Figure S9, related to Figure 4. Hes6 xenograft differentially expressed ...

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Figure S9, related to Figure 4. Hes6 xenograft differentially expressed genes (DEGs) are associated with aggressive clinical disease. Selected Hes6 DEGS (from ...
Benign Primary Metastatic Group

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HES6 NUSAP1 NCAPG NDUFA4L2 CENPE CDKN2C CENPA CDC20 TACC3 ASPM TOP2A DLGAP5 AURKA CDKN2A BIRC5 MCM2 CDKN2C TOP2A CELSR3 RNASEH2A CDKN3 KIF20A RACGAP1 KIF11 SHMT2 NDUFB4 TOP2A CDKN2A TIMELESS CCNA2 AURKA MCM7 DDC CCNA2 NCAPG CEP55 CDCA7 BUB1 SHMT2 PBK CDKN3 PTTG1 RFC4 BUB1 CDCA8 PRC1 CDCA3 UBE2C CELSR3 NUSAP1 AURKB SHMT2 ASPM MCM4 PTTG3P PLK1 MELK RRM2 FOXM1 BIRC5 DDC C7orf68 RCC2 CDC25C C7orf68 TRIP13 CDCA5 KIAA0101 SLC38A1 BUB1 MLF1IP EZH2 TK1 SOX4 RRM2 CENPA MCM7 MCM4 ACOT7 AURKB BIRC5 E2F2 KIAA0101 SOX4 SOX4 MCM4 AIF1L MCM5 ZWILCH LDHA CDCA7 CDCA2 CDCA3 SLC38A1 UBE2I ZWILCH MLF1IP CDC25C CENPM CDCA2 MCM5 ASNS ZMYND19 SLC38A1 UBE2I SDCCAG3 SOX4 DLL3 TK1 PGK1 PDXP SOX4 RFC3 ASPM MLF1IP CLK2 MCM4 GAPDH DLL3 CDK2 MCM10 FABP6 TIMELESS RFC3 CDK4 NOVA1 ACOT7 MCM10 PGK1 E4F1 CCDC130 AURKA UBE2I MCM10 ASNS BUB1 PGK1 HES4 ASAP2 NDUFB4 GAPDH VEGFA CDK2 CCNL1 PGK1 PGK1 ANGPT2 VEGFA VEGFA ANGPT2 PRR7 GAPDH VEGFA VLDLR GAPDH MYO1B CCNL1 DLL3 ANGPT2 ADAM9 CDK10 NOTCH3 CDK10 ANGPT2 RFC3 CCNL1 MAGEA1 NOTCH1 CCNL1 RAD51C AIF1L UBE2I NCAM2 E2F2 GAPDH BUB1 MYO1B CDK10 HES1 PKIB NOS3 DLL3 SDCCAG3 MYO1B NCAM2 CDKN2A NETO1 HES1 SLC38A1 PKIB UBE2I BIRC3 CDK2 HES1 NETO1 DFNA5 UBE2I AMACR GAPDH CENPT FABP6 FAM171A1 NOTCH1 MYC HDAC7 CDC25C STAT3 E2F2 E2F4 NETO1 FABP6 NOTCH3 CENPN HDAC7 AMACR MAGEA8 GRPR AMACR NOVA1 AMACR LDHD BRDT AMACR CLDN8 FFAR2 SOX4 CENPN CCDC84 CENPN RAD51C CENPN ZNF680 C5orf53 E2F4 KLF6 ABP1 C5orf53 KLF6 KLF6 KLF6 TRPM4 KLF6 TSPYL1 NRIP1 STAT3 ACSM3 ADAM9 STAT3 NRIP1 STAT3 KLF4 TSPYL1 KLF4 ADAM9 ACSM3 TSPYL1 MYC MGP STEAP2 MGP TSPO

Figure S9, related to Figure 4. Hes6 xenograft differentially expressed genes (DEGs) are associated with aggressive clinical disease. Selected Hes6 DEGS (from Figure 3A) profiled across 19 benign, primary malignant and metastatic human prostates (Varambally et al) showing consistent differential expression of Hes6-driven genes amongst metastatic tumors.