High expression of RUNX1 is associated with poorer

Oncotarget, Oncotarget, Supplementary Advance Publications Materials 2015 2016

www.impactjournals.com/oncotarget/

High expression of RUNX1 is associated with poorer outcomes in cytogenetically normal acute myeloid leukemia Supplementary Materials

Supplementary Table S1: Patients’ characteristics in the validating group of CN-AML according to the RUNX1 expression Variable RUNX1high, n = 81 RUNX1low, n = 81 P Median age. y (range) 59 (7–81) 56 (20–83) 0.82 Median OS. d (range) 223 (3–1176) 416 (1–1176) 0.03 FAB subtype, no M0 2 3 1 M1 30 15 0.014 M2 18 27 0.16 M3 0 0 1 M4 22 20 0.86 M5 8 11 0.63 M6 1 5 0.21 61 20 < 0.001 High ERG, no 48 33 0.028 High BAALC, no 28 53 < 0.001 High LEF1, no 44 37 0.35 High MN1, no 54 27 < 0.001 High WT1, no 56 25 < 0.001 High DNMT3B, no 60 21 < 0.001 High TCF4, no 63 18 < 0.001 High ITPR2, no 58 23 < 0.001 High MAPKBP1, no High ERG, BAALC, LEF1, MN1,WT1, DNMT3B TCF4, ITPR2 and MAPKBP1 expression were defined as an expression level above the median of all samples, respectively.

www.impactjournals.com/oncotarget

1

Oncotarget

Supplementary Table S2: RUNX1-associated gene-expression profile using microarray in the testing group probes

Symbols

p-value

Fold change

209360_s_at 228280_at 203151_at 217892_s_at 209537_at 225295_at 228550_at 223351_at 224959_at 209434_s_at 229530_at 227335_at 213391_at 226721_at 227426_at 239237_at 218361_at 205097_at 223253_at 206081_at 212653_s_at 209409_at 222589_at 228095_at 221942_s_at 212731_at 218783_at 213395_at 1555881_s_at 227522_at 228696_at 204866_at 227461_at 40472_at 224746_at 221652_s_at 229983_at 227334_at 238499_at 223403_s_at 242414_at

RUNX1 ZC3HAV1L MAP1A LIMA1 EXTL2 SLC39A10 RTN4R C17orf80 SLC26A2 PPAT GUCY1A3 DIDO1 DPY19L4 DPY19L4 SOS1 LOC100506776 GOLPH3L SLC26A2 EPDR1 SLC24A1 EHBP1 GRB10 NLK PHF14 GUCY1A3 ANKRD46 INTS7 MLC1 LZTS2 CMBL SLC45A3 PHF16 STON2 LPCAT4 KIAA1522 ASUN TIGD2 USP54 SLC45A3 POLR1B QPRT

3.68E-34 1.37E-16 1.77E-16 1.89E-15 5.47E-15 4.59E-15 5.27E-15 1.15E-14 5.64E-14 6.33E-14 1.05E-13 1.74E-13 2.21E-13 3.21E-13 3.07E-13 3.23E-13 3.89E-13 4.34E-13 6.21E-13 7.08E-13 8.41E-13 9.52E-13 1.06E-12 1.16E-12 1.65E-12 1.83E-12 2.05E-12 2.37E-12 3.02E-12 3.01E-12 3.35E-12 4.10E-12 4.03E-12 4.09E-12 4.30E-12 5.41E-12 5.90E-12 6.82E-12 7.59E-12 8.95E-12 9.43E-12

1.311753 1.255878 1.239758 0.676639 0.856769 0.814251 0.910439 0.690112 0.637026 0.644608 1.580208 0.736967 0.762041 0.703803 0.635517 1.266409 0.83911 0.763387 1.147946 0.696113 0.68067 1.288065 0.831837 0.73065 1.621215 0.679341 0.675563 1.190422 0.644231 1.235737 0.889049 0.690149 1.391123 0.652861 0.801332 0.691622 0.613728 0.650549 0.82616 0.647463 1.045506


2

Meanexpression of RUNX1high 9.681265 8.327701 8.022762 7.784194 8.097405 8.747474 6.692529 7.413718 8.395491 6.955966 8.302874 7.494155 6.802641 7.753397 7.875537 8.29596 8.197894 7.608132 8.758419 6.15335 7.553831 8.411074 8.267342 8.454919 9.099951 6.939268 6.265776 8.489091 7.859994 8.013945 7.988856 6.661758 7.703123 7.178933 6.404184 9.063173 6.945454 6.790105 7.007895 7.789318 7.57447

Mean expression of RUNX1low 8.369512 7.071823 6.783004 7.107555 7.240636 7.933222 5.782091 6.723606 7.758465 6.311358 6.722666 6.757188 6.0406 7.049594 7.24002 7.029551 7.358783 6.844745 7.610474 5.457237 6.873161 7.123009 7.435505 7.72427 7.478736 6.259927 5.590213 7.298668 7.215763 6.778208 7.099808 5.971609 6.312001 6.526072 5.602852 8.37155 6.331725 6.139556 6.181735 7.141855 6.528965 Oncotarget

212828_at 218889_at 225543_at 227235_at 1553218_a_at 202661_at 219497_s_at 217263_x_at 227026_at 213035_at 203372_s_at 206067_s_at 202630_at 226043_at 212170_at 201664_at 219372_at 211181_x_at 201069_at 203373_at 214670_at 229090_at 225384_at 214806_at 227536_at 229614_at 210347_s_at 213237_at 204044_at 211793_s_at 225112_at 225611_at 225613_at 238122_at 222742_s_at 211180_x_at 209014_at 226157_at 219615_s_at 226098_at 224827_at 225237_s_at 203735_x_at 202561_at 201243_s_at

SYNJ2 NOC3L GTF3C4 GUCY1A3 ZNF512 ITPR2 BCL11A RUNX1 MPHOSPH8 ANKRD28 SOCS2 WT1 APPBP2 GPSM1 RBM12 SMC4 IFT81 RUNX1 MMP2 SOCS2 ZKSCAN1 ZEB1-AS1 DOCK7 BICD1 ZC3H13 ZNF320 BCL11A C16orf88 QPRT ABI2 ABI2 MAST4 MAST4 RBM12B RABL5 RUNX1 MAGED1 TFDP2 KCNK5 IFT80 UBTD2 MSI2 PPFIBP1 TNKS ATP1B1


9.94E-12 1.38E-11 1.64E-11 1.90E-11 1.94E-11 2.03E-11 2.04E-11 2.08E-11 2.08E-11 2.12E-11 2.26E-11 3.30E-11 3.43E-11 3.47E-11 3.72E-11 3.77E-11 4.54E-11 5.07E-11 5.54E-11 5.84E-11 6.62E-11 7.40E-11 7.88E-11 8.21E-11 8.63E-11 9.02E-11 9.31E-11 1.06E-10 1.11E-10 1.19E-10 1.37E-10 1.43E-10 1.50E-10 1.49E-10 1.52E-10 1.68E-10 1.89E-10 1.92E-10 1.96E-10 2.12E-10 2.34E-10 2.42E-10 2.45E-10 2.93E-10 3.11E-10

0.885825 0.605745 0.615082 1.680967 0.599511 0.837715 1.127098 0.644412 0.598302 0.960183 1.652714 1.354219 0.647776 1.137794 0.660824 0.827573 0.64351 0.718017 1.799152 1.675798 0.649262 0.668814 0.650811 0.629724 0.693706 0.809031 0.77071 0.619919 1.091554 0.740015 0.800442 0.835822 0.826681 0.585472 0.739888 0.617015 0.791657 0.962232 1.048902 0.650002 0.656654 1.255849 0.718166 0.617221 1.070357 3

7.022216 7.732919 6.50118 8.01135 8.430813 6.131988 9.235414 6.210369 8.002568 8.405162 7.630611 7.727775 7.048086 8.489718 6.597278 9.984242 5.838252 6.635991 7.976892 8.564958 8.196284 5.987087 7.464311 5.905583 7.91103 6.510343 8.379278 6.23158 6.691436 7.295337 7.825411 7.550219 6.768808 6.720511 6.628553 6.932926 9.06096 9.333389 7.155858 8.027738 7.770819 9.39492 7.225566 7.363787 8.81351

6.13639 7.127174 5.886098 6.330384 7.831302 5.294272 8.108317 5.565958 7.404266 7.444979 5.977898 6.373556 6.40031 7.351924 5.936454 9.156669 5.194743 5.917975 6.17774 6.889161 7.547022 5.318273 6.8135 5.275859 7.217324 5.701311 7.608568 5.611661 5.599883 6.555322 7.024969 6.714397 5.942127 6.135038 5.888665 6.315911 8.269303 8.371158 6.106956 7.377736 7.114165 8.139072 6.5074 6.746567 7.743154 Oncotarget

219498_s_at 228920_at 213005_s_at 220992_s_at 227604_at 238050_at 212274_at 228397_at 230178_s_at 1559078_at 204341_at 55872_at 222891_s_at 225240_s_at 229971_at 222457_s_at 1558700_s_at 210694_s_at 230298_at 212405_s_at 241365_at 235852_at 204484_at 235151_at 215146_s_at 225098_at 228171_s_at 226085_at 201663_s_at 212276_at 218694_at 207011_s_at 228442_at 236738_at 205624_at 218966_at 209386_at 226299_at 1557953_at 227569_at 211182_x_at 212186_at 222819_at 212070_at 219330_at

BCL11A ZNF260 KANK1 TRMT1L TMEM185B ANTXR2 LPIN1 TUG1 ELP2 BCL11A TRIM16 ZNF512B BCL11A MSI2 GPR114 LIMA1 ZNF260 MID1 MBLAC2 METTL13 SATB1 STON2 PIK3C2B LOC283357 TTC28 ABI2 PLEKHG4 CBX5 SMC4 LPIN1 ARMCX1 PTK7 NFATC2 C3orf80 CPA3 MYO5C TM4SF1 PKN3 ZKSCAN1 LNX2 RUNX1 ACACA CTPS2 GPR56 VANGL1



0.950582 0.629619 0.89935 0.650217 0.586977 0.649476 0.598481 0.661525 0.644267 0.916715 0.813715 0.647865 1.085605 1.177446 0.908985 0.623839 0.651056 0.64261 0.667036 0.617068 0.682854 1.103987 0.950514 0.682919 0.743805 0.915933 0.692028 0.731947 0.842318 0.610847 0.837175 0.884413 0.837461 1.628542 1.879526 0.782115 1.280377 0.728137 0.628656 0.616788 0.856856 0.881249 0.588708 1.595233 0.780673 4

8.313535 6.630745 7.755941 6.992926 6.05621 6.260733 7.298144 6.986701 6.856106 7.161695 7.243345 7.887559 9.086235 9.750959 7.60908 5.84958 6.188681 6.35615 7.280972 8.059085 7.377938 6.397485 7.777493 6.629435 6.541984 7.649941 6.750913 8.804413 9.672025 8.448127 7.060708 6.281164 7.321464 7.682784 9.735435 7.590253 7.292272 6.168645 7.753049 6.505421 6.555879 7.453035 7.239247 8.231286 7.250418

7.362953 6.001126 6.856591 6.342709 5.469233 5.611257 6.699663 6.325176 6.211839 6.24498 6.429629 7.239694 8.000631 8.573513 6.700096 5.225742 5.537626 5.71354 6.613935 7.442016 6.695084 5.293499 6.826979 5.946517 5.798179 6.734008 6.058885 8.072465 8.829706 7.83728 6.223533 5.396751 6.484004 6.054241 7.855909 6.808138 6.011895 5.440508 7.124393 5.888633 5.699024 6.571787 6.650538 6.636054 6.469744 Oncotarget

207160_at 242628_at 224722_at 228654_at 213610_s_at 218318_s_at 213058_at 213891_s_at 226327_at 206188_at 218437_s_at 206478_at 203139_at 230266_at 202662_s_at 206954_at 235604_x_at 224901_at 239580_at 210365_at 201242_s_at 202660_at 212692_s_at 218689_at 218792_s_at 230434_at 212387_at 217975_at 207426_s_at 215471_s_at 218984_at 232007_at 223382_s_at 209627_s_at 226771_at 218710_at 226889_at 244043_at 218641_at 204040_at 223268_at 224953_at 223599_at 1558956_s_at 202252_at

IL12A KLRB1 MIB1 SPIN4 KLHL23 NLK TTC28 TCF4 ZNF507 ZNF623 LZTFL1 KIAA0125 DAPK1 RAB7B ITPR2 WT1-AS ZNF493 SCD5 GUCY1A3 RUNX1 ATP1B1 ITPR2 LRBA FANCF BSPRY PHOSPHO2 TCF4 WBP5 TNFSF4 MAP7 PUS7 AGPAT5 ZNRF1 OSBPL3 ATP8B2 TTC27 WDR35 TFDP2 C11orf95 RNF144A C11orf54 YIPF5 TRIM6 IFT80 RAB13



0.590672 0.586534 0.649566 0.900944 0.873247 0.604541 0.611031 1.010695 0.587414 0.644524 0.632234 1.317048 0.80582 0.997714 0.597469 0.706167 0.644125 0.838157 1.160071 0.894292 1.098107 0.64533 0.591174 0.736392 0.724867 0.637819 0.902643 1.145313 0.738166 0.950887 0.637653 0.758791 0.660617 0.655407 0.957116 0.734191 0.5946 0.795148 0.704776 0.750279 0.59396 0.713402 0.941034 0.702345 0.976817 5

5.586478 5.711758 6.905868 8.821685 6.61238 6.988508 6.502538 8.391064 6.675385 6.351424 7.652091 9.120244 9.240368 7.265511 7.112503 5.622387 6.610064 6.754203 6.30121 7.856704 9.116725 7.94127 8.485203 6.739004 6.751989 6.625965 7.85296 7.822912 7.500857 7.04723 7.457865 7.173154 8.871701 7.418257 7.605852 8.010629 7.191059 7.053123 7.491804 7.75904 8.009487 7.326959 6.438198 8.123645 8.81867

4.995807 5.125224 6.256302 7.920741 5.739133 6.383967 5.891507 7.380369 6.087972 5.706901 7.019857 7.803197 8.434548 6.267797 6.515034 4.91622 5.965939 5.916045 5.141139 6.962412 8.018619 7.29594 7.894029 6.002612 6.027122 5.988146 6.950317 6.677599 6.762691 6.096343 6.820213 6.414363 8.211084 6.76285 6.648736 7.276438 6.59646 6.257974 6.787028 7.00876 7.415527 6.613557 5.497164 7.421301 7.841853 Oncotarget

225081_s_at 223075_s_at 202889_x_at 212599_at 213258_at 213394_at 233461_x_at 238043_at 210958_s_at 222746_s_at 206582_s_at 222451_s_at 225671_at 205739_x_at 225550_at 218596_at 229492_at 222594_s_at 212775_at 238418_at 203685_at 207877_s_at 238732_at 205527_s_at 238021_s_at 202890_at 223961_s_at 225959_s_at 212110_at 232489_at 223513_at 219553_at 205497_at 212386_at 229572_at 235900_at 225551_at 1553982_a_at 40016_g_at 213541_s_at 205190_at 217841_s_at 225485_at 228174_at 224847_at

CDCA7L AIF1L MAP7 AUTS2 TFPI MAPKBP1 ZNF226 ARID1B MAST4 BSPRY GPR56 ZDHHC9 SPNS2 ZNF107 CNST TBC1D13 VANGL1 SPATS2 OBSL1 SLC35B4 BCL2 NVL COL24A1 GEMIN4 CRNDE MAP7 CISH ZNRF1 SLC39A14 TRMT13 CENPJ NME7 ZNF175 TCF4 ATP6V0A2 SPNS3 CNST RAB7B MAST4 ERG PLS1 PPME1 CEP41 SCAI CDK6



0.835734 1.132528 0.949628 0.851538 1.158978 0.889245 0.870445 0.65737 0.627104 0.85725 1.139251 0.917335 0.86535 0.593262 0.655581 0.884317 0.929416 0.590331 1.252799 0.634012 0.71907 0.625757 1.068372 0.588464 1.534486 1.233649 0.777771 0.603358 0.589674 0.637991 0.665195 0.64602 0.600278 0.978415 0.705652 1.005015 0.621014 0.965948 0.814327 1.009922 0.942638 0.622004 0.630987 0.616443 0.797717 6

9.288104 6.850402 6.645113 7.547799 7.84644 6.912516 6.293058 7.754008 6.272856 7.400879 6.471457 6.704761 7.792498 7.207121 7.237765 6.561023 6.104295 6.06967 7.251761 6.828204 8.091367 5.703095 7.123518 7.130536 8.135111 7.855193 6.709052 8.171118 6.810692 6.873011 7.539537 7.258876 6.694774 9.026603 7.539911 7.786844 7.174039 6.956019 6.294002 7.931104 6.482297 7.249404 7.182834 7.168679 10.88061

8.45237 5.717874 5.695486 6.696262 6.687462 6.02327 5.422613 7.096638 5.645752 6.543628 5.332205 5.787426 6.927147 6.613859 6.582183 5.676706 5.174878 5.47934 5.998962 6.194192 7.372297 5.077338 6.055145 6.542073 6.600625 6.621544 5.931281 7.56776 6.221018 6.235019 6.874342 6.612857 6.094496 8.048188 6.83426 6.78183 6.553025 5.990071 5.479675 6.921182 5.53966 6.627401 6.551847 6.552236 10.08289 Oncotarget

220918_at 227792_at 231319_x_at 218762_at 229997_at 223404_s_at 216705_s_at 227766_at 203865_s_at 219602_s_at 222240_s_at 227798_at 202813_at 223758_s_at 201440_at 203608_at 226991_at 236837_x_at 220668_s_at 204639_at 219353_at 229838_at 230381_at 210999_s_at 243963_at 213489_at 210993_s_at 221031_s_at 219036_at 201596_x_at 222146_s_at 218397_at 242260_at 231897_at 227329_at 206148_at 212651_at 223475_at 239232_at 201564_s_at 202862_at 225046_at 221223_x_at 227908_at 222811_at

RUNX1-IT1 ITPRIPL2 KIF9 ZNF574 VANGL1 TRMT1L ADA LIG4 ADARB1 PIEZO2 ISYNA1 SMAD1 TARBP1 GTF2H2 DDX23 ALDH5A1 NFATC2 MIPEPP3 DNMT3B ADA NHLRC2 NUCB2 C1orf186 GRB10 SDCCAG8 MAPRE2 SMAD1 APOLD1 CEP70 KRT18 TCF4 FANCL MATR3 PTGR1 ZBTB46 IL3RA RHOBTB1 CRISPLD1 MSI2 FSCN1 FAH LOC389831 CISH TBC1D24 FTSJD1



