCCCTGT-------------------------------------------------------------GGGATACATTAGAGATCAAGGTGATCTAATAGGGAACATCTCTCTCGT-------------------------------------------


410 312 133 268 313 442 456 273 287 201 292 284 276 322 296 261

AATGTTTGATGTGTCAATAGTTTAATGTTTCATGAGTAGATATTATATCGC------CCGTTTGTATATCCTCGT-------------------------------------------TACAGAAATGTGTTAGGTTTGAGAACTCCATCATGGA-----------TTATGCATATTCGTCAGT---------------GACGTGCACAATTCTTTTGA ------------------------------------------------------------TGCGCAGGCCTCGGC--------------------------------------------CAGTCAGAATCCAGATACAGTCGCGCTTGTTAT--------------GGACCTCTAGCCCTGACT-------------------------------------------GGTATCTGCATTTTATATG-----------------------------CAGAGCCTACATGCAGGA----------------------------------CTTGAAAAATTTAGAATCATAGTGTAAAGGTGATACTAGCTGTTTTGCGATT-----TGTAATTTGTTTCCTAGTATATGGTATTTAATCGTCTTAGTCTTTCATGGGTG GTTAATCATTTGGTAAATATTTTATGCAGACATGATTCATTACACTGATG-------AAATGCCTGAACATTGTT-------------------------------------------------------------------------------------------TCAGGCATAGAACACGTT-----------------------------------------------GATATATACCTATTGAATGGAATGTACAATTCTGA---------TCTAACTTATTTATAAGT-------------------------------------------------AGCATGTTGATT------------------------------------------------------------------------------------TGGCAGCAGCTACAGCGTGCTATTCAATTTGTGCTGGCTCCTCTATTGCCAGGTTGAAGATTTCACTTTCAAT-------------------------------------------GGGGACGGTGTCCCAATTGGCCTAAACTTATT----------------GAATGTGAAGATCTTGAA------------------------------------------------------------------------------------------------TCTAGACTCCATT-----------------------------------TTGTATCAGGTAGAAGAACTCTGTTCATGTACTATGGACGAACGC-----------CTCACCGTGTTAACCATT----------------------------------------------AGGCGGATACTGAATTAT---------------------------GCGTTCTTAACCACCATA--------------------------------------AACAATGGGACAGTATTTTATTTTC----------------------------CAAGGCGGATACCTAATT-----------------------------------


479 387 148 319 350 547 524 291 340 213 365 334 289 385 332 304

-------AGTGCAGTGATCTTTGGATTTTAGTATCAGATATATTGGGGACAACGAGTACATATGTGC------------------------------------------AGATAGGAAGAACAAAACTTCAATAATTGCTTTAATAATAT--------TTATGTAGTGA--------------------------------------------------------------------------------------------------CAGTGGGCGGCG--------------------------------------------------------AGGGTCCAGTCTTTGAGATTGTCAGAACAATAT--------TCATGAGTAAACTGTA------------------------------------------------------------------GATGGTATCGAAAAAGTAT--------TCATGAGTAGATTGTA--------------------------------------------TAGAAATCGTTTTGGATCCGTAGTATATGAATTCATGATATATGG----TTATAAATCCATAGCAAGTTGAAATTCATCACTTCTGTAGTCATCGTTGAAGCTATTTCTT -----------TACTTGGTGTAAGGGTTGATGAAAAAATTTTTGA----TCATGAACAGTAATATCA---------------------------------------------------------TCAATTAAGAATCTCCTTTGAATTAT--------TTATGATTGTATGGACC-------------------------------------------------------GATAAGTGTTGCACGTCCCTTTTAAATTTCAATAGTACGAAGTTGACCTATCTCTTAAAGTTGAATGTCTGT----------------------------------------------------TGATTCTCTAGTGT--------TTATGTGTGCACC--------------------------------------------------------TTATTGATGCTCTTTACTCAGCTCCAGTATAT--------TCATGAGTACATAAAC--------------------------------------------------TGGAGCAAATGCCCTTGTTCTCGTCAACTTATTAT--------TTATGCACTGACCCA---------------------------------------------------------------------------------AATATTTT-----ATATGAGTACCT----------------------------------------------------GATGAAGAATGATATTCAACAAGCGCCTTTATAATAT--------TTATGTACTGA------------------------------------------------------------------------------TCTCTGTTATAT--------TTATGAGCACTT------------------------------------------------------------ATGCGTTTTTAATCATATCTCTACAATAT--------TTATGAGCACTTA------------------------------------------------


