Feb 7, 2013 ... effervescent tablets are quick production of solution. Thus, it is faster and ... It is a
reproducible process and suitable to produce granules that.
Advanced Pharmaceutical Bulletin, 2013, 3(1), 217-225 doi: http://dx.doi.org/10.5681/apb.2013.036 http://apb.tbzmed.ac.ir/
Formulation, Characterization and Physicochemical Evaluation of Potassium Citrate Effervescent Tablets Abolfazl Aslani*, Fatemeh Fattahi Department of Pharmaceutics, School of Pharmacy and Novel Drug Delivery Systems Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. ARTICLEINFO
ABSTRACT
Article Type: Research Article
Purpose: The aim of this study was to design and formulation of potassium citrate effervescent tablet for reduction of calcium oxalate and urate kidney stones in patients suffering from kidney stones. Methods: In this study, 13 formulations were prepared from potassium citrate and effervescent base in different concentration. The flowability of powders and granules was studied. Then effervescent tablets were prepared by direct compression, fusion and wet granulation methods. The prepared tablets were evaluated for hardness, friability, effervescent time, pH, content uniformity. To amend taste of formulations, different flavoring agents were used and then panel test was done by using Latin Square method by 30 volunteers. Results: Formulations obtained from direct compression and fusion methods had good flow but low hardness. Wet granulation improves flowability and other physicochemical properties such as acceptable hardness, effervescence time ≤3 minutes, pH