Gene symbol Gene name log (AMD/cnt) - Heliyon

Table S1 DEGs in macular RPE-choroid of early-stage AMD patients (GSE29801) Gene symbol AATK ABAT ABCA1 ABCA6 ABCG2 ABCG4 ABTB1 ACAT2 ACOT11 ACSL1 ACTC1 ACTG2 ADAD2 ADAMTS1 ADAMTS4 ADAMTS9 ADAMTSL1 ADAMTSL2 ADAMTSL3 ADCY2 ADH1C ADORA2B ADRA1B ADRA2A ADRA2C AFAP1L2 AGAP1 AGFG2 AGGF1 AGT AHNAK AIF1 AIPL1 AKR1C1 AKT2 ALAS2 ALDH1A3 ALDH1L1 ALDH4A1 ALG1 ALG14 ALG6 ALOX5AP ALPPL2 AMFR AMOTL2 ANGPT1 ANGPTL2 ANGPTL4 ANK1 ANKRD37 ANKRD9 ANO2 ANXA1 ANXA3 ANXA6 AOX1 APC2 APEH APOC1 APOLD1 AQP1 ARF5 ARGLU1 ARL4C ARL4D ARL6IP1 ARMC9 ARR3 ASGR2 ASPG ASPHD1 ATCAY ATHL1 ATL1 ATN1 ATP1A2 ATP6V1G2 ATP8A2

Gene name apoptosis-associated tyrosine kinase 4-aminobutyrate aminotransferase ATP-binding cassette, sub-family A (ABC1), member 1 ATP-binding cassette, sub-family A (ABC1), member 6 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) ATP-binding cassette, sub-family G (WHITE), member 4 ankyrin repeat and BTB (POZ) domain containing 1 acetyl-CoA acetyltransferase 2 acyl-CoA thioesterase 11 acyl-CoA synthetase long-chain family member 1 actin, alpha, cardiac muscle 1 actin, gamma 2, smooth muscle, enteric adenosine deaminase domain containing 2 ADAM metallopeptidase with thrombospondin type 1 motif, 1 ADAM metallopeptidase with thrombospondin type 1 motif, 4 ADAM metallopeptidase with thrombospondin type 1 motif, 9 ADAMTS-like 1 ADAMTS-like 2 ADAMTS-like 3 adenylate cyclase 2 (brain) alcohol dehydrogenase 1C (class I), gamma polypeptide adenosine A2b receptor adrenoceptor alpha 1B adrenoceptor alpha 2A adrenoceptor alpha 2C actin filament associated protein 1-like 2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 ArfGAP with FG repeats 2 angiogenic factor with G patch and FHA domains 1 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) AHNAK nucleoprotein allograft inflammatory factor 1 aryl hydrocarbon receptor interacting protein-like 1 aldo-keto reductase family 1, member C1 v-akt murine thymoma viral oncogene homolog 2 5'-aminolevulinate synthase 2 aldehyde dehydrogenase 1 family, member A3 aldehyde dehydrogenase 1 family, member L1 aldehyde dehydrogenase 4 family, member A1 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase ALG14, UDP-N-acetylglucosaminyltransferase subunit ALG6, alpha-1,3-glucosyltransferase arachidonate 5-lipoxygenase-activating protein alkaline phosphatase, placental-like 2 autocrine motility factor receptor, E3 ubiquitin protein ligase angiomotin like 2 angiopoietin 1 angiopoietin-like 2 angiopoietin-like 4 ankyrin 1, erythrocytic ankyrin repeat domain 37 ankyrin repeat domain 9 anoctamin 2, calcium activated chloride channel annexin A1 annexin A3 annexin A6 aldehyde oxidase 1 adenomatosis polyposis coli 2 acylaminoacyl-peptide hydrolase apolipoprotein C-I apolipoprotein L domain containing 1 aquaporin 1 (Colton blood group) ADP-ribosylation factor 5 arginine and glutamate rich 1 ADP-ribosylation factor-like 4C ADP-ribosylation factor-like 4D ADP-ribosylation factor-like 6 interacting protein 1 armadillo repeat containing 9 arrestin 3, retinal (X-arrestin) asialoglycoprotein receptor 2 asparaginase aspartate beta-hydroxylase domain containing 1 ataxia, cerebellar, Cayman type ATH1, acid trehalase-like 1 (yeast) atlastin GTPase 1 atrophin 1 ATPase, Na+/K+ transporting, alpha 2 polypeptide ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 ATPase, aminophospholipid transporter, class I, type 8A, member 2

log (AMD/cnt) FDR 0.43 0.05 -0.25 0.13 0.39 0.13 -0.17 0.19 0.06 0.16 -0.26 0.19 -0.18 0.16 0.51 0.02 -0.04 0.07 -0.25 0.03 -0.52 0.00 -0.18 0.09 0.55 0.00 0.53 0.00 0.60 0.00 0.52 0.00 -0.16 0.08 -0.30 0.09 -0.50 0.00 -0.34 0.03 0.56 0.00 0.20 0.01 0.13 0.13 0.07 0.10 0.98 0.00 -0.11 0.01 -0.63 0.00 0.37 0.19 -0.30 0.13 0.64 0.00 -0.20 0.00 -0.41 0.01 -0.29 0.07 -0.35 0.19 0.49 0.03 -0.39 0.00 -0.01 0.00 0.22 0.11 0.35 0.08 0.64 0.02 0.45 0.07 0.62 0.03 -0.21 0.00 -0.35 0.02 0.01 0.16 -0.21 0.07 -0.28 0.00 -0.25 0.05 0.11 0.00 -0.13 0.13 -0.05 0.01 0.38 0.07 -0.80 0.00 -0.41 0.04 -0.54 0.00 0.21 0.05 -0.20 0.00 -0.07 0.09 0.48 0.17 0.21 0.17 0.22 0.00 0.52 0.01 0.41 0.02 0.57 0.11 -0.22 0.04 -0.31 0.05 0.34 0.03 0.46 0.00 -0.74 0.00 0.17 0.12 0.57 0.01 0.13 0.19 -0.36 0.17 -0.20 0.01 -0.18 0.06 0.34 0.00 -0.20 0.02 -0.58 0.00 -0.29 0.07

AZIN1 B2M B3GAT1 B4GALT5 BAG3 BAGE BAIAP2 BAIAP2L2 BATF BCAN BCAS4 BCAT1 BCL2L13 BDKRB2 BEST1 BEX1 BIVM BMP7 BPTF BRD3 BTN2A2 BZW2 C10orf10 C10orf11 C10orf35 C14orf1 C14orf132 C1orf162 C1QA C1QB C1QC C1QTNF2 C1QTNF5 C1R C2orf74 C3 C5orf30 C7orf31 C8orf4 C9orf40 C9orf69 CA10 CA12 CA14 CA4 CACNA1G CACYBP CADM1 CALR CAMK1D CAMK2D CAPS CARD9 CARHSP1 CASKIN1 CBWD5 CCDC136 CCDC144A CCL15 CCL19 CCL2 CCL23 CCL26 CCL3 CCL4 CCL5 CCND1 CCND3 CCNO CCR1 CCR5 CD151 CD163 CD19 CD1D CD2 CD200 CD209 CD34 CD47 CD53 CD59

antizyme inhibitor 1 beta-2-microglobulin beta-1,3-glucuronyltransferase 1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 BCL2-associated athanogene 3 B melanoma antigen BAI1-associated protein 2 BAI1-associated protein 2-like 2 basic leucine zipper transcription factor, ATF-like brevican breast carcinoma amplified sequence 4 branched chain amino-acid transaminase 1, cytosolic BCL2-like 13 (apoptosis facilitator) bradykinin receptor B2 bestrophin 1 brain expressed, X-linked 1 basic, immunoglobulin-like variable motif containing bone morphogenetic protein 7 bromodomain PHD finger transcription factor bromodomain containing 3 butyrophilin, subfamily 2, member A2 basic leucine zipper and W2 domains 2 chromosome 10 open reading frame 10 chromosome 10 open reading frame 11 chromosome 10 open reading frame 35 chromosome 14 open reading frame 1 chromosome 14 open reading frame 132 chromosome 1 open reading frame 162 complement component 1, q subcomponent, A chain complement component 1, q subcomponent, B chain complement component 1, q subcomponent, C chain C1q and tumor necrosis factor related protein 2 C1q and tumor necrosis factor related protein 5 complement component 1, r subcomponent chromosome 2 open reading frame 74 complement component 3 chromosome 5 open reading frame 30 chromosome 7 open reading frame 31 chromosome 8 open reading frame 4 chromosome 9 open reading frame 40 chromosome 9 open reading frame 69 carbonic anhydrase X carbonic anhydrase XII carbonic anhydrase XIV carbonic anhydrase IV calcium channel, voltage-dependent, T type, alpha 1G subunit calcyclin binding protein cell adhesion molecule 1 calreticulin calcium/calmodulin-dependent protein kinase ID calcium/calmodulin-dependent protein kinase II delta calcyphosine caspase recruitment domain family, member 9 calcium regulated heat stable protein 1, 24kDa CASK interacting protein 1 COBW domain containing 5 coiled-coil domain containing 136 coiled-coil domain containing 144A chemokine (C-C motif) ligand 15 chemokine (C-C motif) ligand 19 chemokine (C-C motif) ligand 2 chemokine (C-C motif) ligand 23 chemokine (C-C motif) ligand 26 chemokine (C-C motif) ligand 3 chemokine (C-C motif) ligand 4 chemokine (C-C motif) ligand 5 cyclin D1 cyclin D3 cyclin O chemokine (C-C motif) receptor 1 chemokine (C-C motif) receptor 5 (gene/pseudogene) CD151 molecule (Raph blood group) CD163 molecule CD19 molecule CD1d molecule CD2 molecule CD200 molecule CD209 molecule CD34 molecule CD47 molecule CD53 molecule CD59 molecule, complement regulatory protein