0.702144 0.917805 0.639944 0.734697 0.970547 0.642233 1.061197 0.607359 0.637591 0.840759 0.666745 0.783278 0.669412 0.595513 0.690613 1.009942 0.862183 0.622202 0.689914 0.938825 0.635158 0.614985 0.868651 0.899695 0.59286 0.773439 0.690496 0.590035 0.814867 1.239223 0.799326 0.615572 0.743644 0.614372 0.603366 0.981564 0.750917 0.692003 0.633894 0.92634 0.590804 0.852286 0.587588 0.614715 0.595697 7

7.06045 7.808187 7.161309 6.894685 7.079994 7.180933 8.809603 6.924523 6.632222 6.211832 7.564657 7.570494 8.846837 7.488536 7.211156 8.146988 6.629454 6.008464 7.963872 9.363046 6.355975 8.61494 8.3686 7.496669 6.911274 5.700956 7.203781 5.63371 7.017674 7.185003 7.685545 8.081972 7.874953 6.120257 6.486488 6.89698 6.476541 6.437091 7.11738 7.132529 7.778463 6.795989 7.614699 6.510785 7.859019

6.358306 6.890382 6.521366 6.159987 6.109447 6.5387 7.748407 6.317165 5.994631 5.371072 6.897912 6.787217 8.177426 6.893022 6.520544 7.137046 5.767271 5.386262 7.273958 8.424221 5.720818 7.999955 7.499949 6.596974 6.318414 4.927516 6.513286 5.043675 6.202807 5.945779 6.886219 7.4664 7.131309 5.505885 5.883122 5.915416 5.725624 5.745089 6.483486 6.206189 7.18766 5.943703 7.027111 5.896071 7.263322 Oncotarget

202932_at 241376_at 226025_at 203753_at 223627_at 204429_s_at 222603_at 1552364_s_at 241926_s_at 210473_s_at 224848_at 218096_at 205227_at 238022_at 243579_at 206674_at 224851_at 225233_at 215143_at 203069_at 228885_at 1554067_at 232232_s_at 228245_s_at 201427_s_at 212382_at 239162_at 219871_at 215116_s_at 213670_x_at 226550_at 215034_s_at 205051_s_at 203688_at 205609_at 206589_at 225238_at 241682_at 212385_at 222659_at 209930_s_at 214375_at 221286_s_at 203588_s_at 216953_s_at

YES1 LOC100130097 ANKRD28 TCF4 MEX3B SLC2A5 ERMP1 MSI2 ERG GPR125 CDK6 AGPAT5 IL1RAP CRNDE MSI2 FLT3 CDK6 MSI2 DPY19L2P2 SV2A MAMDC2 C12orf66 SLC22A16 OVOS2 SEPP1 TCF4 DAPK1-IT1 FLJ13197 DNM1 NSUN5P1 SLC9A1 TM4SF1 KIT PKD2 ANGPT1 GFI1 MSI2 KLHL23 TCF4 IPO11 NFE2 PPFIBP1 MZB1 TFDP2 WT1



0.796689 0.630471 0.698185 0.785689 0.820627 0.617154 0.640615 0.728851 0.781151 0.917457 0.772126 0.620626 0.892905 1.115255 0.89907 0.770561 0.741963 0.948288 0.59268 0.825813 1.358977 0.663762 0.590903 0.596314 1.72918 0.823085 0.606295 0.904319 0.795653 0.586963 0.631609 0.895439 1.154241 0.612595 1.083521 0.862855 0.70299 0.696462 0.752461 0.623239 0.667803 0.602649 0.829156 0.682948 0.799979 8

6.670322 6.975627 10.2299 8.134384 6.901553 8.045323 8.67168 6.681239 6.99762 6.975635 10.33227 9.300837 8.364958 6.753048 7.089033 10.22171 11.3552 6.690636 6.548085 6.773621 7.652703 7.617666 7.902477 7.395387 9.309376 7.627322 6.651312 7.407447 6.368983 8.095171 7.97686 5.896306 9.10535 8.010914 8.787223 7.952539 5.909288 6.049998 7.274326 6.816933 9.656321 6.184658 7.046695 7.884271 5.801284

5.873632 6.345155 9.531716 7.348695 6.080926 7.428169 8.031065 5.952388 6.21647 6.058179 9.560144 8.680211 7.472054 5.637794 6.189963 9.451144 10.61323 5.742348 5.955405 5.947808 6.293726 6.953904 7.311574 6.799074 7.580196 6.804237 6.045016 6.503129 5.57333 7.508208 7.345251 5.000867 7.95111 7.398319 7.703702 7.089684 5.206297 5.353536 6.521865 6.193695 8.988518 5.582009 6.217538 7.201323 5.001305 Oncotarget

200986_at 202431_s_at 205349_at 202566_s_at 219412_at 209710_at 226545_at 204798_at 223319_at 227492_at 1554489_a_at 229638_at 205229_s_at 202933_s_at 215248_at 228988_at 220744_s_at 224150_s_at 225285_at 212776_s_at 209387_s_at 204083_s_at 202718_at 205375_at 220643_s_at 226517_at 222632_s_at 213460_x_at 213110_s_at 225532_at 1568619_s_at 1555842_at 220377_at 229507_at 203787_at 1557137_at 227574_at 221606_s_at 210299_s_at 206341_at 243010_at 214452_at 225802_at 230541_at 215016_x_at

SERPING1 MYC GNA15 SVIL RAB38 GATA2 CD109 MYB GPHN OCLN CEP70 IRX3 COCH YES1 GRB10 ZNF711 IFT122 CEP70 BCAT1 OBSL1 TM4SF1 TPM2 IGFBP2 MDFI FAIM BCAT1 LZTFL1 NSUN5P2 COL4A5 CABLES1 ITPRIPL2 CYTH2 KIAA0125 FAM212A SSBP2 TMEM17 OBSL1 HMGN5 FHL1 IL2RA MSI2 BCAT1 TOP1MT LOC149134 DST



0.814006 0.790635 0.635243 0.598317 0.789684 0.886481 0.90883 0.653744 0.622636 0.733578 0.763973 1.444278 0.850076 0.742702 0.721284 1.132186 0.710613 0.713851 0.998204 0.980993 0.974107 0.657273 1.340763 0.674172 0.593305 0.888401 0.658997 0.614559 1.267014 0.618432 0.679959 0.614816 1.192792 0.600668 0.654673 0.588843 0.752814 0.643363 0.834806 0.683231 0.722749 0.59985 0.678636 0.747878 0.718186 9

7.547773 9.747933 9.740821 7.085578 5.750217 8.678826 6.708223 11.25563 5.975942 7.99306 6.909789 7.277347 6.744175 7.067304 6.80954 6.952875 6.754032 6.988393 8.319482 6.100075 6.257496 6.169001 7.452017 6.064444 6.944301 7.587341 6.138986 7.977143 7.614152 6.499303 7.484201 6.101713 7.548698 6.133917 8.670148 5.670979 6.122229 6.355236 7.188513 5.875505 6.939891 6.238708 8.048546 6.250525 6.463993

6.733766 8.957297 9.105578 6.487261 4.960533 7.792346 5.799393 10.60188 5.353306 7.259482 6.145816 5.833068 5.894099 6.324602 6.088257 5.820689 6.043419 6.274542 7.321277 5.119083 5.283389 5.511728 6.111254 5.390272 6.350996 6.69894 5.479989 7.362584 6.347138 5.880871 6.804242 5.486897 6.355906 5.533249 8.015476 5.082136 5.369414 5.711873 6.353707 5.192274 6.217143 5.638858 7.36991 5.502647 5.745807 Oncotarget

204624_at 205608_s_at 218795_at 209676_at 225962_at 1552908_at 219922_s_at 220952_s_at 217974_at 201540_at 206233_at 39248_at 214039_s_at 224516_s_at 219654_at 212764_at 212254_s_at 223374_s_at 1555600_s_at 215111_s_at 215440_s_at 201417_at 1554679_a_at 204430_s_at 224759_s_at 224049_at 231899_at 210933_s_at 209702_at 205801_s_at 202351_at 236562_at 210805_x_at 209191_at 208767_s_at 210612_s_at 201418_s_at 206331_at 1554242_a_at 211071_s_at 217904_s_at 225355_at 208029_s_at 224048_at 235109_at

ATP7B ANGPT1 ACP6 TFPI ZNRF1 GCSAML LTBP3 PLEKHA5 TM7SF3 FHL1 B4GALT6 AQP3 LAPTM4B CXXC5 PTPLA ZEB1 DST B3GALNT1 APOL4 TSC22D1 BEX4 SOX4 LAPTM4B SLC2A5 C12orf23 KCNK17 ZC3H12C FSCN1 FTO RASGRP3 ITGAV ZNF439 RUNX1 TUBB6 LAPTM4B SYNJ2 SOX4 CALCRL COCH MLLT11 BACE1 NEURL1B LAPTM4B USP44 ZBED3



0.629626 0.838176 0.589277 0.676017 0.755265 0.88248 0.658066 0.704598 0.598464 1.007672 0.841437 0.833954 1.238673 0.625382 0.698135 0.692822 0.712088 0.630228 0.723707 0.79458 0.728113 0.70002 1.002147 0.846528 0.678772 0.681965 0.670962 0.798445 0.701409 0.9947 0.626726 0.662357 0.616925 0.932368 0.898084 0.642691 0.94421 0.660068 0.686721 0.651137 0.60166 0.913686 1.125371 0.616305 0.694566 10

6.26686 8.757174 6.952726 6.167455 6.527077 6.848481 7.204799 7.683536 8.023228 8.572693 7.661901 7.115426 9.122628 9.779658 7.369579 7.024449 6.348676 6.898272 6.115384 9.882944 8.937329 10.90419 7.772053 8.242106 7.600641 7.645702 5.967772 8.32634 8.891552 7.653915 7.14063 6.543027 5.694689 8.631533 8.259822 5.608628 8.740306 5.794831 6.016401 8.21547 6.178223 6.996925 8.014379 5.642555 7.021254

5.637233 7.918998 6.363449 5.491438 5.771812 5.966001 6.546734 6.978938 7.424763 7.565021 6.820464 6.281471 7.883955 9.154276 6.671445 6.331627 5.636588 6.268044 5.391676 9.088364 8.209216 10.20417 6.769906 7.395578 6.921869 6.963737 5.29681 7.527896 8.190143 6.659215 6.513904 5.88067 5.077765 7.699166 7.361738 4.965937 7.796096 5.134763 5.32968 7.564333 5.576563 6.083239 6.889008 5.02625 6.326688 Oncotarget

235142_at 226670_s_at 215767_at 223939_at 203817_at 223095_at 209035_at 1552715_a_at 232985_s_at 228372_at 235171_at 207781_s_at 201539_s_at 235333_at 235085_at 222996_s_at 214228_x_at 210425_x_at 209099_x_at 212364_at 235287_at 210239_at 222719_s_at 217963_s_at 203795_s_at 227860_at 214505_s_at 233955_x_at 222920_s_at 204529_s_at 241133_at 206298_at 214390_s_at 210100_s_at 216268_s_at 231982_at 210815_s_at 213415_at 223565_at 205780_at 210298_x_at 1555923_a_at 226282_at 220798_x_at 240766_at

ZBTB8A PABPC1L ZNF804A SUCNR1 GUCY1B3 MARVELD1 MDK RXFP1 DPPA4 C10orf128 LOC100505501 ZNF711 FHL1 B4GALT6 SGK223 CXXC5 TNFRSF4 GOLGA8B JAG1 MYO1B CDK6 IRX5 PDGFC NGFRAP1 BCL7A CPXM1 FHL1 CXXC5 TESPA1 TOX TRBV27 ARHGAP22 BCAT1 ABCA2 JAG1 C19orf77 CALCRL CLIC2 MZB1 BIK FHL1 C10orf114 PTPN14 LPPR3 EPC1


7.9E-05 8.37E-05 8.52E-05 8.69E-05 8.94E-05 9E-05 9.04E-05 9.1E-05 9.66E-05 9.85E-05 9.97E-05 0.000104 0.000106 0.000111 0.000113 0.000121 0.000121 0.000122 0.000124 0.000127 0.000129 0.000133 0.000136 0.000143 0.000152 0.000158 0.00017 0.000172 0.0002 0.000212 0.000215 0.000225 0.000226 0.000236 0.000262 0.000267 0.000273 0.000298 0.000319 0.000319 0.000335 0.000343 0.000367 0.000388 0.000413

0.918937 0.589001 0.612531 0.976361 0.799497 0.637274 0.683746 0.596115 0.888974 0.90597 0.851648 0.682264 0.673251 0.842393 0.632749 0.59023 0.675358 0.693152 0.896965 0.608125 0.708118 0.772332 0.624726 1.108212 0.629398 0.902957 0.941473 0.595752 0.624854 0.795582 1.068105 0.898223 0.589869 0.629759 0.911887 0.938756 0.585023 0.766514 0.701362 0.837719 0.815924 0.595947 0.878254 0.648149 0.959315 11

7.938283 7.578466 6.760708 9.151075 7.35034 7.804185 6.313822 5.544989 6.519209 6.556981 7.530851 5.862244 6.097089 8.069688 6.483424 8.717809 6.126131 9.367791 8.151203 5.463458 9.149825 5.776091 6.53185 8.84187 6.924486 8.693391 6.611862 9.429218 7.454886 7.457742 8.596753 5.736252 6.195476 6.230936 7.867904 8.560813 5.462048 6.282669 6.236702 6.026114 6.317342 5.570599 5.872693 7.086067 7.414098

7.019345 6.989465 6.148178 8.174714 6.550843 7.166911 5.630077 4.948874 5.630235 5.651011 6.679203 5.179979 5.423838 7.227295 5.850674 8.127579 5.450773 8.67464 7.254238 4.855333 8.441707 5.003759 5.907124 7.733658 6.295088 7.790434 5.67039 8.833466 6.830031 6.662159 7.528648 4.838029 5.605607 5.601178 6.956016 7.622057 4.877025 5.516155 5.53534 5.188395 5.501418 4.974651 4.994439 6.437918 6.454783 Oncotarget

208798_x_at 236553_at 202806_at 204082_at 205479_s_at 222281_s_at 218086_at 1565162_s_at 228011_at 242172_at 204069_at 209160_at 225782_at 225665_at 201416_at 213668_s_at 244533_at 205612_at 231736_x_at 243110_x_at 238206_at 204165_at 210664_s_at 231767_at 211748_x_at 224918_x_at 201830_s_at 204548_at 206574_s_at 1566764_at 206637_at 230670_at 205453_at 206310_at 213260_at 238784_at 230158_at 221004_s_at 202729_s_at 226676_at 209487_at 213217_at 201841_s_at 226677_at 228904_at

GOLGA8A LOC100507520 DBN1 PBX3 PLAU LOC100505650 NPDC1 MGST1 FAM92A1 MEIS1 MEIS1 AKR1C3 MSRB3 ZAK SOX4 SOX4 PTPN14 MMRN1 MGST1 NPW RXFP1 WASF1 TFPI HOXB4 PTGDS MGST1 NET1 STAR PTP4A3 MACC1 P2RY14 IGSF10 HOXB2 SPINK2 FOXC1 DPY19L2 DPY19L2 ITM2C LTBP1 ZNF521 RBPMS ADCY2 HSPB1 ZNF521 HOXB3


0.000419 0.000419 0.000457 0.000466 0.000479 0.000531 0.000547 0.000557 0.000596 0.000626 0.000636 0.000646 0.000719 0.000743 0.000783 0.000807 0.000858 0.000944 0.00096 0.00097 0.000978 0.001022 0.001095 0.001097 0.001206 0.00122 0.001241 0.001258 0.001315 0.00138 0.0014 0.001437 0.001473 0.001568 0.001651 0.001745 0.001861 0.001959 0.001989 0.002062 0.002067 0.002138 0.002291 0.002394 0.002504

0.7433 0.594676 0.65793 0.844513 0.589109 0.683173 0.748833 0.748353 0.622642 0.732239 0.943984 0.788867 0.678508 0.637672 0.798647 0.930245 0.619533 0.673663 0.668775 0.728954 0.695497 0.726069 0.633681 0.588521 0.808763 0.644623 0.609782 0.622667 0.640281 0.61013 0.602824 0.674872 0.956468 1.031873 0.828091 0.681382 0.628032 0.627352 0.679165 0.791881 0.606994 0.592401 0.594505 0.89656 1.003047 12

9.24558 6.555712 6.493869 9.100676 6.458919 6.625972 6.390581 9.901949 5.765276 7.030773 8.26407 7.671752 9.425228 7.675723 8.868024 8.228082 5.609589 6.692272 10.40005 5.388839 5.530796 7.756582 6.857935 7.149183 6.494578 10.50847 8.33044 6.218694 6.423388 6.097666 6.296498 7.523435 8.360682 8.8508 7.052017 6.91133 6.527889 8.879225 7.813368 6.224844 5.80365 6.096154 7.938106 6.301288 9.229006

8.50228 5.961035 5.83594 8.256163 5.86981 5.9428 5.641748 9.153596 5.142635 6.298534 7.320087 6.882885 8.746721 7.038051 8.069377 7.297837 4.990056 6.018609 9.73127 4.659885 4.835299 7.030513 6.224254 6.560663 5.685815 9.863845 7.720658 5.596028 5.783107 5.487536 5.693674 6.848563 7.404214 7.818927 6.223926 6.229948 5.899857 8.251873 7.134203 5.432964 5.196656 5.503753 7.3436 5.404728 8.225959 Oncotarget

227923_at 207836_s_at 209488_s_at 229309_at 1555630_a_at 1559477_s_at 1566363_at 219218_at 235753_at 226817_at 228708_at 213479_at 206871_at 1553808_a_at 227297_at 209757_s_at 203305_at 201324_at 204438_at 213844_at 207341_at 206660_at 235521_at 221654_s_at 219582_at 210190_at 244556_at 1553133_at 225582_at 213988_s_at 226026_at 209287_s_at 1552485_at 230492_s_at 1553134_s_at 235593_at 241752_at 201926_s_at 238469_at 215223_s_at 217741_s_at 225685_at 202205_at 212659_s_at 221978_at