539 439 160 368 385 653 576 334 412 240 413 384 309 433 356 346

-----ACGTGAGTTTTA--------------------------------CAATTATTTTGAATA--------------------------------------------------TCTTGATCCTCG--------------------------------CATTCGTTTGAAAAAGAGAG---------------------------------------------GCGCGAAGGACG--------------------------------GGACCGACTGGACGCGGC-----------------------------------------------GCCCGATCTTCG--------------------------------TAGCCTGTTC-------------------------------------------------------GCCCGTTCCTCG--------------------------------TAGTTATTGTTCATCTGAAC----------------------------------------GGAGATTTCGAACCTCAATCACGACACACATATTTTACTGTGCAGTTATTACTCATTTTCCT---------------GAGATATATTTCCATGGATCA----------------TCTGTAGTCTAGTTAATGGAGACCCG------------------TAGAACTTCTTATTTAGGAATTGTTAGCAGAAAAAATTGTCTGAACTAT----------------TCTTGAACCTCTTTGCAGCA------------------------TAACTTCATTCTTGTATATGTATATACCATCACCACTCCCCTCCACAACTCAAGTGTTCAT -----TTTGGACCTTTG--------------------------------TAACCTCTTGATATCAATTAGCCAAATAGTGTAATTTAATGC-----------------------TCTTGAACCTCG--------------------------------TAAAACAATTGAATA--------------------------------------------------CCGTAAACCTCG--------------------------------TAGCATTAAGAATAT--------------------------------------------------TCTTGAACCTCG--------------------------------TAATTTTTTCTTTCAGTTAAGAATTA---------------------------------------TCTTGAACCTCGTAGAAATCTCCATTGTTTTTTTA---------TTGCCATTTGAAACAAG------------------------------------------------TCTTGATCCTCA--------------------------------TTGCCCTTTATGCAAAAAGAGAG------------------------------------------TCTTGAACCTCT--------------------------------TGCACTATTTTTTACAAAGAAAC------------------------------------------CTTGGGCCCTTG--------------------------------CAGACTTTTGTTCCGGGAAAAC---------------------------------------


566 471 190 390 417 736 651 415 466 267 440 422 361 468 391 380

-TTTTCACTAACAAGAAATTA-----------------------------------------------------------------------------------------CGCTCACTAACAA-------------------------------------------------TGGTTGTAATTAT----------------------------------CAGTAACTAACT-------------------------------------------------------------------------------------------------TTAAAACTAACA-------------------------------------------------------------------------------------------------CCATCACTAACG-------------------------------------------------------------------------------------------------AGTTTACTAACAGTTAATGCCTTTTCGAAAATAAAGC-------TATGTTTTATGAGGTACATTGGTTGATTTGTAACGTTTGTTGCGGATACGATCTACACTACACAT -TTTTGACTAACACTTTATTTATACTTGTATGATGTGAGATTGTGTCTATTTGTTGAAGTGTTTTCTCTCACTTTTATCCTGAGCGTGATGCCGAATCAATAGCGATCTA TTTTAAACTAACAACATCAACTTTT--------------------------------------CCATTTAATTT------------------------------------ATTTGACTAACA--------------------------------------------------TAAATTAATCATCACA-------------------------------TGTTAACTAAC--------------------------------------------------------------------------------------------------TTGTATCTAACAA------------------------------------------------------------------------------------------------TTTAAACTAACA--------------------------------------------------TCATTT-----------------------------------------CTGGGACTAACAATTTAAT-------------------------------------------TTTTTTAATTTTT----------------------------------CACTCACTAACAAAA-----------------------------------------------TGATTTAATTAT-----------------------------------TTTTGACTAACAAGT-----------------------------------------------TTATTTCATTATCTGTTTTT---------------------------TTTTGACTAACAAGAATC--------------------------------------------CAATTTTACTT-----------------------------------branchsite