-0.36 0.26 -0.53 0.27 -0.99 -0.37 -0.30 0.36 -0.22 -0.44 -0.40 0.40 -0.50 -0.28 0.61 -0.34 0.45 0.76 0.49 0.34 0.43 0.38 0.36 -0.23 0.42 0.40 -0.29 -0.17 -0.11 -0.36 -0.28 -0.03 0.33 -0.13 -0.47 -0.11 -0.37 0.69 -0.46 -0.39 0.53 -0.27 0.36 0.12 -0.04 -0.29 -0.80 -0.48 -0.31 -0.46 -0.37 -0.26 0.32 0.53 0.57 0.79 0.22 -0.46 0.40 0.53 -0.30 -0.11 -0.35 0.14 -0.12 -0.32 -0.31 -0.29 0.36 -0.03 -0.20 0.55 -0.36 0.37 -0.12 -0.33 0.33 0.06 0.14 -0.27 -0.18 0.45

0.07 0.01 0.04 0.05 0.01 0.16 0.18 0.19 0.01 0.03 0.03 0.00 0.02 0.01 0.00 0.03 0.20 0.00 0.09 0.02 0.14 0.07 0.03 0.10 0.16 0.13 0.18 0.02 0.19 0.00 0.03 0.02 0.04 0.15 0.00 0.07 0.13 0.00 0.00 0.18 0.02 0.11 0.04 0.11 0.07 0.17 0.00 0.00 0.13 0.06 0.04 0.02 0.19 0.00 0.03 0.13 0.01 0.00 0.03 0.00 0.00 0.02 0.00 0.07 0.02 0.04 0.07 0.18 0.03 0.04 0.02 0.01 0.00 0.07 0.03 0.04 0.13 0.03 0.16 0.09 0.03 0.09

CD86 CD8A CDC42BPA CDC42EP3 CDH1 CDH13 CDH18 CDH23 CDH3 CDK6 CDKL5 CDKN1B CDKN2C CEACAM1 CEBPA CEP135 CES1 CETP CFB CFH CH25H CHADL CHCHD7 CHDH CHEK2 CHI3L1 CHI3L2 CHIC2 CHORDC1 CHRAC1 CHRNA3 CHST8 CIAPIN1 CIITA CISD1 CITED4 CKB CKMT1A CLCN3 CLDN19 CLDN5 CLEC3B CLIC5 CLIC6 CLIP3 CLN3 CLUAP1 CMKLR1 CNDP2 CNN2 CNNM4 CNTN2 CNTNAP2 COL10A1 COL13A1 COL20A1 COL25A1 COL5A2 COL8A1 COL8A2 COLEC11 COQ10A CORO6 CPAMD8 CPE CPLX3 CPM CREG1 CRELD1 CRLF1 CRLF3 CRY2 CRYAA CRYM CRYZ CST3 CST5 CSTA CTGF CTH CTSB CTSC

CD86 molecule CD8a molecule CDC42 binding protein kinase alpha (DMPK-like) CDC42 effector protein (Rho GTPase binding) 3 cadherin 1, type 1, E-cadherin (epithelial) cadherin 13 cadherin 18, type 2 cadherin-related 23 cadherin 3, type 1, P-cadherin (placental) cyclin-dependent kinase 6 cyclin-dependent kinase-like 5 cyclin-dependent kinase inhibitor 1B (p27, Kip1) cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) CCAAT/enhancer binding protein (C/EBP), alpha centrosomal protein 135kDa carboxylesterase 1 cholesteryl ester transfer protein, plasma complement factor B complement factor H cholesterol 25-hydroxylase chondroadherin-like coiled-coil-helix-coiled-coil-helix domain containing 7 choline dehydrogenase checkpoint kinase 2 chitinase 3-like 1 (cartilage glycoprotein-39) chitinase 3-like 2 cysteine-rich hydrophobic domain 2 cysteine and histidine-rich domain (CHORD) containing 1 chromatin accessibility complex 1 cholinergic receptor, nicotinic, alpha 3 (neuronal) carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 cytokine induced apoptosis inhibitor 1 class II, major histocompatibility complex, transactivator CDGSH iron sulfur domain 1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 creatine kinase, brain creatine kinase, mitochondrial 1A chloride channel, voltage-sensitive 3 claudin 19 claudin 5 C-type lectin domain family 3, member B chloride intracellular channel 5 chloride intracellular channel 6 CAP-GLY domain containing linker protein 3 ceroid-lipofuscinosis, neuronal 3 clusterin associated protein 1 chemokine-like receptor 1 CNDP dipeptidase 2 (metallopeptidase M20 family) calponin 2 cyclin and CBS domain divalent metal cation transport mediator 4 contactin 2 (axonal) contactin associated protein-like 2 collagen, type X, alpha 1 collagen, type XIII, alpha 1 collagen, type XX, alpha 1 collagen, type XXV, alpha 1 collagen, type V, alpha 2 collagen, type VIII, alpha 1 collagen, type VIII, alpha 2 collectin sub-family member 11 coenzyme Q10 homolog A (S. cerevisiae) coronin 6 C3 and PZP-like, alpha-2-macroglobulin domain containing 8 carboxypeptidase E complexin 3 carboxypeptidase M cellular repressor of E1A-stimulated genes 1 cysteine-rich with EGF-like domains 1 cytokine receptor-like factor 1 cytokine receptor-like factor 3 cryptochrome circadian clock 2 crystallin, alpha A crystallin, mu crystallin, zeta (quinone reductase) cystatin C cystatin D cystatin A (stefin A) connective tissue growth factor cystathionine gamma-lyase cathepsin B cathepsin C

0.89 -0.60 0.48 -0.37 -0.16 -0.09 -0.64 -0.24 0.35 -0.29 -0.37 0.49 -0.40 0.01 -0.32 0.55 0.08 -0.32 0.47 -0.37 0.59 0.57 -0.01 0.69 -0.23 0.25 0.39 -0.37 -0.92 -0.36 0.72 -0.11 0.53 0.42 0.47 -0.24 0.12 -0.20 0.42 0.29 0.30 -0.23 -0.26 0.21 -0.24 0.51 -0.39 -0.61 0.49 -0.38 -0.50 0.03 -0.45 -0.52 -0.41 0.62 -0.15 0.45 0.41 -0.20 0.00 0.40 -0.03 -0.30 -0.41 -0.73 -0.16 -0.37 -0.26 -0.05 -0.19 0.46 -0.53 -0.86 0.23 0.56 0.45 -0.24 -0.35 0.13 -0.19 -0.38

0.00 0.00 0.16 0.03 0.18 0.04 0.00 0.01 0.03 0.15 0.13 0.08 0.09 0.12 0.00 0.04 0.04 0.00 0.02 0.08 0.00 0.00 0.19 0.00 0.15 0.02 0.00 0.12 0.01 0.12 0.00 0.01 0.06 0.07 0.11 0.01 0.18 0.10 0.09 0.01 0.12 0.01 0.02 0.02 0.12 0.04 0.04 0.00 0.13 0.06 0.05 0.16 0.09 0.00 0.00 0.00 0.01 0.03 0.08 0.05 0.01 0.04 0.12 0.00 0.07 0.04 0.03 0.01 0.11 0.04 0.20 0.12 0.16 0.00 0.20 0.01 0.00 0.07 0.00 0.20 0.06 0.01

CTSD cathepsin D CTSG cathepsin G CTTNBP2NL CTTNBP2 N-terminal like CXCL14 chemokine (C-X-C motif) ligand 14 CXCL2 chemokine (C-X-C motif) ligand 2 CXXC4 CXXC finger protein 4 CYB561D1 cytochrome b561 family, member D1 CYB5R3 cytochrome b5 reductase 3 CYBB cytochrome b-245, beta polypeptide CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 CYP4X1 cytochrome P450, family 4, subfamily X, polypeptide 1 CYR61 cysteine-rich, angiogenic inducer, 61 CYTH4 cytohesin 4 CYYR1 cysteine/tyrosine-rich 1 DAAM1 dishevelled associated activator of morphogenesis 1 DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) DAPL1 death associated protein-like 1 DCN decorin DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21 DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 DEFA3 defensin, alpha 3, neutrophil-specific DENND2A DENN/MADD domain containing 2A DHCR24 24-dehydrocholesterol reductase DHCR7 7-dehydrocholesterol reductase DHODH dihydroorotate dehydrogenase (quinone) DHRS7 dehydrogenase/reductase (SDR family) member 7 DHTKD1 dehydrogenase E1 and transketolase domain containing 1 DHX37 DEAH (Asp-Glu-Ala-His) box polypeptide 37 DIO2 deiodinase, iodothyronine, type II DISP2 dispatched homolog 2 (Drosophila) DKFZp779M0652uncharacterized DKFZp779M0652 DLC1 DLC1 Rho GTPase activating protein DLG4 discs, large homolog 4 (Drosophila) DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 DNASE1L3 deoxyribonuclease I-like 3 DNM3 dynamin 3 DOCK7 dedicator of cytokinesis 7 DOK3 docking protein 3 DPF3 D4, zinc and double PHD fingers, family 3 DPT dermatopontin DPYSL3 dihydropyrimidinase-like 3 DPYSL4 dihydropyrimidinase-like 4 DPYSL5 dihydropyrimidinase-like 5 DR1 down-regulator of transcription 1, TBP-binding (negative cofactor 2) DUSP1 dual specificity phosphatase 1 DUSP2 dual specificity phosphatase 2 DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 EBF1 early B-cell factor 1 EBI3 Epstein-Barr virus induced 3 ECE2 endothelin converting enzyme 2 ECM2 extracellular matrix protein 2, female organ and adipocyte specific ECT2 epithelial cell transforming 2 EDN1 endothelin 1 EDN3 endothelin 3 EDNRB endothelin receptor type B EEF2 eukaryotic translation elongation factor 2 EFR3A EFR3 homolog A (S. cerevisiae) EFR3B EFR3 homolog B (S. cerevisiae) EGR1 early growth response 1 EIF1AY eukaryotic translation initiation factor 1A, Y-linked EIF5 eukaryotic translation initiation factor 5 EMD emerin EMP1 epithelial membrane protein 1 EMX2OS EMX2 opposite strand/antisense RNA ENC1 ectodermal-neural cortex 1 (with BTB domain) ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 EPB41L3 erythrocyte membrane protein band 4.1-like 3 EPHA3 EPH receptor A3 ERAP2 endoplasmic reticulum aminopeptidase 2 ERRFI1 ERBB receptor feedback inhibitor 1 EYA1 EYA transcriptional coactivator and phosphatase 1 EYA2 EYA transcriptional coactivator and phosphatase 2 EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit

0.30 -0.17 -0.34 0.36 0.00 -0.28 0.27 0.31 -0.19 0.34 -0.18 -0.14 -0.47 -0.28 0.43 0.31 0.41 -0.34 -0.65 -0.55 -0.58 -0.16 -0.51 0.35 0.32 0.39 0.45 0.50 0.46 -0.35 0.55 0.32 -0.47 -0.26 -0.26 -0.34 -0.39 0.44 -0.76 -0.99 0.29 0.37 0.22 -0.31 0.65 -0.19 -0.37 -0.19 -0.36 0.01 -0.17 -0.38 0.39 -0.20 -0.38 -0.24 -0.27 -0.34 -0.20 -0.13 0.17 -0.62 -0.17 0.57 -0.44 0.31 -0.51 -0.81 -0.48 0.54 -0.40 -0.31 -0.36 -0.66 0.29 -0.22 -0.49 0.25 -0.29 -0.13 -0.37 0.48

0.03 0.00 0.12 0.00 0.00 0.11 0.14 0.13 0.06 0.15 0.07 0.01 0.00 0.00 0.08 0.12 0.00 0.04 0.00 0.00 0.01 0.07 0.00 0.08 0.00 0.04 0.00 0.01 0.18 0.12 0.08 0.12 0.00 0.01 0.03 0.06 0.11 0.02 0.00 0.03 0.04 0.00 0.04 0.01 0.03 0.09 0.06 0.00 0.05 0.12 0.10 0.09 0.03 0.07 0.06 0.12 0.04 0.01 0.04 0.12 0.19 0.00 0.19 0.00 0.05 0.05 0.00 0.00 0.03 0.00 0.03 0.09 0.03 0.00 0.00 0.14 0.00 0.00 0.04 0.11 0.04 0.06

EZR F13A1 F3 FABP5 FADS1 FADS2 FAIM FAM101A FAM102B FAM105A FAM110C FAM126B FAM131C FAM150B FAM155A FAM167B FAM169A FAM171B FAM177A1 FAM181B FAM26F FAM57A FBXL7 FBXO32 FCER1G FCGBP FCGR1B FCGR2A FCGR3A FCN3 FDPS FER1L4 FGF7 FGF9 FGFBP2 FHL1 FHL2 FHOD3 FILIP1L FJX1 FKBP10 FKBP5 FLRT2 FMN1 FMO2 FMO3 FNDC5 FNIP2 FOLR1 FOLR2 FOS FOSL2 FOXF2 FOXP2 FOXQ1 FPR1 FRMPD2 FRZB FST FSTL1 FXYD3 FXYD6 FYB FZD10 FZD7 G0S2 GABRE GADD45B GADD45G GAL GALNT1 GALNT11 GALNT14 GAS1 GATM GBP3 GBP5 GDF11 GDF15 GFOD1 GIMAP1 GIMAP2

ezrin coagulation factor XIII, A1 polypeptide coagulation factor III (thromboplastin, tissue factor) fatty acid binding protein 5 (psoriasis-associated) fatty acid desaturase 1 fatty acid desaturase 2 Fas apoptotic inhibitory molecule family with sequence similarity 101, member A family with sequence similarity 102, member B family with sequence similarity 105, member A family with sequence similarity 110, member C family with sequence similarity 126, member B family with sequence similarity 131, member C family with sequence similarity 150, member B family with sequence similarity 155, member A family with sequence similarity 167, member B family with sequence similarity 169, member A family with sequence similarity 171, member B family with sequence similarity 177, member A1 family with sequence similarity 181, member B family with sequence similarity 26, member F family with sequence similarity 57, member A F-box and leucine-rich repeat protein 7 F-box protein 32 Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide Fc fragment of IgG binding protein Fc fragment of IgG, high affinity Ib, receptor (CD64) Fc fragment of IgG, low affinity IIa, receptor (CD32) Fc fragment of IgG, low affinity IIIa, receptor (CD16a) ficolin (collagen/fibrinogen domain containing) 3 farnesyl diphosphate synthase fer-1-like family member 4, pseudogene (functional) fibroblast growth factor 7 fibroblast growth factor 9 fibroblast growth factor binding protein 2 four and a half LIM domains 1 four and a half LIM domains 2 formin homology 2 domain containing 3 filamin A interacting protein 1-like four jointed box 1 (Drosophila) FK506 binding protein 10, 65 kDa FK506 binding protein 5 fibronectin leucine rich transmembrane protein 2 formin 1 flavin containing monooxygenase 2 (non-functional) flavin containing monooxygenase 3 fibronectin type III domain containing 5 folliculin interacting protein 2 folate receptor 1 (adult) folate receptor 2 (fetal) FBJ murine osteosarcoma viral oncogene homolog FOS-like antigen 2 forkhead box F2 forkhead box P2 forkhead box Q1 formyl peptide receptor 1 FERM and PDZ domain containing 2 frizzled-related protein follistatin follistatin-like 1 FXYD domain containing ion transport regulator 3 FXYD domain containing ion transport regulator 6 FYN binding protein frizzled class receptor 10 frizzled class receptor 7 G0/G1 switch 2 gamma-aminobutyric acid (GABA) A receptor, epsilon growth arrest and DNA-damage-inducible, beta growth arrest and DNA-damage-inducible, gamma galanin/GMAP prepropeptide polypeptide N-acetylgalactosaminyltransferase 1 polypeptide N-acetylgalactosaminyltransferase 11 polypeptide N-acetylgalactosaminyltransferase 14 growth arrest-specific 1 glycine amidinotransferase (L-arginine:glycine amidinotransferase) guanylate binding protein 3 guanylate binding protein 5 growth differentiation factor 11 growth differentiation factor 15 glucose-fructose oxidoreductase domain containing 1 GTPase, IMAP family member 1 GTPase, IMAP family member 2

0.53 -0.37 -0.41 -0.74 0.42 0.47 -0.54 -0.17 -0.30 -0.40 -0.17 -0.27 0.46 -0.37 -0.40 0.31 -0.47 -0.26 -0.42 0.19 -0.12 0.52 -0.30 0.67 -0.29 -0.05 -0.06 -0.17 -0.34 -0.26 0.63 0.99 0.25 0.16 -0.27 -0.32 -0.24 -0.32 -0.39 0.34 0.46 -0.42 -0.28 -0.34 0.07 0.05 0.19 -0.38 0.11 -0.40 -0.12 0.62 -0.23 -0.45 0.16 -0.29 -0.41 0.30 -0.30 -0.33 0.35 -0.31 -0.34 0.58 -0.12 0.09 -0.16 0.21 0.35 0.01 0.34 0.59 -0.18 -0.27 -0.37 0.00 -0.05 0.68 -0.05 -0.24 -0.12 -0.19

0.00 0.00 0.00 0.00 0.02 0.01 0.02 0.09 0.14 0.00 0.08 0.18 0.00 0.00 0.00 0.02 0.04 0.19 0.04 0.19 0.01 0.02 0.05 0.01 0.08 0.00 0.11 0.00 0.00 0.00 0.05 0.00 0.07 0.02 0.00 0.01 0.19 0.01 0.07 0.00 0.03 0.00 0.11 0.01 0.06 0.03 0.14 0.08 0.07 0.00 0.00 0.01 0.04 0.02 0.04 0.00 0.13 0.03 0.00 0.04 0.00 0.13 0.00 0.00 0.14 0.00 0.05 0.14 0.07 0.07 0.12 0.00 0.02 0.00 0.00 0.03 0.08 0.00 0.00 0.09 0.07 0.01

GJA1 GLB1L GLIPR1 GLRX GLRX2 GMPPB GNAT1 GNB1 GNG2 GNGT1 GPAM GPC6 GPIHBP1 GPM6B GPR126 GPR162 GPR183 GPRC5C GPX8 GRAMD1C GSTT1 GSTT2 GTPBP3 GUCA1A GUCA1B GUCY1A3 GYG1 GYLTL1B GZMA GZMB H19 H1F0 HAVCR2 HBA2 HBB HBD HBM HCLS1 HERPUD1 HES5 HGD HHATL HHIP HIST1H1C HIST1H2AD HIST1H2AE HIST1H2BD HIST1H2BE HIST1H2BH HIST1H2BM HIST1H2BN HIST1H4J HIST2H2AA4 HIST2H2AB HIST2H2BE HIST2H4B HIST3H2A HIST3H2BB HK2 HLA-DMA HLA-DMB HLA-DOA HLA-DPA1 HLA-DPB1 HLA-DQB2 HLA-DRA HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 HLCS HMGA1 HMGCS1 HMGN1 HMGN2 HMOX1 HNMT HNRNPC HNRNPK HOPX HP HRASLS5