SHANK3 RBPMS RBPMS ADRB1 RAB34 MEIS1 DNTT BAHCC1 HOXA7 DSC2 RAB27B NPTX2 ELANE NKX2-3 ITGA9 MYCN F13A1 EMP1 MRC1 HOXA5 PRTN3 IGLL1 HOXA3 USP3 OGFRL1 STX11 LCP2 C9orf72 ITPRIP SAT1 DIRC2 CDC42EP3 LACTB GPCPD1 C9orf72 ZEB2 SLC8A1 CD55 OGFRL1 SOD2 ZFAND5 CDC42EP3 VASP IL1RN HLA-F


0.002836 0.002965 0.002978 0.003111 0.003131 0.003755 0.004659 0.00565 0.005815 0.006272 0.006277 0.007762 0.008172 0.009171 0.009725 0.009905 0.010319 0.010613 0.012584 0.013817 0.015581 0.027079 0.027588 6.31E-19 2.21E-12 3.95E-12 6.63E-12 1.52E-11 3.63E-11 6.30E-11 7.08E-11 8.67E-11 2.51E-10 2.53E-10 3.17E-10 4.10E-10 4.75E-10 6.33E-10 6.41E-10 7.46E-10 8.75E-10 9.08E-10 9.82E-10 1.06E-09 1.09E-09

0.769042 0.592304 0.701307 0.638153 0.653136 0.774195 1.047745 0.604503 0.657233 0.719843 0.624367 0.691524 1.042487 0.775222 0.610096 0.826741 0.740325 0.622593 0.609934 0.852044 0.855576 0.6797 0.622885 −0.89623 −0.88141 −1.60632 −0.99436 −1.23883 −0.7273 −1.16928 −0.73919 −0.92934 −0.69828 −0.63381 −0.71071 −0.86928 −0.8295 −0.66382 −0.77867 −1.3709 −0.5907 −1.23064 −0.82225 −1.02478 −0.79886 13

6.517461 5.387292 5.648666 6.161417 8.582193 7.479992 7.26976 8.703588 7.679461 7.27338 8.182219 5.665064 9.576905 7.138799 7.040326 7.696992 9.006593 7.427675 6.483242 8.198733 8.689356 8.819223 7.598642 8.537594 6.69283 5.290153 6.007286 5.862473 6.908772 9.062489 5.949866 6.234473 6.597957 7.365984 4.956158 8.251069 5.350518 8.264291 6.70301 7.511311 10.52773 7.265062 8.877406 5.881044 5.904243

5.74842 4.794988 4.947358 5.523264 7.929057 6.705797 6.222016 8.099084 7.022228 6.553536 7.557852 4.97354 8.534417 6.363578 6.43023 6.870251 8.266267 6.805082 5.873308 7.346689 7.83378 8.139523 6.975757 9.433819 7.574243 6.896476 7.001651 7.101304 7.636072 10.23177 6.689056 7.163813 7.296241 7.999796 5.666867 9.120347 6.180017 8.928107 7.481678 8.882207 11.11843 8.495702 9.699658 6.905826 6.703104 Oncotarget

201502_s_at 230380_at 207574_s_at 229439_s_at 209286_at 203927_at 1569599_at 206584_at 210592_s_at 202388_at 220023_at 209304_x_at 212657_s_at 210992_x_at 1555950_a_at 238546_at 1557197_a_at 205627_at 217388_s_at 1552542_s_at 214467_at 211965_at 227935_s_at 226140_s_at 204440_at 222934_s_at 209288_s_at 202877_s_at 235670_at 233031_at 206130_s_at 210754_s_at 204385_at 211810_s_at 231035_s_at 219947_at 218611_at 216841_s_at 1555214_a_at 203300_x_at 205205_at 216243_s_at 204062_s_at 209367_at 234050_at

NFKBIA THAP2 GADD45B RBM47 CDC42EP3 NFKBIE SAMSN1 LY96 SAT1 RGS2 APOBR GADD45B IL1RN FCGR2C CD55 SLC8A1 LGALS3 CDA KYNU TAGAP GPR65 ZFP36L1 PCGF5 OTUD1 CD83 CLEC4E CDC42EP3 CD93 STX11 ZEB2 ASGR2 LYN KYNU GALC OTUD1 CLEC4A IER5 SOD2 CLEC7A AP1S2 RELB IL1RN ULK2 STXBP2 TAGAP



−0.88873 −0.88076 −1.03431 −0.98414 −1.04385 −0.74049 −1.31806 −0.91533 −0.74963 −1.31366 −0.74461 −0.81852 −1.67166 −1.52335 −0.63021 −0.94304 −0.65521 −1.39277 −1.19344 −0.7928 −1.10152 −0.90835 −0.63159 −1.04128 −1.24882 −1.22014 −1.0529 −1.25306 −1.18543 −0.90822 −1.25966 −0.59671 −0.79775 −0.60075 −1.02103 −1.29231 −0.78572 −1.0432 −1.3783 −0.75643 −0.68687 −1.14942 −0.6942 −0.61011 −0.96008 14

10.71061 5.264447 7.621676 4.61286 7.031993 6.406853 5.980768 5.281492 10.33968 8.785281 6.680544 7.141328 5.837259 5.51574 8.330255 4.776385 4.95092 5.068627 6.92199 6.670254 6.157602 5.44594 7.227878 7.926663 7.762654 5.052891 7.433675 6.538736 6.972295 6.476011 5.376179 9.510818 6.246297 6.063771 5.610848 5.826819 8.789276 6.824636 4.780042 9.132858 6.289778 5.639089 5.576796 8.647205 6.052788

11.59934 6.145204 8.655982 5.597004 8.075845 7.147347 7.298832 6.19682 11.08931 10.09894 7.425159 7.959849 7.508917 7.039091 8.960461 5.719425 5.606134 6.461397 8.115426 7.463058 7.25912 6.354291 7.859468 8.967943 9.011471 6.273034 8.486579 7.791794 8.157729 7.384226 6.635844 10.10753 7.04405 6.664521 6.631881 7.119132 9.575001 7.867832 6.158347 9.889292 6.976648 6.788514 6.270994 9.257312 7.012866 Oncotarget

202626_s_at 1555643_s_at 1555326_a_at 203761_at 218376_s_at 205681_at 215990_s_at 210959_s_at 209305_s_at 203455_s_at 215078_at 206934_at 206420_at 205992_s_at 1566342_at 210663_s_at 215838_at 226561_at 209636_at 211307_s_at 200784_s_at 210538_s_at 226810_at 202637_s_at 1561615_s_at 204790_at 223454_at 228745_at 232311_at 221724_s_at 210422_x_at 1554624_a_at 60084_at 1552807_a_at 217591_at 225142_at 222876_s_at 211962_s_at 36564_at 203299_s_at 219358_s_at 202638_s_at 240103_at 235518_at 210423_s_at

LYN LILRA5 ADAM9 SLA MICAL1 BCL2A1 BCL6 SRD5A1 GADD45B SAT1 SOD2 SIRPB1 IGSF6 IL15 SOD2 KYNU LILRA5 AGFG1 NFKB2 FCAR LRP1 BIRC3 OGFRL1 ICAM1 SLC8A1 SMAD7 CXCL16 SGTB B2M CLEC4A SLC11A1 SIRPB1 CYLD SIGLEC10 SKIL JHDM1D ADAP2 ZFP36L1 RNF19B AP1S2 ADAP2 ICAM1 LOC100996457 SLC8A1 SLC11A1



−0.6171 −1.15432 −0.83881 −0.68725 −0.84701 −1.52817 −1.21129 −0.62148 −0.8641 −0.6499 −1.28716 −0.9656 −1.13829 −0.72393 −0.87885 −1.03103 −0.97892 −0.67509 −0.6606 −1.15229 −0.86045 −0.8237 −0.84564 −1.22045 −0.70103 −0.85839 −0.96531 −0.74376 −0.61975 −1.09711 −0.69852 −1.22661 −0.62808 −0.76494 −0.88099 −0.7311 −1.14001 −1.2531 −0.7628 −0.62371 −0.68132 −1.11509 −0.91532 −1.08239 −1.25532 15

9.151568 5.538494 5.332349 8.079888 8.088334 6.813302 5.782328 5.282091 6.515067 10.35173 4.83679 5.408461 6.065865 5.153424 6.886385 6.622332 5.638196 7.225095 5.060872 4.775218 4.808573 6.00409 8.380204 6.80207 4.842858 5.39045 6.07554 6.197599 6.637161 5.286589 6.666757 5.936192 5.544914 7.149224 6.532587 5.526676 5.298767 7.818815 7.49506 7.150788 6.242132 6.281318 4.693468 5.461757 6.140434

9.768668 6.692813 6.171159 8.767136 8.935344 8.341475 6.993618 5.903574 7.379163 11.00162 6.123946 6.374064 7.204154 5.877352 7.76524 7.653364 6.617117 7.90019 5.721469 5.927504 5.669023 6.827787 9.22584 8.022516 5.543891 6.248837 7.040852 6.941354 7.256908 6.383701 7.365279 7.162799 6.172993 7.914162 7.413578 6.257775 6.438779 9.071913 8.257861 7.774498 6.923448 7.396413 5.608788 6.544151 7.39575 Oncotarget

218454_at 223422_s_at 203561_at 230264_s_at 201489_at 222496_s_at 207535_s_at 202901_x_at 1554406_a_at 222218_s_at 204897_at 227266_s_at 227791_at 1557257_at 228176_at 1554309_at 211395_x_at 204487_s_at 207674_at 209824_s_at 220005_at 204675_at 225059_at 219593_at 202625_at 204907_s_at 1555167_s_at 239704_at 204393_s_at 211732_x_at 213038_at 205686_s_at 202912_at 206244_at 211816_x_at 202902_s_at 231990_at 204122_at 217911_s_at 212423_at 215485_s_at 205660_at 213624_at 205027_s_at 221477_s_at

PLBD1 ARHGAP24 FCGR2A AP1S2 PPIF RBM47 NFKB2 CTSS CLEC7A PILRA PTGER4 FYB SLC9A9 BCL10 S1PR3 EIF4G3 FCGR2C KCNQ1 FCAR ARNTL P2RY13 SRD5A1 AGTRAP SLC15A3 LYN BCL3 NAMPT RNF144B ACPP HNMT RNF19B CD86 ADM CR1 FCAR CTSS USP15 TYROBP BAG3 ZCCHC24 ICAM1 OASL SMPDL3A MAP3K8 SOD2



−1.79814 −0.62086 −1.2935 −0.71064 −0.6511 −1.23378 −0.82595 −0.88556 −1.04416 −1.00981 −0.74143 −0.67104 −0.73306 −0.61652 −0.85786 −0.62414 −1.12008 −0.94867 −1.26762 −0.75484 −1.20047 −0.65719 −0.77299 −1.39268 −0.59885 −0.68279 −1.39766 −1.03283 −0.85553 −0.95366 −0.67434 −0.9523 −1.12652 −1.03503 −1.02428 −0.97936 −0.68416 −0.80669 −0.76272 −0.80905 −0.75752 −0.69363 −1.08063 −0.80121 −0.82875 16

6.792698 5.109768 6.811453 9.37659 8.789337 6.389368 7.171304 9.014888 6.420867 7.583347 9.605343 8.640225 5.645476 6.620867 5.344698 5.776866 6.887099 5.37464 5.717775 5.709137 5.919253 5.839724 7.721104 5.738743 9.371046 5.733212 6.262248 4.507283 5.562592 4.859064 7.394295 5.528831 5.479787 5.229302 5.515862 9.753022 7.295686 9.539269 5.518497 5.220955 5.84653 5.641484 5.219962 6.69513 8.543492

8.590841 5.730625 8.104952 10.08723 9.440437 7.623144 7.997256 9.900452 7.465031 8.593154 10.34678 9.31127 6.378535 7.237382 6.202563 6.401002 8.007182 6.323314 6.985394 6.463972 7.119718 6.496917 8.494095 7.131418 9.969898 6.415998 7.659907 5.540118 6.418122 5.812722 8.068634 6.48113 6.606303 6.264328 6.540139 10.73238 7.979845 10.34596 6.281222 6.030001 6.604046 6.335114 6.300593 7.496342 9.372242 Oncotarget

205863_at 1568957_x_at 211799_x_at 228555_at 205859_at 204118_at 223169_s_at 209545_s_at 201531_at 208092_s_at 202643_s_at 204392_at 232617_at 242903_at 202878_s_at 221210_s_at 213607_x_at 204232_at 218033_s_at 203760_s_at 213006_at 211795_s_at 219788_at 35626_at 222670_s_at 221541_at 200866_s_at 228486_at 200785_s_at 205568_at 207167_at 211776_s_at 218793_s_at 202426_s_at 223019_at 203922_s_at 217739_s_at 225227_at 214211_at 244235_at 222142_at 211794_at 221561_at 223217_s_at 204735_at

S100A12 SRGAP2C HLA-C CAMK2D LY86 CD48 RHOU RIPK2 ZFP36 FAM49A TNFAIP3 CAMK1 CTSS IFNGR1 CD93 NPL NADK FCER1G SNN SLA CEBPD FYB PILRA SGSH MAFB CRISPLD2 PSAP SLC44A1 LRP1 AQP9 CD101 EPB41L3 SCML1 RXRA FAM129B CYBB NAMPT SKIL FTH1 IVNS1ABP CYLD FYB SOAT1 NFKBIZ PDE4A



−1.72351 −0.59098 −0.69968 −0.70104 −1.09412 −1.00402 −0.84729 −0.62365 −1.02413 −0.71494 −1.09321 −0.83778 −0.88163 −0.69972 −1.29578 −0.9538 −0.6174 −1.11908 −0.59355 −0.7675 −0.97087 −0.64612 −1.07818 −0.87933 −1.532 −1.13365 −0.77713 −1.0614 −0.69627 −1.41653 −0.71379 −1.02655 −0.7122 −0.65458 −0.76939 −1.27376 −1.10399 −0.66488 −0.76853 −0.64871 −0.64107 −0.86 −0.62281 −0.84863 −0.70484 17

6.571822 5.819351 10.11576 5.254539 7.89071 7.445389 5.359212 8.44219 9.884471 6.50101 8.832143 5.460887 9.693856 7.777261 7.821219 5.749141 7.003665 9.420812 5.15276 8.133793 5.503979 8.539778 6.109465 6.257375 7.523676 6.288722 10.17251 5.953511 6.018892 5.953108 5.493331 5.309051 4.744101 6.495135 4.865918 6.955118 8.860179 6.119882 9.031375 5.387436 5.108528 6.377998 7.095955 10.08626 5.428903

8.295334 6.410332 10.81544 5.955574 8.984832 8.449409 6.206502 9.065837 10.90861 7.215948 9.925351 6.298665 10.57549 8.476984 9.116999 6.702937 7.621063 10.53989 5.74631 8.901297 6.474848 9.185897 7.187644 7.136707 9.055673 7.422373 10.94964 7.014908 6.715164 7.369639 6.207121 6.335604 5.456305 7.149716 5.635303 8.228877 9.964167 6.784759 9.799907 6.03615 5.749596 7.237993 7.718763 10.93489 6.133747 Oncotarget

202644_s_at 223767_at 205789_at 211530_x_at 230550_at 207270_x_at 1552554_a_at 214696_at 207691_x_at 201739_at 235549_at 1555756_a_at 209473_at 202437_s_at 205118_at 203645_s_at 1552504_a_at 204417_at 205639_at 206765_at 213524_s_at 223314_at 1552701_a_at 201743_at 230499_at 206710_s_at 210176_at 204588_s_at 219694_at 209474_s_at 238987_at 223405_at 204860_s_at 212831_at 203140_at 1552772_at 228153_at 225019_at 205922_at 213002_at 230559_x_at 201473_at 1554899_s_at 202381_at 219872_at

TNFAIP3 GPR84 CD1D HLA-G MS4A6A CD300C NLRC4 MIR22HG ENTPD1 SGK1 RNF144B CLEC7A ENTPD1 CYP1B1 FPR1 CD163 BRSK1 GALC AOAH KCNJ2 G0S2 TSPAN14 CARD16 CD14 BIRC3 EPB41L3 TLR1 SLC7A7 FAM105A ENTPD1 B4GALT1 NPL NAIP MEGF9 BCL6 CLEC4D RNF144B CAMK2D VNN2 MARCKS FGD4 JUNB FCER1G ADAM9 FAM198B



−0.91687 −0.78246 −1.37717 −0.65556 −1.19825 −0.67726 −0.59883 −0.72262 −0.73187 −1.11567 −0.62725 −1.49819 −0.78294 −1.27709 −0.97083 −1.46303 −0.85725 −0.71612 −0.71195 −0.91891 −1.25669 −0.61825 −0.80012 −1.93318 −0.6421 −1.27345 −0.66065 −1.26021 −0.82006 −0.8221 −0.61551 −0.92799 −0.72969 −0.76736 −1.10355 −0.74695 −0.77889 −0.76272 −1.20984 −0.78651 −0.6349 −0.78651 −1.25924 −0.77325 −0.99849 18

9.568376 4.939716 6.136262 10.45635 6.19698 6.682798 4.875896 7.386122 6.216012 7.965596 4.845492 6.621652 6.452011 5.50877 5.084514 5.936739 5.232927 7.478105 7.314118 5.409905 6.724795 6.249812 7.492271 6.774038 6.265827 5.149443 6.326044 7.157143 5.414494 5.605993 7.070318 6.397174 7.92203 6.416314 8.047676 4.848238 7.392459 5.456191 5.777878 6.150059 5.121403 9.514403 8.656191 6.750733 5.474299

10.48525 5.722177 7.513427 11.11191 7.395231 7.360056 5.474723 8.108738 6.947883 9.081264 5.472746 8.119839 7.234955 6.785856 6.05534 7.399773 6.090181 8.19423 8.026063 6.328814 7.981487 6.868066 8.292389 8.707219 6.90793 6.422895 6.986691 8.417352 6.234551 6.428098 7.685828 7.325159 8.651716 7.183678 9.151225 5.595184 8.171347 6.218911 6.987721 6.936573 5.756307 10.30091 9.915431 7.523979 6.472785 Oncotarget

208018_s_at 218559_s_at 235019_at 201670_s_at 205237_at 1555736_a_at 203234_at 37028_at 225251_at 209803_s_at 217192_s_at 1552773_at 217738_at 212681_at 211676_s_at 211100_x_at 204908_s_at 242445_at 215049_x_at 228758_at 209606_at 227131_at 221755_at 1555638_a_at 200998_s_at 221578_at 235568_at 217507_at 207872_s_at 201565_s_at 224790_at 1561880_a_at 223423_at 1554676_at 214370_at 205786_s_at 228485_s_at 208949_s_at 225316_at 211102_s_at 230748_at 229510_at 202464_s_at 203045_at 223944_at

