hupo 4th annual world congress - TUM

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August 29 - September 1, 2005 ... HUPO 2005 • FINAL PROGRAM. 3 .... www.eurokongress.de ..... The program also includes a walking tour of Munich. ..... HUPO 2005 • FINAL PROGRAM. INVITED FACULTY. Hubert Hondermarck,. France.
FINAL PROGRAM

HUPO 4TH ANNUAL WORLD CONGRESS F R O M D E F I N I N G T H E P R OT E O M E T O U N D E R S TA N D I N G F U N C T I O N

Human Proteome Organisation

August 29 - September 1, 2005 International Congress Center Munich Munich, Germany

www.hupo2005.com

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TABLE OF CONTENTS General Information Committees . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .4 Message from the President of the Technical University of Munich . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .5 Message from the HUPO President . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .6 Message from the Congress Co-Chairs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .6 Congress Information . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .7 About Munich . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .11 Social Program . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .12 Accompanying Persons & Tours . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .13

Scientific Program Industry-Sponsored Symposia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .16 How This Program Is Organized . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .21 Instructions to Oral and Poster Presenters . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .22 Invited Faculty . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .23 Detailed Program . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .25 Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .115

Exhibit Directory List of Exhibitors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .129 Exhibit Floor Plan . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .130 Exhibitor Details . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .136

THIS FINAL PROGRAM IS SUPPORTED IN PART BY BD.

Congress Secretariat c/o Events International Conference Planners Inc. 1350 Sherbrooke Street West, Suite 1500 Montreal, Québec, Canada H3G 2T4 Tel.: (514) 286-0855 Fax: (514) 286-6066 E-mail: [email protected] http://www.hupo2005.com/

Local Coordinator www.eurokongress.de Printed in Germany, August 2005

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COMMITTEES Congress Organizing Committee Angelika Görg Co-Chair, HUPO 4th Annual World Congress Matthias Mann Co-Chair, HUPO 4th Annual World Congress John Bergeron HUPO President Paul Stinson HUPO Director General

Arne Skerra, Technische Universität München, Department of Biological Chemistry, Freising, Germany Naoyuki Taniguchi, Osaka University Graduate School of Medicine, Osaka, Japan Mathias Uhlen, Royal Institute of Technology, Stockholm, Sweden

Wehbeh Barghachie HUPO Congress Director

Walter Weiss, Technische Universität München, Department of Proteomics, Freising, Germany

Walter Weiss Director of the Scientific Program Committe

HUPO Executive Committee

Anthony Zitzmann Treasurer Günter Theßeling Congress Consultant

John Bergeron, McGill University, Montreal, Canada Samir Hanash, Fred Hutchinson Cancer Research Center, Seattle, WA, United States

Sandrine Palcy HUPO Education and Training Coordinator

Matthias Mann, University of Southern Denmark, Odense, Denmark; MaxPlanck Institute for Biochemistry, Martinsried, Germany

Abstract Review Committee

Jan Van Oostrum, Novartis Institutes for Biomedical Research, Basel, Switzerland

Rolf Apweiler, EMBL Outstation, European Bioinformatics Institute (EBI), Hinxton, Cambridge, United Kingdom Fuchu He Beijing Institute of Radiation Medicine, Beijing, China; Institutes of Biomedical Sciences, Fudan University, Shanghai, China Bernhard Kuester, Cellzome AG, Heidelberg, Germany Helmut Meyer, Ruhr University Bochum, Bochum, Germany Gil Omenn, University of Michigan, Ann Arbor, MI, United States Young-Ki Paik, Yonsei University, Yonsei Proteome Research Center, Seoul, Korea Peipei Ping, UCLA School of Medicine, Division of Cardiology, Los Angeles, CA, United States Richard Simpson, Ludwig Institute for Cancer Research, Parkville, Australia

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Young-Ki Paik, Yonsei University, Yonsei Proteome Research Center, Seoul, Korea Richard Simpson, Ludwig Institute for Cancer Research, Parkville, Australia

MESSAGES Message from the President of the Technical University of Munich It is a great pleasure for me to host the 4th HUPO World Congress in Munich. Due to the tremendous response from the scientific and industrial communities, the venue of the congress had to be moved from the TUM campus, which is familiar to most of you from the previous international „Proteomic Forum" meetings – organized biannually by Angelika Görg – to the International Congress Center. The hosting of the 4th HUPO World Congress is a significant event for our university. The TECHNISCHE UNIVERSITÄT MÜNCHEN (TUM) holds a unique position in Europe in terms of the choice of fields it offers. With 400 professors and 8,500 total staff, the TUM covers all areas of the natural and engineering sciences, along with medicine and life sciences. We are ranked foremost among German universities in terms of both total research grant turnover and the number of our guest researchers from all over the world, working at our university with the support of the Alexander von Humboldt Foundation. Moreover, our scientists are currently involved in 17 special research programs financed by the German Research Association. The TUM was founded in 1868 by King Ludwig II in the form of the independent 'Royal Polytechnic'. As Karl Max von Bauernfeind, its first rector, said in his inauguration address, the establishment was founded to "bring the vitalizing sparks of science to bear on technology". Since the time of its foundation, the TUM has earned itself an international reputation in many fields, and accordingly we take the greatest possible care in the selection of our professors. We can point out with pride that a number of Nobel prize winners originate from our university, namely Heinrich Wieland, Hans Fischer, Rudolf Mößbauer, Ernst Otto Fischer, and Robert Huber. Other laureates gained their scientific education at the TUM, as in the case of Konrad Bloch, Klaus von Klitzing, and Wolfgang Ketterle. But scientific success it not only a matter of Nobel prizes and other scientific distinctions but is also expressed by technological developments and new processes and machines. For example, the engineer Carl von Linde (1842-1934), one of our first professors, discovered the liquefaction of air back in 1879, a discovery with revolutionary consequences in all areas of life by introducing refrigeration. Linde's student Rudolf Diesel (1858-1913) was inspired at the then "Technische Hochschule München" to invent the motor engine named after him. Further famous scientists, engineers and inventors of our university include Emil Erlenmeyer (chemistry), Claude Dornier (aircraft engineering), and Willy Messerschmidt (aircraft construction). Recent discoveries and developments in the Life Sciences are spawning new industries and technologies at a breathtaking pace. Life Sciences in general, and proteomics in particular, have a great research and economic potential. I wish the 4th HUPO World Congress every success and would like to cordially invite you to participate in the congress.

