Accepted Manuscript Case report Haploidentical transplantation as a promising therapy for relapsed hemophagocytic lymphohistiocytosis in an adult older patient Ernesto Ayala, Denise LaFave, Taiga Nishihori, Mohamed A. Kharfan-Dabaja PII: DOI: Reference:
S1658-3876(16)30030-9 http://dx.doi.org/10.1016/j.hemonc.2016.05.005 HEMONC 141
To appear in:
Hematology/Oncology and Stem Cell Therapy
Received Date: Accepted Date:
3 May 2016 21 May 2016
Please cite this article as: E. Ayala, D. LaFave, T. Nishihori, M.A. Kharfan-Dabaja, Haploidentical transplantation as a promising therapy for relapsed hemophagocytic lymphohistiocytosis in an adult older patient, Hematology/ Oncology and Stem Cell Therapy (2016), doi: http://dx.doi.org/10.1016/j.hemonc.2016.05.005
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Haploidentical transplantation as a promising therapy for relapsed hemophagocytic lymphohistiocytosis in an adult older patient Ernesto Ayala1,2,*, Denise LaFave1, Taiga Nishihori1,2, Mohamed A. Kharfan-Dabaja1,2
1. Dept. of Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center, Tampa, FL, USA
2. Dept. of Oncologic Sciences, University of South Florida Morsani College of Medicine, Tampa, FL, USA
Word count: 1034 (including headings) Number of references=10 Number of tables=1 Number of figures=1
*Corresponding author
Ernesto Ayala, M.D. Dept. of Blood and Marrow Transplantation H. Lee Moffitt Cancer Center and Research Institute 12902 Magnolia Drive, FOB-3 Tampa, FL, 33612, USA Phone: +1-813-745-8248 Fax: +1-813-745-8468 E-mail:
[email protected]
No conflict of interest to report
CASE REPORT
Haploidentical Transplantation as a Promising Therapy for Relapsed Hemophagocytic Lymphohistiocytosis in an Older Adult Patient
Ernesto Ayala a,b,*, Denise LaFave a, Taiga Nishihori a,b, Mohamed A. Kharfan-Dabaja a,b
a
Department of Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center,
Tampa, FL, USA b
Department of Oncologic Sciences, University of South Florida Morsani College of
Medicine, Tampa, FL, USA * Corresponding author. Department of Blood and Marrow Transplantation, H. Lee
Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, FOB-3, Tampa, FL, 33612, USA. E-mail address:
[email protected] (E. Ayala). Running title: Haploidentical transplantationin an adult patient $EVWUDFW .H\ZRUGV
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patients
type
65
Primary
91
Primary
8
OuacheeChardin et al
HLH
4
Baker et al
No. of
9
48
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Type
Conditioning
Graft
Survival
failure (%) Prospective
Busulfan/cyclophosphamide/etoposide
multicenter
+ ATG
Retrospective
Busulfan/cyclophosphamide/etoposide
multicenter
+ ATG
Single center
Busulfan/cyclophosphamide/etoposide + ATG
10
62% at 3y
9
53% at 5y
22
58% at 6y
Cooper et al
Cesaro et al
12
Primary
Single center
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0
6
10
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61
Primary
Retrospective
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multicenter
etoposide,
5
58% at 8y
busulfan/fludarabine/melphalan, or busulfan/fludarabine/thiotepa
Note. ATG = anti-thymocyte globulin; HCT = hematopoietic cell transplantation; HLH = hemophagocytic lymphohistiocytosis; y = year.