HCK MAFB CPM MARCKS FCN1 AGTRAP UPP1 PPP1R15A RAB24 PHLDA2 PRDM1 CLEC4D NAMPT EPB41L3 IFNGR1 LILRA2 BCL3 FGD4 CD163 BCL6 CYTIP MAP3K3 EHBP1L1 SAMSN1 CKAP4 RASSF4 C19orf59 SLC11A1 LILRA1 ID2 ASAP1 SIGLEC16 GPR160 SRGN S100A8 ITGAM SLC44A1 LGALS3 MFSD2A LILRA2 SLC16A6 MS4A14 PFKFB3 NINJ1 NLRP12


5.41E-06 5.51E-06 5.53E-06 5.60E-06 5.72E-06 5.79E-06 5.80E-06 5.81E-06 5.83E-06 5.89E-06 5.93E-06 6.02E-06 6.05E-06 6.11E-06 6.18E-06 6.35E-06 6.42E-06 6.42E-06 6.54E-06 6.55E-06 7.11E-06 7.27E-06 7.41E-06 7.78E-06 7.81E-06 7.83E-06 7.83E-06 7.85E-06 7.98E-06 8.33E-06 8.38E-06 8.76E-06 9.03E-06 9.15E-06 9.25E-06 9.37E-06 9.37E-06 9.41E-06 9.55E-06 9.69E-06 9.83E-06 9.94E-06 1E-05 1.01E-05 1.01E-05

−0.97409 −1.71557 −0.65001 −1.22683 −1.6105 −0.81039 −0.9252 −0.69684 −0.60036 −0.95638 −0.70816 −0.6577 −0.8733 −1.22608 −0.62224 −0.80763 −0.71073 −0.59984 −1.40634 −0.95062 −0.70519 −0.59888 −0.6533 −0.613 −0.71863 −0.85552 −0.94849 −0.71582 −0.67044 −0.83673 −0.64404 −0.68941 −0.6199 −0.79835 −0.93118 −0.95616 −0.7082 −1.16991 −0.67742 −0.97124 −0.69904 −0.80156 −0.8538 −1.00743 −0.81483 19

8.44515 7.038153 5.187274 6.542208 8.048907 8.060549 6.052394 9.343239 7.682737 5.128848 5.214219 5.169469 7.952211 5.032693 8.466923 7.633975 7.324265 5.47361 5.798242 5.811113 8.314164 6.499936 7.028912 7.741011 7.310629 5.111782 6.441482 5.014969 5.988797 9.187253 6.854618 4.602686 7.211281 8.679086 5.405071 8.492231 6.225665 7.887706 4.800489 5.77578 5.244907 5.691653 7.552453 6.735748 6.18364

9.419235 8.753719 5.83728 7.76904 9.659403 8.870938 6.977593 10.04008 8.283094 6.085232 5.922379 5.827166 8.825511 6.258768 9.089158 8.4416 8.034994 6.073446 7.20458 6.761733 9.01935 7.098814 7.682216 8.354013 8.029263 5.967306 7.38997 5.730785 6.659238 10.02398 7.498654 5.292097 7.831176 9.477435 6.336248 9.448392 6.933862 9.057614 5.477908 6.747015 5.943944 6.493213 8.406251 7.743174 6.998468 Oncotarget

229770_at 209696_at 201631_s_at 214590_s_at 203665_at 211135_x_at 201668_x_at 229040_at 206025_s_at 209037_s_at 202436_s_at 210660_at 207224_s_at 202295_s_at 203932_at 1568955_at 213418_at 210225_x_at 204619_s_at 213537_at 220832_at 1560058_at 201642_at 204614_at 232829_at 213475_s_at 203186_s_at 205685_at 210152_at 1552553_a_at 221698_s_at 207104_x_at 203771_s_at 206026_s_at 202895_s_at 229584_at 224583_at 210184_at 200871_s_at 220330_s_at 201566_x_at 1568768_s_at 212956_at 204081_at 202435_s_at

GLT1D1 FBP1 IER3 UBE2D1 HMOX1 LILRB3 MARCKS ITGB2-AS1 TNFAIP6 EHD1 CYP1B1 LILRA1 SIGLEC7 CTSH HLA-DMB SRGAP2C HSPA6 LILRB3 VCAN HLA-DPA1 TLR8 LOC399900 IFNGR2 SERPINB2 OR52K3P ITGAL S100A4 CD86 LILRB4 NLRC4 CLEC7A LILRB1 BLVRA TNFAIP6 SIRPA LRRK2 COTL1 ITGAX PSAP SAMSN1 ID2 BRE-AS1 TBC1D9 NRGN CYP1B1


1.03E-05 1.04E-05 1.08E-05 1.08E-05 1.1E-05 1.13E-05 1.17E-05 1.24E-05 1.25E-05 1.31E-05 1.33E-05 1.36E-05 1.41E-05 1.42E-05 1.44E-05 1.46E-05 1.56E-05 1.57E-05 1.58E-05 1.6E-05 1.61E-05 1.64E-05 1.66E-05 1.66E-05 1.66E-05 1.66E-05 1.7E-05 1.7E-05 1.74E-05 1.75E-05 1.82E-05 1.85E-05 1.85E-05 1.94E-05 1.96E-05 1.97E-05 1.97E-05 1.98E-05 2E-05 2.1E-05 2.11E-05 2.14E-05 2.18E-05 2.21E-05 2.24E-05

−0.81803 −1.04095 −1.25216 −0.76344 −1.00137 −0.98897 −1.05663 −0.7421 −0.70599 −0.62927 −0.99245 −0.94603 −0.71717 −1.24458 −0.7561 −0.7362 −0.93327 −0.97386 −1.60606 −1.08272 −1.11198 −0.77205 −0.6273 −1.4332 −0.59225 −0.62822 −0.78131 −0.74935 −0.65166 −0.73559 −1.2864 −1.11277 −0.61501 −0.6511 −0.63558 −0.91419 −0.87022 −0.68311 −0.66182 −0.61139 −0.80541 −0.84584 −0.90083 −1.06566 −0.81003 20

4.899157 6.418708 6.909173 6.51504 6.369972 6.961851 5.387709 6.062918 5.258574 6.610432 5.92067 6.474672 6.002544 7.617637 7.913442 6.400619 5.876852 7.041154 7.380619 6.908847 5.484286 5.80285 9.16784 6.143553 5.022545 8.206249 10.07921 6.118499 6.219214 5.606278 6.786298 5.820211 4.792355 5.137546 5.751351 5.703375 9.091989 6.727046 10.76903 8.617966 7.135174 5.654567 5.722473 7.101539 5.593685

5.717183 7.459655 8.161328 7.278481 7.371347 7.950818 6.444338 6.805017 5.964561 7.239699 6.913118 7.420703 6.719717 8.862216 8.669537 7.136817 6.810122 8.015017 8.986681 7.991571 6.596265 6.574901 9.795135 7.576754 5.614795 8.834466 10.86052 6.867844 6.870871 6.341866 8.072696 6.93298 5.407365 5.78865 6.386926 6.617567 9.96221 7.410157 11.43086 9.229354 7.940581 6.500409 6.6233 8.167199 6.403717 Oncotarget

214511_x_at 214770_at 224130_s_at 205076_s_at 203271_s_at 210773_s_at 210895_s_at 206488_s_at 235385_at 228585_at 211429_s_at 223280_x_at 223922_x_at 203923_s_at 228325_at 211571_s_at 1554952_s_at 210873_x_at 202201_at 204912_at 230413_s_at 216016_at 221718_s_at 227948_at 229067_at 223218_s_at 204182_s_at 1552501_a_at 211336_x_at 212501_at 211764_s_at 201669_s_at 205936_s_at 219403_s_at 1554999_at 211824_x_at 200782_at 203060_s_at 1559034_at 207697_x_at 202609_at 218035_s_at 210785_s_at 244313_at 235086_at

FCGR1B MSR1 SRA1 MTMR11 UNC119 FPR2 CD86 CD36 1-Mar ENTPD1 SERPINA1 MS4A6A MS4A6A CYBB KIAA0146 VCAN NLRP12 APOBEC3A BLVRB IL10RA AP1S2 NLRP3 AKAP13 FGD4 SRGAP2C NFKBIZ ZBTB43 GPBAR1 LILRB1 CEBPB UBE2D1 MARCKS HK3 HPSE RASGEF1B NLRP1 ANXA5 PAPSS2 SIRPB2 LILRB2 EPS8 RBM47 THEMIS2 CR1 THBS1


2.32E-05 2.4E-05 2.41E-05 2.42E-05 2.43E-05 2.43E-05 2.5E-05 2.5E-05 2.61E-05 2.66E-05 2.7E-05 2.76E-05 2.76E-05 2.78E-05 2.79E-05 2.88E-05 2.89E-05 2.89E-05 2.93E-05 2.94E-05 2.98E-05 2.99E-05 3E-05 3.02E-05 3.21E-05 3.22E-05 3.29E-05 3.44E-05 3.45E-05 3.47E-05 3.53E-05 3.57E-05 3.61E-05 3.63E-05 3.69E-05 3.76E-05 3.97E-05 3.97E-05 4.03E-05 4.12E-05 4.26E-05 4.27E-05 4.34E-05 4.37E-05 4.52E-05

−1.01988 −0.78133 −0.65997 −0.80539 −0.68912 −0.81826 −1.06499 −1.08108 −0.99471 −0.75555 −1.2975 −1.23947 −0.95441 −1.16095 −0.95192 −1.73194 −0.72165 −1.19904 −0.78697 −0.98267 −0.61298 −0.81562 −0.63343 −0.79245 −0.70729 −0.6261 −0.88338 −0.8026 −1.06219 −0.74643 −0.61577 −1.2641 −1.41319 −0.77618 −0.7681 −0.67718 −1.27752 −0.70326 −0.74936 −1.24701 −0.73171 −0.978 −0.70153 −1.05377 −0.80728 21

7.136377 4.714736 5.948357 5.647682 5.53657 5.307442 6.57453 8.298137 5.873891 5.263351 8.778287 7.901938 7.970818 8.03604 6.165973 7.764091 5.60335 6.613033 7.620924 7.817007 7.370443 4.613967 7.883935 6.332788 8.225042 10.71832 5.895731 5.269783 6.218742 10.20887 7.950042 7.537512 6.714821 5.218862 5.525195 5.133579 7.523022 5.388082 6.953108 6.49389 5.504756 6.472486 8.580823 6.308585 4.847723

8.156262 5.496067 6.608332 6.453074 6.225685 6.125706 7.639518 9.379218 6.868599 6.0189 10.07579 9.141405 8.925228 9.196993 7.117897 9.496026 6.325001 7.812076 8.40789 8.79968 7.983427 5.429584 8.517365 7.125236 8.93233 11.34442 6.779108 6.072382 7.280934 10.9553 8.56581 8.801607 8.128006 5.995044 6.293298 5.810758 8.800546 6.09134 7.702464 7.740903 6.236463 7.450484 9.282349 7.362352 5.655 Oncotarget

222068_s_at 1556034_s_at 202014_at 1555728_a_at 227276_at 205119_s_at 209823_x_at 229221_at 206756_at 209555_s_at 243296_at 208450_at 225800_at 205067_at 205207_at 206513_at 219607_s_at 204863_s_at 206157_at 211656_x_at 205099_s_at 219434_at 207571_x_at 233888_s_at 1554240_a_at 204834_at 206881_s_at 210279_at 219574_at 243099_at 203535_at 207237_at 210904_s_at 206707_x_at 217552_x_at 39402_at 218950_at 217362_x_at 215646_s_at 218217_at 224301_x_at 221345_at 229041_s_at 201850_at 207857_at

DNAAF1 MTMR11 PPP1R15A MS4A4A PLXDC2 FPR1 HLA-DQB1 CD44 CHST7 CD36 NAMPT LGALS2 JAZF1 IL1B IL6 AIM2 MS4A4A IL6ST PTX3 HLA-DQB1 CCR1 TREM1 THEMIS2 SRGAP1 ITGAL FGL2 LILRA3 GPR18 1-Mar NFAM1 S100A9 KCNA3 IL13RA1 FAM65B CR1 IL1B ARAP3 HLA-DRB6 VCAN SCPEP1 H2AFJ FFAR2 ITGB2-AS1 CAPG LILRA2


4.61E-05 4.68E-05 5.16E-05 5.18E-05 5.27E-05 5.32E-05 5.33E-05 5.41E-05 5.43E-05 5.44E-05 5.67E-05 5.74E-05 5.92E-05 6.03E-05 6.2E-05 6.24E-05 6.42E-05 6.48E-05 6.53E-05 6.74E-05 6.85E-05 6.87E-05 6.98E-05 7E-05 7.16E-05 7.35E-05 7.39E-05 7.43E-05 7.5E-05 7.66E-05 7.77E-05 7.78E-05 7.88E-05 8.01E-05 8.06E-05 8.14E-05 8.18E-05 8.46E-05 8.64E-05 8.67E-05 9.17E-05 9.49E-05 9.5E-05 9.63E-05 9.74E-05

−0.64657 −0.77743 −0.75645 −0.84995 −0.59451 −1.43279 −1.06671 −0.67934 −0.64526 −1.12224 −0.93135 −1.18378 −0.89916 −0.99962 −0.9173 −0.63766 −0.9232 −0.60412 −1.07597 −0.8735 −0.87405 −1.02741 −0.66294 −0.66097 −0.60553 −1.23308 −0.89011 −0.60417 −0.86893 −0.59795 −1.67394 −0.64952 −0.74699 −0.68535 −0.95561 −0.97875 −0.62281 −0.6408 −1.70619 −0.90891 −0.73684 −0.70064 −0.80088 −0.6686 −0.84022 22

4.707505 4.962174 8.776421 5.902657 6.60407 7.190914 6.674233 6.643912 4.812922 8.406145 9.766472 5.385094 6.2822 8.274988 5.050341 5.619592 5.748297 5.822549 6.619685 7.445865 6.847398 6.776773 8.331275 4.673486 8.987177 7.736882 4.775068 5.582684 6.057594 6.499223 8.240565 5.062312 6.187644 8.156201 5.897562 8.275233 5.651049 7.612149 8.035602 7.943945 6.426209 4.694839 7.471026 8.253319 7.651154

5.354079 5.739605 9.532874 6.75261 7.198575 8.623701 7.740947 7.323249 5.458178 9.528385 10.69782 6.568872 7.181363 9.274611 5.967639 6.257251 6.671497 6.426669 7.695656 8.319362 7.721446 7.804182 8.99421 5.334456 9.592707 8.96996 5.665178 6.186857 6.92652 7.097171 9.914501 5.711828 6.934634 8.841551 6.853175 9.253985 6.273855 8.252953 9.741787 8.852856 7.163051 5.395481 8.271904 8.921919 8.491374 Oncotarget

207091_at 208748_s_at 220088_at 208488_s_at 229383_at 205159_at 219666_at 212188_at 211306_s_at 211612_s_at 203979_at 217763_s_at 229937_x_at 225897_at 210113_s_at 210166_at 242814_at 217897_at 215666_at 223816_at 214054_at 235818_at 204858_s_at 229228_at 227995_at 225009_at 207704_s_at 49306_at 206278_at 219714_s_at 205098_at 221042_s_at 239336_at 208540_x_at 223344_s_at 201939_at 201109_s_at 211101_x_at 228685_at 225798_at 224356_x_at 210146_x_at 204759_at 206034_at 204319_s_at

P2RX7 FLOT1 C5AR1 CR1 1-Mar CSF2RB MS4A6A KCTD12 FCAR IL13RA1 CYP27A1 RAB31 LILRB1 MARCKS NLRP1 TLR5 SERPINB9 FXYD6 HLA-DRB4 SLC46A2 DOK2 VSTM1 TYMP CREB5 LOC100509635 CMTM4 GAS7 RASSF4 PTAFR CACNA2D3 CCR1 CLMN THBS1 S100A11 MS4A7 PLK2 THBS1 LILRA2 IL17RA JAZF1 MS4A6A LILRB2 RCBTB2 SERPINB8 RGS10


0.000104 0.000105 0.000106 0.000106 0.000107 0.000109 0.00011 0.000112 0.000113 0.000114 0.000114 0.000115 0.000115 0.000117 0.000118 0.000119 0.00012 0.00012 0.000123 0.000126 0.000129 0.00013 0.00013 0.000132 0.000133 0.000133 0.000135 0.000135 0.000137 0.00014 0.000141 0.000145 0.000145 0.000148 0.00015 0.00015 0.000152 0.000161 0.000161 0.000161 0.000165 0.000166 0.000172 0.000172 0.000176

−0.59379 −0.58914 −1.34484 −0.67983 −0.83857 −0.67914 −1.14474 −1.24071 −0.66868 −0.67334 −0.6746 −1.17496 −0.96316 −0.95023 −0.73952 −0.62354 −0.75538 −0.74113 −0.86107 −0.60355 −0.72447 −0.84088 −0.94484 −0.71774 −0.63466 −0.587 −0.61763 −0.73447 −0.62633 −0.73284 −0.97219 −0.60689 −0.76978 −0.76145 −0.91279 −0.72825 −1.13896 −0.81655 −0.63929 −0.83163 −1.17976 −1.08181 −0.61523 −0.69664 −0.67685 23

5.198278 4.951035 7.154855 6.303503 6.753194 8.705814 7.58271 7.675565 4.552549 6.471353 5.037475 6.861697 6.403852 6.115856 5.354804 6.430758 7.098903 5.540326 4.845589 4.595053 7.151688 4.90095 6.57112 5.467084 5.382875 6.320541 6.733803 6.048187 5.561423 5.142161 6.884819 4.938184 4.60792 8.58073 6.790738 5.278722 5.429123 7.42776 6.756329 6.74136 7.945364 6.827963 7.005374 5.945838 7.066855

5.792065 5.540174 8.499696 6.983332 7.591762 9.384952 8.72745 8.916278 5.221228 7.144689 5.712077 8.036652 7.367009 7.06609 6.094323 7.054295 7.854286 6.281455 5.706661 5.198599 7.876156 5.741826 7.515963 6.184828 6.017532 6.90754 7.351436 6.782662 6.187752 5.874998 7.857013 5.545073 5.377699 9.34218 7.703533 6.006974 6.568087 8.244313 7.395616 7.572986 9.12512 7.909774 7.620602 6.642483 7.743704 Oncotarget