Prof. Dr. Dr. hc mult. Wolfgang A. Herrmann President of the TECHNISCHE UNIVERSITÄT MÜNCHEN

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MESSAGES Message from the HUPO President Dear Colleagues, On behalf of the Human Proteome Organisation, I would like to welcome you to the HUPO 4th Annual World Congress in Munich. This year’s congress is entitled "From defining the proteome to understanding function" and it emphasizes the theme of biological function. Building on the success of HUPO’s past congresses, HUPO’s strength and leadership in the field of Proteomics and the success of the Proteomic Forum led by Prof. Görg, the congress has generated a great interest that is represented by the participation of delegates from 50 different countries. This tremendous response requiring a space capacity that exceeded the originally planned venue forced us to move the congress from the Technical University to the International Congress Center. Whether you are attending the congress to share information, to learn, to discover new technologies or to simply have the opportunity to network with scientists of similar interests, I trust that you will find that HUPO’s passion to the field of Proteomics and its commitment to bring the best science to its congress will help you achieve your goal and will re-confirm that the HUPO Annual Congress is the "Can’t Miss Congress of the Year" for you and your colleagues throughout the World. Enjoy your stay in Munich and hope to see you in Long Beach, California next year for HUPO 5th Annual World Congress October 27 to November 1, 2006.

John Bergeron HUPO President

Message from the Congress Co-Chairs Proteomics is becoming one of the hottest areas of research, driven by breathtaking advances in technology and ever more sophisticated applications to almost every area of biology and biomedicine. Proteomics provides us with data about the actual actors in the cell and is thus also in a unique position to integrate data from all of functional genomics into a coherent picture of cellular function. So far, proteomics has just given us a taste of what will be possible. Emphasizing the theme of biological function, the 4th Annual HUPO conference is bringing together leading scientists from all over the world that share an interest in making an impact on biological understanding through the use of proteomics tools. The conference continues the tradition of the previous HUPO conferences and will be the official main event in the field. It will also draw on the tradition of the bi-annual international conference Proteomic Forum, established by Angelika Görg in Munich – another 'can’t miss' event in proteomics. Apart from demonstrating the breadth of proteomics applications to biological function and updating you on the status of major proteomics initiatives, we are bringing together the world’s leading technology pioneers. The conference also offers authoritative tutorials on technology and a 'doctor’s office' to guide proteomics researchers. We welcome you to HUPO 2005!

Angelika Görg, Technische Universität München, Munich Germany

Matthias Mann, Department of Proteomics and Signal Transduction, Max-Planck Institute for Biochemistry, Martinsried, Germany

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CONGRESS INFORMATION BEST ABSTRACT AWARD Sponsored by GE Healthcare Three abstract awards will be presented during the Closing Ceremonies on September 1. BOOK OF ABSTRACTS The Journal of Molecular & Cellular Proteomics is the publisher of the book of abstracts which is included as a separate publication in your delegate bag. Late-breaking abstracts are printed and included in the delegate bag as a separate document. BUSINESS CENTRE A business centre is available at the ICM during the conference dates and will be able to handle your requests for photocopies, faxes etc. CERTIFICATE OF ATTENDANCE Sponsored by Applied Biosystems A personalized certificate of attendance is included in your registration package as proof of attendance. COAT CHECK During the HUPO congress, there will be a coat check available for delegates to leave their jackets and suitcases. CME CREDITS This event is approved for up to 35.5 credits by the Centre for Continuing Medical Education (“CME”). The Centre for CME, Faculty of Medicine, McGill University is fully accredited by the Committee on Accreditation of Canadian Medical Schools (CACMS), and through the CACMS is accredited to award AMA PRA: Category 1 credits. This event is an accredited group learning activity (Section 1) as defined by the Maintenance of Certification program of the Royal College of Physicians and Surgeons of Canada. The Centre for CME, Faculty of Medicine, McGill University designates this activity for Category 1 credit towards the AMA Physicians Recognition Award up to the maximum number of credit hours noted above. Each physician should claim only those hours of credit that he/she actually spent at the educational activity. Delegates requiring CME Credits must sign in at the CME desk every day that they are present at the congress. Attestation certificates must be collected on your last day of attendance at the congress. COFFEE BREAKS Daily coffee breaks will be served in the Exhibit Hall. Sunday and Thursday coffee breaks are served in the foyer of the ICM. For exact timing, please refer to the detailed program. CONGRESS EVALUATION A congress evaluation form is included in your delegate bag. Please complete it and drop it off at the Registration Desk in the box provided. DELEGATE LANYARD Sponsored by GE Healthcare

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CONGRESS INFORMATION DELEGATE BAG Sponsored by GE Healthcare EXHIBITION The HUPO Congress is proud to host a commercial exhibition featuring state-of-the-art products and services. Please refer to pages 131 - 135 for a directory of exhibitors and exhibit floor plan. The Exhibit Hall is located in Hall B0. EXHIBIT HOURS Sunday, August 28, 2005

18:00-20:00

(Official Exhibit Opening and Welcoming Reception)

Monday, August 29, 2005 Tuesday, August 30, 2005 Wednesday, August 31, 2005

10:00-18:00 10:00-18:00 10:00-18:00

INFORMATION Should you require any assistance during the Congress, please call the Congress Services desk at 089-949 79 400. The Conference desk will be located in the registration area. This information desk will be in service for the duration of the congress. INTERNET ACCESS Internet Café Sponsored by Applied Biosystems The Internet Café, located in the Exhibit Hall, will allow delegates to have access to E-mail and Internet. The terminals will operate during exhibit hours. Wireless Internet Area Sponsored by BD Wireless Internet is available for delegates carrying a laptop and can be accessed in the foyer in front of the Exhibit Hall B0. Access cards are available at the BD booth, #200. LANGUAGE English is the official language of the congress. LOST AND FOUND Any lost and found items will be held at the Congress Services desk for the duration of the event. For any unclaimed items after the conferences, contact Events International. MEALS AND REFRESHMENTS Coffee breaks will be served daily, in the morning and afternoon in the Exhibit Hall from Monday to Wednesday and in the foyer on Sunday and Thursday. For times of service, please refer to the detailed program section. A concession stand will be available inside the Exhibit Hall and in the foyer, near the Wireless Internet Area. The Industry-Sponsored Symposia taking place during lunch will cater lunch to their attendees exclusively. PORTFOLIO Sponsored by Thermo Electron Corporation The portfolio is included in your delegate bag for your use during the congress.

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CONGRESS INFORMATION PUBLIC NOTICE The ICM is a smoke-free convention centre. Smoking is permitted only outside the building. REGISTRATION Registration is located in the foyer of the ICM. REGISTRATION HOURS Sunday, August 28 Monday, August 29 Tuesday, August 30 Wednesday, August 31 Thursday, September 1

07:30-18:30 07:30-18:00 07:00-18:00 07:00-18:00 07:30-15:30

Name Badges For security purposes, delegates, accompanying guests and exhibitors must wear their name badges when onsite at the ICM as well as to the Congress Dinner on Wednesday evening. Name badges will be given to you when you register. Ribbon Colours Blue: Regular Delegate and Invited Speakers Orange: Students Red: Single Day Purple: Accompanying Persons Green: Exhibitors Black: Press None: Staff SECURITY Full security staffing has been implemented for the safety of participants. For any emergency or first aid services inside the ICM, please call 949 24 556. TOURS Should you be interested in obtaining information on guided tours, please refer to the tour sections on page 13: or discuss with the concierge at your hotel. TRANSPORTATION PASS Your name badge is automatically your transportation pass. On the reverse side, you will find the logo of MVV (Münchner Verkehrs- and Tarifverbund). You do not need to show your badge when entering the Underground. However, on an occasional basis, a ticket controller may ask you to show your pass.