gap junction protein, alpha 1, 43kDa galactosidase, beta 1-like GLI pathogenesis-related 1 glutaredoxin (thioltransferase) glutaredoxin 2 GDP-mannose pyrophosphorylase B guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 guanine nucleotide binding protein (G protein), beta polypeptide 1 guanine nucleotide binding protein (G protein), gamma 2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 glycerol-3-phosphate acyltransferase, mitochondrial glypican 6 glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 glycoprotein M6B G protein-coupled receptor 126 G protein-coupled receptor 162 G protein-coupled receptor 183 G protein-coupled receptor, class C, group 5, member C glutathione peroxidase 8 (putative) GRAM domain containing 1C glutathione S-transferase theta 1 glutathione S-transferase theta 2 (gene/pseudogene) GTP binding protein 3 (mitochondrial) guanylate cyclase activator 1A (retina) guanylate cyclase activator 1B (retina) guanylate cyclase 1, soluble, alpha 3 glycogenin 1 glycosyltransferase-like 1B granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) H19, imprinted maternally expressed transcript (non-protein coding) H1 histone family, member 0 hepatitis A virus cellular receptor 2 hemoglobin, alpha 2 hemoglobin, beta hypophosphatemic bone disease hemoglobin, mu hematopoietic cell-specific Lyn substrate 1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 hes family bHLH transcription factor 5 homogentisate 1,2-dioxygenase hedgehog acyltransferase-like hedgehog interacting protein histone cluster 1, H1c histone cluster 1, H2ad histone cluster 1, H2ae histone cluster 1, H2bd histone cluster 1, H2be histone cluster 1, H2bh histone cluster 1, H2bm histone cluster 1, H2bn histone cluster 1, H4j histone cluster 2, H2aa4 histone cluster 2, H2ab histone cluster 2, H2be histone cluster 2, H4b histone cluster 3, H2a histone cluster 3, H2bb hexokinase 2 major histocompatibility complex, class II, DM alpha major histocompatibility complex, class II, DM beta major histocompatibility complex, class II, DO alpha major histocompatibility complex, class II, DP alpha 1 major histocompatibility complex, class II, DP beta 1 major histocompatibility complex, class II, DQ beta 2 major histocompatibility complex, class II, DR alpha major histocompatibility complex, class II, DR beta 1 major histocompatibility complex, class II, DR beta 3 major histocompatibility complex, class II, DR beta 4 major histocompatibility complex, class II, DR beta 5 holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) high mobility group AT-hook 1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) high mobility group nucleosome binding domain 1 high mobility group nucleosomal binding domain 2 heme oxygenase (decycling) 1 histamine N-methyltransferase heterogeneous nuclear ribonucleoprotein C (C1/C2) heterogeneous nuclear ribonucleoprotein K HOP homeobox haptoglobin HRAS-like suppressor family, member 5

0.17 0.40 -0.20 -0.12 -0.28 0.19 -0.56 -0.41 -0.26 -1.46 0.48 -0.30 -0.12 -0.31 0.26 -0.39 -0.13 0.62 -0.28 0.34 -0.30 0.33 -0.30 -0.71 -0.67 -0.32 0.48 0.64 -0.45 0.11 -0.27 0.35 -0.24 -0.52 -0.11 -0.73 -0.22 -0.23 -0.27 0.21 0.43 -0.15 -0.06 -0.29 -0.41 -0.26 -0.42 -0.36 -0.35 -0.30 -0.30 -0.44 -0.44 -0.07 -0.29 -0.38 -0.29 -0.12 -0.46 -0.20 -0.11 -0.25 -0.45 0.10 0.01 -0.25 -0.19 -0.25 -0.13 -0.24 0.28 0.63 0.53 -0.36 -0.31 -0.48 -0.42 -0.32 0.42 -0.06 0.27 0.31

0.18 0.14 0.15 0.12 0.13 0.10 0.00 0.09 0.06 0.00 0.00 0.08 0.00 0.06 0.02 0.07 0.11 0.01 0.01 0.02 0.00 0.14 0.16 0.00 0.00 0.05 0.17 0.00 0.00 0.02 0.00 0.03 0.02 0.00 0.00 0.00 0.00 0.15 0.12 0.00 0.00 0.03 0.04 0.05 0.00 0.09 0.01 0.03 0.06 0.18 0.15 0.02 0.00 0.07 0.02 0.01 0.06 0.13 0.00 0.10 0.18 0.10 0.00 0.04 0.03 0.09 0.09 0.01 0.01 0.05 0.19 0.03 0.00 0.10 0.18 0.02 0.03 0.08 0.19 0.06 0.01 0.12

HSD11B1 HSDL2 HSP90AA1 HSP90B1 HSPA1A HSPA4 HSPA5 HSPA6 HSPA8 HSPD1P6 HSPE1 HSPH1 HTRA3 ID1 ID2 IDI1 IER5 IFI44L IFI6 IFIT1 IGF2 IGFBP3 IGFBP4 IGFBP6 IGHA1 IGHM IGLL1 IKZF2 IL18BP IL1R1 IL1R2 IL33 IL3RA IL6ST IL7R IMP4 INA INHBB INPP5K INSIG1 IPO9 IPP IRX3 IRX5 ISG15 ISLR2 ITGA8 ITGAM ITGAV ITGB1BP1 ITGB8 ITPRIPL2 JAKMIP1 JPH2 KATNA1 KAZALD1 KBTBD2 KCNB1 KCNC1 KCNE4 KCNJ13 KCNJ14 KCNK1 KCNMB4 KCNS3 KCNV2 KDR KGFLP1 KIAA0485 KIAA1324L KIAA1462 KIAA1549 KIAA1683 KIF1A KIF25 KIF5C KIT KITLG KLF16 KLF2 KLHL18 KLHL21

hydroxysteroid (11-beta) dehydrogenase 1 hydroxysteroid dehydrogenase like 2 heat shock protein 90kDa alpha (cytosolic), class A member 1 heat shock protein 90kDa beta (Grp94), member 1 heat shock 70kDa protein 1A heat shock 70kDa protein 4 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) heat shock 70kDa protein 6 (HSP70B') heat shock 70kDa protein 8 heat shock 60kDa protein 1 (chaperonin) pseudogene 6 heat shock 10kDa protein 1 heat shock 105kDa/110kDa protein 1 HtrA serine peptidase 3 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein inhibitor of DNA binding 2, dominant negative helix-loop-helix protein isopentenyl-diphosphate delta isomerase 1 immediate early response 5 interferon-induced protein 44-like interferon, alpha-inducible protein 6 interferon-induced protein with tetratricopeptide repeats 1 insulin-like growth factor 2 insulin-like growth factor binding protein 3 insulin-like growth factor binding protein 4 insulin-like growth factor binding protein 6 immunoglobulin heavy constant alpha 1 immunoglobulin heavy constant mu immunoglobulin lambda-like polypeptide 1 IKAROS family zinc finger 2 (Helios) interleukin 18 binding protein interleukin 1 receptor, type I interleukin 1 receptor, type II interleukin 33 interleukin 3 receptor, alpha (low affinity) interleukin 6 signal transducer interleukin 7 receptor IMP4, U3 small nucleolar ribonucleoprotein internexin neuronal intermediate filament protein, alpha inhibin, beta B inositol polyphosphate-5-phosphatase K insulin induced gene 1 importin 9 intracisternal A particle-promoted polypeptide iroquois homeobox 3 iroquois homeobox 5 ISG15 ubiquitin-like modifier immunoglobulin superfamily containing leucine-rich repeat 2 integrin, alpha 8 integrin, alpha M (complement component 3 receptor 3 subunit) integrin, alpha V integrin beta 1 binding protein 1 integrin, beta 8 inositol 1,4,5-trisphosphate receptor interacting protein-like 2 janus kinase and microtubule interacting protein 1 junctophilin 2 katanin p60 (ATPase containing) subunit A 1 Kazal-type serine peptidase inhibitor domain 1 kelch repeat and BTB (POZ) domain containing 2 potassium voltage-gated channel, Shab-related subfamily, member 1 potassium voltage-gated channel, Shaw-related subfamily, member 1 potassium voltage-gated channel, Isk-related family, member 4 potassium inwardly-rectifying channel, subfamily J, member 13 potassium inwardly-rectifying channel, subfamily J, member 14 potassium channel, subfamily K, member 1 potassium large conductance calcium-activated channel, subfamily M, beta member 4 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3 potassium channel, subfamily V, member 2 kinase insert domain receptor (a type III receptor tyrosine kinase) fibroblast growth factor 7 pseudogene uncharacterized LOC57235 KIAA1324-like KIAA1462 KIAA1549 KIAA1683 kinesin family member 1A kinesin family member 25 kinesin family member 5C v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog KIT ligand Kruppel-like factor 16 Kruppel-like factor 2 kelch-like family member 18 kelch-like family member 21

0.05 0.43 -0.70 -0.50 -0.94 -0.51 -0.16 -0.40 -0.30 -0.47 -0.36 -1.69 -0.27 -0.23 -0.10 0.35 -0.43 -0.58 -0.01 -0.08 -0.22 0.06 0.47 -0.16 0.32 0.91 0.74 -0.32 0.27 -0.23 0.18 0.19 0.02 -0.39 -0.45 0.63 -0.65 -0.13 0.39 0.46 0.37 0.31 -0.15 -0.45 0.25 -0.06 -0.30 -0.36 0.26 -0.15 0.46 0.05 -0.54 -0.21 0.48 -0.25 -0.38 -0.54 -0.41 -0.06 -0.03 -0.79 -0.39 0.00 0.29 -0.99 -0.28 -0.07 0.15 -0.26 -0.28 -0.57 -0.28 -0.26 -0.36 -0.50 0.24 0.20 0.48 0.27 -0.17 0.53

0.03 0.19 0.00 0.00 0.00 0.14 0.12 0.13 0.12 0.15 0.20 0.00 0.16 0.05 0.01 0.02 0.06 0.00 0.17 0.14 0.13 0.19 0.01 0.15 0.00 0.00 0.00 0.10 0.18 0.01 0.00 0.16 0.05 0.02 0.00 0.03 0.00 0.00 0.00 0.01 0.19 0.18 0.16 0.00 0.13 0.02 0.01 0.01 0.07 0.13 0.00 0.17 0.00 0.13 0.16 0.01 0.12 0.00 0.03 0.09 0.09 0.00 0.01 0.15 0.12 0.00 0.13 0.02 0.11 0.10 0.18 0.02 0.06 0.19 0.00 0.00 0.08 0.14 0.05 0.17 0.12 0.06

