M. Clara Bicho: None. I. Rebelo: c.None. M. José Areias: None. ... Yusra Septivera, Ernawati Ernawati, Muhammad Ilham. Aldika Akbar, Agus Sulistyono Sr., ...
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Abstracts / Pregnancy Hypertension: An International Journal of Women’s Cardiovascular Health 5 (2015) 53–156
Health Institute, University of Lisbon, Faculty of Medicine, Lisbon, Portugal, b Laboratory of Biochemistry, Faculty of Pharmacy/Institute for Molecular and Cell Biology, University of Porto, Porto, Portugal, c Júlio Diniz Maternity, Maria Pia Hospital, Porto, Portugal, d Genetics Laboratory and Environmental Health Institute, University of Lisbon, Faculty of Medicine, Rocha Cabral Institute, Lisbon, Portugal) Objectives: To study the MTHFR and COMT polymorphisms and its interactions as susceptibility factors for the development of PE, as well as, to study in a follow up group, its influence on some biomarkers of cardiovascular risk at long term. Methods: A sample of 327 women (28.85 ! 5.59 years old), with 142 controls (normal blood pressure in pregnancy, NBPP) and 185 with preeclampsia (PE). We also performed a prospective study in a sub-sample of 138 women (35.24 ! 5.48 years old), 90 of these presented previous PE, 2–16 years ago. The MTHFR and COMT functional polymorphisms were evaluated by PCR-RFLP. We evaluated demographic, anthropometric, hemodynamic and other parameters: C-reactive protein (CRP), liver function (AST, ALT and GGT) and lipid profile (cholesterol total LDL, HDL, non-HDL, Apo A and B) which were determined by conventional methods. Results: The MTHFR CC+CT genotypes were associated with risk for the development of PE (OR = 4.175, 95% IC 1.361–12.806, p = 0.015). Previously PE women, with these risk genotypes, presented significant differences in some risk parameters (BMI, WC, SBP, DBP, Pulse Pressure and Apo B) (p < 0.05). There were no significant differences of COMT genotypes between PE and NBPP, but there were differences between NBPP and PE, when considered an epistatic and epigenetic interactions of MTHFR and COMT genotypes (p = 0.008). In the prospective study, considering the MTHFR CC+CT genotypes in previously PE women, some parameters (BMI, waist, SBP, DBP, PP and Apo B, p < 0.05) were increased compared with normotensive women, both before and after pregnancy. Conclusions: The distributions of MTHFR CC+CT genotypes were associated with the development and susceptibility of PE. These risk genotypes may modulate the history of PE leading to an increase of some risk cardiovascular parameters, even in women previously PE that became normotensive years after pregnancy. A. Matos; None. A. Pereira da Silva: None. H. Maia: None. M. Clara Bicho: None. I. Rebelo: c.None. M. José Areias: None. M. Bicho: None. doi:10.1016/j.preghy.2014.10.143
[138-POS] Gestational age as a determining factor for successful conservative treatment of severe preeclampsia Yusra Septivera, Ernawati Ernawati, Muhammad Ilham Aldika Akbar, Agus Sulistyono Sr., Aditiawarman Aditiawarman Sr., Hermanto Tri Joewono Sr., Erry
Gumilar Dachlan Sr. (Dr. Soetomo General Hospital/ Airlangga University, Surabaya, Indonesia) Objectives: The study is intended to analyze determining factors of successful conservative treatment of preeclampsia before 34 weeks of gestation. Methods: This is a retrospective analytic observational study. Data were retrieved from medical records of patients admitted to Obstetric Ward of Dr Soetomo Hospital, from July to August 2013. The population of the study was patients with severe preeclampsia going through conservative treatment from January 2008–December 2012. The inclusion criteria included population with complete medical record and without renal disease, SLE, premature rupture of membrane, and IUGR. The dependent variable in this study is the successful or unsuccessful conservative treatment for severe preeclampsia and the independent variables are gestational age, Esbach protein level, albumin serum level, uric acid level, blood pressure stage, Resistance Index and Pulsatility Index of uterine artery Doppler velocimetry, body mass index, parity, and maternal age. Double regression logistic analysis test was used with significant value if the p < 0.05. During five years of study, we obtain 120 cases whereas only 58 cases fulfill inclusion criteria. Patients were divided into those with severe preeclampsia with successful conservative treatment (n = 15) and those with severe preeclampsia who failed conservative treatment (n = 43, controls). Results: Gestational age was significantly different (p < 0.05) between control and study groups (p = 0.003); the ROC curve obtained a cutoff point value of gestational age 31.5 weeks with sensitivity of 80% and specificity of 76.72%. Therefore, gestational age can be used as a determining factor for conservative treatment. Other determining factors were not significantly different (p < 0.05): Esbach protein p = 0.226, uric acid p = 0.225, blood pressure p = 0.140, uterine artery PI p = 0.358, uterine artery RI p = 0.292, parity p = 0.133, serum albumin p = 0.943, serum creatinine p = 0.699, body mass index p = 0.962, and maternal age p = 0.589. Conclusions: Gestational age is a determining factor for the success of conservative treatment of severe preeclampsia. Disclosures: Y. Septivera: None. E. Ernawati: None. M.A. Akbar: None. A. Sulistyono: None. A. Aditiawarman: None. H.T. Joewono: None. E.G. Dachlan: None. doi:10.1016/j.preghy.2014.10.144
[139-POS] Preeclampsia and arterial stiffness – A 10-year follow up of previous preeclamptic women Martin Christensen a, Camilla J.s. Kronborg b, Ulla B. Knudsen c (a Clinical Research Unit, Randers Regional Hospital, Randers, Denmark, b Department of Oncology, Aarhus University Hospital, Aarhus, Denmark, c Department of Obstetrics and Gynecology, Aarhus University Hospital, Aarhus, Denmark)