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ABOUT MUNICH & USEFUL INFORMATION Welcome to Munich, the often called ‘City with Heart’ which is Germany’s most popular destination and has something to offer to everyone, from culture, high-tech, parks and greenery, to night-life, architecture, beer gardens, shopping or the nearby mountains and lakes. Munich is much more than just the venue for the world-famous Oktoberfest, it is the high-tech capital of Germany with many headquarters of international companies such as BMW, MAN, Siemens and many others. You could lose yourself for days in one of the numerous museums and famous art galleries as well as the countless beautiful churches and other historic buildings, not to mention the royal castles in and around Munich. Tour information is available on page 13. COMMUNICATION Public telephones are easy to locate and calling cards may be used. They can be purchased at most convenience stores and newsstands. Major credit cards are also acceptable billing alternatives. CREDIT CARD NUMBERS In order to report lost or stolen credit cards, there is now one central number serving any credit card and EC card. American Express Mastercard Visa

069-97971000 069-79331910 0800-8149100

CURRENCY The Euro is the national currency. At press time $1 US = €0.827; €1 = $1.209 US (July 2005). Automatic teller machines and exchange offices are readily available. Most hotels, restaurants and shops accept major credit cards. DRESS CODE The dress code during the conference as well as for the Congress Dinner is casual. ELECTRICITY The electrical voltage is 220-volts, 50 Hz AC. GETTING AROUND MUNICH Clean, safe, and comfortable, the underground subway system called the “U-Bahn” is an ideal, economical way to reach many of Munich’s hotels, attractions as well as the ICM. Given the traffic in Munich, it is also an efficient and environmentally responsible means of commuting. A transportation pass is provided for each delegate and is printed on the reverse side of the registration badge.

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ABOUT MUNICH & USEFUL INFORMATION IMPORTANT TELEPHONE NUMBERS 089 is the area code for Munich. When making phone calls within Munich, the area code must not be dialed. HOTEL INFORMATION Best Western Apart Hotel Conrad Hotel de Ville Dorint Sofitel Bayerpost Dorint Novotel Messe München Eden Hotel Wolff Hotel 3 Löwen Hotel 3 Löwen Residenz Hotel EUROPA Hotel Ibis München City Hotel Mercure München City Hotel Präsident Hotel Wallis King’s Hotel Center King’s Hotel First Class NH Hotel Deutscher Kaiser

089-1592570 089-545560 089-599480 089-994000 089-551150 089-551040 089-551040 089-542420 089-551930 089-551320 089-5490060 089-5490290 089-515530 089-551870 089-54530

SHOPPING In Munich you will find something for everyone! All shops of the exclusive labels such as Escada, Prada, Louis Vuitton, Versace, Giorgio Armani etc. are in the city centre pedestrian areas. In the city centre shops are usually open Monday through Saturday from 09:00h – 20:00h. All shops are closed on Sunday. Popular shopping districts are located around the Frauenkirche, Theatinerstrasse, Residenzstrasse and Odeonsplatz, Maximillianstrasse as well as Marienplatz and Sendlinger Strasse For more information, visit the tour desk or consult with the concierge at your hotel. TIME DIFFERENCE GMT + 1 hour VAT REFUND All goods sold in Germany are subject to 16% value-added tax. Delegates who reside outside the European Union can obtain a partial refund of sales tax on goods purchased during their stay. For further information, please consult with the concierge at your hotel.

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SOCIAL PROGRAM SUNDAY, AUGUST 28, 2005 Welcome Reception 18:00 to 20:00 ICM, Exhibit Hall B0 (included in registration fee) Dress Code: Casual Delegates will have a chance to meet with colleagues and exhibitor representatives as we inaugurate the congress exhibition with a welcome reception, where light refreshments will be served. WEDNESDAY, AUGUST 31, 2005 20:00 to midnight Bavarian Night Congress Dinner Löwenbräukeller, Nymphenburger Strasse 2 (1 ticket included in registration fee per delegate; each additional ticket E35) Dress Code: Casual Located in the heart of Munich, the Löwenbräukeller is the right place to experience Bavarian tradition and taste Bavarian specialties. All the Bavarian traditions are waiting for you during the Congress Dinner. Experience the variety of the Bavarian cuisine, taste the famous Bavarian beer and enjoy typical music in a traditional Bavarian atmosphere. How to get here: The easiest way to get from the ICM to the Löwenbräukeller is by subway (U-Bahn). You can take all trains leaving from the ICM (subway station ‘Messestadt West) in direction to the city centre/main train station. Get off the train at the main train station (Hauptbahnhof) and change to train number U1 in direction to Rotkreuzplatz/Westfriedhof, which leaves on the same platform. You need to disembark at the next station (Stiglmaierplatz). Please follow the signs to Stiglmaierplatz/Dachauer Str. and take the exit on the left hand side to leave the underground station. Please do not forget your conference name badge that also serves as ticket for the Munich public transport.

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ACCOMPANYING PERSONS PROGRAM Accompanying Persons have access to the Exhibit Hall, the Welcoming Reception and the Congress Dinner. The program also includes a walking tour of Munich. Accompanying Persons Tour – Munich at a Glance: First Impressions Monday, August 29 at 14:30 Duration: 2.5 hours Meeting Point: in front of the town hall (Rathaus), Marienplatz 8 Starting from the town hall you will cover and visit various aspects of Munich’s history – baroque churches, Royal Residence, Opera House as well as the fruit and vegetable market ‘Viktualienmarkt’ - on this instructional walking tour through the city centre. Get an overview and insider information about the offers and attractions of Munich, find your way to landmarks and shopping districts, explore the ambiance of the open food market and taste some delicate specialities and enjoy the catching ambiance of Maximilianstraße, Munich’s haute couture-boulevard. A relaxing prelude for your time in Munich! You may also decide to participate in other city tours or excursions below. OPTIONAL TOURS Panorama Tours offers regular full-day and half-day excursions to the most popular sights in Bavaria and Austria. Trips to Neuschwanstein and Herrenchiemsee have become truly classic tours. They also offer city sightseeing tours for visitors to Munich, focusing on different aspects of the city. A small selection of available city tours and excursions is presented below. These and other tours may be booked at the tour booth in the registration area or with your concierge. Munich Highlights The tour gives you a comprehensive survey of Munich including its major historical sights: the classical architecture of King’s Square, the former artists quarter Schwabing, Arch of Victory, Hall of Generals, Angel of Peace, Deutsches Museum and the world-famous Hofbräuhaus, the Nationaltheater and the Royal Palace. Departure: daily at the full hour between 10:00 and 16:00; Duration: 1 hour; Fee: €11.00 Comprehensive City Tour incl. a guided visit to the Nymphenburg Palace This tour offers a good general impression of the city as we pass the Olympic grounds on our way to the Palace of Nymphenburg, the former summer residence of the Bavarian elector princes and kings. One of the highlights on your guided tour through the palace will be the famous beauty gallery of King Ludwig I. Departure: daily at 14:30; Duration: 2.5 hours; Fee: €19.00 Munich at Its Best This tour gives you a comprehensive survey of the major and most beautiful sights of Munich. On a short guided tour through the Nymphenburg Palace you will learn some interesting details from Bavarian history. To give you an impression of modern Munich as well, you are taken for a short walk through the Olympic Grounds. Departure: daily at 10:30; Duration: 3 hours; Fee: €21.00

