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29. November 2010 14:34
Dear Dr. Daniel Belavý , I am pleased to inform you that the revised version of your manuscript ( JEI-00369-2009.R3 ) entitled: The effects of bed rest and countermeasure exercise on the endocrine system in male adults - evidence for immobilization induced reduction in SHBG levels has been accepted for publication in the “Journal of Endocrinological Investigation”. The accepted manuscript will be E-published ahead of print on the journal’s website. The Publisher will keep in touch with you for publication charges and provide you the galley proofs for your final approval. Then the print version of your manuscript will be published in a forthcoming issue of the journal. Please find here attached the “Declaration of Originality and Transfer of Copyright” to be submitted via fax to the Publisher (fax: +39 0248201219) within 48 hours form receipt. For any further information please contact Dr Laura Veber in Editrice Kurtis by e-mail at [email protected]
Thank you for choosing our journal. Looking forward to receiving your contributions in the future I remain, Prof. L. Bartalena Editor in Chief Journal of Endocrinological Investigation * Copyright-JEI-2010---A.pdf 61K
The effects of bed rest and countermeasure exercise on the endocrine system in male adults - evidence for immobilization induced reduction in SHBG levels DL Belavý1, MJ Seibel2,3, HJ Roth4, G Armbrecht1, J Rittweger5,6 and D Felsenberg1 1
Charité Universitätsmedizin Berlin, Center for Muscle and Bone Research, Hindenburgdamm 30, 12203 Berlin, Germany. 2 Bone Research Program, ANZAC Research Institute, The University of Sydney, Sydney, Australia 3 Dept. of Endocrinology & Metabolism, Concord Hospital Medical Centre, Hospital Rd, Concord West NSW 2138, Australia 4 Labor Limbach, Abteilung für Endokrinologie und Onkologie, Im Breitspiel 15, 69126 Heidelberg, Germany 5 Institute for Biomedical Research into Human Movement and Health, Manchester Metropolitan University, Oxford Rd, Manchester, M1 5GD, England. 6 Institute of Aerospace Medicine, German Aerospace Center, 51147 Cologne, Germany. Abbreviated Title: Endocrine system in bed-rest Key Words: spaceflight; microgravity; inactivity; Berlin Bed Rest Study Correspondence: Daniel L. Belavý B.Phty, PhD; Zentrum für Muskel- und Knochenforschung; Charité Campus Benjamin Franklin; Hindenburgdamm 30; D-12200 Berlin; Germany. Tel: +49 178 979 5006; Fax: +49 30 793 5918; E-mail: [email protected]
Acknowledgements: The authors wish to thank the subjects who participated in the study and the staff of ward 18A at the Charité Campus Benjamin Franklin Hospital, Berlin, Germany. Tina Bongrazio and Ulf Gast are thanked for assistance in blood sample handling. The Berlin Bed-Rest Study was supported by grant 14431/02/NL/SH2 from the European Space Agency. The investigations in the current study were supported by grant 50WB0522 from the German Aerospace Center (Deutsches Zentrum für Luft- und Raumfahrt). The Berlin Bed-Rest Study was also sponsored by the Charité Campus Benjamin Franklin, MSD Sharp & Dohme, Lilly Germany, Novartis, Servier Germany, P&G, Wyeth, Siemens, and Seca. Daniel L. Belavý was supported by a post-doctoral fellowship from the Alexander von Humboldt Foundation. List of Abbreviations: testosterone (T), estradiol (E2), cortisol (C), resistive vibration exercise (RVE) group, inactive control (CTRL) group, whole body dual X-ray absorptiometry (DXA), Analysis of variance (ANOVA) Disclosure Statement: Dieter Felsenberg and Jörn Rittweger are acting as consultants to the European Space Agency and Novotec Medical for the exploitation of this study’s results. All other authors have no conflicts of interest.
Abstract Background and Aim. There is limited data on the effects of inactivity (prolonged bed-rest) on parameters of endocrine and metabolic function; we therefore aimed to examine changes in these systems during and after prolonged (56-day) bed-rest in male adults. Subjects and Methods. 20 healthy male subjects underwent 8 weeks of strict bed-rest and 12 months follow-up as part of the Berlin Bed-Rest Study. Subjects were randomised to an inactive group or a group that performed resistive vibration exercise (RVE) during bed-rest. All outcome parameters were measured before, during and after bed-rest. These included body composition (by whole body dual X-ray absorptiometry), sex hormone-binding globulin (SHBG), testosterone (T), estradiol (E2), prolactin (PRL), cortisol (C), thyroid stimulating hormone (TSH) and free triiodothyronine (FT3). Results. Serum SHBG levels decreased in inactive subjects but remained unchanged in the RVE group (p