Grade heterogeneity in clear cell renal cell carcinoma ...

CASE REPORTS: Grade heterogeneity in clear cell renal cell carcinoma A significant number of CCRCC are composed of different grades that can be incompletely sampled with current protocols. This fact may contribute to the unexpected poor behaviour of some CCRCC.

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Keywords: Clear cell renal cell carcinoma, grade heterogeneity, tumour sampling, pathologic protocols Authors: López, JI; Guarch,R; Camarasa, N; Cáceres, M; Moreno, V; Muñiz, G; García-Prats, MD; Orozco, R Corresponding Author: López, José I ABSTRACT Objective: To evaluate grade heterogeneity in a group of unselected clear cell renal cell carcinomas (CCRCC). Patients and Methods: Forty-seven totally sampled CCRCC were classified as homogeneous or heterogeneous depending on the presence of one or more different grades, and on the identification of necrosis and/or sarcomatoid change in different tumour areas. Data were compared with those previously obtained in the conventional sampling procedure of each case. Results: Twenty-eight CCRCC were histologically heterogeneous and 17 of them had high grade areas. The conventional sampling previously performed showed that 17 of them were heterogeneous and only seven had high grade component. This difference was statistically significant (p