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ACCOMPANYING PERSONS PROGRAM Bavarian Film City This tour introduces you to the most beautiful and most outstanding sights of Munich and then takes you to the film studios on the southern city fringes where you learn about the studio premises’ long tradition and you are invited to view what goes on behind the scenes of television and motion picture sets. Departure: Mon, Sat, Sun at 10:00; Duration: 2.5 hours; Fee: €23.00 Munich By Night On this tour you will pass beautifully illuminated monuments, fountains, and buildings. In the famous Hofbräuhaus you will be treated to an evening Bavarian style with music, show and dinner. After that you will be driven through the former artists’ quarter-Schwabing and on to the Olympic Grounds where you can ascend the Olympic Tower to enjoy the marvellous view of the city by night. To end the evening we will have a drink at a nightclub with live music. Price includes: Guided tour, dinner at the Hofbräuhaus, ascent of Olympic Tower, visit to a nightclub including one drink, entrance fees. Single travellers are welcome. Evening dress is not necessary. Subject to change. Departure: Fri, Sat at 19:30; Duration: 4.5 hours; Fee: €60.00 National Garden Show 2005 Munich This tour passes the most beautiful and important sights of Munich before taking you to the 190 hectare grounds of the National Garden Show 2005. Allow yourself to be inspired by the variety in the plant and flower world and experience the fascinating impression of the Garden Show by a short cable car trip. Departure: daily at 10:15; Duration: 4 hours; Fee: €33.00 The Royal Castle of the Herrenchiemsee On the largest of the Bavarian lakes, Chiemsee, we take a boat ride to the Herreninsel. Here you visit Ludwig’s II castle, a replica of the palace of Versailles. We continue by boat to Fraueninsel. You will have time to visit the Benedictine church and a walk on the island. Departure: Monday at 8:30; Duration: 10 hours; Fee: €41.00 (plus entrance fees) The Royal Castles Neuschwanstein and Linderhof Hidden in the seclusion of the mountains King Ludwig II built two of his dream castles: Neuschwanstein and Linderhof. This excursion shows you two extraordinary castles, both testifying to the vision of Bavaria’s fairytale King. Short shopping stop in Oberammergau. Approx. 4 hours time to visit Neuschwanstein and for lunch. Departure: daily at 8:30; Duration: 10.5 hours; Fee: €43.00 (entrance fee €14.50) Other excursions are available to Rothenburg, Eagle’s Nest, Salzburg, Dachau, Zugspitze and Innsbruck.

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SCIENTIFIC PROGRAM

INDUSTRY-SPONSORED SYMPOSIA Sunday, August 28, 2005 16:30-18:00 Room 13 BIO-RAD LABORATORIES Current Sample Preparation and Fractionation Strategies for Proteomics How Can the Preparation of Proteomic Samples Be Optimized? Dr. Anton Posch talks about tips and techniques for high quality protein extraction and discusses critical success factors in 2-D electrophoresis. The MicroRotofor A novel and powerful tool for the fractionation of complex protein samples by micro-preparative isoelectric focusing will be introduced by Dr. Aran Paulus. Protein Visualization and Quantification You Can Rely on Dr. Tom Berkelman presents Flamingo Pink, a novel sensitive fluorescent dye in gel-based Expression Proteomics. Monday, August 29, 2005 12:45-14:15 Room 1 BRUKER DALTONICS Further Dimensions in Proteomics Technology Uwe Rapp European Sales Director, Bruker Daltonics, Bremen, Germany A Universal Toolbox for Quantitative Proteomics After an initial discovery phase, proteomics is now entering a second phase, where the monitoring of changes in protein abundances becomes of major importance. Bruker supports various strategies for protein quantitation by label freeapproaches, stable-isotope labeling, ICAT or the new ICPL technology which is worldwide applicatively supported by Bruker Daltonics. Especially the latter allows for the full range of protein separation technologies providing the scientist with the maximum flexibility in sample preparation and fractionation for his experiments. Wolfgang Albrecht European Director Sales Clinical Proteomics, Bruker Daltonik GmbH, Bremen, Germany ClinProt, an Expandable Platform for Biomarker Discovery Magnetic Beads had been shown as a powerful tool for Biomarker Discovery. In combination with other MS Technologies like Depletion, LC-MALDI and MALDI-Imaging this MALDI-TOF or TOF/TOF approach can be used as a general tool for clinical proteomics, Biomarker Discovery and Identification. Novel beads for antibody-capturing and glycoproteinenrichment expand the opportunities for the research and clinical applications. Marcus Macht Director European Life Science Applications, Bruker, Daltonik GmbH, Bremen, Germany Unique Technologies for Certainty in PTM Discovery In Proteomics projects the reliable detection and characterisation of post-translational modifications (PTMs) such as phosphorylation, sulfatation and glycosylation is a major challenge. However, more refined and dedicated strategies in

16

HUPO 2005 • FINAL PROGRAM

INDUSTRY-SPONSORED SYMPOSIA MS/MS and MSn make PTMs better accessible now by mass spectrometry. Various kinds of new MS/MS technologies like ETD (electron transfer dissociation) combined with elaborate software tools for the elucidation of PTM will be presented. Monday, August 29, 2005 12:45-14:15 Room 13 SIGMA-ALDRICH CORPORATION Novel Tools for Proteomics: Identification of Plasma Proteins and Scoring Proteomics with Proteotypic Peptide Probes Chair: Klaus Herick, Sigma-Aldrich Corporation, Munich, Germany 12:45-13:00 13:00-13:05 13:05-13:45

