Heart rate and blood pressure variability in children ... - Springer Link
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Heart rate and blood pressure variability in children ... - Springer Link
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Pediatr Nephrol (2014) 29:1059–1065 DOI 10.1007/s00467-013-2737-8
ORIGINAL ARTICLE
Heart rate and blood pressure variability in children with chronic kidney disease: a report from the CKiD study Gina-Marie Barletta & Joseph Flynn & Mark Mitsnefes & Joshua Samuels & Lisa Aronson Friedman & Derek Ng & Christopher Cox & Timothy Poffenbarger & Bradley Warady & Susan Furth
Received: 19 August 2013 / Revised: 4 December 2013 / Accepted: 16 December 2013 / Published online: 2 February 2014 # IPNA 2014
Abstract Background Autonomic nervous system dysfunction and sympathetic nervous system over-activity play important roles in the development of hypertension associated with chronic kidney disease (CKD). In adults, increased blood pressure variability (BPV) appears to be directly related to sympathetic over-activity with increased risk of end-organ damage and cardiovascular events. Decreased heart rate variability (HRV) has been observed in adults with CKD, and is an independent predictor of mortality. Methods The purpose of this study was to evaluate BPV and HRV in pediatric patients enrolled in the Chronic Kidney Disease in Children Study. Ambulatory blood pressure
