Figure S2 - PLOS

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1 1. |. HHHHHH. ILI IH. III i III. 1. LILI HII. |. ILI I ZI. II II III. 1. |. 1 1. |. Archaea a3. --. 1. II. 1. 1 a4 a5. Sce 366 GLSADEALKFWSEAFTRNGNMTMEKFNK-.
Eukarya

Archaea

Sce Dme Ath Hsa Mma Sso Hma Pfu

332 294 276 283 219 212 230 248

α1 α2 NYPLCIKNLMEGLKKN----------HHLRYYGRQQ---------LSLFLKGI- -----SMPLCMRMCHEHIRAN----------HHIKHSGRMQ---------YGLFLKGI- -----SFPLCMRHL FEK L R E D ---------- H HLKHGG R M Q --------- LGL F L K GV- -----SFPPCMRQLHKALREN----------HHLRHGGRMQ---------YGLFLKGI- -----WHPPCMREILNDILSG----------GSPSHYARRSFVVYRFVSQFDPNLRPIE EGIITN IIPPCIENILAKEKLNE---------EEIRT--------------LITFYIDI- -----LFPPCMKSLLDQVQKG----------EHLEHHSRFA---------IATFLVGI- -----LFPPCVKNALRGVPQGMRNYAITVLLTSFLSYARICPNPPRRNVKIRDCIKDM- ------

Sce Dme Ath Hsa Mma Sso Hma Pfu

366 328 310 317 269 242 264 301

α3 α4 α5 ----GLSADEALKFWSEAFTRNGNMTMEKFNK------------EYRYSFRHNY GLE-GN ----GVALEDSLRFWREEFTK--KMDADKFTR------------SYEYNIYHNY GKK-GS ----GLKLDDALAFWREEFTK--KVGSERFDK------------EYAYAIRHNY GKE-GK ----GLTLEQALQFWKQEFIK-GKMDPDKFDK------------GYSYNIRHSF GKE-GK RSAQDIATEEQIERFLDEIINIFKSVGDFDVE------------KTKYYISHNI GYKVAN α9 ----GKGLSGIVSIMKKYNVS----NVEDLYR------------KYR------GDK-GT ----GMTTDEIVDLF--------QVNPGFGEE------------ATRYQVDHIR GDT--S ----RVITEEILPIIIEAGNR---CSPPLFEDQPNEIKNIWYHLGFGYTANPTL EDS-GN

Sce Dme Ath Hsa Mma Sso Hma Pfu

409 369 351 359 317 274 298 353

α6 α7 α8 α9 RINYKPWDCHTILSKPRPGRGDYHGCPFRDWSHERLSAELRSMKLTQAQIISVL DSCQKG MVNYTPYSCAKII-KDVAGPGDCHGCPYKNMDQGSLKTKLSSYGLSASAIDEVM FFVSRG RTDYTPYACSKII-TSAPGAGDHHGCPYRHFSEDNLKAALSRMGLSSRGMEDVM DKVRNR RTDYTPFSCLKIILSNPPSQGDYHGCPFRHSDPELLKQKLQSYKISPGGISQIL DLVKGT HITHCEY-CKNW--RDDGGKGLGYYCRPDST----------------------- -----R--YIVYSCAKM----------------------------KQLGLCVSS----- -----PTEYSTPACSTM-----QSYGDCVNMDDL------------------------- -----STWYFPPNCDKI-----KANAPQLCTPDKH------------------------ ------

Sce Dme Ath Hsa Mma Sso Hma Pfu

469 428 410 419 317 293 322 353

α10 α11 EYTIACTKVFEMTHNSASADLEIGEQTHIAHPNLYFERSRQLQKKQQ--KLEKEKLFNNG HYQIGCGKYFQLTHNS-PVE------PSINHPNNYFEESQ-IAMGNR--QKRANGSAPPK HYQLACTLTFEAVYGT-SCD------TGINHPNQYFEESQKILKSKT----------PAA HYQVACQKYFEMIHNVDDCG------FSLNHPNQFFCESQRILNGGK--DIKKEPIQPET -----CSR------------------KDIIHPLDYLCHNINRHVKKS--E---- ----------C---------------------NVKNPLQLYFLSNE------------- ----------C--------------------EAISHPMGYYEQKLDDTDEEELVDWRED EGEEEA -----C--------------------RYIRNPLTYYLRRLYLEEKRR--AKHAD EGSDKG

Sce Dme Ath Hsa Mma Sso Hma Pfu

527 478 453 471

NH---------------------------------------------------- -ARIRPDIKGHGDRSMLMGDDDDELWRIAETQERIMQSQKDISEAFNDDLDLTQI DY PV---------------------------------------------------- -PQPKPSVQKTKDASSAL----------ASLNSSLEMDMEGLEDYFSEDS----- ------------------------------------------------------- ------------------------------------------------------- -357 DA---------------------------------------------------- -411 GKERILQ----------------------------------------------- --

Figure S2