13:45-14:15

Registration Introduction & Welcome Klaus Herick, Sigma-Aldrich Corporation, Munich, Germany Scoring Proteomics with Proteotypic Peptide Probes Ruedi Aebersold, Institute for Molecular Systems Biology, ETH Zurich, Faculty of Natural Science, University of Zurich, Switzerland and Institute for Systems Biology, Seattle, WA, USA Identification of Proteins in Human Plasma Following Removal of 20 High Abundance Proteins Michael Pisano, President and Cofounder, Proteomic Research Services Inc., Ann Arbor, MI, USA

Tuesday, August 30, 2005 07:00-08:00 Room 5 NONLINEAR DYNAMICS Modas 2D/MS – The First Fully Integrated Proteomics Platform Chair: John Spreadbury, Group Sales & Marketing Director, CEO Nonlinear USA, Nonlinear Dynamics 07:00-07:10 07:10-07:30 07:30-07:50 07:50-08:00

Buffet Breakfast Analysing Data across the Proteomics Workflow Professor Mark S. Baker, CEO, Australian Proteome Analysis Facility (APAF) MODAS 2D/MS – The Integrated Platform for Proteomics Analysis Stephen David & Philippe Bogard, Strategic Marketing, Nonlinear Dynamics, UK Questions and Further Discussion Prize draw - Attend HUPO 2006, Long Beach, California (Your chance to win complimentary registration and hotel accommodation)

Tuesday, August 30, 2005 12:45-14:15 Room: 1 BD Breaking Through Hurdles in Clinical Proteomics: New Techniques for Protein Collection & Stabilization, Separation, and Phosphorylation Event Analysis Chair: Bruce C. Haywood, Business Development Leader, BD Diagnostics, Preanalytical Systems, Franklin Lakes, USA

HUPO 2005 • FINAL PROGRAM

17

INDUSTRY-SPONSORED SYMPOSIA 12:45-12:55

12:55-13:30

13:30-14:05 14:05-14:15

Overview Bruce C. Haywood, Business Development Leader, BD Diagnostics, Preanalytical Systems, Franklin Lakes, USA Novel Methods for Sample Collection, Stabilization, and High-Resolution Separation of Plasma Proteins Christoph Eckerskorn, Dr., PD, Vice President, Science & Technology Proteomics, BD Diagnostics, Im Innovationszentrum Biotechnologie, Martinsried, Germany Signaling Network Analysis in Single Cells: Techniques and Clinical Applications Robert Balderas, Vice President, Research and Development, BD Biosciences, San Diego, USA Questions and Answers

Tuesday, August 30, 2005 12:45-14:15 Room 13 THERMO ELECTRON CORPORATION Proteomicsn – Proven Solutions for Proteomics Chair: Michaela Scigelova, Thermo Electron Corporation 12:45-12:55 12:55-13:25

13:30-14:00

14:00-14:15

Welcome and Introduction Michaela Scigelova, Ph.D, Thermo Electron Corporation, Hemel, Hempstead, UK The Quest for Biomarkers of Human Brain Disorders Prof. Chris Turck, Ph.D, Dept. Proteomics, Max Planck Institute of Psychiatry, Martinsried, Germany Protein Identification with Near Certainty on an LTQ-FT Prof. Matthias Mann, Ph.D, Director Center for Experiment Bio-Informatics (CEBI) and Max Planck Institute for Biochemistry, Martinsried, Germany Discussion with Speakers

Wednesday, August 31, 2005 07:00-08:00 Room 5 AGILENT TECHNOLOGIES Latest Trends in Proteomics Chair: Dr. Rudolf Grimm, Agilent Technologies, Santa Clara, CA, United States 07:00-07:05 07:05-07:35

07:35-07:55 07:55-08:00

Introduction & Breakfast Dr. Rudolf Grimm, Agilent Technologies, Santa Clara, CA, United States Quantitative Proteomics: Current Technologies and New Directions Professor Ruedi Aebersold, ETH Zurich, Switzerland, Institute for Systems Biology, Seattle, WA, United States Recent Technology Advances and Latest Trends to Enhance Proteomics Research Dr. Friedrich Mandel, Agilent Technologies, Germany Closing Remarks Dr. Rudolf Grimm, Agilent Technologies, Santa Clara, CA, United States

12:45-14:15 18

HUPO 2005 • FINAL PROGRAM

INDUSTRY-SPONSORED SYMPOSIA Wednesday, August 31, 2005 Hall 14 GE HEALTHCARE 12:45-13:00 13:00-13:20

13:20-13:40 13:40-14:00 14:00-14:15

Introduction Dr. Joakim Rodin, V.P. Development, GE Healthcare 2-D DIGE as an Analytical Tool for Quantitative Multivariable Differential Display Proteomics Dr. David Friedman, Research Assistant Professor of Biochemistry Associate Director, Proteomics Laboratory Mass Spectrometry Research Center Vanderbilt University Peptidomics and Parkinson’s Disease Dr. Per Andren, Laboratory for Biological and Medical Mass Spectrometry Uppsala University Expanding the Potential of Proteomic Analysis Using DeCyderTM EDA Dr. Mark O’Connor, KuDOS Pharmaceuticals Ltd. Questions & Answers - Closing Remarks Dr. Joakim Rodin, V.P. Development, GE Healthcare

Wednesday, August 31, 2005 12:45-14:15 Room 13 WATERS CORPORATION A Novel Methodology That Enables More Than Label Free Quantitation 12:45-13:05 13:05-13:35 13:35-14:05 14:05-14:15

Welcome and Lunch An Introduction to the Waters Protein Expression System ® Applications Of The Waters Protein Expression System ® Discussion

Thursday, September 1, 2005 12:15-13:30 Room 5 APPLIED BIOSYSTEMS Innovative Solutions for Protein Biomarker Discovery and Validation Chair: Volker Kruft, Manager Application Support Proteomics, Applied Biosystems, Darmstadt, Germany 12:15-13:30 12:15-12:40

12:50-13:20

13:20-13:30

Lunch Introducing the 4800 MALDI TOF/TOFTM Analyzer – the Most Direct Path to Definitive Protein Identification and Quantitation Matthew Willetts, Senior Specialist Technical Marketing Proteomics, Applied Biosystems, Framingham, United States Volker Kruft, Manager Application Support Proteomics, Applied Biosystems, Darmstadt, Germany New Developments in LC/MS for Protein Biomarker Discovery and Validation Dominic Gostick, Director, 4800 and QSTAR Product Lines, Applied Biosystems, Framingham, United States Christof Lenz, Senior Specialist Mass Spectrometry Protein, Applied Biosystems, Darmstadt, Germany Summary & Conclusions HUPO 2005 • FINAL PROGRAM

19

HOW THIS PROGRAM IS ORGANIZED EP = Educational Program PL = Plenary Session PS = Parallel Session IS = Industry Symposium MP = Monday Poster Display TP = Tuesday Poster Display WP = Wednesday Poster Display The Plenary Sessions are coded as follows:

PL1.1.02  Plenary On the first day of the Congress The first plenary of the day The second speaker in plenary session

Parallel Sessions are coded as follows:

PS2.3.05  Parallel Session On the second day of the Congress The fifth speaker in the parallel session

Poster sessions are coded as follows:

T P 18  Day of Display Poster Poster Number TP18, will be displayed on Tuesday found on the 18th Poster Board Surface.

