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Highly effective silica gel-supported N-heterocyclic carbene–Pd catalyst for Suzuki–Miyaura coupling reaction Huili Qiu, Shaheen M. Sarkar, Dong-Hwan Lee and Myung-Jong Jin* Received 16th August 2007, Accepted 29th October 2007 First published as an Advance Article on the web 2nd November 2007 DOI: 10.1039/b712624g

The immobilized N-heterocyclic carbene–Pd complex was readily prepared by reaction of silica gel-supported imidazolium chloride with Pd(OAc)2. The Pd complex exhibited excellent catalytic activity in the coupling reaction of aryl halides with arylboronic acid. The heterogeneous Pd catalyst was reusable as well as air-stable to allow easy use.

Introduction Metal-catalyzed coupling reactions have been recognized as convenient one-step methods for assembling complex structures.1 Among them, Suzuki–Miyaura coupling reaction of aryl halides with arylboronic acids is one of the most powerful tools for the synthesis of biaryl derivatives.2 Palladium catalysts are known to possess high activity for the coupling reaction.3 However, the traditional homogeneous catalysis causes major problems in purification of product and separation of expensive palladium catalyst that leads to toxic wastes. These problems are of environmental and economic concern in large scale-synthesis. Immobilized Pd catalysts have been developed in order to overcome these problems facing green chemistry.4,5 The search for an effective and recyclable catalyst is still a major challenge. Recently, N-heterocyclic carbene (NHC)–Pd complexes were found to act as efficient catalysts in coupling reactions.6,7 Our interest in this area led us to explore the NHC–Pd complex immobilized onto the surface of amorphous silica gel, which can be easily separated from the reaction mixture. Silica gel as an inorganic support has some advantageous properties such as excellent stability, good accessibility, and the fact that organic groups can be robustly anchored to the surface.8 Herein, we wish to describe the synthesis of reusable silica-supported NHC–Pd complex 3 and its catalytic activity in the Suzuki–Miyaura coupling reaction.

Experimental Immobilization of ionic liquid 1 onto the surface of silica gel To a solution of triethoxysilylpropylimidazolium chloride ionic liquid 1 (0.70 g, 2.2 mmol) in toluene was added commercially available silica gel (2.0 g, Merck1 9385, particle size 230–400 mesh, surface area 550 m2 g21). The mixture was stirred at 105 uC for 12 h. After cooling, the reaction mixture was filtered and washed

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with CH2Cl2 (10 mL 6 3), and dried at 60 uC under vacuum to yield silica-supported ionic liquid 2 (2.39 g). Elemental analysis and weight gain showed that 0.89 mmol of ionic liquid 1 was anchored on 1.0 g of 2. Preparation of silica-supported NHC–Pd complex 3 To a solution of silica-supported ionic liquid 2 (1.0 g, 0.89 mmol g21) in DMSO (4.5 mL) was added Pd(OAc)2 (101 mg, 0.45 mmol). The mixture was stirred for 4 h at 60 uC. The reaction was then allowed to proceed for an additional 30 min at 100 uC. Silica-supported NHC–Pd complex 3 was collected on a glass frit and washed with CH2Cl2 (10 mL 6 3) to remove unreacted Pd(OAc)2, and dried at 50 uC under vacuum. ICP analysis (atomic %): Pd 3.65. The ICP analysis showed that 0.34 mmol of Pd was anchored on 1.0 g of 3. The IR spectrum of 3 showed an absorption band at 1575 cm21 which is attributed to the CLC stretching vibration of the imidazolium group. General procedure for heterogeneous Suzuki reaction Aryl halide (1.0 mmol), phenylboronic acid (134 mg, 1.1 mmol), Na2CO3 (212 mg, 2.0 mmol), dodecane (40 mg, internal standard) and catalyst 3 (3 mg, 0.34 mmol g21, 0.1 mol%) were mixed in DMF–H2O (3.6 mL, 1 : 1, v/v). The mixture was stirred at 65 uC in an air atmosphere. The samples were withdrawn periodically and analysed by GC/GC-MS. The reaction mixture was filtered and washed with H2O and Et2O. The organic phase was separated and dried over MgSO4, and the solvent was evaporated under reduced pressure. The product was isolated by column chromatography on silica gel. GC/GC-MS analyses were performed on an Agilent 6890N GC (He carrier gas, HP-5MS column, 30 m 6 0.25 m 6 0.25 mm) coupled to an Agilent 5975 Network Mass Selective Detector (electron impact ionization at 70 eV). The initial temperature of the column was set at 80 uC for 5 min, and ramped at 10 uC min21 to a final temperature of 240 uC. The carrier gas was set at a constant velocity of 40 cm s21. The reuse of silica-supported Pd catalyst 3 In the recycling experiment, the reaction was performed by using a mixture of iodobenzene or 1-bromo-4-nitrobenzene (4.0 mmol), phenylboronic acid (4.4 mmol), Na2CO3 (8.0 mmol), and catalyst 3 (0.2 mol%) at 65 uC. After completion of the reaction, the reaction mixture was worked up as described above. The filtered catalyst was successively reused in the same reaction. Green Chem., 2008, 10, 37–40 | 37