202833_s_at 239012_at 204620_s_at 208594_x_at 206743_s_at 218831_s_at 218810_at 238320_at 200660_at 1559975_at 226841_at 218319_at 1559502_s_at 226818_at 204896_s_at 217728_at 233555_s_at 232213_at 217818_s_at 207113_s_at 1559883_s_at 238893_at 220532_s_at 203388_at 212647_at 225626_at 204103_at 211367_s_at 202498_s_at 201888_s_at 235458_at 205241_at 202087_s_at 241098_at 209791_at 235421_at 213716_s_at 205819_at 203066_at 210772_at 225245_x_at 205476_at 242197_x_at 212464_s_at 210569_s_at

SERPINA1 RNF144B VCAN LILRA6 ASGR1 FCGRT ZC3H12A NEAT1 S100A11 BTG1 MPEG1 PELI1 LRRC25 MPEG1 PTGER4 S100A6 SULF2 PELI1 ARPC4 TNF SAMHD1 LOC338758 TMEM176B ARRB2 RRAS PAG1 CCL4 CASP1 SLC2A3 IL13RA1 HAVCR2 SCO2 CTSL1 CLEC7A PADI2 MAP3K8 SECTM1 MARCO CHST15 FPR2 H2AFJ CCL20 CD36 FN1 SIGLEC9


0.000178 0.000183 0.000183 0.000184 0.000184 0.000186 0.000189 0.000191 0.0002 0.000202 0.000202 0.000208 0.000208 0.000208 0.00021 0.000216 0.000216 0.000218 0.000221 0.000222 0.000229 0.000229 0.000233 0.000238 0.000238 0.00024 0.000246 0.000249 0.000251 0.000252 0.000258 0.000278 0.000278 0.000287 0.000288 0.000294 0.000304 0.000305 0.000308 0.000309 0.00032 0.000324 0.00033 0.000333 0.000371

−1.4978 −0.62672 −1.37792 −0.90206 −0.67772 −0.87677 −0.76687 −0.65665 −0.94483 −0.65533 −1.35131 −0.779 −0.98164 −1.35946 −0.82134 −0.83168 −0.86619 −0.71192 −0.72828 −0.92169 −0.85855 −0.79126 −1.1299 −0.59975 −0.6725 −0.61913 −1.15414 −0.59993 −0.73711 −0.68823 −0.72513 −0.59105 −0.68649 −0.68774 −0.7508 −0.61036 −0.86196 −0.69749 −1.02974 −0.67274 −0.59819 −0.99598 −0.76182 −0.69565 −0.6021 24

8.172471 5.450904 8.85911 6.85908 4.435721 7.152253 6.894491 8.909219 8.658157 6.784144 7.679872 8.140044 6.603009 8.338094 6.021128 9.183363 5.817417 7.400108 6.188056 5.939994 7.022946 8.807861 6.504096 8.86062 5.609571 6.792742 6.665001 7.918002 7.395765 5.818746 6.219569 7.469586 6.776813 4.426574 6.027592 6.788226 6.380836 4.582801 6.205673 5.428892 7.000515 4.463314 5.288904 4.655202 4.486024

9.670273 6.077628 10.23703 7.761138 5.113444 8.029026 7.661363 9.565869 9.602992 7.439477 9.031179 8.91904 7.584647 9.697555 6.842472 10.01504 6.683604 8.112024 6.916338 6.861688 7.8815 9.59912 7.633991 9.460374 6.282074 7.411871 7.819145 8.517933 8.132873 6.506976 6.944695 8.060631 7.463305 5.114317 6.778397 7.398584 7.242795 5.280286 7.235412 6.101635 7.598709 5.459295 6.050724 5.350852 5.088122 Oncotarget

224596_at 209684_at 213446_s_at 1554173_at 212830_at 206359_at 208438_s_at 221731_x_at 229101_at 202340_x_at 201108_s_at 202497_x_at 204057_at 201110_s_at 232724_at 224358_s_at 1553906_s_at 211719_x_at 211661_x_at 210495_x_at 209949_at 207275_s_at 212196_at 200999_s_at 234985_at 204655_at 229560_at 203973_s_at 209581_at 1405_i_at 218345_at 205715_at 1567628_at 219890_at 220146_at 205174_s_at 1555349_a_at 209728_at 226722_at 200766_at 203508_at 211924_s_at 217762_s_at 207072_at 202859_x_at

SLC44A1 RIN2 IQGAP1 CD300LB MEGF9 SOCS3 FGR VCAN IL17RA NR4A1 THBS1 SLC2A3 IRF8 THBS1 MS4A6A MS4A7 FGD2 FN1 PTAFR FN1 NCF2 ACSL1 IL6ST CKAP4 LDLRAD3 CCL5 TLR8 CEBPD PLA2G16 CCL5 TMEM176A BST1 CD74 CLEC5A TLR7 QPCT ITGB2 HLA-DRB4 FAM20C CTSD TNFRSF1B PLAUR RAB31 IL18RAP IL8


0.000373 0.000386 0.000396 0.000404 0.000418 0.000428 0.000433 0.000449 0.00045 0.000457 0.000459 0.000467 0.000478 0.000489 0.00049 0.000502 0.000502 0.000509 0.000516 0.000519 0.000529 0.00054 0.000542 0.00055 0.00055 0.000555 0.000627 0.000629 0.000635 0.000685 0.000687 0.000687 0.000688 0.000736 0.000756 0.000758 0.000763 0.000774 0.000796 0.000803 0.000823 0.000828 0.000838 0.000846 0.000848

−0.62418 −0.71192 −0.60182 −0.62775 −0.76521 −0.61291 −0.96985 −1.39521 −0.62829 −0.78476 −0.85074 −0.72853 −0.78304 −1.04051 −0.67048 −0.76674 −0.71466 −0.74892 −0.6659 −0.72246 −1.21014 −0.74514 −0.6044 −0.80934 −0.76083 −0.5881 −1.03396 −0.93734 −0.66916 −0.78226 −0.9117 −0.73 −0.78 −0.7957 −0.67276 −0.60935 −0.60666 −1.53138 −0.61659 −0.61151 −0.74207 −0.80027 −1.00556 −0.67523 −0.99537 25

9.234417 5.981099 7.996199 5.665913 7.872601 5.967657 8.535822 8.890808 8.190233 6.114019 5.529849 8.227928 8.259723 5.944678 5.586548 6.224173 8.125548 4.649568 7.226701 4.787968 7.988664 8.410457 6.400657 6.829627 5.998618 7.774449 7.075289 9.321231 4.840749 7.400067 6.458347 6.10296 8.537264 5.614784 5.195141 4.98143 10.49587 6.021607 5.380696 8.521239 7.711185 8.09948 7.139975 5.375525 9.826633

9.858598 6.693017 8.598019 6.293659 8.637812 6.580566 9.505676 10.28601 8.818527 6.898778 6.380585 8.956462 9.042767 6.985191 6.257027 6.990916 8.840204 5.398489 7.892603 5.510431 9.198807 9.155596 7.005057 7.638971 6.759452 8.362553 8.109247 10.25857 5.509906 8.182323 7.370047 6.832957 9.317263 6.410487 5.867904 5.590784 11.10253 7.552982 5.997284 9.132748 8.453256 8.899753 8.145532 6.050755 10.822 Oncotarget

219505_at 208894_at 201107_s_at 206940_s_at 204502_at 201373_at 202499_s_at 235306_at 211506_s_at 208981_at 219093_at 211991_s_at 214366_s_at 201163_s_at 211990_at 200838_at 227396_at 1563088_a_at 225175_s_at 213566_at 201422_at 228532_at 223343_at 232304_at 224724_at 212192_at 201963_at 208983_s_at 209683_at 231124_x_at 232068_s_at 226436_at 203773_x_at 205220_at 219279_at 210982_s_at 218232_at 211474_s_at 1555759_a_at 211372_s_at 217764_s_at 205249_at 204794_at 220066_at 224277_at

CECR1 HLA-DRA THBS1 POU4F1 SAMHD1 PLEC SLC2A3 GIMAP8 IL8 PECAM1 PID1 HLA-DPA1 ALOX5 IGFBP7 HLA-DPA1 CTSB PTPRJ LOC284837 SLC44A2 RNASE6 IFI30 C1orf162 MS4A7 PELI1 SULF2 KCTD12 ACSL1 PECAM1 FAM49A LY9 TLR4 RASSF4 BLVRA HCAR3 DOCK10 HLA-DRA C1QA SERPINB6 CCL5 IL1R2 RAB31 EGR2 DUSP2 NOD2 MOP-1


0.00093 0.000936 0.001 0.001009 0.001011 0.001017 0.001018 0.001026 0.00105 0.001067 0.001097 0.001098 0.001102 0.001107 0.001112 0.001116 0.001151 0.001185 0.001193 0.001207 0.001233 0.001238 0.00127 0.001278 0.001323 0.00142 0.00144 0.001445 0.001458 0.001504 0.001538 0.001543 0.001582 0.001585 0.001704 0.001705 0.001837 0.001871 0.001883 0.001922 0.001936 0.001975 0.002052 0.002133 0.002134

−0.84808 −0.86141 −0.61208 −0.67459 −0.9438 −0.59619 −0.64223 −0.65274 −1.08075 −0.61655 −0.6196 −0.94602 −0.72378 −0.5873 −0.79313 −0.61906 −0.73743 −0.64354 −0.59343 −1.06964 −1.19417 −0.64406 −0.89264 −0.68864 −0.85376 −1.08655 −0.63659 −0.63539 −0.58891 −0.58714 −0.77163 −0.79604 −0.59364 −0.8668 −0.70591 −0.92008 −0.76943 −0.5857 −0.6313 −0.69334 −0.84836 −0.67822 −0.72594 −0.6605 −0.59906 26

8.936696 10.52419 4.494745 4.94603 7.80657 5.968115 8.346703 6.04302 8.402024 9.336252 4.843722 9.149905 6.137406 9.360844 10.45658 9.46918 7.062924 5.692539 5.907763 7.249108 8.844132 8.809535 8.089348 7.177742 7.017951 7.876868 9.145901 8.302681 6.214303 5.975968 6.097734 7.24909 6.613156 6.534194 6.962113 10.16277 5.383984 8.20934 7.10553 4.815358 7.926955 5.610348 6.616834 6.066724 4.420287

9.784774 11.3856 5.106824 5.620615 8.750371 6.564307 8.988937 6.695758 9.482774 9.952805 5.463322 10.09593 6.861182 9.94814 11.24971 10.08824 7.800358 6.336082 6.501194 8.318752 10.03831 9.453597 8.981992 7.866379 7.871715 8.963421 9.782489 8.93807 6.803208 6.563105 6.869366 8.045128 7.206793 7.400998 7.668022 11.08285 6.153414 8.795043 7.736834 5.508697 8.775314 6.28857 7.342773 6.72722 5.019348 Oncotarget

201162_at 213241_at 201044_x_at 223204_at 202007_at 212998_x_at 202687_s_at 228056_s_at 205403_at 201811_x_at 204787_at 204621_s_at 212993_at 219243_at 209616_s_at 201506_at 223168_at 228094_at 211302_s_at 216015_s_at 210512_s_at 204470_at 201393_s_at 220091_at 206380_s_at 1554997_a_at 227265_at 220266_s_at 214329_x_at 210845_s_at 202284_s_at 227184_at 204112_s_at 217143_s_at 204748_at 228766_at 202510_s_at 202917_s_at 207794_at 211864_s_at 221558_s_at 200872_at 216248_s_at 201137_s_at 202688_at

IGFBP7 PLXNC1 DUSP1 FAM198B NID1 HLA-DQB1 TNFSF10 NAPSB IL1R2 SH3BP5 VSIG4 NR4A2 NACC2 GIMAP4 CES1 TGFBI RHOU AMICA1 PDE4B NLRP3 VEGFA CXCL1 IGF2R SLC2A6 CFP PTGS2 FGL2 KLF4 TNFSF10 PLAUR CDKN1A PTAFR HNMT YME1L1 PTGS2 CD36 TNFAIP2 S100A8 CCR2 MYOF LEF1 S100A10 NR4A2 HLA-DPB1 TNFSF10


0.002155 0.002163 0.002214 0.002249 0.002298 0.002303 0.002351 0.002448 0.002582 0.002584 0.002671 0.002902 0.002945 0.002945 0.002986 0.003107 0.003214 0.003217 0.003272 0.003379 0.003528 0.00359 0.003715 0.003819 0.003839 0.00391 0.004095 0.004319 0.004695 0.004742 0.005008 0.00513 0.005173 0.00552 0.005545 0.005605 0.005633 0.005681 0.005847 0.005983 0.006079 0.006614 0.006743 0.006849 0.00696

−0.69115 −0.6077 −0.64593 −0.91262 −0.89467 −1.05093 −0.6171 −0.71617 −0.73608 −0.60026 −0.64809 −0.68889 −0.63739 −0.70764 −0.75488 −0.82839 −0.63073 −0.74063 −0.66829 −0.67504 −0.63984 −0.58722 −0.75513 −0.62414 −0.73356 −0.81902 −0.94602 −0.7093 −0.65267 −0.67052 −0.60756 −0.59504 −0.77009 −0.59081 −0.77941 −0.77742 −0.58812 −1.06114 −0.61884 −0.6564 −0.71325 −0.65685 −0.68193 −0.69009 −0.64772 27

7.862872 7.854594 7.958744 7.277875 5.469988 7.460208 6.511251 5.308653 5.306744 7.366324 5.746116 8.063423 6.267435 5.888597 5.389587 5.670766 6.37449 7.202711 7.407099 6.360279 6.572391 5.41446 6.924197 5.928607 7.915656 6.011836 8.606341 7.442947 6.414328 8.740113 7.377775 8.473261 6.111453 5.868867 7.028158 8.32487 8.390278 10.0832 6.040878 5.821984 6.380833 9.619589 8.014288 9.590469 7.494082

8.554023 8.462294 8.604672 8.190496 6.364657 8.511142 7.128356 6.024826 6.042823 7.966588 6.394201 8.75231 6.904827 6.596233 6.144468 6.499152 7.005215 7.943337 8.075385 7.035315 7.212233 6.001683 7.679332 6.552745 8.649216 6.830856 9.552365 8.152251 7.067 9.410634 7.98533 9.0683 6.881541 6.459676 7.807568 9.102287 8.978402 11.14433 6.659723 6.478385 7.09408 10.27644 8.696218 10.28056 8.141799 Oncotarget

204622_x_at 203708_at 231577_s_at 202391_at 204141_at 210427_x_at 209774_x_at 235964_x_at 201798_s_at 201590_x_at 202820_at 203290_at 213503_x_at 228055_at 234987_at 200762_at 207850_at 206978_at 205557_at 204446_s_at 235529_x_at 216834_at 1555745_a_at

NR4A2 PDE4B GBP1 BASP1 TUBB2A ANXA2 CXCL2 SAMHD1 MYOF ANXA2 AHR HLA-DQA1 ANXA2 NAPSB SAMHD1 DPYSL2 CXCL3 CCR2 BPI ALOX5 SAMHD1 RGS1 LYZ


0.0071 0.007132 0.008655 0.009813 0.010032 0.01026 0.010609 0.011765 0.013034 0.013458 0.014847 0.015291 0.015777 0.016381 0.017 0.017366 0.021428 0.023224 0.025467 0.02558 0.026019 0.029001 0.02939

−0.6741 −0.71694 −0.65048 −0.80116 −0.65912 −0.60813 −0.77181 −0.7287 −0.66839 −0.59642 −0.59056 −0.60598 −0.6056 −0.69557 −0.6921 −0.60526 −0.65848 −0.62185 −0.66681 −0.60971 −0.59524 −0.62085 −0.70725

28

8.087097 7.571509 6.188489 7.876467 6.097405 9.403321 8.014726 8.789307 6.626148 9.406298 8.279072 5.436743 9.287027 6.310889 9.096218 8.267419 6.857597 6.718405 5.923219 8.132672 9.312416 6.626317 10.66354

8.761199 8.288454 6.838967 8.677627 6.75652 10.01145 8.78654 9.518008 7.29454 10.00271 8.869627 6.042724 9.89263 7.006464 9.788319 8.872677 7.516078 7.340259 6.590024 8.742377 9.90766 7.247171 11.37078

Oncotarget

Supplementary Table S3: Correlation between RUNX1 expression and microRNA profiles using whole-genome high-throughput sequencing microRNA symbol hsa-mir-16-2.MIMAT0004518 hsa-mir-146b.MIMAT0002809 hsa-mir-146b.MIMAT0004766 hsa-mir-16.MIMAT0000069 hsa-mir-196b.MIMAT0001080 hsa-mir-15b.MIMAT0000417 hsa-mir-550.MIMAT0004800 hsa-mir-1249.MIMAT0005901 hsa-mir-940.MIMAT0004983 hsa-let-7a.MIMAT0000062 hsa-mir-193a.MIMAT0004614 hsa-mir-320c.MIMAT0005793 hsa-mir-125a.MIMAT0000443 hsa-let-7e.MIMAT0000066 hsa-let-7e.MIMAT0004485 hsa-mir-1307.MIMAT0005951 hsa-mir-133a.MIMAT0000427 hsa-mir-22.MIMAT0000077 hsa-mir-23a.MIMAT0000078 hsa-mir-92a-1.MIMAT0004507 hsa-mir-1289.MIMAT0005879 hsa-mir-876.MIMAT0004924 hsa-mir-551b.MIMAT0003233 hsa-let-7d.MIMAT0000065 hsa-mir-1.MIMAT0000416 hsa-mir-1323.MIMAT0005795 hsa-mir-135a-1.MIMAT0004595 hsa-mir-15b.MIMAT0004586 hsa-mir-200c.MIMAT0000617 hsa-mir-30b.MIMAT0000420 hsa-mir-600.MIMAT0003268 hsa-mir-582.MIMAT0004797 hsa-mir-576.MIMAT0003241 hsa-mir-132.MIMAT0000426 hsa-mir-132.MIMAT0004594 hsa-mir-133b.MIMAT0000770 hsa-mir-2110.MIMAT0010133 hsa-mir-187.MIMAT0000262 hsa-mir-22.MIMAT0004495 hsa-mir-651.MIMAT0003321 hsa-mir-99b.MIMAT0000689 hsa-mir-616.MIMAT0003284 www.impactjournals.com/oncotarget

