RESEARCH ARTICLE
HIV-Helicobacter pylori Co-Infection: Antibiotic Resistance, Prevalence, and Risk Factors Marcel Nkuize1*, Stéphane De Wit2, Vinciane Muls1, Marc Delforge2, Véronique Y. Miendje Deyi3, Guy B. Cadière4, Michel Buset1 1 Department of Gastroenterology and Hepatology, CHU Saint-Pierre, Université Libre de Bruxelles, Brussels, Belgium, 2 Division of Infectious Diseases, CHU Saint-Pierre, Université Libre de Bruxelles, Brussels, Belgium, 3 Department of Microbiology, CHU Brugmann, Université Libre de Bruxelles, Brussels, Belgium, 4 Department of Digestive Surgery, CHU Saint-Pierre, Université Libre de Bruxelles, Brussels, Belgium *
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Abstract Background
OPEN ACCESS Citation: Nkuize M, De Wit S, Muls V, Delforge M, Miendje Deyi VY, Cadière GB, et al. (2015) HIVHelicobacter pylori Co-Infection: Antibiotic Resistance, Prevalence, and Risk Factors. PLoS ONE 10(12): e0145119. doi:10.1371/journal. pone.0145119 Editor: Anil Kumar Tyagi, University of Delhi, INDIA Received: August 10, 2015 Accepted: November 28, 2015 Published: December 21, 2015 Copyright: © 2015 Nkuize et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the paper. Funding: The authors have no support or funding to report. Competing Interests: The authors have declared that no competing interests exist.
Patients infected with human immunodeficiency virus (HIV) are living longer due to the availability of more potent treatments. However, prescription of antibiotics to treat or prevent infections in these patients may increase the likelihood of co-infection with antibiotic-resistant species.
Aim To compare antimicrobial susceptibility of Helicobacter pylori (H. pylori) in HIV-positive and HIV-negative patients and assess risk-factors for resistance.
Methods We prospectively collected data from consecutive HIV-positive and HIV-negative patients undergoing upper gastrointestinal endoscopy. Patients with H. pylori-positive gastric biopsies who had never received H. pylori treatment were included.
Results Of the 353 patients included, 93 were HIV-positive and 260 HIV-negative. Among the HIVpositive patients, 56 (60%) had been infected for
