Gene name Specie name GenBank GIEST

Table S1 Gene accession numbers in GenBank

Gene name

PPARα

PPARβ

Specie name Homosapiens Macaca mulatta Gorilla gorilla gorilla Xenopus laevis Danio rerio Salmo salar Odobenus rosmarus divergens Orcinus orca Tursiops truncatus Gallus Anser anser Anas platyrhynchos Felis catus Canis lupus familiaris Oryctolagus cuniculus Mustela putorius furo Equus caballus Ovis aries Bos taurus Bubalus bubalis Sus scrofa Ceratotherium simum simum Loxodonta africana Mus musculus Rattus norvegicus Cavia porcellus Octodon degus Homosapiens Gorilla gorilla gorilla Pan troglodytes Xenopus laevis Danio rerio Gallus Anas platyrhynchos Canis lupus familiaris Oryctolagus cuniculus Dasypus novemcinctus Equus caballus Bos taurus Sus scrofa

GenBank GIEST Nucleotide length Protein length Y07619.1 1407 468 NM_001033029.1 1404 467 XM_004063652.1 9881 468 NM_001089813.1 3355 474 DQ839548.1 1380 459 NM_001123560.1 1644 464 XM_004415835.1 2002 468 XM_004279591.1 1932 469 XM_004322234.1 1802 469 NM_001001464.1 2100 468 AF481797.1 1455 468 EF534215.1 1430 468 XM_003989394.1 1420 468 NM_001003093.1 2032 468 XM_002723354.1 1407 468 XM_004813909.1 8279 468 NM_001242553.1 1763 468 XM_004007050.1 1445 470 NM_001034036.1 1979 470 JQ070333.1 1548 470 NM_001044526.1 1488 468 XM_004437986.1 1803 467 XM_003420893.1 1407 468 BC016892.1 2336 468 NM_013196.1 2022 468 NM_001173004.1 2073 467 XM_004642403.1 1404 467 AY919140.1 1326 441 XM_004043869.1 3454 343 XM_003311239.1 3425 402 NM_001087841.1 1537 396 NM_131468.2 3219 517 NM_204728.1 1756 443 XM_005023480.1 2268 345 NM_001048102.1 1864 459 NM_001082000.1 1326 441 XM_004458309.1 2521 442 XM_001498870.3 1375 402 NM_001083636.1 3300 441 GU565977.1 2717 441

PPARγ

Mus musculus Rattus norvegicus Cavia porcellus Homosapiens Macaca mulatta Nomascus leucogenys Pan troglodytes Xenopus laevis Danio rerio Salmo salar Gallus Anas platyrhynchos Ficedula albicollis Felis catus Canis lupus familiaris Ovis aries Bos taurus Bubalus bubalis Sus scrofa Mus musculus Rattus norvegicus Cavia porcellus Octodon degus

U10375.1 U75918.1 XM_003473900.2 X90563.1 NM_001032860.1 XM_004091756.1 XM_003950030.1 NM_001087843.1 NM_131467.1 NM_001123546.1 NM_001001460.1 EF546801.2 XM_005052821.1 NM_001113176.1 NM_001024632.2 NM_001100921.1 BC116098.1 HQ270143.1 NM_214379.1 U10374.1 Y12882.2 XM_003462736.2 XM_004645604.1

1323 1975 3245 1766 1759 1663 1663 2046 1994 2528 2089 1650 4207 1841 1830 1428 1801 1624 1758 1428 1570 1431 1449

440 440 440 477 505 483 483 477 527 544 475 475 475 529 529 475 475 505 504 475 505 475 475

Table S2 All of the predicted TFBS in human and in chicken

PPARα Homo sapiens Gallus gallus Sp1 Oct-1 Oct-1 C/EBPα GATA-1 TBP CREB AP-2α CPE_bind NF-1 CP1 GR NF-1 HSTF AP-2α Pit-1a GR Sp1 Egr-1 Hb WT1 GATA-1 CACCC-bi SGF-1 MyoD HSE-bind C/EBPα Pit-1 GLI3 NF-A ENKTF-1 Elk-1 E1 GCN4 ICSBP Antp Krox-20 SRY ETF CoS MIG1 MEB-1 RAR-α GLO REV-ErbAα CREB CoS PU.1 NF-kappa SRF Adf-1 ICSBP CTF HNF-3 RAP1 NRL NF-muE1 NF-kappaB Elk-1 C/EBPβ SRF SGF-3 NF-ATc3 RSRFC4 CTF Odd CeMyoD PEA3 Ftz C/EBP

PPARβ Homo sapiens Gallus gallus NF-1 p40x C/EBPα GR Sp1 C/EBPα AP-2α ICSBP GR ISGF-3 Hb REV-ErbA p40x Sp1 AP-1 AP-2α GATA-1 USF TBP c-Fos Pit-1a NF-1 HSE-bind ACE2 HSF NF-E2 MBP-1_(1) c-Jun NF-kappa AP-1 NF-kappaB ITF-2 Kr MRF4 ARP-1 Id2 ATF NF-kappaB Oct-1 GATA-1 USF COUP CeMyoD RAR-α YY1 RXR-α N-Myc ER CP1 c-Ets-1 CTF SRF ETF PR MIG1 Ftz c-Jun Oct-1 CRE-BP1 IRF-1 CREB REB1 CPE_bind YY1 Adf-1 AP-2 WT1 Egr-1 NF-muE1 CPE_bind Krox-20 ETF ATF EFI CP1

PPARγ Homo sapiens Gallus gallus p40x Oct-1 Oct-1 ICSBP Zen-1 GATA-1 TBP Erg-1 MEB-1 C/EBPα Hb c-Jun AP-2α c-Fos Sp1 Pap1+ C/EBPα AP-1 YY1 NF-1 HNF-3B GR REB1 HNF-3B ER SRF NF-1 Dl Id3 TBP HNF-1 MATα2 NF-ATc3 Hb USF Dfd CP1 MEB-1 GATA-1 GLO LyF-1 ATF T3R Oct-21 ICSBP Eve RAP1 Ftz C/EBPδ HNF-1C TSF3 ER c-Ets-1_ PR GR CREB PR Pit-1 T3R-α USF IRF-1 E2 E1 Pit-1a REV-ErbA AP-2α COUP c-Rel c-Jun TCF-1α NF-kappaB Antp CPE_bind ISGF-3 Dfd HNF-3 Ftz NF-EM5

CPC1 AP-1 p40x HNF-1C CPE_bind Zen-1

CREB WT1 CRE-BP1 Adf-1 AhR

HNF-1C

Table S3 The predicted miRNAs targets in PPAR gene family in human

miRNA hsa-miR-128 hsa-miR-27abc hsa-miR-454 hsa-miR-142-3p hsa-miR-9 hsa-miR-17 hsa-miR-152 hsa-miR-138 hsa-miR-29abcd hsa-miR-873 hsa-miR-21 hsa-miR-22 hsa-miR-539 hsa-miR-202-3p hsa-let-7 hsa-miR-93 hsa-miR-144 hsa-miR-19ab hsa-miR-508 hsa-miR-141 hsa-miR-335 hsa-miR-24 hsa-miR-33ab hsa-miR-125a-5p hsa-miR-124 hsa-miR-181abcd hsa-miR-101 hsa-miR-10abc

Gene name PPARα, PPARγ PPARα, PPARγ PPARγ PPARα PPARα, PPARβ PPARα, PPARβ PPARβ PPARβ PPARβ PPARα PPARα PPARα PPARα PPARα PPARα PPARα PPARα PPARα PPARα PPARα PPARα PPARα PPARα PPARα PPARα PPARα PPARα PPARα