Gene symbol P value r Gene symbol P value r CYP7A1 0.001 ... - Plos

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CASS4. 0.008. 0.72 FAS. 0.023 -0.70. MEGF8. 0.017. 0.72 ARHGAP22. 0.020 -0.70. ITGAL. 0.010. 0.72 TRIM11. 0.024 -0.70. IL23A. 0.009. 0.71 CHSY3. 0.019 - ...
Supplementary Table 2: Gene transcripts correlated with BMI* Gene symbol P value r Gene symbol P value r Gene transcripts positively correlated Gene transcripts negatively correlated CYP7A1 0.001 0.85 ERCC2 0.002 -0.80 LINC00616 0.000 0.84 TRIM49 0.004 -0.80 MGC39372 0.001 0.83 GDF11 0.005 -0.79 TMEM235 0.001 0.82 ZFYVE28 0.006 -0.78 CCDC79 0.005 0.79 AANAT 0.006 -0.78 SLC26A5 0.005 0.78 LAMTOR2 0.004 -0.78 ZNF852 0.006 0.78 BAAT 0.007 -0.78 DDR1 0.004 0.77 DIEXF 0.003 -0.77 LRRC2 0.007 0.77 FGD1 0.008 -0.77 LYPD6 0.008 0.77 SLC35B1 0.010 -0.76 FFAR1 0.008 0.76 TMEM243 0.002 -0.76 IGLV4-69 0.008 0.76 HEXIM1 0.010 -0.76 CDHR3 0.010 0.76 MICB 0.010 -0.75 RGS21 0.011 0.75 PSIMCT-1 0.003 -0.75 ATXN3L 0.008 0.75 SGOL1-AS1 0.011 -0.75 RASSF10 0.012 0.75 HIST1H2AJ 0.010 -0.75 LINC00235 0.009 0.74 KIAA0247 0.002 -0.74 RBMS3-AS2 0.008 0.74 RNASEH2B-AS1 0.005 -0.74 SORBS2 0.013 0.74 CCDC28B 0.015 -0.73 HAO2 0.007 0.74 ZNF846 0.008 -0.73 HNRNPKP3 0.014 0.74 MIR4703 0.012 -0.73 RIC8A 0.014 0.73 PGP 0.003 -0.73 0.73 RHOA-IT1 0.004 -0.73 SLC6A15 0.008 AADACL4 0.011 0.73 FAM174B 0.016 -0.72 ANK1 0.008 0.73 NXPH4 0.014 -0.72 MGC21881 0.005 0.73 ARFIP2 0.007 -0.72 HES3 0.015 0.73 AGBL5 0.013 -0.72 GPR26 0.015 0.73 OXNAD1 0.014 -0.72 FLJ42842 0.010 0.73 FERD3L 0.020 -0.71 ACSS2 0.017 0.72 GPR141 0.006 -0.71 ISM2 0.011 0.72 CPOX 0.021 -0.71 LINC00467 0.013 0.72 SLFNL1-AS1 0.019 -0.70 RPL29 0.014 0.72 MICA 0.013 -0.70 HLA-A 0.017 0.72 CEL 0.023 -0.70 CASS4 0.008 0.72 FAS 0.023 -0.70 MEGF8 0.017 0.72 ARHGAP22 0.020 -0.70 ITGAL 0.010 0.72 TRIM11 0.024 -0.70 IL23A 0.009 0.71 CHSY3 0.019 -0.70 LRRC71 0.003 0.71 FASN 0.018 -0.69 TTPA 0.015 0.71 TOP3A 0.022 -0.69 GABRG1 0.010 0.71 CRIP2 0.018 -0.69 PTH2 0.020 0.71 MIR4282 0.016 -0.69 FAM47C 0.016 0.71 HTR1B 0.027 -0.69

TERT KCNH8 HPYR1 MIR4765 RIPPLY3 CARD17 PPP2R2B-IT1 UPF3A AKAP14 CLCN7 LINC00879 XCR1 TAS2R14 COL4A3 NRCAM AP4S1 ZNF676 ELF3 KCNQ1DN RASGRF1 IGF2BP3 MRGPRD NIPA1 PSG11 ZNF345 DMD-AS3 EMX2OS FLJ27255 GDF5 MROH2A LINC00502 MIR129-1 RMDN3 FGF12-AS2 LINC00951 GYPA LINC00933 ANKDD1A OR3A4P PATE3 MIR4268 POU2F3 PTRH1 EXPH5 NPFFR1 ANKRD2 LINC00494

