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DNA and could be an important source of genetic instability within eukaryotic genomes or within fragments cloned into other organisms. Long inverted repeats ...
MOLECULAR AND CELLULAR BIOLOGY, Sept. 1993, p. 5315-5322
Vol. 13, No. 9
0270-7306/93/095315-08$02.00/0 Copyright X 1993, American Society for Microbiology
Inverted DNA Repeats: a Source of Eukaryotic Genomic Instability DMITRY A. GORDENIN,1,2* KIRILL S. LOBACHEV,1 NATASHA P. DEGTYAREVA,1 ANNA L. MALKOVA,1 EDWARD PERKINS,2 AND MICHAEL A. RESNICK2 Department of Genetics, St. Petersburg State University, St. Petersburg 199034, Russia, 1 and Laboratory of Molecular Genetics, National Institute of Environmental Health Science, P.O. Box 12233, Research Triangle Park, North Carolina 277092* Received 20 April 1993/Returned for modification 1 June 1993/Accepted 8 June 1993
While inverted DNA repeats are generally acknowledged to be an important source of genetic instability in prokaryotes, relatively little is known about their effects in eukaryotes. Using bacterial transposon Tn5 and its derivatives, we demonstrate that long inverted repeats also cause genetic instability leading to deletion in the yeast Saccharomyces cerevisiae. Furthermore, they induce homologous recombination. Replication plays a major role in the deletion formation. Deletions are stimulated by a mutation in the DNA polymerase 8 gene (pol3). The majority of deletions result from imprecise excision between small (4- to 6-bp) repeats in a polar fashion, and they often generate quasipalindrome structures that subsequently may be highly unstable. Breakpoints are clustered near the ends of the long inverted repeats (