Scheme 1

Results and discussion As shown in Scheme 1, the immobilization of the NHC–Pd complex onto the surface of amorphous silica gel was attempted through two methods: (A) immobilization of triethoxysilylated ionic liquid 19 onto silica gel, followed by reaction with Pd(OAC)2 and (B) preparation of triethoxysilylated NHC–Pd complex 4, followed by the immobilization onto the silica gel. Method A was chosen as a better strategy for the immobilization of the NHC–Pd complex because it is difficult to immobilize complex 4 which has very low solubility in most organic solvents. A similar procedure was previously used in the conversion of 2 to 3.10 With the heterogeneous catalyst 3 in hand, we first tested Suzuki coupling of iodobenzene with phenylboronic acid in DMF–H2O (1 : 1, v/v) as a model reaction. The reaction was initially performed in the presence of 1 mol% of 3 and Na2CO3 as a base. High conversion was obtained at 50–65 uC within 0.5 h (entries 1 and 2). It is noteworthy that the catalyst 3 shows outstanding performance even at a low temperature of 40 uC (entry 3). When the loading of 3 was decreased from 1 mol% to 0.01 mol%, reactivity was slightly influenced (entries 4–7). Surprisingly, high conversion could be still maintained at 0.01 mol% of very low catalyst loading, in which high TOF of 9100 h21 was obtained for the coupling (entry 7). The results are summarized in Table 1. Further optimization of the reaction conditions was not attempted to obtain higher TOF. Solvent effect on the activity of 3 was surveyed with different polar solvents. When the reaction was conducted in aqueous DMSO, DMA, ethanol and methanol instead of aqueous DMF, similar results were obtained under the same conditions (entries 8–18). It is interesting that the reactions in aqueous ethanol and methanol gave excellent results. Aqueous solvent appears to be necessary for mild conditions because of low solubility of Na2CO3 in organic solvents. The complex is very stable to oxygen and moisture. Less change of its activity was observed when the Pd complex was exposed to air and water in the Suzuki reaction. We next examined the catalytic activity of 3 for reaction of aryl halides with arylboronic acid. As shown in Table 2, high catalytic activity was observed in the coupling of deactivated aryl iodides such as 2-iodoanisole, 4-iodo-anisole, 2-iodotoluene and 38 | Green Chem., 2008, 10, 37–40

4-iodophenol (entries 1–4) as well as activated 1-iodo-4-nitrobenzene and 1-iodo-3-nitrobenzene (entries 5 and 6). Deactivated aryl iodides possessing an electron-donating group showed a slight drop in reactivity compared to those possessing an electronwithdrawing group. However, only a little longer reaction time was required to reach almost quantitative conversion. In order to investigate the scope on aryl halides in the coupling with phenylboronic acid, different aryl bromides were employed in the reaction (entries 7–13). Electron-rich, electron-neutral, and electron-poor aryl bromides were readily coupled in the presence of catalyst 3. The catalytic system was further extended to the coupling reactions with arylboronic acids containing electrondonating and electron-withdrawing substituents(entries 14–19). Most of the reactions could be also conducted with high yields. Table 1

Susuki coupling of iodobenzene with phenylboronic acida

Entry Solvent (1 : 1) 3 (mol%) Temp./uC Time/h Yieldb (%) 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18

DMF–H2O DMF–H2O DMF–H2O DMF–H2O DMF–H2O DMF–H2O DMF–H2O DMA–H2O DMA–H2O DMA–H2O DMA–H2O DMSO–H2O DMSO–H2O DMSO–H2O EtOH–H2O EtOH–H2O MeOH–H2O MeOH–H2O