POSTER CATEGORIES ON DISPLAY PER DAY MONDAY POSTER DISPLAY Medical, Clinical, Pharmaceutical and Disease Proteomics MP001 – MP090 Cancer Proteomics MP091 – MP157 Clinical Biomarker Discovery MP158 – MP171 Heart & Stroke MP172 – MP183 Liver

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HUPO 2005 • FINAL PROGRAM

HOW THIS PROGRAM IS ORGANIZED MP184 – MP212 MP213 – MP219 MP220 – MP230 MP231 – MP239 MP240 – MP250 MP251 – MP270 MP271 – MP290

Neuroproteomics Obesity & Diabetes Plasma Target Identification and Validation Toxicology Other Tissues Other

TUESDAY POSTER DISPLAY TP001 – TP042

News Corner

Post-Translational Modifications TP043 – TP055 Glycosylation and Glycoproteomics TP056 – TP079 Phosphorylation and Phosphoproteomics TP080 – TP090 Other Proteomics Technologies TP091 – TP114 2D Electrophoresis TP115 – TP147 Mass Spectrometry Technology TP148 – TP185 Mass Spectrometry based Quantitative Proteomics TP186 – TP203 Nanotechnology/ Protein Arrays TP204 – TP208 Protein Chemistry TP209 – TP234 Protein Prefractionation Technologies TP235 – TP252 Other TP253 – TP292

Bioinformatics

WEDNESDAY POSTER DISPLAY Functional Proteomics WP001 – WP020 Cell Signaling WP021 – WP057 Protein-Protein Interactions and Networks WP069 – WP087 Antibodies WP088 – WP100 Brain WP101 – WP106 Glycoproteomics WP107 – WP116 New Technologies WP117 – WP123 Plasma WP124 – WP126 Standards Model Organisms WP127 – WP168 Microbial Proteomes WP169 – WP178 Other Non-Mammalian Proteomes WP179 – WP190 Plant Proteomes WP191 – WP208 WP209 – WP220 WP221 – WP224 WP225 – WP233

Organellar Proteomics Proteomics in Biotechnology Structural Proteomics Other HUPO 2005 • FINAL PROGRAM

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INSTRUCTIONS FOR ORAL AND POSTER PRESENTERS SPEAKER PREPARATION ROOM HOURS The speaker preparation room is located in room 3, located on the ground floor of the ICM. Sunday, August 28 Monday, August 29 Tuesday, August 30 Wednesday, August 31 Thursday, September 1

13:00-18:30 07:30-18:00 07:00-18:00 07:00-18:00 07:30-15:30

INVITED SPEAKERS AND ORAL ABSTRACT PRESENTERS Speakers are asked to check into the Speaker Preparation Room, located in room 3 on the first floor of the ICM, at least 24 hours before their scheduled presentation time. This is the only way that we can be sure that you are present, and that the chairs of your session are updated on any last-minute changes. It is also very important that you ensure the seamless functioning of your data presentation. You will be required to leave the diskette or CD-ROM containing your presentation in the Speaker Preparation Room where the technician will load it onto the main network server. NON-MODERATED POSTER PRESENTERS Posters will change daily from Monday through Wednesday. Poster presenters should mount their posters in the designated area of the Exhibit Hall (B0) between 08:00-09:30 and dismount no later than 18:00. Congress staff are available at the Poster Service Desk in the exhibit hall. Any posters that are not dismounted by 18:00 from Monday through Wednesday will be removed by Congress staff and stored at the Congress Services desk in the registration area. Posters still unclaimed by 15:00 on Thursday, September 1 will be discarded.

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HUPO 2005 • FINAL PROGRAM

INVITED FACULTY HONORARY SPEAKERS

INVITED FACULTY

Amos Bairoch, Switzerland

Ruedi Aebersold, Switzerland

Frantisek Foret, Czech Republic

John Fenn, United States

Per E. Andren, Sweden

Leonard Foster, Canada

Franz Hillenkamp, Germany

Ron Appel, Switzerland

David Friedman, United States

Patrick O'Farrell, United States

Rolf Apweiler, United Kingdom

Angelika Görg, Germany

Alexander Archakov, Russia

Samir Hanash, United States

Yoshinobu Baba, Japan

Franz Ulrich Hartl, Germany

Helene Barbier-Brygoo, France

Fuchu He, P.R. China

Laura Beretta, United States

Albert Heck, The Netherlands

John J. M. Bergeron, Canada

Michael Hecker, Germany

Luca Bini, Italy

Udo Heinemann, Germany

Pierre-Alain Binz, Switzerland

Wolfgang A. Herrmann, Germany

Peer Bork, Germany

Henning Hermjakob, United Kingdom

Soren Brunak, Denmark

Karin Hjernœ, Denmark

Maxey C. M. Chung, Singapore

Denis Hochstrasser, Switzerland

Michael J. Dunn, Ireland

Hans Rudolf Hoepker, Sweden

HUPO 2005 • FINAL PROGRAM

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INVITED FACULTY Hubert Hondermarck, France

Gilbert Omenn, United States

Naoyuki Taniguchi, Japan

Ole Noerregaard Jensen, Denmark

Young-Ki Paik, Korea

Mathias Uhlen, Sweden

Jesus Jorrin Novo, Spain

Steven Pennington, Ireland

Jan van Oostrum, Switzerland

Walter Kolch, United Kingdom

Peipei Ping, United States

Joel Vandekerckhove, Belgium

Bernard Küster, Germany

Herbert Platsch, Germany

Walter Weiss, Germany

Hanno Langen, Switzerland

Thierry Rabilloud, France

Reiner Westermeier, Germany

Martin R. Larsen, Denmark

Fred Regnier, United States

Lothar Willmitzer, Germany

Frédérique Lisacek, Switzerland

Pier-Giorgio Righetti, Italy

E. L. Winnacker, Germany

Boris Macek, Germany

Peter Roepstorff, Denmark

John III Yates, United States

Erika Mann, Belgium

Gerd Schmitz, Germany

Roman Zubarev, Sweden

Matthias Mann, Denmark

Luis Serrano, Germany

Helmut E. Meyer, Germany

Richard J. Simpson, Australia

Kazuyuki Nakamura, Japan

Arne Skerra, Germany

Erin K. O'Shea, United States

Toni Slabas, United Kingdom

Yoshiya Oda, Japan

Thomas Szyperski, United States

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HUPO 2005 • FINAL PROGRAM

DETAILED PROGRAM • SUNDAY, AUGUST 28TH, 2005 08:30 – 10:15

EP1

EDUCATIONAL PROGRAM I

08:30 – 08:35

EP1.01

Welcome Address Angelika Görg, Chair of the HUPO-Education and Training Committee