Correlation Coefficient 0.561794 0.539189 0.53209 0.482745 0.475145 0.462283 0.456991 −0.44456 −0.4433 0.42284 −0.42424 0.41689 0.400943 0.393968 0.39366 −0.39776 0.390996 −0.39675 −0.39171 0.377269 0.369158 0.369158 0.366498 0.361157 0.36041 0.353902 0.354976 0.355271 −0.35441 0.35445 0.353902 −0.34991 0.345916 −0.345 −0.34051 0.340571 −0.34135 −0.33489 −0.33449 0.334358 0.333352 −0.33235 29

P-value 7.17E-08 2.95E-07 4.50E-07 6.62E-06 9.66E-06 1.8E-05 2.3E-05 4.05E-05 4.29E-05 0.000104 9.76E-05 0.000132 0.00025 0.000328 0.000332 0.000283 0.000367 0.000295 0.000357 0.000609 0.000814 0.000814 0.000894 0.001076 0.001103 0.001376 0.001327 0.001314 0.001353 0.001351 0.001376 0.001572 0.001793 0.001847 0.002137 0.002132 0.002079 0.002555 0.002588 0.002598 0.002682 0.002767

False Discover Rate 4.68E-05 9.62E-05 9.79E-05 0.00108 0.001261 0.001954 0.002145 0.00311 0.00311 0.006147 0.006147 0.007207 0.012583 0.01261 0.01261 0.01261 0.01261 0.01261 0.01261 0.019899 0.024166 0.024166 0.025377 0.028822 0.028822 0.028985 0.028985 0.028985 0.028985 0.028985 0.028985 0.032081 0.035477 0.035482 0.037707 0.037707 0.037707 0.042416 0.042416 0.042416 0.042712 0.04302 Oncotarget

hsa-mir-21.MIMAT0000076 hsa-mir-193a.MIMAT0000459 hsa-mir-501.MIMAT0004774 hsa-mir-326.MIMAT0000756 hsa-mir-550.MIMAT0003257 hsa-mir-1976.MIMAT0009451 hsa-mir-1179.MIMAT0005824 hsa-mir-320b.MIMAT0005792 hsa-mir-320d.MIMAT0006764 hsa-mir-374b.MIMAT0004955 hsa-mir-1266.MIMAT0005920 hsa-mir-30b.MIMAT0004589 hsa-mir-720.MIMAT0005954 hsa-mir-155.MIMAT0000646 hsa-mir-624.MIMAT0003293 hsa-mir-103.MIMAT0000101 hsa-mir-1228.MIMAT0005582 hsa-mir-152.MIMAT0000438 hsa-mir-99b.MIMAT0004678 hsa-mir-449a.MIMAT0001541 hsa-mir-508.MIMAT0002880 hsa-mir-185.MIMAT0004611 hsa-mir-1250.MIMAT0005902 hsa-mir-140.MIMAT0004597 hsa-mir-196b.MIMAT0009201 hsa-mir-582.MIMAT0003247 hsa-mir-125a.MIMAT0004602 hsa-mir-378.MIMAT0000732 hsa-mir-484.MIMAT0002174 hsa-mir-877.MIMAT0004949 hsa-mir-491.MIMAT0002807 hsa-mir-607.MIMAT0003275 hsa-mir-500.MIMAT0002871 hsa-let-7b.MIMAT0004482 hsa-mir-185.MIMAT0000455 hsa-mir-219-1.MIMAT0004567 hsa-let-7f-1.MIMAT0004486 hsa-mir-362.MIMAT0000705 hsa-let-7a.MIMAT0004481 hsa-mir-19b-1.MIMAT0004491 hsa-mir-223.MIMAT0000280 hsa-mir-103-2.MIMAT0009196 hsa-mir-130a.MIMAT0004593 hsa-mir-192.MIMAT0004543 hsa-mir-548k.MIMAT0005882 www.impactjournals.com/oncotarget

−0.32892 −0.32552 −0.3245 −0.32119 0.320172 −0.31591 0.311755 0.311609 0.312624 0.311124 0.309796 0.31013 0.308327 0.30645 0.306433 −0.3055 −0.30381 −0.30301 0.302174 0.295665 0.294437 −0.29316 −0.29169 −0.29033 0.290748 −0.28932 0.287194 −0.28722 −0.28774 −0.28781 0.282895 0.28291 −0.2807 0.279636 −0.27905 0.273578 0.27133 −0.27174 0.268414 0.266058 −0.26473 −0.26043 0.260744 0.260488 0.260189 30

0.003079 0.003419 0.003527 0.003899 0.004021 0.004567 0.005161 0.005183 0.005031 0.005257 0.005464 0.005411 0.005701 0.006018 0.006021 0.006184 0.00649 0.006639 0.006799 0.008158 0.008439 0.008742 0.0091 0.009445 0.009337 0.009706 0.01028 0.010272 0.01013 0.01011 0.011531 0.011526 0.01222 0.012566 0.012758 0.014704 0.015574 0.015412 0.016768 0.017789 0.018389 0.020447 0.020292 0.020419 0.02057

0.046758 0.050736 0.051178 0.055347 0.055864 0.06213 0.06601 0.06601 0.06601 0.06601 0.066071 0.066071 0.06769 0.068977 0.068977 0.069619 0.071826 0.072249 0.072778 0.085919 0.087475 0.089195 0.091423 0.092053 0.092053 0.093211 0.093237 0.093237 0.093237 0.093237 0.101753 0.101753 0.106392 0.107964 0.108198 0.123098 0.127122 0.127122 0.135179 0.141665 0.144676 0.154392 0.154392 0.154392 0.154392 Oncotarget

hsa-mir-155.MIMAT0004658 hsa-mir-130a.MIMAT0000425 hsa-mir-361.MIMAT0000703 hsa-mir-1538.MIMAT0007400 hsa-mir-629.MIMAT0003298 hsa-mir-25.MIMAT0000081 hsa-mir-212.MIMAT0000269 hsa-mir-551a.MIMAT0003214 hsa-mir-107.MIMAT0000104 hsa-mir-24.MIMAT0000080 hsa-mir-589.MIMAT0004799 hsa-mir-532.MIMAT0002888 hsa-mir-10a.MIMAT0004555 hsa-mir-1234.MIMAT0005589 hsa-mir-24-2.MIMAT0004497 hsa-mir-574.MIMAT0003239 hsa-mir-135a.MIMAT0000428 hsa-mir-30d.MIMAT0004551 hsa-mir-149.MIMAT0000450 hsa-let-7f.MIMAT0000067 hsa-mir-584.MIMAT0003249 hsa-mir-30d.MIMAT0000245 hsa-mir-514.MIMAT0002883 hsa-mir-708.MIMAT0004927 hsa-mir-642.MIMAT0003312 hsa-mir-376b.MIMAT0002172 hsa-let-7g.MIMAT0000414 hsa-mir-502.MIMAT0004775 hsa-mir-221.MIMAT0004568 hsa-mir-92a-2.MIMAT0004508 hsa-mir-1224.MIMAT0005458 hsa-let-7b.MIMAT0000063 hsa-mir-490.MIMAT0002806 hsa-mir-190.MIMAT0000458 hsa-mir-616.MIMAT0004805 hsa-mir-513a.MIMAT0002877 hsa-mir-874.MIMAT0004911 hsa-mir-106b.MIMAT0000680 hsa-mir-548n.MIMAT0005916 hsa-mir-92a.MIMAT0000092 hsa-mir-1914.MIMAT0007889 hsa-mir-151.MIMAT0004697 hsa-mir-106b.MIMAT0004672 hsa-mir-130b.MIMAT0000691 hsa-mir-27b.MIMAT0004588 www.impactjournals.com/oncotarget

0.258245 0.257085 0.257294 −0.25615 0.256554 0.243254 −0.24138 0.239394 −0.23856 −0.23817 −0.2378 −0.23633 0.235879 0.235108 −0.23262 −0.23303 0.230895 0.230554 −0.22969 0.222385 0.222201 0.220067 0.218682 −0.21877 −0.21775 −0.21651 0.213108 −0.21324 −0.21183 0.211767 0.21084 0.209575 0.208499 0.207349 −0.20692 0.206411 0.20342 0.201271 0.201525 0.201881 −0.19952 0.197602 0.195422 0.19511 0.194901 31

0.021569 0.022185 0.022073 0.022693 0.022472 0.030758 0.032108 0.033598 0.03424 0.034541 0.034832 0.036002 0.036371 0.037005 0.039112 0.03876 0.040631 0.040937 0.041716 0.048857 0.049049 0.051321 0.052841 0.052748 0.053883 0.055305 0.059338 0.059172 0.06092 0.060995 0.062161 0.063783 0.065189 0.066718 0.067293 0.067988 0.072166 0.075294 0.074918 0.074396 0.077924 0.080883 0.084357 0.084863 0.085205

0.160052 0.160963 0.160963 0.161074 0.161074 0.215971 0.223052 0.23094 0.232092 0.232092 0.232092 0.237467 0.237505 0.239247 0.247965 0.247965 0.254588 0.254588 0.256987 0.296562 0.296562 0.307457 0.310859 0.310859 0.314155 0.319592 0.336936 0.336936 0.340424 0.340424 0.343993 0.350001 0.354735 0.360057 0.360181 0.360944 0.380037 0.387142 0.387142 0.387142 0.397534 0.409432 0.418586 0.418586 0.418586 Oncotarget

hsa-mir-378.MIMAT0000731 hsa-mir-26a.MIMAT0000082 hsa-mir-144.MIMAT0004600 hsa-mir-216b.MIMAT0004959 hsa-mir-589.MIMAT0003256 hsa-mir-194.MIMAT0000460 hsa-mir-548d.MIMAT0003323 hsa-mir-126.MIMAT0000445 hsa-mir-744.MIMAT0004945 hsa-mir-26a-1.MIMAT0004499 hsa-mir-496.MIMAT0002818 hsa-mir-1275.MIMAT0005929 hsa-mir-374a.MIMAT0000727 hsa-mir-188.MIMAT0004613 hsa-mir-21.MIMAT0004494 hsa-mir-1228.MIMAT0005583 hsa-mir-296.MIMAT0000690 hsa-mir-1226.MIMAT0005577 hsa-mir-1254.MIMAT0005905 hsa-mir-27a.MIMAT0000084 hsa-mir-34c.MIMAT0004677 hsa-mir-636.MIMAT0003306 hsa-mir-345.MIMAT0000772 hsa-mir-10a.MIMAT0000253 hsa-mir-139.MIMAT0000250 hsa-mir-141.MIMAT0000432 hsa-mir-215.MIMAT0000272 hsa-mir-26a-2.MIMAT0004681 hsa-mir-423.MIMAT0004748 hsa-mir-508.MIMAT0004778 hsa-mir-611.MIMAT0003279 hsa-mir-628.MIMAT0004809 hsa-mir-7-1.MIMAT0004553 hsa-mir-765.MIMAT0003945 hsa-mir-493.MIMAT0003161 hsa-mir-506.MIMAT0002878 hsa-mir-188.MIMAT0000457 hsa-mir-181d.MIMAT0002821 hsa-mir-489.MIMAT0002805 hsa-mir-625.MIMAT0004808 hsa-mir-572.MIMAT0003237 hsa-mir-937.MIMAT0004980 hsa-mir-641.MIMAT0003311 hsa-mir-513c.MIMAT0005789 hsa-mir-1915.MIMAT0007892 www.impactjournals.com/oncotarget

−0.19487 0.192372 0.190282 0.190596 −0.19061 0.189669 0.18925 0.187599 −0.18745 0.186657 −0.18618 0.184779 0.184309 −0.18339 −0.18335 −0.18223 −0.18077 −0.17876 0.178488 −0.17844 −0.17864 0.178493 0.175605 0.174952 −0.17135 −0.16972 −0.17214 0.172007 0.17167 0.170547 0.170103 −0.1699 0.169758 −0.17215 −0.16894 0.169062 −0.16831 0.16703 −0.16662 0.166445 −0.16592 −0.16552 0.165102 0.164696 0.16371 32

0.085256 0.089416 0.093018 0.09247 0.09244 0.094096 0.094838 0.097808 0.098073 0.099536 0.100413 0.103049 0.103943 0.105708 0.10578 0.107967 0.110875 0.114977 0.115529 0.115621 0.115211 0.11552 0.121626 0.12304 0.131073 0.134832 0.129278 0.129575 0.130338 0.13291 0.133936 0.134406 0.134738 0.129241 0.136663 0.13637 0.13815 0.141214 0.142195 0.142631 0.143906 0.144892 0.145927 0.146936 0.149404

0.418586 0.435735 0.443364 0.443364 0.443364 0.44525 0.445532 0.454194 0.454194 0.457724 0.458529 0.4673 0.468104 0.469893 0.469893 0.476369 0.485916 0.490262 0.490262 0.490262 0.490262 0.490262 0.512397 0.515031 0.530394 0.530394 0.530394 0.530394 0.530394 0.530394 0.530394 0.530394 0.530394 0.530394 0.531197 0.531197 0.533799 0.5415 0.5415 0.5415 0.543182 0.543763 0.544516 0.545166 0.548094 Oncotarget

hsa-mir-216a.MIMAT0000273 hsa-mir-101-1.MIMAT0004513 hsa-let-7g.MIMAT0004584 hsa-mir-1913.MIMAT0007888 hsa-mir-29c.MIMAT0004673 hsa-mir-548f.MIMAT0005895 hsa-mir-663b.MIMAT0005867 hsa-mir-1271.MIMAT0005796 hsa-mir-1225.MIMAT0005572 hsa-mir-885.MIMAT0004947 hsa-mir-1255a.MIMAT0005906 hsa-mir-183.MIMAT0000261 hsa-mir-184.MIMAT0000454 hsa-mir-320a.MIMAT0000510 hsa-mir-501.MIMAT0002872 hsa-mir-30c-2.MIMAT0004550 hsa-mir-877.MIMAT0004950 hsa-mir-18a.MIMAT0002891 hsa-mir-425.MIMAT0003393 hsa-mir-30a.MIMAT0000088 hsa-mir-190b.MIMAT0004929 hsa-mir-20a.MIMAT0004493 hsa-mir-211.MIMAT0000268 hsa-mir-217.MIMAT0000274 hsa-mir-218.MIMAT0000275 hsa-mir-29a.MIMAT0004503 hsa-mir-31.MIMAT0004504 hsa-mir-330.MIMAT0000751 hsa-mir-340.MIMAT0004692 hsa-mir-374b.MIMAT0004956 hsa-mir-454.MIMAT0003884 hsa-mir-541.MIMAT0004919 hsa-mir-548a-3.MIMAT0004803 hsa-mir-625.MIMAT0003294 hsa-mir-629.MIMAT0004810 hsa-mir-934.MIMAT0004977 hsa-mir-365.MIMAT0000710 hsa-mir-451.MIMAT0001631 hsa-mir-628.MIMAT0003297 hsa-mir-148a.MIMAT0004549 hsa-mir-760.MIMAT0004957 hsa-let-7c.MIMAT0004483 hsa-mir-106a.MIMAT0004517 hsa-mir-129.MIMAT0000242 hsa-mir-138-1.MIMAT0004607 www.impactjournals.com/oncotarget

0.164021 0.162644 0.159002 0.159027 0.157208 −0.15693 −0.15558 0.15463 −0.15294 −0.15316 −0.1512 −0.15215 0.151519 0.151527 −0.15182 −0.15048 −0.15018 0.149859 −0.14942 −0.14834 −0.14317 0.14566 −0.14638 0.147136 −0.143 −0.14297 0.146061 −0.14441 −0.14279 0.144505 −0.14387 −0.14363 −0.14353 0.14276 0.143852 −0.14377 −0.14175 0.14178 −0.13993 −0.13952 0.1392 −0.13559 0.137392 −0.13791 −0.13697 33

0.148622 0.152109 0.161621 0.161555 0.166468 0.167222 0.170959 0.173616 0.178413 0.177798 0.183478 0.180694 0.182539 0.182516 0.181649 0.185583 0.186471 0.187434 0.188756 0.192003 0.208132 0.200241 0.198003 0.195671 0.208658 0.208784 0.198993 0.204173 0.209351 0.203872 0.205889 0.20666 0.206965 0.209443 0.205945 0.206211 0.212719 0.212621 0.218726 0.220091 0.221147 0.233469 0.227264 0.225486 0.228694

0.548094 0.554901 0.583087 0.583087 0.596698 0.596698 0.60672 0.612817 0.623014 0.623014 0.624015 0.624015 0.624015 0.624015 0.624015 0.627658 0.627658 0.627665 0.628864 0.636437 0.642096 0.642096 0.642096 0.642096 0.642096 0.642096 0.642096 0.642096 0.642096 0.642096 0.642096 0.642096 0.642096 0.642096 0.642096 0.642096 0.646072 0.646072 0.661243 0.6623 0.662426 0.672254 0.672254 0.672254 0.672254 Oncotarget

hsa-mir-202.MIMAT0002811 hsa-mir-204.MIMAT0000265 hsa-mir-30a.MIMAT0000087 hsa-mir-361.MIMAT0004682 hsa-mir-509.MIMAT0002881 hsa-mir-664.MIMAT0005949 hsa-mir-1185.MIMAT0005798 hsa-mir-338.MIMAT0004701 hsa-let-7f-2.MIMAT0004487 hsa-mir-126.MIMAT0000444 hsa-mir-145.MIMAT0004601 hsa-mir-301a.MIMAT0000688 hsa-mir-365-2.MIMAT0009199 hsa-mir-539.MIMAT0003163 hsa-mir-708.MIMAT0004926 hsa-mir-873.MIMAT0004953 hsa-mir-7.MIMAT0000252 hsa-mir-18a.MIMAT0000072 hsa-mir-192.MIMAT0000222 hsa-mir-33b.MIMAT0004811 hsa-mir-146a.MIMAT0000449 hsa-mir-20a.MIMAT0000075 hsa-mir-20b.MIMAT0001413 hsa-mir-432.MIMAT0002814 hsa-mir-433.MIMAT0001627 hsa-mir-483.MIMAT0004761 hsa-mir-543.MIMAT0004954 hsa-mir-624.MIMAT0004807 hsa-mir-664.MIMAT0005948 hsa-mir-876.MIMAT0004925 hsa-mir-346.MIMAT0000773 hsa-mir-1226.MIMAT0005576 hsa-mir-548l.MIMAT0005889 hsa-mir-301b.MIMAT0004958 hsa-mir-429.MIMAT0001536 hsa-mir-101.MIMAT0000099 hsa-mir-10b.MIMAT0000254 hsa-mir-1180.MIMAT0005825 hsa-mir-1256.MIMAT0005907 hsa-mir-1306.MIMAT0005950 hsa-mir-137.MIMAT0000429 hsa-mir-139.MIMAT0004552 hsa-mir-18b.MIMAT0001412 hsa-mir-1909.MIMAT0007883 hsa-mir-197.MIMAT0000227 www.impactjournals.com/oncotarget

