hematological and histopathological changes induced by cadmium ...
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Bas.J.Vet.Res.Vol.14,No.2,2016.
ISI Impact Factor:3.461
HEMATOLOGICAL AND HISTOPATHOLOGICAL CHANGES INDUCED BY CADMIUM CHLORIDE TOXICITY IN SHEEP, WITH USING ALPHA LIPOIC ACID AS ANTIOXIDANT.
Hussein Ali Naji.* , Mohammad Mushgil Zenad** *Department of Internal and preventive medicine, College of Veterinary Medicine. University of Basrah ,Basrah, Iraq. **Department of Internal and preventive Medicine, College of Veterinary Medicine, University of Baghdad - Iraq. (Received 20 January 2016, Accepted 27 January 2016)
Key words: Heavy toxic metal, Antioxidant agent, CdCl2.
ABSTRACT Cadmium (Cd) is a heavy toxic metal, with harmful effects on animals and public health. Recently the risk of cadmium toxicity is substantially regarded. Therefore the present study was performed to clarify the effects of acute cadmium toxicity in sheep with using alpha lipoic acid (ALA) as an antioxidant agent. Fifteen male lambs 5 - 7 months old were divided equally in to three groups, they were supplied with ordinary diet and provided with water ad-lib, The first group (I) was administered a single dose of CdCl2 3 mg/kg.bw subcutaneously (S/C), the second group(II) was injected with the same dose of CdCl2 and via by the same route, and then simultaneously administered an alpha lipoic acid 50 mg/kg.B.W intramuscularly, the later drug was repeated after 12 hours via the same route also. The third group (III) was left as control and given normal saline (S/C). Resulted revealed a significant decrease (P