KLRB1 KPNA4 KRT18 KRT18P19 KRT18P33 KRT18P42 KRT19 KYNU LAIR1 LAPTM4B LAPTM5 LAYN LCK LDHA LDLR LEF1 LEPR LEPREL1 LGI1 LHFPL4 LHX2 LIFR LIPA LIPE LMCD1 LMO1 LOC100129104 LOC100133315 LOC388242 LOC400099 LPL LRP4 LRP8 LRRC25 LRRC39 LRRC8A LSS LTB LTBP2 LXN LY86 LY96 LYPD1 LYRM2 MAFB MAFF MAGED2 MAGED4B MALAT1 MAN2A1 MAP1B MAP2K3 MAP2K6 MAP4K4 MAP6D1 MAP7D3 MAPT MARCKS MARCO MAST1 MATN4 MCL1 MCOLN1 MDK MERTK MEST METRN METTL1 METTL7A MGAT5B MGC24103 MIAT MICAL2 MID1 MKNK2 MLC1 MLLT11 MMD MMP15 MMP19 MMP9 MNDA

killer cell lectin-like receptor subfamily B, member 1 karyopherin alpha 4 (importin alpha 3) keratin 18 keratin 18 pseudogene 19 keratin 18 pseudogene 33 keratin 18 pseudogene 42 keratin 19 kynureninase leukocyte-associated immunoglobulin-like receptor 1 lysosomal protein transmembrane 4 beta lysosomal protein transmembrane 5 layilin LCK proto-oncogene, Src family tyrosine kinase lactate dehydrogenase A low density lipoprotein receptor lymphoid enhancer-binding factor 1 leptin receptor leprecan-like 1 leucine-rich, glioma inactivated 1 lipoma HMGIC fusion partner-like 4 LIM homeobox 2 leukemia inhibitory factor receptor alpha lipase A, lysosomal acid, cholesterol esterase lipase, hormone-sensitive LIM and cysteine-rich domains 1 LIM domain only 1 (rhombotin 1) uncharacterized LOC100129104 transient receptor potential cation channel, subfamily C, member 2-like coiled-coil domain containing 101 pseudogene uncharacterized LOC400099 lipoprotein lipase low density lipoprotein receptor-related protein 4 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor leucine rich repeat containing 25 leucine rich repeat containing 39 leucine rich repeat containing 8 family, member A lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) lymphotoxin beta (TNF superfamily, member 3) latent transforming growth factor beta binding protein 2 latexin lymphocyte antigen 86 lymphocyte antigen 96 LY6/PLAUR domain containing 1 LYR motif containing 2 v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F melanoma antigen family D, 2 melanoma antigen family D, 4B metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) mannosidase, alpha, class 2A, member 1 microtubule-associated protein 1B mitogen-activated protein kinase kinase 3 mitogen-activated protein kinase kinase 6 mitogen-activated protein kinase kinase kinase kinase 4 MAP6 domain containing 1 MAP7 domain containing 3 microtubule-associated protein tau myristoylated alanine-rich protein kinase C substrate macrophage receptor with collagenous structure microtubule associated serine/threonine kinase 1 matrilin 4 myeloid cell leukemia 1 mucolipin 1 midkine (neurite growth-promoting factor 2) MER proto-oncogene, tyrosine kinase mesoderm specific transcript meteorin, glial cell differentiation regulator methyltransferase like 1 methyltransferase like 7A mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B uncharacterized MGC24103 myocardial infarction associated transcript (non-protein coding) microtubule associated monooxygenase, calponin and LIM domain containing 2 midline 1 MAP kinase interacting serine/threonine kinase 2 megalencephalic leukoencephalopathy with subcortical cysts 1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 monocyte to macrophage differentiation-associated matrix metallopeptidase 15 (membrane-inserted) matrix metallopeptidase 19 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) myeloid cell nuclear differentiation antigen

-0.32 -0.41 0.11 0.47 0.21 0.14 -0.23 -0.28 -0.27 0.16 -0.29 0.41 -0.44 -0.28 0.15 -0.13 -0.28 -0.58 0.27 -0.55 0.29 0.13 -0.14 0.45 -0.14 0.39 -0.28 0.56 0.32 0.22 -0.31 -0.37 0.31 -0.23 -0.73 0.48 0.49 0.13 -0.15 0.07 -0.24 -0.29 0.28 0.44 -0.44 0.36 -0.32 -0.28 0.39 0.64 -0.35 -0.37 -0.30 0.44 0.45 -0.19 -0.26 -0.33 -0.03 -0.38 -0.10 -0.31 0.15 -0.50 -0.22 -0.47 0.70 0.16 -0.26 -0.10 0.30 -0.10 -0.28 -0.38 -0.64 -0.44 -0.40 -0.36 0.44 -0.55 -0.06 -0.47

0.00 0.07 0.19 0.00 0.15 0.17 0.01 0.02 0.02 0.16 0.02 0.01 0.03 0.01 0.06 0.07 0.00 0.00 0.05 0.00 0.02 0.17 0.17 0.02 0.03 0.02 0.03 0.06 0.17 0.06 0.00 0.13 0.01 0.12 0.00 0.06 0.07 0.15 0.08 0.01 0.13 0.00 0.01 0.03 0.00 0.08 0.02 0.10 0.19 0.00 0.03 0.10 0.08 0.04 0.03 0.20 0.07 0.06 0.00 0.01 0.11 0.10 0.16 0.01 0.10 0.00 0.00 0.17 0.14 0.03 0.03 0.00 0.12 0.02 0.00 0.10 0.00 0.11 0.07 0.00 0.00 0.01

MPEG1 MPHOSPH8 MPP1 MPZL1 MRAP2 MRPL36 MRPS10 MRVI1 MS4A4A MS4A6A MS4A7 MSR1 MT1A MT1B MT1E MT1G MT1H MT1JP MT1L MT1M MT1X MT2A MT3 MTCH2 MTHFD2 MTRF1 MYC MYH11 MYL4 MYL5 MYO1E MYO5B MYOC MYOF MYOT MYOZ3 MYRIP NAMPT NAV3 NBL1 NCOA7 NDRG4 NECAB1 NEDD4L NEFH NEFL NEFM NELL2 NEURL2 NEUROG3 NEXN NFE2 NFIL3 NKX2-8 NLGN1 NNMT NOSTRIN NOTCH2NL NOTCH4 NPHP3 NPL NPM3 NR4A1 NR4A3 NRL NRP2 NRXN3 NT5DC2 NTNG2 NTRK2 NTRK3 NUDT22 NUDT3 NUDT4 OCA2 ODC1 OGFRL1 OGN OLFM1 OLFML2A OLFML3 OPHN1

macrophage expressed 1 M-phase phosphoprotein 8 membrane protein, palmitoylated 1, 55kDa myelin protein zero-like 1 melanocortin 2 receptor accessory protein 2 mitochondrial ribosomal protein L36 mitochondrial ribosomal protein S10 murine retrovirus integration site 1 homolog membrane-spanning 4-domains, subfamily A, member 4A membrane-spanning 4-domains, subfamily A, member 6A membrane-spanning 4-domains, subfamily A, member 7 macrophage scavenger receptor 1 metallothionein 1A metallothionein 1B metallothionein 1E metallothionein 1G metallothionein 1H metallothionein 1J, pseudogene metallothionein 1L (gene/pseudogene) metallothionein 1M metallothionein 1X metallothionein 2A metallothionein 3 mitochondrial carrier 2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase mitochondrial translational release factor 1 v-myc avian myelocytomatosis viral oncogene homolog myosin, heavy chain 11, smooth muscle myosin, light chain 4, alkali; atrial, embryonic myosin, light chain 5, regulatory myosin IE myosin VB myocilin, trabecular meshwork inducible glucocorticoid response myoferlin myotilin myozenin 3 myosin VIIA and Rab interacting protein nicotinamide phosphoribosyltransferase neuron navigator 3 neuroblastoma 1, DAN family BMP antagonist nuclear receptor coactivator 7 NDRG family member 4 N-terminal EF-hand calcium binding protein 1 neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase neurofilament, heavy polypeptide neurofilament, light polypeptide neurofilament, medium polypeptide NEL-like 2 (chicken) neuralized E3 ubiquitin protein ligase 2 neurogenin 3 nexilin (F actin binding protein) nuclear factor, erythroid 2 nuclear factor, interleukin 3 regulated NK2 homeobox 8 neuroligin 1 nicotinamide N-methyltransferase nitric oxide synthase trafficking notch 2 N-terminal like notch 4 nephronophthisis 3 (adolescent) N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) nucleophosmin/nucleoplasmin 3 nuclear receptor subfamily 4, group A, member 1 nuclear receptor subfamily 4, group A, member 3 neural retina leucine zipper neuropilin 2 neurexin 3 5'-nucleotidase domain containing 2 netrin G2 neurotrophic tyrosine kinase, receptor, type 2 neurotrophic tyrosine kinase, receptor, type 3 nudix (nucleoside diphosphate linked moiety X)-type motif 22 nudix (nucleoside diphosphate linked moiety X)-type motif 3 nudix (nucleoside diphosphate linked moiety X)-type motif 4 oculocutaneous albinism II ornithine decarboxylase 1 opioid growth factor receptor-like 1 osteoglycin olfactomedin 1 olfactomedin-like 2A olfactomedin-like 3 oligophrenin 1

