Oct 9, 2015 - Program, Ohio State University College of Medicine, Columbus, Ohio; 2The ... Institute at Nationwide Children's Hospital, Columbus, Ohio.
1236. Hepatitis C Virus (HCV)-Specific Postpartum T-Cell Function in Women Chronically Infected With HCV Samantha Ohmer BA1; Jonathan Honegger, MD2; 1Biomedical Sciences Graduate Program, Ohio State University College of Medicine, Columbus, Ohio; 2The Research Institute at Nationwide Children’s Hospital, Columbus, Ohio Session: 159. Viral Infections: Pathogenesis and Immunity Friday, October 9, 2015: 12:30 PM Background. Chronic hepatitis C virus (HCV) infection is typically characterized by stable high-level viremia and exhaustion of virus-specific CD8+ and CD4+ T-cell responses. Nevertheless, some chronically infected women experience substantial transient decreases in viral load after childbirth. We hypothesized that resurgent HCV-specific Th1 and Tc1 activity may contribute to improved viral control following pregnancy. Methods. Cryopreserved peripheral blood mononuclear cells collected from HCV-infected women during and after pregnancy were thawed, stimulated with peptides corresponding to HCV NS3 and NS4 proteins, and analyzed for production of IFNγ, IL2, IL10, IL17a, and IL21 by intracellular cytokine staining and flow cytometry. Longitudinal HCV-specific T cell responses were compared between 6 women with ≥1 log10 declines in viral load between the 3rd trimester of
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OFID 2015:2 (Suppl 1)
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Poster Abstracts
pregnancy and 3 months postpartum and 12 women with