08:35 – 09:15

EP1.02

Gel Based Proteomics: Two-Dimensional Electrophoresis and DIGE Reiner Westermeier, GE Healthcare, Freiburg, Germany

09:15 – 10:15

EP1.03

Non-Gel Based Proteomics: Multidimensional LC and MudPIT Per E. Andren, Uppsala University, Uppsala, Sweden Hans Rudolf Höpker, GE Healthcare, Freiburg, Germany

10:15 – 10:30

COFFEE BREAK

10:30 – 12:00

EDUCATIONAL PROGRAM II

10:30 – 12:00

EP1.03

ROOM: 5

ROOM: 5

Protein Identification: MALDI Peptide Mass Fingerprinting and Peptide Sequencing with LC-ESI MS/MS Peter Roepstorff, University of Southern Denmark, Odense, Denmark Karin Hjernø, University of Southern Denmark, Odense, Denmark

12:00 – 12:30

LUNCH

12:30 – 14:45

EDUCATIONAL PROGRAM III

ROOM: 5

12:30 – 14:00

EP1.05

PTM Proteomics: Phosphoproteomics and Glycoproteomics Ole Noerregaard Jensen, University of Southern Denmark, Odense, Denmark Martin Røssel Larsen, University of Southern Denmark, Odense, Denmark

14:00 – 14:45

EP1.06

Quantitative Proteomics by Mass Spectrometry with and without Stable Isotopes Boris Macek, University of Southern Denmark, Odense, Denmark

14:45 – 15:00

COFFEE BREAK

15:00 – 16:30

EDUCATIONAL PROGRAM IV

15:00 – 16:30

EP1.07

ROOM: 5

Bioinformatics for Proteomics Henning Hermjakob, European Bioinformatics Institute, Hinxton, United Kingdom Pierre-Alain Binz, Swiss Institute of Bioinformatics, Geneva, Switzerland

HUPO 2005 • FINAL PROGRAM

25

DETAILED PROGRAM • SUNDAY, AUGUST 28TH, 2005 16:30 – 18:00 IS1 – INDUSTRY SPONSORED SYMPOSIUM BIO-RAD LABORATORIES CURRENT SAMPLE PREPARATION AND FRACTIONATION STRATEGIES FOR PROTEOMICS ROOM: 13 How Can the Preparation of Proteomic Samples Be Optimized? Dr. Anton Posch talks about tips and techniques for high quality protein extraction and discusses critical success factors in 2-D electrophoresis. The MicroRotofor A novel and powerful tool for the fractionation of complex protein samples by micro-preparative isoelectric focusing will be introduced by Dr. Aran Paulus. Protein Visualization and Quantification You Can Rely on Dr. Tom Berkelman presents Flamingo Pink, a novel sensitive fluorescent dye in gel-based Expression Proteomics.

18:00-20:00 Welcome Reception Exhibit Hall BO

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HUPO 2005 • FINAL PROGRAM

DETAILED PROGRAM • MONDAY, AUGUST 29TH, 2005 08:30 – 10:15

PL1.1

OPENING AND WELCOME ADDRESS

08:30 – 08:45

PL1.1.01

Welcome Address Wolfgang. A. Herrmann, President of the Technische Universität München, Munich, Germany

08:45 – 09:00

PL1.1.02

Welcome Address John J. M. Bergeron, HUPO President, Montreal, QC, Canada

09:00 – 09:15

PL1.1.03

Opening Remarks Angelika Görg, Technische Universität München, Munich, Germany Matthias Mann, Max Planck Institute of Biochemistry, Martinsried, Germany

09:15 – 09:45

PL1.1.04

Challenges for research Funding on the National and international Level E.-L. Winnacker, President of the German Research Foundation (DFG), Munich, Germany

09:45 – 10:15

PL1.1.05

An Organized Effort in Proteomics: The HUPO Initiatives Samir Hanash, Fred Hutchinson Cancer Research Center, Seattle, WA, United States

10:15 – 10:45

ROOM: 14

COFFEE AND POSTER BREAK

10:45 – 12:45

PL1.2

PROTEOMICS PLENARY LECTURES Chairs: Angelika Görg & Matthias Mann

ROOM: 14

10:45 – 11:15

PL1.2.01

Clinical Chemistry and Proteomics Denis Hochstrasser, Geneva University Hospital, Geneva, Switzerland

11:15 – 11:45

PL1.2.02

Function Prediction at the Protein, Proteome and Community Level Peer Bork, European Molecular Biology Laboratory EMBL, Heidelberg, Germany

11:45 – 12:15

PL1.2.03

Functional Proteomics on Cell-Lines and Tissues This presentation is supported by a grant from Novartis Institutes for BioMedical Research. Jan van Oostrum, Novartis Institute for Biomedical Research, Basel, Switzerland

12:15 – 12:45

PL1.2.04

A Human Proteome Atlas for Normal and Disease Tissue Mathias Uhlen, Royal Institute of Technology (KTH), Stockholm, Sweden

HUPO 2005 • FINAL PROGRAM

27

DETAILED PROGRAM • MONDAY, AUGUST 29TH, 2005 12:45 – 14:15 IS2 – LUNCHEON INDUSTRY SPONSORED SYMPOSIUM BRUKER DALTONICS FURTHER DIMENSIONS IN PROTEOMICS TECHNOLOGY ROOM: 13 Uwe Rapp, European Sales Director, Bruker Daltonics, Bremen, Germany A Universal Toolbox for Quantitative Proteomics After an initial discovery phase, proteomics is now entering a second phase, where the monitoring of changes in protein abundances becomes of major importance. Bruker supports various strategies for protein quantitation by label freeapproaches, stable-isotope labeling, ICAT or the new ICPL technology which is worldwide applicatively supported by Bruker Daltonics. Especially the latter allows for the full range of protein separation technologies providing the scientist with the maximum flexibility in sample preparation and fractionation for his experiments. Wolfgang Albrecht, European Director Sales Clinical Proteomics, Bruker Daltonik GmbH, Bremen, Germany ClinProt, an Expandable Platform for Biomarker Discovery Magnetic Beads had been shown as a powerful tool for Biomarker Discovery. In combination with other MS Technologies like Depletion, LC-MALDI and MALDI-Imaging this MALDI-TOF or TOF/TOF approach can be used as a general tool for clinical proteomics, Biomarker Discovery and Identification. Novel beads for antibody-capturing and glycoprotein-enrichment expand the opportunities for the research and clinical applications. Marcus Macht, Director European Life Science Applications, Bruker Daltonik GmbH, Bremen, Germany Unique Technologies for Certainty in PTM Discovery In Proteomics projects the reliable detection and characterisation of post-translational modifications (PTMs) such as phosphorylation, sulfatation and glycosylation is a major challenge. However, more refined and dedicated strategies in MS/MS and MSn make PTMs better accessible now by mass spectrometry. Various kinds of new MS/MS technologies like ETD (electron transfer dissociation) combined with elaborate software tools for the elucidation of PTM will be presented. 12:45 – 14:15 IS3 – LUNCHEON INDUSTRY SPONSORED SYMPOSIUM SIGMA-ALDRICH CORPORATION NOVEL TOOLS FOR PROTEOMICS: IDENTIFICATION OF PLASMA PROTEINS AND SCORING PROTEOMICS WITH PROTEOTYPIC PEPTIDE PROBES ROOM: 1 Chair: Klaus Herick, Sigma-Aldrich Corporation, Munich, Germany 12:45 – 13:00 Registration 13:00 – 13:05 Introduction & Welcome Klaus Herick, Sigma-Aldrich Corporation, Munich, Germany