-0.35 0.20 -0.35 -0.29 -0.30 0.47 -0.35 -0.23 -0.29 -0.46 -0.65 -0.85 -0.28 -0.40 -0.29 -0.39 -0.26 0.08 -0.28 -0.36 -0.10 -0.48 -0.37 -0.25 -0.14 0.35 -0.30 0.33 -0.52 -0.28 0.32 -0.35 -0.36 -0.24 -0.24 0.20 0.61 -0.15 0.33 -0.27 -0.35 -0.29 -0.22 0.43 -0.60 -0.58 -1.05 0.41 -0.20 0.22 -0.23 -0.04 -0.07 0.47 -0.30 0.09 -0.07 0.27 0.43 0.46 -0.52 0.50 0.13 -0.20 -0.35 -0.37 -0.29 0.26 -0.38 -0.38 0.50 0.55 -0.16 -0.42 -0.24 -0.25 -0.40 -0.40 -0.12 0.03 -0.29 0.22

0.03 0.07 0.18 0.02 0.01 0.16 0.13 0.02 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.01 0.00 0.00 0.00 0.00 0.05 0.14 0.01 0.13 0.03 0.07 0.00 0.13 0.17 0.11 0.00 0.06 0.00 0.00 0.00 0.03 0.13 0.01 0.02 0.02 0.00 0.00 0.00 0.00 0.00 0.00 0.03 0.18 0.05 0.04 0.18 0.06 0.15 0.14 0.06 0.13 0.14 0.19 0.00 0.00 0.03 0.00 0.04 0.07 0.03 0.19 0.19 0.05 0.05 0.12 0.04 0.06 0.00 0.09 0.03 0.00 0.10 0.02 0.03 0.09

OSCAR OVOS2 P2RY6 P4HA3 PABPC4L PACSIN2 PAIP2B PAPSS2 PAQR6 PAQR8 PARP12 PAX3 PBX2 PBX4 PCDHB16 PCMTD1 PCP4L1 PDAP1 PDE2A PDE6A PDE6G PDE6H PDGFRA PDK4 PDLIM5 PDPN PDXK PER1 PER2 PEX6 PFDN6 PFKL PGD PGF PGK1 PGM2L1 PGPEP1 PHC2 PHF19 PHLDA2 PI16 PIGX PIK3C2B PIK3R1 PIK3R3 PITPNA PITX2 PLA2G2A PLA2G4A PLAGL1 PLAU PLCD4 PLCE1 PLCH2 PLEKHA6 PLEKHM3 PLK2 PLN PLP1 PLTP PLVAP PNPLA3 PODXL POLE4 PON3 PPAP2B PPIC PPME1 PPP1R1A PPP1R1C PPP1R3C PPP2R2B PQLC1 PRAM1 PRB3 PRELP PRINS PRKX PRMT2 PRPF31 PRPH PRPH2

osteoclast associated, immunoglobulin-like receptor ovostatin 2 pyrimidinergic receptor P2Y, G-protein coupled, 6 prolyl 4-hydroxylase, alpha polypeptide III poly(A) binding protein, cytoplasmic 4-like protein kinase C and casein kinase substrate in neurons 2 poly(A) binding protein interacting protein 2B 3'-phosphoadenosine 5'-phosphosulfate synthase 2 progestin and adipoQ receptor family member VI progestin and adipoQ receptor family member VIII poly (ADP-ribose) polymerase family, member 12 paired box 3 pre-B-cell leukemia homeobox 2 pre-B-cell leukemia homeobox 4 protocadherin beta 16 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 Purkinje cell protein 4 like 1 PDGFA associated protein 1 phosphodiesterase 2A, cGMP-stimulated phosphodiesterase 6A, cGMP-specific, rod, alpha phosphodiesterase 6G, cGMP-specific, rod, gamma phosphodiesterase 6H, cGMP-specific, cone, gamma platelet-derived growth factor receptor, alpha polypeptide pyruvate dehydrogenase kinase, isozyme 4 PDZ and LIM domain 5 podoplanin pyridoxal (pyridoxine, vitamin B6) kinase period circadian clock 1 period circadian clock 2 peroxisomal biogenesis factor 6 prefoldin subunit 6 phosphofructokinase, liver phosphogluconate dehydrogenase placental growth factor phosphoglycerate kinase 1 phosphoglucomutase 2-like 1 pyroglutamyl-peptidase I polyhomeotic homolog 2 (Drosophila) PHD finger protein 19 pleckstrin homology-like domain, family A, member 2 peptidase inhibitor 16 phosphatidylinositol glycan anchor biosynthesis, class X phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta phosphoinositide-3-kinase, regulatory subunit 1 (alpha) phosphoinositide-3-kinase, regulatory subunit 3 (gamma) phosphatidylinositol transfer protein, alpha paired-like homeodomain 2 phospholipase A2, group IIA (platelets, synovial fluid) phospholipase A2, group IVA (cytosolic, calcium-dependent) pleiomorphic adenoma gene-like 1 plasminogen activator, urokinase phospholipase C, delta 4 phospholipase C, epsilon 1 phospholipase C, eta 2 pleckstrin homology domain containing, family A member 6 pleckstrin homology domain containing, family M, member 3 polo-like kinase 2 phospholamban proteolipid protein 1 phospholipid transfer protein plasmalemma vesicle associated protein patatin-like phospholipase domain containing 3 podocalyxin-like polymerase (DNA-directed), epsilon 4, accessory subunit paraoxonase 3 phosphatidic acid phosphatase type 2B peptidylprolyl isomerase C (cyclophilin C) protein phosphatase methylesterase 1 protein phosphatase 1, regulatory (inhibitor) subunit 1A protein phosphatase 1, regulatory (inhibitor) subunit 1C protein phosphatase 1, regulatory subunit 3C protein phosphatase 2, regulatory subunit B, beta PQ loop repeat containing 1 PML-RARA regulated adaptor molecule 1 proline-rich protein BstNI subfamily 3 proline/arginine-rich end leucine-rich repeat protein psoriasis associated non-protein coding RNA induced by stress protein kinase, X-linked protein arginine methyltransferase 2 pre-mRNA processing factor 31 peripherin peripherin 2 (retinal degeneration, slow)

-0.20 -0.45 -0.21 -0.12 -0.37 0.22 -0.42 -0.40 -0.05 -0.31 0.40 0.40 0.74 0.47 0.43 -0.35 -0.69 0.34 -0.23 -0.51 -0.51 -1.34 -0.44 0.47 -0.20 0.30 0.45 -0.30 -0.39 -0.14 0.38 0.42 0.58 -0.46 -0.18 0.54 0.46 0.82 -0.31 0.31 -0.72 0.56 0.40 -0.29 -0.17 0.34 -0.40 0.27 -0.24 -0.34 0.18 -0.41 0.51 -0.53 -0.28 0.58 -0.23 -0.34 -0.19 -0.43 -0.24 0.38 -0.30 -0.30 0.43 -0.21 -0.24 -0.34 -0.54 -0.51 -0.27 -0.90 -0.28 0.28 0.43 -0.20 -0.15 0.29 0.42 0.59 0.02 -0.70

0.12 0.02 0.05 0.12 0.00 0.16 0.05 0.00 0.19 0.00 0.14 0.07 0.00 0.02 0.06 0.13 0.00 0.08 0.05 0.00 0.00 0.00 0.00 0.00 0.14 0.02 0.10 0.03 0.00 0.15 0.02 0.04 0.01 0.00 0.16 0.05 0.08 0.00 0.09 0.15 0.00 0.07 0.11 0.15 0.13 0.01 0.00 0.00 0.04 0.00 0.11 0.01 0.18 0.05 0.02 0.01 0.17 0.00 0.00 0.00 0.10 0.00 0.06 0.09 0.04 0.17 0.15 0.06 0.01 0.00 0.08 0.00 0.14 0.15 0.14 0.17 0.10 0.19 0.11 0.02 0.00 0.00

PRR7 PRUNE2 PRX PSAT1 PSMB3 PSMD6 PSPH PTAFR PTGDS PTGER4 PTGIR PTGIS PTN PTP4A1 PTPRJ PTPRZ1 PTX3 PUSL1 PVALB PYCR1 PYY2 QPCT RAB15 RAB22A RAB33A RAB8B RABEP1 RAI2 RAN RAP2A RARRES1 RASD1 RASGRP2 RASL10A RAX RBBP8 RBM3 RBM47 RBP1 RCAN2 RCCD1 RCOR3 RDH10 RDH11 RDH5 REEP1 REEP2 REEP6 RELT RETSAT RGN RGPD2 RGR RGS1 RGS10 RGS2 RGS9 RGS9BP RHO RIMS3 RLBP1 RMI1 RNASE6 RND3 RNF13 RNF14 ROM1 RPGRIP1 RRAD RSPH1 RSPO2 RSPO3 RTBDN RUNX1 RUNX3 S100A12 S100A6 S100A8 S100A9 S100P SAA1 SAA2