0.016 0.020 0.012 0.020 0.023 0.022 0.021 0.015 0.013 0.015 0.019 0.021 0.018 0.024 0.023 0.016 0.012 0.026 0.025 0.017 0.019 0.023 0.010 0.025 0.015 0.028 0.022 0.019 0.027 0.024 0.015 0.028 0.020 0.016 0.029 0.030 0.026 0.023 0.005 0.028 0.025 0.030 0.022 0.023 0.031 0.033 0.025

0.71 0.71 0.71 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.69 0.69 0.69 0.69 0.69 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67

EMC8 CDC14B FAM118A MIR451A EPS8L2 ZNF77 EXOC8 PYCR2 PPAT TRBV21OR9-2 IL1RAP SPAG1 DGCR2 DIAPH3-AS1 FAM120C RASL12 USP42 EIF2S3L LYRM7 CLIC6 TMEM5 KHSRP CACNA1C-AS4 IL36RN MIR450A2 ADAT1 PRRT3 ZMAT2 KDM4A-AS1 CHD6 ASB8 GDI1 BTD ETV6 RNA5SP268 NPRL2 F8A3 MIR1184-1 POLD4 MIMT1 KIAA1958 SLC35F1 TIGD4 CBLN3 MYO10 MRPL52 PRSS48

0.011 0.015 0.028 0.016 0.023 0.023 0.029 0.013 0.011 0.025 0.022 0.027 0.030 0.030 0.027 0.019 0.031 0.031 0.012 0.020 0.027 0.033 0.029 0.024 0.029 0.016 0.032 0.036 0.031 0.033 0.036 0.031 0.032 0.032 0.014 0.021 0.022 0.022 0.028 0.038 0.035 0.030 0.040 0.030 0.024 0.025 0.033

-0.69 -0.68 -0.68 -0.68 -0.68 -0.68 -0.68 -0.68 -0.68 -0.68 -0.68 -0.68 -0.68 -0.68 -0.68 -0.68 -0.67 -0.67 -0.67 -0.67 -0.67 -0.67 -0.67 -0.67 -0.67 -0.67 -0.67 -0.66 -0.66 -0.66 -0.66 -0.66 -0.66 -0.66 -0.66 -0.66 -0.66 -0.66 -0.65 -0.65 -0.65 -0.65 -0.65 -0.65 -0.65 -0.65 -0.65

TMCO5A ENTHD2 GINS1 ANKRD53 HBQ1 TTC29 PRSS12 FLJ45513 RAMP2-AS1 LINC00910 SOX1 CNTNAP3 LINC00427 ARMC2 TSRM GPHB5 PNPLA2 ALX3 CHRNB2 OCA2 GPR25 KCNK17 SLC22A14 MIR4791 FAM156A HOXA-AS3 AIPL1 PDIK1L HELZ2 VMAC AGFG2 MIR4540 CORIN RNA5SP66 TBX22 F2RL1 GOLGA2P2Y FUT2 FLJ44385 HTR2A-AS1 KIAA1875 PLIN4 SLC6A20 OR14I1 SP2 STK11 FAM138A

0.034 0.001 0.032 0.008 0.010 0.022 0.023 0.009 0.035 0.022 0.013 0.013 0.030 0.032 0.017 0.010 0.028 0.036 0.030 0.032 0.029 0.024 0.032 0.029 0.024 0.025 0.035 0.035 0.036 0.030 0.036 0.020 0.035 0.024 0.038 0.032 0.019 0.030 0.038 0.038 0.039 0.038 0.032 0.034 0.034 0.039 0.026

0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65

CYP7B1 CCT6P3 SNORD13P2 TMEM127 ARL14 SEC22C LAIR2 CRYM-AS1 OR1Q1 SNORA58 LRRC37A2 CEP152 DEDD2 RBM42 MIR376C PPIL2 XBP1 MROH1 ATAT1 CCRL1 LOXL4 HOXD9 MIR3167 FAM3C CACNA1D SKAP2 PLGRKT CRMP1 SF3A2 FRMD6-AS1 HAVCR1P1 RNF40 MIR7-3 ZSWIM3 SNORA70G AP4B1-AS1 SNAI1 NIPSNAP1 RNA5SP63 PARD3B LIMS1 MRRF DHRSX ANKRD13C MIR3173 WWTR1 BAX