586 497 202 402 429 838 760 451 494 278 453 440 393 495 426 409

-------------------TTATC-------------CAAACAGGAGCCCCAAGAACTTACTCCAAGACTTACTCTACTCCAAAGAGACCTTACGAATCCGCTCGTTTGG -------------------CTTGT-------------AAAACAGGAGCCCCAAGAACATATTCCAAGACTTACTCTACCCCAAAGAGACCTTACGAATCTTCTCGTTTGG -------------------------------------CGAGCAGGAGCCCCAAGAACCTACTCCAAGACGTACTCCACGCCAAAGAGACCATACGAGTCTGCGCGTCTAG -------------------TCCTT----------------TCAGGAGCCCCAAGAACCTACTCTAAGACTTACTCTACCCCAAAGAGACCTTACGAGTCCGCTCGTCTGG -------------------TTCCC-------------CCTTCAGGAGCCCCAAGAACCTACTCCAAGACTTACTCTACCCCAAAGAGACCTTACGAGTCTGCTCGTTTGG TTAGCATAAAAGAAGTTAATTTTTGAAAACTGAAATAAATACAGGAGCCCCAAGAACTTACTCTAAGACCTACTCTACCCCAAAGAGACCTTACGAATCTTCTCGTTTGG ATCACAAGTCTTTAAATTATTTTT----------------ATAGGAGCTCCAAGAACTTATTCTAAGACTTATTCTACCCCAAAGAGACCTTACGAATCTTCTCGTTTGG -------------------------------------AATTCAGGAGCCCCAAGAACTTACTCCAAGACCTACTCTACCCCAAAGAGACCATACGAATCTTCTCGTTTGG -------------------CTTTT-------------ATAACAGGAGCCCCAAGAACTTACTCTAAGACTTACTCTACCCCAAAGAGACCATACGAATCTTCTCGTTTGG -------------------GTAGT-------------ACTTTAGGAGCCCCAAGAACCTACTCTAAGACCTACTCTACTCCAAAGAGACCATTCGAGTCTTCTCGTTTGG -------------------TTTTT----------------ACAGGAGCTCCAAGAACTTACTCCAAGACTTACTCTACTCCAAAGAGACCATACGAATCTGCTCGTTTGG -------------------CTTTTAA-----------ACTATAGGAGCTCCAAGAACTTACTCAAAGACCTACTCAACTCCATCTAGACCATACGAATCTTCCCGTTTGG -------------------TTTTT-------------TAAATAGGAGCCCCAAGAACTTACTCTAAGACTTACTCCACTCCATCCAGACCATACGAATCTTCTCGTTTGG -------------------CTTGT-------------AAAACAGGAGCCCCAAGAACATACTCTAAGACCTATTCTACACCAAAGAGACCTTACGAATCTTCTCGTTTGG -------------------ATTTT-------------TCTATAGGAGCCCCAAGAACATACTCTAAGACTTACTCTACCCCAAAGAGACCTTACGAATCTTCTCGTTTGG -------------------TTTTT-------------TTTTTAGGAGCTCCAAGAACTTACTCTAAGACTTACTCTACACCAAAGAGACCTTACGAATCTTCTCGTTTGG 3’ ss