proline rich 7 (synaptic) prune homolog 2 (Drosophila) periaxin phosphoserine aminotransferase 1 proteasome (prosome, macropain) subunit, beta type, 3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 phosphoserine phosphatase platelet-activating factor receptor prostaglandin D2 synthase 21kDa (brain) prostaglandin E receptor 4 (subtype EP4) prostaglandin I2 (prostacyclin) receptor (IP) prostaglandin I2 (prostacyclin) synthase pleiotrophin protein tyrosine phosphatase type IVA, member 1 protein tyrosine phosphatase, receptor type, J protein tyrosine phosphatase, receptor-type, Z polypeptide 1 pentraxin 3, long pseudouridylate synthase-like 1 parvalbumin pyrroline-5-carboxylate reductase 1 peptide YY, 2 (pseudogene) glutaminyl-peptide cyclotransferase RAB15, member RAS oncogene family RAB22A, member RAS oncogene family RAB33A, member RAS oncogene family RAB8B, member RAS oncogene family rabaptin, RAB GTPase binding effector protein 1 retinoic acid induced 2 RAN, member RAS oncogene family RAP2A, member of RAS oncogene family retinoic acid receptor responder (tazarotene induced) 1 RAS, dexamethasone-induced 1 RAS guanyl releasing protein 2 (calcium and DAG-regulated) RAS-like, family 10, member A retina and anterior neural fold homeobox retinoblastoma binding protein 8 RNA binding motif (RNP1, RRM) protein 3 RNA binding motif protein 47 retinol binding protein 1, cellular regulator of calcineurin 2 RCC1 domain containing 1 REST corepressor 3 retinol dehydrogenase 10 (all-trans) retinol dehydrogenase 11 (all-trans/9-cis/11-cis) retinol dehydrogenase 5 (11-cis/9-cis) receptor accessory protein 1 receptor accessory protein 2 receptor accessory protein 6 RELT tumor necrosis factor receptor retinol saturase (all-trans-retinol 13,14-reductase) regucalcin RANBP2-like and GRIP domain containing 2 retinal G protein coupled receptor regulator of G-protein signaling 1 regulator of G-protein signaling 10 regulator of G-protein signaling 2 regulator of G-protein signaling 9 regulator of G protein signaling 9 binding protein rhodopsin regulating synaptic membrane exocytosis 3 retinaldehyde binding protein 1 RecQ mediated genome instability 1 ribonuclease, RNase A family, k6 Rho family GTPase 3 ring finger protein 13 ring finger protein 14 retinal outer segment membrane protein 1 retinitis pigmentosa GTPase regulator interacting protein 1 Ras-related associated with diabetes radial spoke head 1 homolog (Chlamydomonas) R-spondin 2 R-spondin 3 retbindin runt-related transcription factor 1 runt-related transcription factor 3 S100 calcium binding protein A12 S100 calcium binding protein A6 S100 calcium binding protein A8 S100 calcium binding protein A9 S100 calcium binding protein P serum amyloid A1 serum amyloid A2

0.46 -0.28 -0.10 0.41 0.53 -0.35 -0.21 -0.17 0.41 0.06 0.38 0.24 0.25 0.22 0.42 0.55 -0.90 0.50 -0.37 -0.04 0.50 0.07 -0.12 -0.33 0.69 -0.29 -0.36 -0.43 -0.20 -0.33 0.15 0.37 0.72 -0.45 -0.90 0.48 0.11 0.12 0.35 -0.27 0.39 0.47 0.17 0.35 0.19 0.25 -0.50 -0.25 0.44 0.28 0.24 0.35 0.40 -0.25 -0.37 0.04 -0.37 0.31 -0.30 -0.37 0.22 0.44 -0.39 -0.06 0.49 0.56 -0.34 -0.58 -0.35 -0.51 -0.18 -0.17 -0.25 0.23 -0.35 -0.66 -0.21 -0.33 -0.16 -0.54 0.36 0.56

0.01 0.00 0.18 0.14 0.05 0.05 0.00 0.13 0.02 0.13 0.08 0.14 0.05 0.13 0.11 0.00 0.00 0.14 0.00 0.02 0.00 0.00 0.18 0.19 0.00 0.05 0.00 0.01 0.17 0.16 0.00 0.05 0.00 0.02 0.00 0.14 0.01 0.12 0.09 0.00 0.17 0.12 0.14 0.01 0.04 0.04 0.00 0.19 0.08 0.04 0.20 0.03 0.01 0.06 0.07 0.18 0.00 0.04 0.00 0.14 0.00 0.02 0.00 0.19 0.02 0.06 0.11 0.02 0.00 0.03 0.01 0.00 0.06 0.20 0.05 0.00 0.14 0.00 0.00 0.00 0.00 0.00

SAG SAMD11 SAV1 SCARA5 SCARNA17 SCD SCD5 SCG5 SCHIP1 SCN2B SCN4B SDC4 SDF2L1 SDHD SDSL SELP SEMA3E SEMA3G SEPP1 SERPINA3 SERPINA5 SERPINB8 SERPINB9 SERPINF1 SERPINH1 SESN1 SET SFRP1 SFRP4 SFRP5 SFTPC SGCA SGIP1 SGK3 SH3YL1 SKAP1 SKI SLA SLAMF8 SLC12A2 SLC13A3 SLC16A1 SLC16A14 SLC16A3 SLC16A8 SLC1A1 SLC1A3 SLC22A8 SLC24A1 SLC24A3 SLC26A4 SLC2A14 SLC31A2 SLC38A1 SLC38A2 SLC39A7 SLC40A1 SLC4A4 SLC4A7 SLC6A13 SLC6A20 SLC6A6 SLC7A10 SLC8A1 SLC9A3R1 SLC9A9 SLCO2B1 SLPI SMAD7 SMAD9 SMARCA2 SMG6 SMN1 SMOC1 SMOC2 SMPD3 SNAI1 SNAI2 SNCG SNHG7 SNRPB SNX10

S-antigen; retina and pineal gland (arrestin) sterile alpha motif domain containing 11 salvador family WW domain containing protein 1 scavenger receptor class A, member 5 small Cajal body-specific RNA 17 stearoyl-CoA desaturase (delta-9-desaturase) stearoyl-CoA desaturase 5 secretogranin V (7B2 protein) schwannomin interacting protein 1 sodium channel, voltage-gated, type II, beta subunit sodium channel, voltage-gated, type IV, beta subunit syndecan 4 stromal cell-derived factor 2-like 1 succinate dehydrogenase complex, subunit D, integral membrane protein serine dehydratase-like selectin P (granule membrane protein 140kDa, antigen CD62) sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G selenoprotein P, plasma, 1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 serpin peptidase inhibitor, clade B (ovalbumin), member 8 serpin peptidase inhibitor, clade B (ovalbumin), member 9 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) sestrin 1 SET nuclear proto-oncogene secreted frizzled-related protein 1 secreted frizzled-related protein 4 secreted frizzled-related protein 5 surfactant protein C sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) SH3-domain GRB2-like (endophilin) interacting protein 1 serum/glucocorticoid regulated kinase family, member 3 SH3 and SYLF domain containing 1 src kinase associated phosphoprotein 1 SKI proto-oncogene Src-like-adaptor SLAM family member 8 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 solute carrier family 16 (monocarboxylate transporter), member 1 solute carrier family 16, member 14 solute carrier family 16 (monocarboxylate transporter), member 3 solute carrier family 16 (monocarboxylate transporter), member 8 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 solute carrier family 1 (glial high affinity glutamate transporter), member 3 solute carrier family 22 (organic anion transporter), member 8 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 solute carrier family 26 (anion exchanger), member 4 solute carrier family 2 (facilitated glucose transporter), member 14 solute carrier family 31 (copper transporter), member 2 solute carrier family 38, member 1 solute carrier family 38, member 2 solute carrier family 39 (zinc transporter), member 7 solute carrier family 40 (iron-regulated transporter), member 1 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 solute carrier family 4, sodium bicarbonate cotransporter, member 7 solute carrier family 6 (neurotransmitter transporter), member 13 solute carrier family 6 (proline IMINO transporter), member 20 solute carrier family 6 (neurotransmitter transporter), member 6 solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10 solute carrier family 8 (sodium/calcium exchanger), member 1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9 solute carrier organic anion transporter family, member 2B1 secretory leukocyte peptidase inhibitor SMAD family member 7 SMAD family member 9 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 SMG6 nonsense mediated mRNA decay factor survival of motor neuron 1, telomeric SPARC related modular calcium binding 1 SPARC related modular calcium binding 2 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) snail family zinc finger 1 snail family zinc finger 2 synuclein, gamma (breast cancer-specific protein 1) small nucleolar RNA host gene 7 (non-protein coding) small nuclear ribonucleoprotein polypeptides B and B1 sorting nexin 10

-0.65 -0.34 -0.38 -0.39 0.30 0.58 -0.40 -0.22 -0.35 -0.64 -0.13 -0.22 -0.12 -0.32 -0.02 -0.18 -0.31 -0.28 -0.54 0.01 -0.16 -0.25 -0.24 0.36 -0.54 -0.17 -0.31 0.18 -0.55 0.35 -0.32 0.26 -0.39 0.33 -0.25 -0.29 -0.02 -0.22 -0.11 0.60 0.55 0.20 0.70 0.44 0.70 -0.17 -0.72 0.29 -0.84 -0.24 0.38 0.21 -0.15 -0.56 -0.17 0.15 -0.40 0.28 -0.54 0.49 0.93 -0.09 0.31 -0.27 0.54 -0.25 -0.10 0.37 -0.27 -0.41 -0.26 -0.46 -0.22 -0.91 0.44 -0.36 -0.29 -0.54 -0.21 0.15 -0.39 -0.42

0.00 0.17 0.04 0.00 0.11 0.00 0.00 0.03 0.07 0.00 0.04 0.17 0.05 0.07 0.07 0.16 0.04 0.06 0.00 0.08 0.01 0.03 0.13 0.02 0.02 0.07 0.19 0.00 0.00 0.01 0.03 0.11 0.11 0.12 0.04 0.05 0.12 0.01 0.02 0.01 0.00 0.04 0.00 0.01 0.00 0.10 0.00 0.02 0.00 0.06 0.02 0.16 0.08 0.00 0.08 0.01 0.01 0.03 0.00 0.00 0.00 0.11 0.17 0.14 0.00 0.06 0.01 0.00 0.07 0.00 0.13 0.02 0.09 0.00 0.00 0.07 0.06 0.00 0.04 0.17 0.03 0.01

