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Nov 19, 2014 - 1 Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, China.
Sep 25, 2012 - Disorders and The Affiliated Hospital, Hangzhou Normal University, Hangzhou, Zhejiang, .... scanner at the Third Hospital, Peking University.
Behavioral Apparatus and Imaging Parameters. Visual stimuli were presented using an Apple G3 laptop computer running PsyScope 1.2.5 software (Cohen,.
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CONNECTIVITY DURING MAINTENANCE. 581 most delay tasks, although effectively segregating WM processes into stages, do not take into account the mul-.
May 16, 2017 - 1Department of Radiology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China, 2Department of. Neurology, Xuanwu ...
depending on the content of the switch: Increased functional connectivity with .... pattern for the two types of switching would support the assumption that the IFJ ...
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OPEN
received: 21 July 2016 accepted: 08 November 2016 Published: 08 December 2016
Functional connectivity changes resemble patterns of pTDP-43 pathology in amyotrophic lateral sclerosis Ines Schulthess1,*, Martin Gorges1,*, Hans-Peter Müller1, Dorothée Lulé1, Kelly Del Tredici2, Albert C. Ludolph1 & Jan Kassubek1 ‘Resting-state’ fMRI allows investigation of alterations in functional brain organization that are associated with an underlying pathological process. We determine whether abnormal connectivity in amyotrophic lateral sclerosis (ALS) in a priori-defined intrinsic functional connectivity networks, according to a neuropathological staging scheme and its DTI-based tract correlates, permits recognition of a sequential involvement of functional networks. ‘Resting-state’ fMRI data from 135 ALS patients and 56 matched healthy controls were investigated for the motor network (corresponding to neuropathological stage 1), brainstem (stage 2), ventral attention (stage 3), default mode/hippocampal network (stage 4), and primary visual network (as the control network) in a cross-sectional analysis and longitudinally in a subgroup of 27 patients after 6 months. Group comparison from cross-sectional and longitudinal data revealed significantly increased functional connectivity (p