664 575 275 477 507 948 854 524 572 356 528 520 471 573 504 487

ACGCCGAATTGAAGTTGGCTGGTGAATACGGTTTGAAGAACAAGAGAGAAATTTACAGAATTTCTTTCCAATTGTCTAAGATCAGAAGAGCCGCCAGAGATTTGTTGACC ACGCAGAATTGAAGTTGGCCGGTGAATTCGGTTTGAAGAACAAGAAGGAAATTTACAGAATTTCCTTCCAGTTATCTAAGATTCGTCGTGCTGCAAGAGACTTGTTGACA ACGCGGAGTTGAAGCTAGCGGGTGAGTACGGTTTGAAGAACAAGCGTGAAATCTACCGTATCTCGTTCCAGCTGTCCAAGATCAGACGTGCTGCCAGAGACTTGTTGACG ACGCTGAGTTGAAGTTGGCTGGTGAATACGGCCTGAAGAACAAGAAGGAGATTTACAGAATCTCTTTCCAGTTGTCTAAGATCCGTCGTGCTGCCAGAGACTTGCTGACC ACGCCGAGTTGAAGTTGGCCGGTGAATACGGTTTGAAGAACAAGAGAGAGATTTACAGAATCTCTTTCCAATTGTCTAAGATCCGTCGTGCTGCCAGAGACTTGCTGACC ACGCTGAATTGAAGCTTGCTGGTGAATTCGGTTTGAAGAACAAGAGAGAAATTTACAGAATTTCTTTCCAATTGTCCAAGATCAGAAGAGCTGCTAGAGATCTTTTGACC ACGCTGAATTGAAGCTTGCTGGTGAATTCGGTTTGAAGAACAAGAGAGAAATTTACAGAATTTCTTTCCAATTGTCTAAGATCAGAAGAGCTGCTAGAGATCTTTTGACC ACGCTGAATTGAAATTGGCTGGTGAATTCGGTTTGAAGAACAAGAGAGAAATCTACAGAATTTCTTTCCAATTGTCTAAGATTCGTCGTGCTGCCAGAGACTTATTGACC ACGCTGAATTGAAATTGGCTGGTGAATTCGGTTTGAAGAACAAGAGAGAAATCTACAGAATTTCTTTCCAATTGTCTAAGATTCGTCGTGCTGCCAGAGACTTATTGACC ACGCCGAATTGAAAATTGCCGGTGAATATGGTTTGAGAAACAAGAGAGAAATTTACAGAATTACTTTCCAATTGTCTAAGATTCGTCGTGCTGCCAGAGAATTGTTGACC ACGCTGAATTGAAGTTGGCCGGTGAATACGGTTTGAAGAACAAGAGAGAGATTTACAGAATTTCTTTCCAATTGTCTAAGATTCGTCGTGCTGCCAGAGACTTGTTGACC ACGCCGAATTGAAATTGGCTGGTGAATTCGGTTTGAAAAACAAGAGAGAAATTTACAGAATTTCTTTCCAATTATCTAAGATTCGTCGTGCCGCTAGAGACTTGTTAACT ACGCTGAATTGAAGTTGGCCGGTGAATTCGGTTTGAAGAACAAGAGAGAAATTTACAGAATTTCTTTCCAATTATCCAAGATTCGTCGTGCTGCCAGAGATTTATTGACC ATGCTGAATTGAAGTTGGCCGGTGAATTCGGTTTGAAGAACAAGAAGGAAATTTACAGAATTTCTTTCCAATTGTCCAAGATTCGTCGTGCTGCCAGAGATTTATTGACC ACGCTGAATTGAAGTTGGCCGGTGAATTCGGTTTGAAGAACAAGAAGGAAATTTACAGAATTTCTTTCCAATTGTCTAAGATTCGTCGTGCTGCCAGAGATTTATTGACC ACGCAGAATTGAAGTTGGCCGGTGAATTCGGTTTGAAGAACAAGAGAGAAATTTACAGAATTTCTTTCCAATTGTCTAAAATTCGTCGTGCTGCCAGAGACTTGTTAACT