−0.13547 −0.13577 −0.13722 0.136233 0.135232 0.136114 −0.13423 −0.13442 0.132257 0.132651 −0.13322 −0.13181 −0.13353 −0.13306 −0.13193 −0.13211 −0.13151 −0.13067 0.130787 0.13048 0.127517 0.129395 0.128621 −0.12752 −0.12907 0.129524 −0.12854 0.129285 0.128201 −0.12768 −0.12648 −0.12499 0.125198 −0.12436 −0.12357 0.119638 −0.11796 −0.12156 −0.1176 −0.12056 0.119525 −0.11755 −0.121 0.119123 −0.12022 34

0.233884 0.232841 0.227855 0.231245 0.234723 0.231657 0.238243 0.237577 0.245276 0.243858 0.241831 0.246907 0.240709 0.242388 0.24646 0.24581 0.247979 0.251033 0.250607 0.251733 0.262753 0.255728 0.258608 0.262723 0.25692 0.255252 0.258916 0.256138 0.260181 0.262151 0.266697 0.272413 0.271603 0.274854 0.277943 0.293627 0.300509 0.285905 0.302005 0.289916 0.294087 0.302213 0.288113 0.295726 0.291285

0.672254 0.672254 0.672254 0.672254 0.672254 0.672254 0.676402 0.676402 0.677437 0.677437 0.677437 0.677437 0.677437 0.677437 0.677437 0.677437 0.677531 0.679263 0.679263 0.679263 0.680863 0.680863 0.680863 0.680863 0.680863 0.680863 0.680863 0.680863 0.680863 0.680863 0.688353 0.697592 0.697592 0.701092 0.706214 0.712438 0.712438 0.712438 0.712438 0.712438 0.712438 0.712438 0.712438 0.712438 0.712438 Oncotarget

hsa-mir-29a.MIMAT0000086 hsa-mir-32.MIMAT0000090 hsa-mir-33a.MIMAT0000091 hsa-mir-380.MIMAT0000735 hsa-mir-423.MIMAT0001340 hsa-mir-513b.MIMAT0005788 hsa-mir-548j.MIMAT0005875 hsa-mir-581.MIMAT0003246 hsa-mir-610.MIMAT0003278 hsa-mir-744.MIMAT0004946 hsa-mir-23b.MIMAT0000418 hsa-mir-145.MIMAT0000437 hsa-mir-200b.MIMAT0004571 hsa-mir-411.MIMAT0003329 hsa-mir-592.MIMAT0003260 hsa-mir-148b.MIMAT0004699 hsa-mir-182.MIMAT0000260 hsa-mir-218-2.MIMAT0004566 hsa-mir-31.MIMAT0000089 hsa-mir-654.MIMAT0003330 hsa-mir-663.MIMAT0003326 hsa-mir-767.MIMAT0003883 hsa-mir-1915.MIMAT0007891 hsa-mir-1287.MIMAT0005878 hsa-mir-136.MIMAT0000448 hsa-mir-27b.MIMAT0000419 hsa-mir-29b-1.MIMAT0004514 hsa-mir-324.MIMAT0000762 hsa-mir-335.MIMAT0004703 hsa-mir-34b.MIMAT0000685 hsa-mir-369.MIMAT0001621 hsa-mir-943.MIMAT0004986 hsa-mir-143.MIMAT0000435 hsa-mir-28.MIMAT0000085 hsa-mir-653.MIMAT0003328 hsa-mir-1284.MIMAT0005941 hsa-mir-19b.MIMAT0000074 hsa-mir-181a-1.MIMAT0000270 hsa-mir-105.MIMAT0000102 hsa-mir-1204.MIMAT0005868 hsa-mir-1227.MIMAT0005580 hsa-mir-124.MIMAT0004591 hsa-mir-1298.MIMAT0005800 hsa-mir-142.MIMAT0000433 hsa-mir-154.MIMAT0000452 www.impactjournals.com/oncotarget

0.119203 0.119694 −0.11773 −0.1193 0.11763 0.122346 0.118097 −0.1201 0.119103 −0.12124 −0.11519 −0.11334 −0.11318 −0.11296 −0.11362 0.112187 −0.1109 −0.11064 0.110441 −0.11067 −0.11066 0.1112 0.110113 0.106954 −0.10809 0.108995 0.108015 −0.10758 −0.10827 0.107922 −0.10714 −0.107 −0.10569 0.106059 −0.10589 −0.10518 0.10501 −0.10443 −0.09528 −0.09573 −0.10087 0.10094 −0.09876 0.095931 −0.09848 35

0.295401 0.293401 0.301453 0.294995 0.301863 0.282759 0.299935 0.291757 0.295809 0.287179 0.312088 0.319963 0.32065 0.321601 0.318774 0.324941 0.330545 0.331704 0.332574 0.331581 0.331613 0.329242 0.334022 0.348156 0.343049 0.338979 0.343367 0.345309 0.342226 0.343784 0.347308 0.347926 0.353898 0.352229 0.352984 0.356263 0.357037 0.359704 0.403579 0.40134 0.376402 0.376081 0.386537 0.400346 0.387884

0.712438 0.712438 0.712438 0.712438 0.712438 0.712438 0.712438 0.712438 0.712438 0.712438 0.73307 0.7447 0.7447 0.7447 0.7447 0.749776 0.751457 0.751457 0.751457 0.751457 0.751457 0.751457 0.752125 0.760354 0.760354 0.760354 0.760354 0.760354 0.760354 0.760354 0.760354 0.760354 0.765218 0.765218 0.765218 0.766924 0.766924 0.770121 0.782009 0.782009 0.782009 0.782009 0.782009 0.782009 0.782009 Oncotarget

hsa-mir-199a.MIMAT0000231 hsa-mir-328.MIMAT0000752 hsa-mir-330.MIMAT0004693 hsa-mir-335.MIMAT0000765 hsa-mir-382.MIMAT0000737 hsa-mir-409.MIMAT0001639 hsa-mir-505.MIMAT0004776 hsa-mir-512.MIMAT0002823 hsa-mir-516b.MIMAT0002859 hsa-mir-517c.MIMAT0002866 hsa-mir-518a.MIMAT0005457 hsa-mir-518c.MIMAT0002847 hsa-mir-518e.MIMAT0002861 hsa-mir-518f.MIMAT0002842 hsa-mir-519a-1.MIMAT0005452 hsa-mir-519a.MIMAT0002869 hsa-mir-519d.MIMAT0002853 hsa-mir-520a.MIMAT0002834 hsa-mir-520d.MIMAT0002856 hsa-mir-522.MIMAT0002868 hsa-mir-526b.MIMAT0002835 hsa-mir-527.MIMAT0002862 hsa-mir-891a.MIMAT0004902 hsa-mir-98.MIMAT0000096 hsa-mir-99a.MIMAT0004511 hsa-mir-214.MIMAT0004564 hsa-mir-598.MIMAT0003266 hsa-mir-100.MIMAT0004512 hsa-mir-1236.MIMAT0005591 hsa-mir-1247.MIMAT0005899 hsa-mir-1277.MIMAT0005933 hsa-mir-1285.MIMAT0005876 hsa-mir-1286.MIMAT0005877 hsa-mir-129-2.MIMAT0004605 hsa-mir-1291.MIMAT0005881 hsa-mir-134.MIMAT0000447 hsa-mir-182.MIMAT0000259 hsa-mir-191.MIMAT0001618 hsa-mir-214.MIMAT0000271 hsa-mir-223.MIMAT0004570 hsa-mir-28.MIMAT0004502 hsa-mir-299.MIMAT0000687 hsa-mir-29b-2.MIMAT0004515 hsa-mir-29c.MIMAT0000681 hsa-mir-34c.MIMAT0000686 www.impactjournals.com/oncotarget

−0.09955 −0.09702 −0.10195 −0.09853 −0.09607 −0.09694 0.096746 −0.09528 −0.09528 −0.09528 −0.09528 −0.09528 −0.09528 −0.09528 −0.09528 −0.09528 −0.09528 −0.09528 −0.09528 −0.09528 −0.09528 −0.09528 −0.09972 −0.10044 0.095938 −0.09478 −0.09427 0.0895 −0.09173 0.090265 −0.08739 −0.08933 0.087127 0.086886 0.092432 −0.08972 −0.09204 −0.08948 −0.09127 −0.09061 0.092193 −0.08992 0.088325 0.090166 −0.08891 36

0.382725 0.394983 0.371306 0.387651 0.399647 0.395366 0.396338 0.403579 0.403579 0.403579 0.403579 0.403579 0.403579 0.403579 0.403579 0.403579 0.403579 0.403579 0.403579 0.403579 0.403579 0.403579 0.381913 0.378466 0.400311 0.406054 0.408602 0.432809 0.421401 0.428873 0.443788 0.433691 0.445157 0.446422 0.417827 0.431688 0.419793 0.432899 0.423733 0.427127 0.419039 0.430654 0.4389 0.429379 0.435859

0.782009 0.782009 0.782009 0.782009 0.782009 0.782009 0.782009 0.782009 0.782009 0.782009 0.782009 0.782009 0.782009 0.782009 0.782009 0.782009 0.782009 0.782009 0.782009 0.782009 0.782009 0.782009 0.782009 0.782009 0.782009 0.784476 0.787071 0.792407 0.792407 0.792407 0.792407 0.792407 0.792407 0.792407 0.792407 0.792407 0.792407 0.792407 0.792407 0.792407 0.792407 0.792407 0.792407 0.792407 0.792407 Oncotarget

hsa-mir-363.MIMAT0003385 hsa-mir-421.MIMAT0003339 hsa-mir-485.MIMAT0002176 hsa-mir-497.MIMAT0002820 hsa-mir-499.MIMAT0002870 hsa-mir-551b.MIMAT0004794 hsa-mir-556.MIMAT0004793 hsa-mir-564.MIMAT0003228 hsa-mir-606.MIMAT0003274 hsa-mir-658.MIMAT0003336 hsa-mir-93.MIMAT0004509 hsa-mir-1292.MIMAT0005943 hsa-mir-143.MIMAT0004599 hsa-mir-1911.MIMAT0007885 hsa-mir-29b.MIMAT0000100 hsa-mir-138-2.MIMAT0004596 hsa-mir-363.MIMAT0000707 hsa-mir-379.MIMAT0004690 hsa-mir-495.MIMAT0002817 hsa-mir-802.MIMAT0004185 hsa-mir-520g.MIMAT0002858 hsa-mir-1257.MIMAT0005908 hsa-mir-127.MIMAT0004604 hsa-mir-129-1.MIMAT0004548 hsa-mir-1301.MIMAT0005797 hsa-mir-138.MIMAT0000430 hsa-mir-144.MIMAT0000436 hsa-mir-1910.MIMAT0007884 hsa-mir-218-1.MIMAT0004565 hsa-mir-24-1.MIMAT0000079 hsa-mir-338.MIMAT0000763 hsa-mir-340.MIMAT0000750 hsa-mir-490.MIMAT0004764 hsa-mir-497.MIMAT0004768 hsa-mir-511.MIMAT0002808 hsa-mir-518c.MIMAT0002848 hsa-mir-520h.MIMAT0002867 hsa-mir-532.MIMAT0004780 hsa-mir-548b.MIMAT0003254 hsa-mir-612.MIMAT0003280 hsa-mir-671.MIMAT0003880 hsa-mir-887.MIMAT0004951 hsa-mir-1262.MIMAT0005914 hsa-mir-1269.MIMAT0005923 hsa-mir-1304.MIMAT0005892 www.impactjournals.com/oncotarget

0.090324 −0.08686 −0.0871 −0.08978 −0.08787 0.093147 −0.09336 −0.0889 −0.08712 −0.09188 0.087402 −0.08639 −0.08633 −0.08581 0.085707 −0.08434 0.083508 −0.08318 −0.08324 −0.08351 −0.08251 0.078564 −0.08056 0.077664 0.079934 −0.07799 −0.07981 0.081306 −0.0788 −0.07811 −0.07768 −0.07889 0.078564 −0.08103 −0.08036 −0.08042 −0.07792 −0.08044 −0.07806 −0.08101 0.080443 −0.07789 −0.07558 −0.07689 0.075687 37

0.428571 0.446563 0.445295 0.431353 0.441297 0.414218 0.413135 0.435898 0.445184 0.420604 0.443716 0.449044 0.449362 0.452073 0.452638 0.459908 0.464361 0.466103 0.465795 0.464337 0.469725 0.491311 0.480329 0.496303 0.483761 0.494501 0.484459 0.476264 0.490009 0.49382 0.496206 0.489492 0.491311 0.477747 0.481421 0.481091 0.494875 0.480976 0.494092 0.477874 0.480973 0.495026 0.507979 0.500603 0.507363

0.792407 0.792407 0.792407 0.792407 0.792407 0.792407 0.792407 0.792407 0.792407 0.792407 0.792407 0.793062 0.793062 0.79455 0.79455 0.805147 0.807334 0.807334 0.807334 0.807334 0.811457 0.812245 0.812245 0.812245 0.812245 0.812245 0.812245 0.812245 0.812245 0.812245 0.812245 0.812245 0.812245 0.812245 0.812245 0.812245 0.812245 0.812245 0.812245 0.812245 0.812245 0.812245 0.813015 0.813015 0.813015 Oncotarget

hsa-mir-148a.MIMAT0000243 hsa-mir-1914.MIMAT0007890 hsa-mir-373.MIMAT0000726 hsa-mir-377.MIMAT0004689 hsa-mir-493.MIMAT0002813 hsa-mir-92b.MIMAT0004792 hsa-mir-106a.MIMAT0000103 hsa-mir-1181.MIMAT0005826 hsa-mir-127.MIMAT0000446 hsa-mir-337.MIMAT0004695 hsa-mir-34b.MIMAT0004676 hsa-mir-379.MIMAT0000733 hsa-mir-505.MIMAT0002876 hsa-mir-654.MIMAT0004814 hsa-mir-410.MIMAT0002171 hsa-mir-369.MIMAT0000721 hsa-mir-381.MIMAT0000736 hsa-mir-1276.MIMAT0005930 hsa-mir-17.MIMAT0000070 hsa-mir-30c.MIMAT0000244 hsa-mir-1229.MIMAT0005584 hsa-mir-151.MIMAT0000757 hsa-mir-186.MIMAT0004612 hsa-mir-302d.MIMAT0000718 hsa-mir-487b.MIMAT0003180 hsa-mir-542.MIMAT0003389 hsa-mir-769.MIMAT0003886 hsa-mir-92b.MIMAT0003218 hsa-mir-425.MIMAT0001343 hsa-mir-136.MIMAT0004606 hsa-mir-141.MIMAT0004598 hsa-mir-23b.MIMAT0004587 hsa-mir-337.MIMAT0000754 hsa-mir-517a.MIMAT0002852 hsa-mir-517b.MIMAT0002857 hsa-let-7a-2.MIMAT0010195 hsa-mir-25.MIMAT0004498 hsa-mir-100.MIMAT0000098 hsa-mir-375.MIMAT0000728 hsa-mir-19a.MIMAT0000073 hsa-mir-380.MIMAT0000734 hsa-mir-485.MIMAT0002175 hsa-mir-140.MIMAT0000431 hsa-mir-146a.MIMAT0004608 hsa-mir-579.MIMAT0003244 www.impactjournals.com/oncotarget

−0.07665 0.076383 0.076045 0.076822 −0.07701 −0.07577 0.074054 −0.07371 −0.07369 −0.07362 −0.07454 −0.0749 0.073716 −0.07423 −0.07243 −0.07196 −0.07218 −0.07152 0.071149 0.071314 0.069595 0.070351 0.069809 −0.07011 −0.06947 −0.06955 0.069391 0.070831 −0.06911 −0.06777 −0.06844 0.067899 −0.06876 −0.06811 −0.06811 0.067133 0.06708 0.066586 −0.0662 0.065731 −0.06583 −0.06505 −0.06368 0.063696 0.063738 38

0.501958 0.503454 0.50535 0.500998 0.499943 0.506905 0.516593 0.518572 0.518682 0.519045 0.513843 0.511809 0.518515 0.515583 0.525843 0.528544 0.527307 0.531082 0.533218 0.532268 0.542225 0.537836 0.540981 0.539236 0.542965 0.542471 0.543409 0.535058 0.545069 0.552905 0.548936 0.552134 0.547113 0.550918 0.550918 0.556639 0.556949 0.559865 0.562171 0.564924 0.564346 0.568956 0.577179 0.577058 0.576807

0.813015 0.813015 0.813015 0.813015 0.813015 0.813015 0.814751 0.814751 0.814751 0.814751 0.814751 0.814751 0.814751 0.814751 0.823442 0.823721 0.823721 0.825098 0.825098 0.825098 0.825223 0.825223 0.825223 0.825223 0.825223 0.825223 0.825223 0.825223 0.825824 0.826194 0.826194 0.826194 0.826194 0.826194 0.826194 0.828445 0.828445 0.830891 0.83242 0.832721 0.832721 0.836776 0.84129 0.84129 0.84129 Oncotarget

hsa-mir-675.MIMAT0006790 hsa-mir-135b.MIMAT0004698 hsa-let-7i.MIMAT0004585 hsa-mir-181c.MIMAT0000258 hsa-mir-200b.MIMAT0000318 hsa-mir-323.MIMAT0000755 hsa-mir-33b.MIMAT0003301 hsa-mir-499.MIMAT0004772 hsa-mir-573.MIMAT0003238 hsa-mir-200a.MIMAT0001620 hsa-mir-181a-2.MIMAT0004558 hsa-mir-889.MIMAT0004921 hsa-mir-665.MIMAT0004952 hsa-mir-770.MIMAT0003948 hsa-mir-339.MIMAT0000764 hsa-mir-33a.MIMAT0004506 hsa-mir-452.MIMAT0001636 hsa-mir-766.MIMAT0003888 hsa-mir-96.MIMAT0004510 hsa-mir-125b.MIMAT0000423 hsa-mir-590.MIMAT0004801 hsa-mir-942.MIMAT0004985 hsa-let-7i.MIMAT0000415 hsa-mir-128.MIMAT0000424 hsa-mir-1293.MIMAT0005883 hsa-mir-1912.MIMAT0007887 hsa-mir-196a-2.MIMAT0004562 hsa-mir-196a.MIMAT0000226 hsa-mir-376c.MIMAT0000720 hsa-mir-409.MIMAT0001638 hsa-mir-449b.MIMAT0009203 hsa-mir-541.MIMAT0004920 hsa-mir-597.MIMAT0003265 hsa-mir-617.MIMAT0003286 hsa-mir-618.MIMAT0003287 hsa-mir-933.MIMAT0004976 hsa-mir-944.MIMAT0004987 hsa-mir-1909.MIMAT0007882 hsa-mir-577.MIMAT0003242 hsa-mir-181c.MIMAT0004559 hsa-mir-639.MIMAT0003309 hsa-mir-486.MIMAT0002177 hsa-mir-99a.MIMAT0000097 hsa-mir-494.MIMAT0002816 hsa-mir-19a.MIMAT0004490 www.impactjournals.com/oncotarget