1 1 1 0.5 0.1 0.05 0.01 1 0.5 0.1 0.05 1 0.5 0.1 1 0.5 1 0.5

65 50 40 65 65 75 85 65 65 65 75 65 65 65 65 65 65 65

0.3 0.5 1.0 0.4 0.5 0.5 1.0 0.3 0.3 0.4 0.5 0.3 0.4 0.5 0.4 0.5 0.4 0.5

100 93 90 100 100 (96) 95 (90) 91 100 100 100 96 100 99 99 98 96 98 97

a Molar ratio: iodobenzene (1.0 equiv.), phenylboronic acid (1.1 equiv.), Pd complex 3 (1–0.01 mol%. Pd loading ratio = 0.34 mmol g21), and Na2CO3 (2.0 equiv.). b GC yield determined using n-dodecane as an internal standard and based on the amount of iodobenzene employed. Isolated yield is given in parenthesis.


Table 2 Suzuki coupling of various aryl halides with arylboronic acida

Substrate 1

ArB(OH)2

Time/h

Yieldb (%)

0.6

92

2

0.5

95 (91)

3

0.8

90

4

0.4

100

5

6

0.3

0.3

Table 2 Suzuki coupling of various aryl halides with arylboronic acida (Continued )

Time/h

Yieldb (%)

18

0.7

100

19

0.8

99

20

3

46

21

12

99 (92)

22

12

66/23c

23

20

50/29c

Substrate

100

100

7

0.5

95 (90)

8

0.8

91

9

0.7

92

10

0.6

95

11

1.0

96

12

0.4

100

13

0.4

100

14

1.0

95

a Molar ratio: aryl halide (1.0 equiv.), arylboronic acid (1.1 equiv.), Pd complex 3 (0.1 mol%. Pd loading ratio = 0.34 mmol g21), and Na2CO3 (2.0 equiv.). b GC yield determined using n-dodecane as an internal standard and based on the amount of iodobenzene employed. Isolated yield is given in parenthesis. c The GC yield of biphenyl. Entries 21–23: reactions were performed in the presence of 1 mol% of catalyst 3 at 85 uC.

However, catalyst 3 showed low activity in the reaction of deactivated 2-bromoanisole with electron-rich 2-methoxyphenylboronic acid (entry 20). A trace amount of biphenyl was detected as a by-product in the reactions of aryl iodides and aryl bromides. Encouraged by these results, we tested the coupling of several aryl chlorides in the presence of 1 mol% of 3 at 85 uC. The reaction of chlorobenzene with phenylboronic acid proceeded smoothly to afford biphenyl product with high yield (entry 21). However, low yields were observed in the coupling of substituted aryl chlorides (entries 22 and 23). In addition, biphenyl by-product from homocoupling of phenylboronic acid was remarkably formed with the increase of temperature and the prolongation of reaction time. The recycling of the catalyst is an important issue in the heterogeneous reaction. We turn our attention to reusability of our Pd catalyst. As shown in Table 3, the catalyst 3 was recycled in the Table 3

Reusability of Pd complex 3 in Suzuki couplinga

Aryl halide 15

0.7

92

16

3

83

17

3

ArB(OH)2

91


Cycle

Yieldb (%)

Cycle

Yieldb (%)

1 2 3

100 100 100

4 5 6

100 98 96

1 2 3

100 100 100

4 5 6

100 99 98

a Molar ratio: aryl halide (1.0 equiv.), phenylboronic acid (1.1 equiv.), 3 (0.2 mol%.), and Na2CO3 (2.0 equiv.). b GC yield determined using n-dodecane as an internal standard and based on the amount of aryl halide employed.

Green Chem., 2008, 10, 37–40 | 39

reactions of iodobenzene and 1-bromo-4-nitrobenzene with phenylboronic acid. We have observed that the catalyst could be reused six times without significant loss of activity. Furthermore, analysis of the solution by atomic absortion indicated that no Pd species leached into the reaction solution. This excellent reusability and high stability of the catalyst would be explained by strong binding of the NHC to palladium and site isolation, that is, the absence of interactions between catalytic sites, which are followed by aggregation of the Pd complex and formation of less active Pd catalyst.

4

5

Conclusions In conclusion, we have easily prepared a silica-supported NHC–Pd complex 3 from triethoxysilylated ionic liquid 1. The heterogeneous complex showed high catalytic activity for Suzuki coupling reaction in an aqueous medium. Furthermore, this catalyst could be simply recovered and reused without a significant loss of catalytic activity. Further studies of other coupling reactions catalyzed by this system are currently in progress.

6 7

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