774 685 385 587 617 1058 964 634 682 466 638 630 581 683 614 597

AGAGACGAAAAGGACCCAAAGAGATTGTTCGAAGGTAATGCTTTGATCAGAAGATTGGTGAGAATTGGTGTCTTGTCTGAAGACAAGAAGAAGTTGGATTATGTCTTGGC AGAGACGAAAAGGACCCAAAGAGATTGTTCGAAGGTAATGCTTTGATTAGGAGACTAGTTAGAGTCGGTGTTTTATCCGAAGATAAGAAGAAGTTAGATTATGTTTTAGC CGTGACGAGAAGGACCCTAAGCGTCTGTTCGAGGGTAACGCGTTGATCCGCCGTCTTGTGAGAATCGGTGTCTTGTCCGAGGACAAGAAGAAGTTGGATTACGTGTTGGC AGAGATGAGAAGGACCCAAGAAGACTTTTCGAGGGTAACGCCATGATCAGAAGACTGGTCAGACTTGGTGTCTTGTCCGAGGACAAGAAGAAGTTGGATCACGTCTTGGC AGAGATGAGAAGGACCCAAGAAGACTTTTCGAGGGTAACGCCATGATCAGAAGATTGGTGAGACTAGGTGTCTTGTCTGAGGACAAGAAGAAGCTGGATTACGTCTTGGC AGAGACGAAAAGGACCCAAAGAGATTGTTCGAAGGTAATGCTTTGATCAGAAGATTGGTGAGAATCGGTGTCTTGTCCGAAGACAAGAAGAAGTTGGATTATGTCTTGGC AGAGACGAAAAGGACCCAAAGAGATTGTTCGAAGGTAATGCTTTGATCAGAAGATTGGTGAGAATCGGTGTCTTGTCCGAAGACAAGAAGAAGTTGGATTATGTCTTGGC AGAGACGAAAAAGACCCAAAGAGATTATTCGAAGGTAATGCTTTGATCAGAAGATTGACCAGAGTCGGTGTCTTATCTGAAGACAAGAGAAAGTTAGATTATGTCTTGGC AGAGACGAAAAAGACCCAAAGAGATTATTCGAAGGTAATGCTTTGATCAGAAGATTGACCAGAGTCGGTGTCTTATCTGAAGACAAGAGAAAATTAGATTATGTCTTGGC AAGGACGAAAAAGACCAAAAGAGATTATTCGAAGGTAATGCCTTGATCAGAAGATTGGTCAGAGTGGGTGTCTTGTCTGAAGACAAAAAGAAGCTCGATTATGTCTTGGC AGAGATGAAAAGGACCCAAAGAGATTGTTCGATGGTAACGCCTTGATCAGAAGATTGGTGAGAATCGGTGTCTTGTCCGAAGACAAGAAGAAGTTGGATTACGTCTTGGC AGAGATGAAAAGGATCCAAAGAGATTATTCGAAGGTAATGCCTTGATCAGAAGATTAGTGAGAATTGGTGTCTTGTCTGAAGATAAGAAGAAGTTAGATTATGTTTTAGC AGAGATGAAAAGGACCCAAAGAGATTGTTCGAAGGTAATGCCTTGATCAGAAGATTGGTGAGAATTGGTGTCTTGTCCGAAGATAAGAAGAAGTTAGATTATGTTTTGGC AGAGACGAAAAGGACCCAAAGAGATTGTTCGAAGGTAATGCTTTGATCAGAAGATTGGTTAGAATCGGTGTCTTGTCCGAAGACAAGAAGAAGTTGGATTATGTCTTAGC AGAGACGAAAAGGACCCAAAGAGATTGTTCGAAGGTAACGCTTTGATCAGAAGATTGGTTAGAATTGGTGTCTTGTCCGAAGACAAGAAGAAGTTGGATTATGTTTTAGC AGAGACGAAAAGGACCCAAAGAGATTGTTCGAAGGTAATGCCTTGATCAGAAGATTGGTTAGAGTTGGTGTCTTGTCCGAAGACAAGAAGAAGTTGGATTATGTTTTGGC


884 795 495 697 727 1168 1074 744 792 576 748 740 691 793 724 707

TTTGAAGGTTGAAGATTTCTTGGAAAGAAGATTGCAAACCCAAGTCTACAAGTTGGGTTTGGCCAAGTCTGTTCACCACGCTAGAGTCTTGATCTCCCAAAGACACATTG CTTGAAGGTCGAAGATTTCTTGGAAAGAAGATTGCAAACTCAAGTCTACAAGCTAGGTTTAGCCAAGTCTGTCCACCATGCAAGAGTTTTAATCACTCAAAGGCACATTG CTTGAAGATCGAGGACTTCTTGGAGAGAAGACTGCAGACCCAGGTGTACAAGCTGGGCCTAGCCAAGTCCGTGCACCACGCCAGAGTCTTGATCACCCAGAGACACATTG CTTGAAGGTTGAGGACTTCTTGGAGAGAAGACTGCAAACCCAGGTCTACAAGTTGGGTTTGGCCAAGTCCGTTCACCACGCTAGAGTCTTGATCACCCAGAGACACATTG CTTGAAGATTGAGGACTTCTTGGAGAGAAGACTCCAGACCCAAGTCTACAAGTTGGGTTTGGCCAAGTCTGTGCACCACGCCAGAGTCTTGATCACCCAAAGACACATTG TTTGAAGATTGAAGATTTCTTGGAAAGAAGATTGCAAACTCAAGTTTACAAGCTAGGTTTGGCCAAGTCTGTTCACCACGCTAGAGTCTTGATCACTCAAAGACACATTG TTTGAAGATTGAAGATTTCTTGGAAAGAAGATTGCAAACTCAAGTTTACAAGCTAGGTTTGGCCAAGTCTGTTCACCATGCTAGAGTCTTGATCACTCAAAGACACATTG TTTGAAGGTCGAAGATTTCTTGGAAAGAAGATTGCAAACTCAAGTTTACAAGTTGGGTTTGGCCAAGTCTGTCCACCACGCTAGAGTCTTGATTTCCCAAAGACACATTG TTTGAAGGTTGAAGATTTCTTGGAAAGAAGATTGCAAACCCAAGTCTACAAGTTGGGTTTGGCCAAGTCTGTCCACCACGCTAGAGTCTTGATTTCCCAAAGACACATTG CTTGAAACCAGAAGATTTCTTGGAAAGAAGATTGCAAACTCAAGTTTACAAGTTGGGTTTGGCTAAGTCCATCCACCACGCTAGAGTTTTGATCACCCAAAGACACATTG TTTGAAGATTGAAGATTTCTTGGAAAGAAGATTGCAAACTCAAGTTTACAAGTTGGGTTTGGCCAAGTCTGTCCACCACGCCAGAGTCTTGATCACTCAAAGACACATTG CTTAAAGGTTGAAGATTTCTTGGAAAGAAGATTACAAACTCAAGTGTACAAGTTGGGTTTGGCCAAGTCTGTTCACCACGCTAGAGTATTGATTTCTCAAAGACATATTG TTTGAAGGTCGAAGATTTCTTGGAAAGAAGATTGCAAACTCAAGTTTACAAGTTGGGTTTGGCCAAGTCTGTTCACCACGCTAGAGTCTTGATTTCCCAAAGACATATTG TTTGAAGGTTGAAGATTTCTTGGAAAGAAGACTGCAAACTCAAGTCTACAAGTTGGGTTTGGCCAAGTCTGTTCACCACGCAAGAGTTTTGATCACTCAAAGACACATTG TTTGAAGGTTGAAGATTTCTTGGAAAGAAGACTACAAACTCAAGTCTACAAGTTGGGTTTGGCCAAGTCCGTTCACCACGCCAGAGTTTTGATCACTCAAAGACACATTG TTTGAAGGTTGAAGATTTCTTGGAAAGAAGATTGCAAACTCAAGTCTACAAGTTGGGTTTGGCCAAGTCTGTCCACCACGCCAGAGTTTTAATCACTCAAAGACACATTG