0.064123 −0.06299 0.061735 0.06104 −0.06115 −0.06136 −0.06107 −0.06081 0.060801 −0.06044 0.06017 −0.05969 −0.05911 0.058811 −0.05845 −0.05833 −0.05698 −0.05693 −0.0573 0.05526 0.055054 0.055344 0.053545 −0.05259 −0.05269 −0.05221 0.053979 0.051667 −0.05352 0.05381 −0.05245 −0.05208 −0.05357 −0.05189 0.051815 −0.05221 0.051514 −0.05064 −0.05065 0.049991 −0.05006 −0.04935 0.049371 0.048453 0.047971 39

0.574503 0.581306 0.588862 0.593071 0.592387 0.591115 0.592896 0.594441 0.594524 0.596716 0.598363 0.601291 0.604815 0.606669 0.608869 0.609626 0.617945 0.618227 0.615958 0.628595 0.629882 0.628073 0.639308 0.645285 0.644664 0.647673 0.636591 0.651121 0.639487 0.637646 0.646178 0.648542 0.639167 0.649712 0.650187 0.647671 0.652087 0.657612 0.657576 0.661735 0.661311 0.66581 0.66568 0.671536 0.674618

0.84129 0.845418 0.851369 0.851369 0.851369 0.851369 0.851369 0.851369 0.851369 0.852638 0.853124 0.855431 0.858574 0.859338 0.859797 0.859797 0.866314 0.866314 0.866314 0.876999 0.876999 0.876999 0.879779 0.879779 0.879779 0.879779 0.879779 0.879779 0.879779 0.879779 0.879779 0.879779 0.879779 0.879779 0.879779 0.879779 0.879779 0.883581 0.883581 0.885477 0.885477 0.887294 0.887294 0.893101 0.89445 Oncotarget

hsa-mir-32.MIMAT0004505 hsa-mir-296.MIMAT0004679 hsa-mir-191.MIMAT0000440 hsa-mir-205.MIMAT0000266 hsa-mir-370.MIMAT0000722 hsa-mir-376a-1.MIMAT0003386 hsa-mir-455.MIMAT0003150 hsa-mir-590.MIMAT0003258 hsa-mir-605.MIMAT0003273 hsa-mir-660.MIMAT0003338 hsa-mir-939.MIMAT0004982 hsa-mir-1537.MIMAT0007399 hsa-mir-195.MIMAT0000461 hsa-mir-331.MIMAT0004700 hsa-mir-342.MIMAT0000753 hsa-mir-424.MIMAT0001341 hsa-mir-518b.MIMAT0002844 hsa-mir-671.MIMAT0004819 hsa-let-7d.MIMAT0004484 hsa-mir-1182.MIMAT0005827 hsa-mir-183.MIMAT0004560 hsa-mir-627.MIMAT0003296 hsa-mir-938.MIMAT0004981 hsa-mir-1258.MIMAT0005909 hsa-mir-150.MIMAT0004610 hsa-mir-154.MIMAT0000453 hsa-mir-203.MIMAT0000264 hsa-mir-452.MIMAT0001635 hsa-mir-542.MIMAT0003340 hsa-mir-545.MIMAT0004785 hsa-mir-638.MIMAT0003308 hsa-mir-675.MIMAT0004284 hsa-mir-374a.MIMAT0004688 hsa-mir-1973.MIMAT0009448 hsa-mir-1908.MIMAT0007881 hsa-mir-17.MIMAT0000071 hsa-mir-224.MIMAT0000281 hsa-mir-324.MIMAT0000761 hsa-mir-518a.MIMAT0002863 hsa-mir-331.MIMAT0000760 hsa-mir-431.MIMAT0001625 hsa-mir-122.MIMAT0000421 hsa-mir-186.MIMAT0000456 hsa-mir-34a.MIMAT0000255 hsa-mir-450a.MIMAT0001545 www.impactjournals.com/oncotarget

−0.04787 −0.04715 0.046567 −0.04579 −0.04567 0.045151 0.046155 −0.04487 −0.04519 −0.04498 0.045027 −0.04406 −0.04358 −0.04356 −0.04368 0.04458 −0.0436 −0.04297 0.042688 0.041843 −0.0419 0.042204 −0.04184 −0.04094 −0.03962 −0.03972 0.03999 −0.04061 −0.04012 0.040645 −0.04007 −0.04049 0.039363 −0.03849 −0.03809 −0.0378 −0.03718 −0.03694 0.037049 −0.0364 0.036317 0.03606 0.034986 −0.03498 −0.0355 40

0.675289 0.679877 0.683623 0.688602 0.689385 0.69276 0.68628 0.694594 0.692497 0.693838 0.693562 0.699818 0.702939 0.703068 0.702277 0.696452 0.702784 0.706921 0.708743 0.714257 0.713873 0.711899 0.714263 0.720139 0.728841 0.728161 0.726405 0.722344 0.725545 0.722106 0.725902 0.72313 0.730525 0.736286 0.73894 0.740872 0.744964 0.746512 0.745817 0.750117 0.750673 0.752381 0.759528 0.759573 0.756124

0.89445 0.898704 0.90173 0.90173 0.90173 0.90173 0.90173 0.90173 0.90173 0.90173 0.90173 0.901971 0.901971 0.901971 0.901971 0.901971 0.901971 0.905136 0.905657 0.905657 0.905657 0.905657 0.905657 0.908269 0.908269 0.908269 0.908269 0.908269 0.908269 0.908269 0.908269 0.908269 0.908634 0.914059 0.915613 0.916268 0.918027 0.918027 0.918027 0.91968 0.91968 0.920047 0.921014 0.921014 0.921014 Oncotarget

hsa-mir-504.MIMAT0002875 hsa-mir-632.MIMAT0003302 hsa-mir-10b.MIMAT0004556 hsa-mir-206.MIMAT0000462 hsa-mir-26b.MIMAT0000083 hsa-mir-491.MIMAT0004765 hsa-mir-30e.MIMAT0000693 hsa-mir-18b.MIMAT0004751 hsa-mir-224.MIMAT0009198 hsa-mir-9.MIMAT0000441 hsa-mir-148b.MIMAT0000759 hsa-mir-125b-2.MIMAT0004603 hsa-mir-30c-1.MIMAT0004674 hsa-mir-20b.MIMAT0004752 hsa-mir-588.MIMAT0003255 hsa-mir-147b.MIMAT0004928 hsa-mir-329.MIMAT0001629 hsa-mir-342.MIMAT0004694 hsa-mir-502.MIMAT0002873 hsa-mir-125b-1.MIMAT0004592 hsa-mir-1280.MIMAT0005946 hsa-mir-1294.MIMAT0005884 hsa-mir-193b.MIMAT0004767 hsa-mir-195.MIMAT0004615 hsa-mir-222.MIMAT0004569 hsa-mir-26b.MIMAT0004500 hsa-mir-27a.MIMAT0004501 hsa-mir-34a.MIMAT0004557 hsa-mir-431.MIMAT0004757 hsa-mir-454.MIMAT0003885 hsa-mir-455.MIMAT0004784 hsa-mir-503.MIMAT0002874 hsa-mir-545.MIMAT0003165 hsa-mir-615.MIMAT0003283 hsa-mir-96.MIMAT0000095 hsa-mir-488.MIMAT0004763 hsa-mir-15a.MIMAT0004488 hsa-mir-221.MIMAT0000278 hsa-mir-483.MIMAT0002173 hsa-let-7c.MIMAT0000064 hsa-mir-150.MIMAT0000451 hsa-mir-153.MIMAT0000439 hsa-mir-200a.MIMAT0000682 hsa-mir-376a.MIMAT0000729 hsa-mir-449b.MIMAT0003327 www.impactjournals.com/oncotarget

0.034882 −0.03495 −0.03403 0.03354 −0.03356 0.033595 −0.03312 0.032577 −0.03225 −0.03175 0.031513 0.031051 0.031111 0.029724 −0.02951 −0.02878 −0.02874 −0.02878 −0.02855 0.027995 −0.02521 0.026721 −0.02528 −0.02558 0.02506 −0.02635 0.025679 0.026578 −0.02655 0.025721 0.028106 −0.02603 −0.0265 0.025646 −0.02734 0.024512 −0.024 0.023837 0.023682 0.023086 −0.02193 0.022088 −0.02227 0.021553 −0.02157 41

0.760224 0.759741 0.765935 0.769183 0.769032 0.768815 0.771996 0.775633 0.777859 0.781158 0.782781 0.785889 0.785483 0.794831 0.796278 0.801215 0.801498 0.801234 0.802743 0.806525 0.825454 0.815173 0.825003 0.822953 0.826477 0.817674 0.822258 0.816147 0.816348 0.821972 0.805778 0.81988 0.816706 0.822481 0.810969 0.830216 0.833676 0.834821 0.835882 0.839955 0.84785 0.846786 0.845521 0.850456 0.850362

0.921014 0.921014 0.925002 0.925002 0.925002 0.925002 0.926679 0.929336 0.930296 0.932534 0.932766 0.933065 0.933065 0.941968 0.941974 0.94279 0.94279 0.94279 0.94279 0.943513 0.943513 0.943513 0.943513 0.943513 0.943513 0.943513 0.943513 0.943513 0.943513 0.943513 0.943513 0.943513 0.943513 0.943513 0.943513 0.946127 0.947623 0.947623 0.947623 0.95029 0.95029 0.95029 0.95029 0.95029 0.95029 Oncotarget

hsa-mir-659.MIMAT0003337 hsa-mir-885.MIMAT0004948 hsa-mir-95.MIMAT0000094 hsa-mir-219.MIMAT0000276 hsa-mir-432.MIMAT0002815 hsa-mir-222.MIMAT0000279 hsa-mir-411.MIMAT0004813 hsa-mir-299.MIMAT0002890 hsa-mir-548e.MIMAT0005874 hsa-mir-93.MIMAT0000093 hsa-mir-935.MIMAT0004978 hsa-mir-1278.MIMAT0005936 hsa-mir-548o.MIMAT0005919 hsa-mir-362.MIMAT0004683 hsa-mir-556.MIMAT0003220 hsa-mir-655.MIMAT0003331 hsa-mir-1288.MIMAT0005942 hsa-mir-142.MIMAT0000434 hsa-mir-199a.MIMAT0000232 hsa-mir-199b.MIMAT0004563 hsa-mir-383.MIMAT0000738 hsa-mir-1246.MIMAT0005898 hsa-mir-1260.MIMAT0005911 hsa-mir-15a.MIMAT0000068 hsa-mir-181a.MIMAT0000256 hsa-mir-181b.MIMAT0000257 hsa-mir-193b.MIMAT0002819 hsa-mir-339.MIMAT0004702 hsa-mir-422a.MIMAT0001339 hsa-mir-450b.MIMAT0004909 hsa-mir-488.MIMAT0002804 hsa-mir-548a.MIMAT0003251 hsa-mir-552.MIMAT0003215 hsa-mir-580.MIMAT0003245 hsa-mir-609.MIMAT0003277 hsa-mir-7-2.MIMAT0004554 hsa-mir-586.MIMAT0003252 hsa-mir-1468.MIMAT0006789 hsa-mir-377.MIMAT0000730 hsa-mir-199b.MIMAT0000263 hsa-mir-210.MIMAT0000267 hsa-mir-1237.MIMAT0005592 hsa-mir-1238.MIMAT0005593 hsa-mir-124.MIMAT0000422 hsa-mir-1248.MIMAT0005900 www.impactjournals.com/oncotarget

−0.02143 −0.02157 0.021428 −0.02101 0.020561 0.020176 0.019996 −0.01868 −0.01715 0.016603 −0.01672 −0.01616 −0.0163 −0.01542 −0.01526 −0.01562 −0.01413 −0.0143 −0.01429 −0.01416 0.014782 0.011506 −0.01096 0.012683 −0.01128 0.011905 −0.01233 0.010893 −0.01079 −0.01251 −0.01087 −0.01087 −0.01335 0.012841 −0.01079 −0.0129 0.010566 0.009547 −0.00929 0.008848 0.008805 0.005956 −0.00633 0.0057 0.005861 42

0.851332 0.850362 0.851315 0.854174 0.857264 0.859913 0.861146 0.870234 0.880756 0.884529 0.883689 0.887557 0.886589 0.892713 0.893834 0.891329 0.901659 0.900443 0.900508 0.901444 0.89712 0.919838 0.9236 0.911664 0.921428 0.917064 0.914083 0.924096 0.924836 0.912894 0.924245 0.924245 0.907017 0.910573 0.924836 0.910145 0.926369 0.93345 0.935265 0.938313 0.938613 0.958454 0.955854 0.960235 0.959118

0.95029 0.95029 0.95029 0.951835 0.953652 0.954717 0.954717 0.963157 0.973153 0.974026 0.974026 0.974076 0.974076 0.976043 0.976043 0.976043 0.976424 0.976424 0.976424 0.976424 0.976424 0.977214 0.977214 0.977214 0.977214 0.977214 0.977214 0.977214 0.977214 0.977214 0.977214 0.977214 0.977214 0.977214 0.977214 0.977214 0.977252 0.983134 0.983459 0.983811 0.983811 0.987454 0.987454 0.987454 0.987454 Oncotarget

hsa-mir-130b.MIMAT0004680 hsa-mir-149.MIMAT0004609 hsa-mir-200c.MIMAT0004657 hsa-mir-202.MIMAT0002810 hsa-mir-30e.MIMAT0000692 hsa-mir-486.MIMAT0004762 hsa-mir-500.MIMAT0004773 hsa-mir-652.MIMAT0003322 hsa-mir-570.MIMAT0003235 hsa-mir-194-2.MIMAT0004671 hsa-mir-23a.MIMAT0004496 hsa-mir-758.MIMAT0003879 hsa-mir-769.MIMAT0003887 hsa-mir-9.MIMAT0000442 hsa-mir-1295.MIMAT0005885 hsa-mir-135b.MIMAT0000758 hsa-mir-19b-2.MIMAT0004492 hsa-mir-643.MIMAT0003313 hsa-mir-16-1.MIMAT0004489 hsa-mir-875.MIMAT0004923 hsa-mir-487a.MIMAT0002178 hsa-mir-1270.MIMAT0005924 hsa-mir-1296.MIMAT0005794 hsa-mir-187.MIMAT0004561 hsa-mir-424.MIMAT0004749 hsa-mir-656.MIMAT0003332


−0.00681 0.005731 −0.0072 0.006659 0.006965 −0.00637 0.006306 0.007424 −0.00521 0.003883 −0.00433 0.003919 −0.00417 −0.00429 −0.00309 −0.00291 −0.00333 0.003034 −0.00237 −0.00241 0.001442 −7.5E−05 −0.0006 0.000397 −9.59E−06 0.000233

43

0.952532 0.960022 0.949818 0.953556 0.951421 0.955602 0.956012 0.948228 0.963624 0.972907 0.969817 0.972659 0.970882 0.970094 0.978426 0.979708 0.976794 0.978829 0.98343 0.983198 0.989934 0.999479 0.995807 0.997233 0.999933 0.998373

0.987454 0.987454 0.987454 0.987454 0.987454 0.987454 0.987454 0.987454 0.989381 0.99112 0.99112 0.99112 0.99112 0.99112 0.991859 0.991859 0.991859 0.991859 0.99255 0.99255 0.997572 0.999933 0.999933 0.999933 0.999933 0.999933

Oncotarget

Supplementary Figure S1: Association between RUNX1 expression and prognostic markers in CN-AML.

Supplementary Figure S2: OS of CN-AML patients in the validating group.


44

Oncotarget

Supplementary Figure S3: Genome-wide methylation profiling associated with RUNX1 expression. (A) Gene promoter methylation profiling and (B) Gene body methylation profiling associated with RUNX1 expression.


45

Oncotarget

Supplementary Figure S4: Therapeutic strategies of CN-AML patients.


46

Oncotarget

Supplementary Figure S5: RUNX1 expression is normally distributed.


47

Oncotarget

High expression of RUNX1 is associated with poorer

High expression of RUNX1 is associated with poorer

Suggest Documents

High XRCC1 Protein Expression Is Associated with Poorer Survival in ...

idiopathic myelofibrosis is associated with poorer ...

Is central obesity associated with poorer health

High miR-100 expression is associated with

High CD49f expression is associated with

High Heregulin Expression Is Associated with

Vitamin D deficiency is associated with poorer satisfaction with ...

Insulin resistance is associated with poorer verbal ... - Diabetologia

Shorter Adult Height is Associated with Poorer Cognitive ... - IOS Press

Pain catastrophizing is associated with poorer health ...

high expression of aKr1C1 is associated with ...

High Expression of Wee1 Is Associated with Poor Disease ... - CiteSeerX

High expression of wee1 is associated with ... - Springer Link

High expression of mTOR is associated with radiation resistance in ...

Reduced expression of NGEP is associated with high-grade prostate ...

High expression level of MMP9 is associated with poor ... - PeerJ

High expression of gabarapl1 is associated with a better ... - Nature

Decreased Motor Function Is Associated with Poorer ... - BioMedSearch

Foxp3 expression is associated with

Reduced Heart Rate Recovery Is Associated with Poorer Cognitive ...

High Heregulin Expression Is Associated with Activated HER3 ... - PLOS

High tumoral maspin expression is associated with improved ... - Nature

High RAB25 expression is associated with good ... - Wiley Online Library

High Bak Expression Is Associated with a Favorable Prognosis ... - PLOS