buckthorn (Hippophae Rhamnoides L.) Oil as Depot Formulation. ALIRASHID, ALI ... act as depot and provide sustained effect for prolong period of time.
International Journal of Drug Development & Research | July-September 2011 | Vol. 3 | Issue 3 | ISSN 0975-9344 | Available online http://www.ijddr.in Covered in Official Product of Elsevier, The Netherlands ©2010 IJDDR Safety and Efficacy Study of Intramuscularly Administered Sea buckthorn (Hippophae Rhamnoides L.) Oil as Depot Formulation
FULL Length Research Paper Covered in Index Copernicus with IC Value 4.68 for 2010
ALI RASHID, ALI RAISUDDIN, NISHAD DHRUV KUMAR*, JAIMINI ABHINAV, TYAGI AMIT, MITTAL GAURAV, SULTANA SARWAT AND BHATNAGAR ASEEM Institute of Nuclear Medicine and Allied Sciences, Brig. SK Mazumdar Marg, Delhi, India. Department of Medical Elementology & Toxicology, Faculty of Science, Jamia Hamdard, Delhi, India. Abstract
Key words:
The present study was performed to assess the sub-chronic toxicity and efficacy study of seabuckthorn (Hippophae rhamnoides L) oil administered intramuscularly in New
Seabuckthorn oil; Intramuscular administration; Antioxidant Status; Rabbit; Histopathology.
Zealand white rabbits. Seabuckthorn oil was administered intramuscularly, at doses of 0.5, 1 and 1.5 ml/kg body weight
How to Cite this Paper:
in three groups of animals and the dose was scheduled once in
Ali Rashid, Ali Raisuddin, Nishad Dhruv Kumar,
a week up to seven weeks. Total antioxidant status was
Jaimini Abhinav, Tyagi Amit, Mittal Gaurav, Sultana
studied after the first intramuscular administration of oil that act as depot and provide sustained effect for prolong period of time. The clinical signs of toxicity data were collected and
Sarwat And Bhatnagar Aseem , “Safety and Efficacy Study
Of
Intramuscularly
Administered
observed daily. No mortality was seen in any of the treatment
Seabuckthorn (Hippophae Rhamnoides L.) Oil As
groups during the course of study. Various physiological,
Depot Formulation”, Int. J. Drug Dev. & Res., July-
hematological, biochemical (AST, ALT, ALP, Uric acid, Urea
Sep 2011, 3(3): 356-365
and creatinine) as well as histopathological parameters were studied and found not to be changed significantly, indicating that intramuscular seabuckthorn oil is non toxic even at higher dose level in rabbits. The studies revealed significant
Copyright © 2010 IJDDR, Nishad Dhruv Kumar et al. This is an open access paper
increase (p