994 905 605 807 837 1278 1184 854 902 686 858 850 801 903 834 817

CTGTTGGTAAGCAAATCGTCAACATCCCATCTTTCATGGTCAGATTGGAATCTGAGAAGCACATTGACTTCGCTAGAACCTCTCCATTCGGTGGTGCTAGACCAGGTAGA CTGTTGGTAAGCAAATTGTCAACATCCCCTCTTTCATGGTCAGATTGGACTCTGAGAAGCACATTGACTTTGCTCCAACATCTCCATTCGGTGGTGCTAGACCAGGCAGA CTGTGGGCAAGCAGATTGTCAACGTCCCATCCTTCATGGTGAGATTGGACTCCGAGAAGCACATTGACTTTGCCGTCACCTCTCCATTCGGCGGTGGCAGACCAGGTAGA CTGTCGGTAAGCAGCTGGTCAACGTCCCATCTTTCTTGGTTAGATTGGAGTCCGAGAAGCACGTTGACTTCGCTAGAGGTTCTCCATTCGGCGGTGGCAGACCAGGTAGA CTGTCGGTAAGCAATTGGTCAACGTCCCATCCTTCATGGTGAGATTGGAGTCCGAGAAGCACATCGACTTCACCAGAGGTTCTCCATTCGGTGGTGGCAGACCAGGTAGA CTGTTGGTAAGCAAATCGTCAACATCCCATCTTTCATGGTCAGATTGGACTCTGAGAAGCACATTGACTTCGCTCCAACTTCTCCATTCGGTGGTGCCAGACCAGGTAGA CTGTTGGTAAGCAAATCGTCAACATCCCATCTTTCATGGTCAGATTGGACTCTGAGAAGCACATTGACTTTGCTCCAACTTCTCCATTCGGTGGTGCCAGACCAGGTAGA CTGTTGGTAAGCAAATCGTCACCATCCCATCCTTCATGGTCAGATTAGACTCTGAAAAGCACATTGACTTTGCTACTACTTCTCCATTCGGTGGTGCTAGACCAGGTAGA CTGTTGGTAAGCAAATCGTCACCATCCCATCTTTCATGGTCAGATTAGACTCTGAAAAGCACATTGACTTTGCTACTACTTCTCCATTCGGTGGTGCTAGACCAGGTAGA CCGTCGGTAAGCAAATCGTTAACGTCCCATCTTTCGTTGTTAGATTGGACTCTGAAAAGCACATCGATTTCGCTCCATCCTCTCCATTCGGTGGTGGTAGACCAGGTAGA CTGTTGGTAAGCAAATTGTCAACATTCCATCCTTCATGGTCAGATTGGAATCTGAAAAGCACATTGATTTTGCTAGAACTTCTCCATTCGGTGGTGCTAGACCAGGTAGA CTGTTGGTAAGCAAATCGTCAACATCCCATCTTTCATGGTCAGATTAGACTCTGAAAAACACATTGACTTTGCTTCTACTTCTCCATTTGGTGGTGCCAGACCAGGTAGA CTGTTGGTAAGCAAATCGTCAACATCCCATCTTTCATGGTCAGATTAGACTCTGAAAAGCACATTGACTTTGCTTCTACTTCTCCATTCGGTGGTGCCAGACCAGGTAGA CTGTTGGTAAGCAAATCGTCAACATTCCTTCTTTCATGGTCAGATTGGACTCTGAAAAGCATGTCGACTTCGCCTCAACTTCTCCATTTGGCGGTGCTAGACCAGGTAGA CTGTTGGTAAGCAAATTGTCAACATCCCATCTTTCATGGTCAGATTGGACTCTGAAAAGCATGTCGACTTCGCCTCAACTTCTCCATTTGGTGGTGCTAGACCAGGTAGA CTGTTGGTAAGCAAATCGTCAACATCCCATCTTTCATGGTCAGATTGGACTCTGAAAAGCACATTGACTTCGCTCCAACTTCTCCATTCGGTGGTGCTAGACCAGGTAGA


