Haploidentical transplantation as a promising therapy ...

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May 21, 2016 - Dept. of Blood and Marrow Transplantation, H. Lee Moffitt Cancer ... Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, ...
Accepted Manuscript Case report Haploidentical transplantation as a promising therapy for relapsed hemophagocytic lymphohistiocytosis in an adult older patient Ernesto Ayala, Denise LaFave, Taiga Nishihori, Mohamed A. Kharfan-Dabaja PII: DOI: Reference:

S1658-3876(16)30030-9 http://dx.doi.org/10.1016/j.hemonc.2016.05.005 HEMONC 141

To appear in:

Hematology/Oncology and Stem Cell Therapy

Received Date: Accepted Date:

3 May 2016 21 May 2016

Please cite this article as: E. Ayala, D. LaFave, T. Nishihori, M.A. Kharfan-Dabaja, Haploidentical transplantation as a promising therapy for relapsed hemophagocytic lymphohistiocytosis in an adult older patient, Hematology/ Oncology and Stem Cell Therapy (2016), doi: http://dx.doi.org/10.1016/j.hemonc.2016.05.005

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Haploidentical transplantation as a promising therapy for relapsed hemophagocytic lymphohistiocytosis in an adult older patient Ernesto Ayala1,2,*, Denise LaFave1, Taiga Nishihori1,2, Mohamed A. Kharfan-Dabaja1,2

1. Dept. of Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center, Tampa, FL, USA

2. Dept. of Oncologic Sciences, University of South Florida Morsani College of Medicine, Tampa, FL, USA

Word count: 1034 (including headings) Number of references=10 Number of tables=1 Number of figures=1

*Corresponding author

Ernesto Ayala, M.D. Dept. of Blood and Marrow Transplantation H. Lee Moffitt Cancer Center and Research Institute 12902 Magnolia Drive, FOB-3 Tampa, FL, 33612, USA Phone: +1-813-745-8248 Fax: +1-813-745-8468 E-mail: [email protected]

No conflict of interest to report 

CASE REPORT

Haploidentical Transplantation as a Promising Therapy for Relapsed Hemophagocytic Lymphohistiocytosis in an Older Adult Patient

Ernesto Ayala a,b,*, Denise LaFave a, Taiga Nishihori a,b, Mohamed A. Kharfan-Dabaja a,b

a

Department of Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center,

Tampa, FL, USA b

Department of Oncologic Sciences, University of South Florida Morsani College of

Medicine, Tampa, FL, USA * Corresponding author. Department of Blood and Marrow Transplantation, H. Lee

Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, FOB-3, Tampa, FL, 33612, USA. E-mail address: [email protected] (E. Ayala). Running title: Haploidentical transplantationin an adult patient $EVWUDFW  .H\ZRUGV 

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type

65

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91

Primary

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48

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Graft

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failure (%) Prospective

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multicenter

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Retrospective

Busulfan/cyclophosphamide/etoposide

multicenter

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9

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22

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Cesaro et al

12

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0

6

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Note. ATG = anti-thymocyte globulin; HCT = hematopoietic cell transplantation; HLH = hemophagocytic lymphohistiocytosis; y = year.