0.028 0.034 0.043 0.030 0.044 0.027 0.041 0.046 0.044 0.045 0.019 0.028 0.045 0.036 0.041 0.047 0.018 0.048 0.049 0.024 0.039 0.047 0.048 0.019 0.030 0.044 0.042 0.047 0.044 0.032 0.017 0.036 0.047 0.048 0.017 0.037 0.046 0.043 0.041 0.039 0.042 0.028 0.037 0.035 0.045 0.022 0.047

-0.64 -0.64 -0.64 -0.64 -0.64 -0.64 -0.64 -0.64 -0.64 -0.64 -0.64 -0.64 -0.64 -0.64 -0.64 -0.63 -0.63 -0.63 -0.63 -0.63 -0.63 -0.63 -0.63 -0.63 -0.63 -0.62 -0.62 -0.62 -0.62 -0.62 -0.62 -0.62 -0.62 -0.62 -0.62 -0.62 -0.62 -0.61 -0.61 -0.61 -0.61 -0.61 -0.61 -0.61 -0.61 -0.61 -0.60

PRR15L RCOR2 SPP1 DGAT2 GAL3ST3 MIR4502 FAM87A SLC25A1 SDIM1 PYGM NOS1 RASA2-IT1 MARS2 ATP6V0E2-AS1 EHHADH TRPM2 IGLV3-1 HS3ST3B1 TAPBPL AMY2B OR1A2 RNA5SP361 SHROOM3 RFPL4B PRDM14 NLGN4X CDC42EP2 BEND3 FLJ16341 ALOX15B PUS1 OR1N2 WT1 MIR3178 SOSTDC1 STAT4 LGALS3BP PPP3R1 AVPR2 IQSEC3 RNA5SP486 BPIFB2 CLEC1A MOV10L1 HOXB9 DEFB132 PTPRT

0.041 0.040 0.033 0.042 0.034 0.035 0.031 0.026 0.043 0.034 0.041 0.040 0.041 0.042 0.020 0.013 0.027 0.016 0.035 0.044 0.034 0.020 0.036 0.037 0.027 0.038 0.020 0.039 0.044 0.012 0.039 0.028 0.037 0.013 0.047 0.034 0.034 0.042 0.016 0.034 0.039 0.030 0.030 0.039 0.050 0.049 0.032

0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63

TRIM33 AMZ2 HELLPAR MED13L COX6A1 KATNBL1 SH3D21 CHURC1-FNTB LETMD1 KCNQ5-IT1 SNRPN BTBD6 PPP1R11 TLE4 ITGB3BP COX7A2 ENTPD3-AS1 IRF9 TMEM214 GPATCH8 HECTD3 SNORA11C ITCH-IT1 MIR340 TMEM183B TMEM30B UGCG BAG4 FAM57A FGF18 NMT1 ELOF1 GRK4 EXOC4 STAT3 ZDHHC16 STON1-GTF2A1L POC1B-GALNT4 CRIPT GNAT2 ZBED6 ARFGEF1 OSBP SERPINB9 SYNPO AHCY TGFBRAP1

0.025 0.021 0.049 0.020 0.049 0.038 0.044 0.048 0.015 0.020 0.026 0.049 0.050 0.031 0.026 0.029 0.032 0.037 0.044 0.029 0.029 0.041 0.048 0.041 0.025 0.043 0.045 0.033 0.027 0.047 0.020 0.050 0.038 0.044 0.027 0.049 0.045 0.047 0.046 0.041 0.036 0.035 0.027 0.044 0.045 0.042 0.032

-0.60 -0.60 -0.60 -0.60 -0.60 -0.60 -0.60 -0.60 -0.60 -0.59 -0.59 -0.59 -0.59 -0.59 -0.59 -0.59 -0.58 -0.58 -0.58 -0.58 -0.58 -0.58 -0.58 -0.58 -0.57 -0.57 -0.57 -0.57 -0.56 -0.56 -0.56 -0.56 -0.56 -0.56 -0.56 -0.55 -0.55 -0.55 -0.55 -0.55 -0.54 -0.54 -0.53 -0.52 -0.52 -0.52 -0.51