1104 1015 715 917 947 1388 1294 964 1012 796 968 960 911 1013 944 927

GTGGCCAGAAAGAGAGCTGCT------------GCTGCTGGTGGTGAAGAAGCT------------------GACGAAGAATAA GTTGCTAGAAGAAATGCTGCAAGGAAGGCGGAAGCTTCT---GGTGAAGCTGCTGATGAAGCTGATGAGGCCGATGAAGAATAA GTGGCCAGAAAGAGAGCTGCT------------GCTGCT---GCTGGTGGGGCTGAA---------------GACGAAGAATAG GTCGCCAGAAAGAACGCCGCCAGAAAGGCCGAGGCTGCT---GGTGGTGACGCCGAAGAG------------GACGCCGAGTAA GTCGCCAGAAAGAACGCCGCCAGAAAGGCCGAGGCCTCC---GGTGACGCCGAGGAG---------------GACGCTGAATAA GTTGCTAGAAAGAACTCCGGTAAGGCCTCCGAAGGTGGT---GACGATGCCGCTGAAGAAGCT---------GACGAAGAGTAA GTTGCCAGAAAGAATTCTGGTAAGGCCTCTGAAGGTGGT---GAAGATGCCGCTGACGAAGCA---------GACGAAGAGTAA GTCGCCAGAAAGAACACCGGTAAGGGTTCTGAAGGTGCT---GAAGAAGCCGCTGAA---------------GACGAAGAATAA GTTGCCAGAAAGAACACCGGTAAGGGTTCTGAAGGTGCT---GAAGAAGCCGCTGAA---------------GACGAAGAATAA GTCGCCAGAAGAAACGCCGCTAGAAAGGCTGAAAGCGGTGGTGGTGAAGAAGGTGGTGAAGAAAACGAAGAAGAAGAAGAATAA GTTGCTAGAAGGAACAACAACAAGGGTTCTGAAGCTGCT---------GAAGCTGAG---------------GACGAAGAATAA GTTGCAAGAAAGAACGCTGCTAGAAAATCGGAAGGTGCTGATGAAGAAGCTGCCGAT---------------GAAGAAGAATAA GTTGCCAGAAAGAACGCTGCCAGAAAGTCTGAAGGTGCTGAAGAAGAAGCCGCTGAA---------------GACGAAGAATAA GTTGCTAGAAGAAACGCCGCTAGAAAGGCCGAATCTTCT---GGTGAAGCTGCTGAAGAAGCT---------GACGAAGAATAA GTTGCTAGAAGAAACGCCGCTAGAAAGGCCGAATCTTCT---GGTGAAGCTGCTGAAGAAGCT---------GACGAAGAATAA GTTGCTAGAAGAAACGCTGCTAGAAAGGCTGAAGCTTCC---GGTGAAGCTGCTGAAGAAGCCGAA------GACGAAGAATAA Stop