GRAFIP: a Framework for the Representation of ...

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GRAFIP framework. Objectives: Extraction, structuration and integration of information from pathological cerebral images into a generic model of the human ...
GRAFIP: a Framework for the Representation of Healthy and Pathological Anatomical and Functional Cerebral Information C. Hudelot, J. Atif, O. Nempont, B. Batrancourt, E. Angelini and I. Bloch ENST-GET, Dept TSI, CNRS UMR 5141 LTCI, Paris, France

Context Context

GRAFIP GRAFIP framework framework

Importance of the integration of image-based information in medical information systems. Structured representation of image content: related to generic medical knowledge, numerical information specific to individual patients. GRAFIP : Graph(s) of Representation of Anatomical and Functional data for Individual patients including Pathologies.

Objectives: Extraction, structuration and integration of information from pathological cerebral images into a generic model of the human brain. Methodology: Modeling human brain generic knowledge (anatomical, functional and pathological). Instantiation of the generic model on image data. Knowledge-based image segmentation [4]. GRAFIP updating via integration of image-based information.

Generic Generic human human brain brain model model Anatomical knowledge: (1) “neuraxis part” of the Foundational Model of Anatomy [1] + (2) Neuranat complex spatial relations between cerebral structures [2]. Pathological knowledge: brain tumor ontology: taxonomical relations (tumor classification), related findings, structural descriptions of pathological structures. Linked to anatomical knowledge through an has_anotomical_location relation. Functional knowledge: description of functional activity areas, in particular Brodmann areas. Linked to anatomical knowledge (on the Cerebral cortex) through an is_part_of relation.

Overview of the GRAFIP framework

GRAFIP: GRAFIP: aa graph graph based based representation representation Node representation of brain structures with multiple viewpoints [3]: semantic viewpoint: semantic medical interpretation, spatial viewpoint: spatial description and spatial relations, perceptual viewpoint: visual appearance in images and numerical description. Hypergraph structure to manage complex relations with cardinality >2 (e.g. between, anatomo-functional relations). Patient GRAFIP initialized with a generic healthy anatomical model. GRAFIP built up and updated by a collaborative process between image segmentation and knowledge-based reasoning. GRAFIP structure

Conclusion Conclusion An original framework for cerebral information representation: Combines generic knowledge representation and specific patient information extracted from medical images. A pathology-dependent paradigm. A better understanding of pathological impacts on surrounding structures and on functional brain organization. Future works: longitudinal GRAFIP studies, GRAFIP-based case comparison, EPR formatting.

References References [1] http://sig.biostr.washington.edu/projects/fm/AboutFM.html [2] http://www.chups.jussieu.fr/ext/neuranat/ [3] O. Dameron, B. Gibaud and X. Morandi : Numeric and symbolic representation of the cerebral cortex anatomy: methods and preliminary results. Surg. Rad .Ana. 26(3), 2004 [4] O. Colliot, O. Camara and I. Bloch: Integration of fuzzy spatial relations in deformable models - Application to brain MRI segmentation. Pattern Recognition, 2006.

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