SLFN14 LIM2 TMEM88B ACTRT1 NECAB2 ERVMER34-1 CLIC5 FCGRT FLJ20444 ASTN2 FAM83C-AS1 LEP MLK7-AS1 FAM25G PSKH2 NT5DC4 MIR519B SRL KRTAP10-4 GNAT1 GUCY2C SYT15 CAPS2 KRTAP2-1 SLC13A1 VSX1 DPP3 GYS1 RNA5-8SP4 ERVV-1 OR4D9 LMO2 SSTR5-AS1 IL17B TRAV4 MIR3914-1 SLC22A3 PDGFD NEIL2 MKRN7P FCAMR TTLL11-IT1 TMEM233 CCK SPACA5 PZP LGALS7B

0.048 0.040 0.037 0.047 0.016 0.047 0.035 0.037 0.036 0.043 0.028 0.045 0.009 0.033 0.045 0.028 0.014 0.014 0.019 0.044 0.047 0.025 0.045 0.037 0.035 0.046 0.043 0.040 0.026 0.034 0.047 0.042 0.037 0.043 0.034 0.043 0.049 0.033 0.034 0.032 0.016 0.043 0.022 0.037 0.044 0.049 0.033

0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61

TMEM161B HSPA5 INF2 SETD5 SDHC TPSD1 EMC1 GNAT3

0.031 0.018 0.027 0.048 0.036 0.045 0.046 0.047

-0.50 -0.46 -0.46 -0.46 -0.46 -0.45 -0.43 -0.42

HBD TEX13B MIR3180-4 MIR551B GRIN3A MOS IGHG1 PON1 OR56A4 HSP90AB2P MIR3161 GLUD1P2 OR2A4 SPRY1 TRAJ14 VASP LINC00052 CASQ1 SEMA3G RBM22P1 MIR4708 ISL1 AQP7 IFNG-AS1 SLC9A7 FGF5 AGAP9 MIR128-2 RNU6-54 ZNF485 PIGL MIR134 SLC4A1 SLC51B TMEM229A GBP6 OPTC GOLGA8UP OLFM3 KLK1 RNA5SP338 FIGN SOX13 NAALADL2-AS2 FFAR4 OSBPL7 CCL13

0.017 0.042 0.045 0.037 0.049 0.019 0.032 0.047 0.047 0.050 0.033 0.045 0.038 0.042 0.039 0.047 0.025 0.030 0.021 0.046 0.044 0.041 0.048 0.035 0.042 0.022 0.039 0.040 0.047 0.023 0.047 0.044 0.027 0.038 0.045 0.028 0.037 0.023 0.047 0.043 0.033 0.050 0.035 0.042 0.050 0.014 0.028

0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.58 0.58 0.58 0.58 0.58 0.58 0.58 0.58 0.58 0.58 0.57 0.57

TSSK1B 0.049 0.57 LINC00869 0.031 0.57 ATP7B 0.037 0.57 FAM19A3 0.048 0.57 REG3G 0.048 0.56 LINC00279 0.039 0.56 GLP1R 0.011 0.56 PROKR1 0.047 0.56 TMEM92 0.042 0.55 MMRN1 0.049 0.55 FAM92B 0.044 0.55 CNTD2 0.025 0.55 FLJ46134 0.040 0.54 CXCL13 0.044 0.54 DCXR 0.046 0.54 LY6G6F 0.022 0.54 A2MP1 0.040 0.54 SPANXN5 0.022 0.54 EFNA3 0.022 0.53 MIR1295A 0.046 0.53 KCTD17 0.025 0.53 MIR96 0.042 0.53 MIR3119-1 0.029 0.53 P2RX1 0.048 0.53 UBE2U 0.045 0.52 CXorf67 0.039 0.51 SLC35G3 0.027 0.51 FLJ42351 0.024 0.51 ZAN 0.047 0.51 MIR302E 0.040 0.50 TACR3 0.025 0.49 WBSCR16 0.037 0.49 SORCS3-AS1 0.043 0.49 CASR 0.033 0.49 MT1DP 0.046 0.48 HPCAL4 0.045 0.46 ARC 0.047 0.45 MIR4486 0.049 0.44 SATB2-AS1 0.032 0.43 *Duplicate, uncharacterized and non-annotated gene transcripts were removed BMI = body mass index