SOCS3 SOD2 SORBS1 SOX1 SOX17 SPEG SPOCD1 SPOCK1 SPOCK2 SPP1 SPRY1 ST3GAL4 STAC2 STAT1 STEAP1 STEAP2 STK19 STMN1 STMN2 STON1 STRA6 STX1A SUMO3 SV2B SVEP1 SYNC SYT1 SYT17 SYTL3 TAF15 TAOK2 TAPT1 TBC1D9 TBXAS1 TCAP TCEA3 TCF15 TCF25 TDRD9 TEK TEX2 TF TFRC TGFB2 TGM2 THBS1 THBS4 THNSL2 THSD4 THY1 TIAM2 TIE1 TIMP1 TIPARP TK1 TLR2 TLR4 TM4SF18 TMEFF2 TMEM100 TMEM145 TMEM151A TMEM159 TMEM183B TMEM191A TMEM38A TMEM45A TMEM98 TMSB10 TMSB4X TMTC1 TNFAIP3 TNFRSF11B TNFRSF12A TNFRSF21 TNFRSF25 TNFRSF6B TNFSF10 TNK2 TOB2 TOM1L1 TOP1

suppressor of cytokine signaling 3 superoxide dismutase 2, mitochondrial sorbin and SH3 domain containing 1 SRY (sex determining region Y)-box 1 SRY (sex determining region Y)-box 17 SPEG complex locus SPOC domain containing 1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 secreted phosphoprotein 1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) ST3 beta-galactoside alpha-2,3-sialyltransferase 4 SH3 and cysteine rich domain 2 signal transducer and activator of transcription 1, 91kDa six transmembrane epithelial antigen of the prostate 1 STEAP family member 2, metalloreductase serine/threonine kinase 19 stathmin 1 stathmin 2 stonin 1 stimulated by retinoic acid 6 syntaxin 1A (brain) small ubiquitin-like modifier 3 synaptic vesicle glycoprotein 2B sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 syncoilin, intermediate filament protein synaptotagmin I synaptotagmin XVII synaptotagmin-like 3 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa TAO kinase 2 transmembrane anterior posterior transformation 1 TBC1 domain family, member 9 (with GRAM domain) thromboxane A synthase 1 (platelet) titin-cap transcription elongation factor A (SII), 3 transcription factor 15 (basic helix-loop-helix) transcription factor 25 (basic helix-loop-helix) tudor domain containing 9 TEK tyrosine kinase, endothelial testis expressed 2 transferrin transferrin receptor transforming growth factor, beta 2 transglutaminase 2 thrombospondin 1 thrombospondin 4 threonine synthase-like 2 (S. cerevisiae) thrombospondin, type I, domain containing 4 Thy-1 cell surface antigen T-cell lymphoma invasion and metastasis 2 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 TIMP metallopeptidase inhibitor 1 TCDD-inducible poly(ADP-ribose) polymerase thymidine kinase 1, soluble toll-like receptor 2 toll-like receptor 4 transmembrane 4 L six family member 18 transmembrane protein with EGF-like and two follistatin-like domains 2 transmembrane protein 100 transmembrane protein 145 transmembrane protein 151A transmembrane protein 159 transmembrane protein 183B transmembrane protein 191A (pseudogene) transmembrane protein 38A transmembrane protein 45A transmembrane protein 98 thymosin beta 10 thymosin beta 4, X-linked transmembrane and tetratricopeptide repeat containing 1 tumor necrosis factor, alpha-induced protein 3 tumor necrosis factor receptor superfamily, member 11b tumor necrosis factor receptor superfamily, member 12A tumor necrosis factor receptor superfamily, member 21 tumor necrosis factor receptor superfamily, member 25 tumor necrosis factor receptor superfamily, member 6b, decoy tumor necrosis factor (ligand) superfamily, member 10 tyrosine kinase, non-receptor, 2 transducer of ERBB2, 2 target of myb1 (chicken)-like 1 topoisomerase (DNA) I

-0.19 0.24 -0.29 0.42 -0.02 0.50 0.57 0.39 -0.33 -0.15 0.59 0.70 -0.29 0.24 -0.06 0.44 -0.20 -0.43 -0.30 -0.13 0.14 0.46 0.58 -0.61 0.02 -0.36 -0.49 0.60 0.20 0.49 0.43 -0.38 -0.39 -0.27 -0.31 -0.15 0.24 0.57 0.38 -0.22 0.28 -0.41 -0.02 0.26 -0.12 -0.36 0.33 -0.18 -0.34 -0.22 0.38 -0.52 0.20 -0.21 -0.08 -0.09 -0.25 0.22 -0.45 -0.48 -0.33 0.45 -0.23 0.42 0.47 0.28 -0.37 0.45 -0.33 -0.43 -0.25 0.12 -0.44 -0.64 -0.58 0.23 0.21 0.30 0.43 -0.18 0.45 -0.31

0.01 0.02 0.16 0.04 0.03 0.06 0.02 0.04 0.13 0.04 0.04 0.00 0.08 0.16 0.00 0.08 0.13 0.05 0.00 0.14 0.12 0.06 0.06 0.00 0.05 0.00 0.00 0.00 0.12 0.10 0.14 0.15 0.12 0.14 0.17 0.19 0.02 0.12 0.01 0.05 0.14 0.00 0.07 0.01 0.02 0.00 0.02 0.18 0.00 0.01 0.01 0.00 0.03 0.03 0.10 0.03 0.15 0.13 0.00 0.00 0.13 0.05 0.19 0.17 0.00 0.12 0.00 0.00 0.20 0.03 0.13 0.07 0.00 0.00 0.00 0.14 0.16 0.18 0.14 0.19 0.14 0.08

TPD52L1 TPM1 TPM3 TPM4 TPPP3 TPST1 TRAF6 TRBV5-4 TRERF1 TRIM10 TRIM45 TRIM63 TRIT1 TRPC3 TRPM3 TSPAN11 TSPAN8 TSR2 TTC12 TTLL4 TTR TUBB TUBB2B TUBB3 TYR U2AF1 U2AF2 UBD UBE2H UBL4B UCHL1 UCN2 UCP3 UGCG UNC13B USP34 UTS2R VASN VAV1 VCAM1 VCAN VGLL3 VILL VNN2 VPS18 VSIG4 VTI1A WASF1 WASF2 WDR4 WFDC1 WNT6 WWOX XAF1 XBP1 XIST YIPF5 YPEL2 YPEL4 ZBTB16 ZC3H7A ZDHHC11 ZFP36 ZFYVE9 ZMYND19 ZNF100 ZNF331 ZNF92 ZP3 ZRANB2

tumor protein D52-like 1 tropomyosin 1 (alpha) tropomyosin 3 tropomyosin 4 tubulin polymerization-promoting protein family member 3 tyrosylprotein sulfotransferase 1 TNF receptor-associated factor 6, E3 ubiquitin protein ligase T cell receptor beta variable 5-4 transcriptional regulating factor 1 tripartite motif containing 10 tripartite motif containing 45 tripartite motif containing 63, E3 ubiquitin protein ligase tRNA isopentenyltransferase 1 transient receptor potential cation channel, subfamily C, member 3 transient receptor potential cation channel, subfamily M, member 3 tetraspanin 11 tetraspanin 8 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) tetratricopeptide repeat domain 12 tubulin tyrosine ligase-like family, member 4 transthyretin tubulin, beta class I tubulin, beta 2B class IIb tubulin, beta 3 class III tyrosinase U2 small nuclear RNA auxiliary factor 1 U2 small nuclear RNA auxiliary factor 2 ubiquitin D ubiquitin-conjugating enzyme E2H ubiquitin-like 4B ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) urocortin 2 uncoupling protein 3 (mitochondrial, proton carrier) UDP-glucose ceramide glucosyltransferase unc-13 homolog B (C. elegans) ubiquitin specific peptidase 34 urotensin 2 receptor vasorin vav 1 guanine nucleotide exchange factor vascular cell adhesion molecule 1 versican vestigial-like family member 3 villin-like vanin 2 vacuolar protein sorting 18 homolog (S. cerevisiae) V-set and immunoglobulin domain containing 4 vesicle transport through interaction with t-SNAREs 1A WAS protein family, member 1 WAS protein family, member 2 WD repeat domain 4 WAP four-disulfide core domain 1 wingless-type MMTV integration site family, member 6 WW domain containing oxidoreductase XIAP associated factor 1 X-box binding protein 1 X inactive specific transcript (non-protein coding) Yip1 domain family, member 5 yippee-like 2 (Drosophila) yippee-like 4 (Drosophila) zinc finger and BTB domain containing 16 zinc finger CCCH-type containing 7A zinc finger, DHHC-type containing 11 ZFP36 ring finger protein zinc finger, FYVE domain containing 9 zinc finger, MYND-type containing 19 zinc finger protein 100 zinc finger protein 331 zinc finger protein 92 zona pellucida glycoprotein 3 (sperm receptor) zinc finger, RAN-binding domain containing 2

-0.53 -0.60 -0.50 -0.26 -0.29 -0.31 -0.36 -0.25 -0.17 0.39 -0.07 -0.30 -0.29 -0.13 0.88 0.40 -0.06 -0.27 0.32 0.60 0.26 -0.36 -0.21 -0.12 -0.32 0.12 -0.35 -0.07 -0.31 0.36 -0.42 0.35 -0.30 -0.05 0.57 -0.06 0.47 0.43 -0.29 -0.29 0.54 0.33 0.48 -0.07 0.56 -0.36 -0.29 -0.35 0.33 -0.19 0.51 0.21 -0.25 -0.10 -0.44 0.86 -0.34 -0.38 -0.28 -0.16 0.57 -0.54 -0.07 0.06 -0.41 0.70 -0.23 0.75 0.31 -0.38

0.00 0.00 0.02 0.10 0.00 0.15 0.19 0.08 0.08 0.17 0.06 0.12 0.15 0.18 0.00 0.07 0.00 0.09 0.02 0.00 0.00 0.15 0.10 0.01 0.03 0.15 0.15 0.00 0.17 0.04 0.00 0.04 0.14 0.07 0.02 0.13 0.03 0.02 0.11 0.02 0.04 0.02 0.01 0.00 0.00 0.00 0.20 0.04 0.02 0.03 0.00 0.13 0.02 0.01 0.03 0.00 0.14 0.08 0.07 0.00 0.03 0.01 0.18 0.07 0.03 0.08 0.19 0.00 0.10 0.06