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HUPO 2005 • FINAL PROGRAM

DETAILED PROGRAM • MONDAY, AUGUST 29TH, 2005 13:05 – 13:45 Scoring Proteomics with Proteotypic Peptide Probes Ruedi Aebersold, Institute for Molecular Systems Biology, ETH Zurich, Faculty of Natural Science, University of Zurich, Switzerland and Institute for Systems Biology, Seattle, WA, United States 13:45 – 14:15 Identification of Proteins in Human Plasma Following Removal of 20 High Abundance Proteins Michael Pisano, President and Cofounder, Proteomic Research Services Inc., Ann Arbor, MI, United States 14:15 – 15:00

POSTER VIEWING PARALLEL SESSIONS

15:00 – 16:55

PS1.1

CANCER PROTEOMICS I Chairs: Richard J. Simpson & Maxey C.M. Chung

15:00 – 15:20

PS1.1.01

Proteomic Analysis of Colorectal Cancer: Strategies for Novel Biomarker Discovery Richard J. Simpson, Ludwig Institute for Cancer Research and the Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia

15:20 – 15:40

PS1.1.02

Proteome Analyses of Butyrate-Treated HCT 116 Colorectal Cancer Cells Maxey C.M. Chung, National University of Singapore, Singapore

15:40 – 15:55

PS1.1.03

Multiplex Detection of Surface Molecules on Colorectal Cancers Richard Christopherson, University of Sydney, Sydney, Australia

15:55 – 16:10

PS1.1.04

Proteomic Analysis of Sulindac and Celecobix Induced Protein Expression Profile Changes in Colon Carcinoma Cells Hong Ji, Ludwig Institute for Cancer Research and the Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia

16:10 – 16:25

PS1.1.05

Proteomics of Human Breast Cancer Serhiy Souchelnytskyi, Ludwig Institute for Cancer Research, Uppsala, Sweden

16:25 – 16:40

PS1.1.06

Phosphoproteomic Analysis of IGF1R-Driven Proliferation and Signalling in MCF-7 Breast Cancer Cells Laurence Brill, Genomics Institute of the Novartis Research Foundation, San Diego, CA, United States

15:00 – 16:55

PS1.2

CLINICAL PROTEOMICS I Chairs: Young-Ki Paik & David Speicher

ROOM: 14

ROOM: 1

HUPO 2005 • FINAL PROGRAM

29

DETAILED PROGRAM • MONDAY, AUGUST 29TH, 2005 15:00 – 15:20

PS1.2.01

In Search for the Biomarker Proteins from the Liver and Lung Cancer Specimens Young-Ki Paik, Yonsei University, Seoul, Korea

15:20 – 15:35

PS1.2.02

Systematic Analysis for Liver and Liver Cancer Proteome: From Lab to Bedsides Rhong Zeng, Shanghai Institutes for Biological Sciences, Shanghai, P.R. China

15:35 – 15:50

PS1.2.03

Strategy Optimization for the Constructing of Chinese Human Liver Proteome Expression Profile X. Qian, Beijing Institute of Radiation Medicine, Beijing, P.R. China

15:50 – 16:05

PS1.2.04

Impact of the nm23-M1 Metastasis Suppressor Gene Invalidation on Mouse Liver Proteome Mathieu Boissan, INSERM 680, UPMC, Paris, France

16:05 – 16:25

PS1.2.05

Enhanced Detection of Low Abundance Human Plasma Proteins By Optimizinga Multi-Dimensional Protein/Peptide Separation Strategy David Speicher, The Wistar Institute, Philadelphia, PA, United States

16:25 – 16:40

PS1.2.06

A Plasma Protein Reference Set: A Set of Plasma Proteins Identified with Extremely High Confidence Through two Consecutive Stages of Tandem Mass Spectrometry (MS3) and ppm Precursor Mass Accuracy Susann Schenk, University of Southern Denmark, Odense, Denmark

16:40 – 16:55

PS1.2.07

Characterization of Degradation Markers in Plasma Used For Transfusion Cécile Cren-Olivé, Université des Sciences et Technologies de Lille, Villeneuve D’Ascq, France

15:00 – 16:55

PS1.3

ANTIBODIES / ARRAYS Chairs: Mathias Uhlen & Alexander Archakov

15:00 – 15:20

PS1.3.01

Antibody-Based Proteomics For Human Tissue Profiling – The Swedish Human Proteome Resource Project (HPR) Fredrik Ponten, IPG, Rudbeck Laboratory, Uppsala, Sweden

15:20 – 15:35

PS1.3.02

Antibody Microarrays: Technology and Analysis of Serum Proteomes from Cancer Patients Christer Wingren, Lund University, Lund, Sweden

15:35 – 15:50

PS1.3.03

Serum Microarrays for Screening of Protein Levels Peter Nilsson, KTH – Royal Institute of Technology, Stockholm, Sweden

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HUPO 2005 • FINAL PROGRAM

ROOM: 13

DETAILED PROGRAM • MONDAY, AUGUST 29TH, 2005 15:50 – 16:05

PS1.3.04

Protein Microarray Technology: Technologies & Applications & Market O. Thomas Joos, NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany

16:05 – 16:20

PS1.3.05

High-throughput Identification of Arabidopsis MAP Kinase Substrates Using Protein Microarrays Birgit Kersten, Max-Delbrück-Centrum für Molekulare Medizin, Berlin, Germany

16:20 – 16:40

PS1.3.06

AFM Nanotechnology with Biospecific Irreversible Fishing is the Way to Reverse Avogadro Number Alexander Archakov, Research Institute of Biomedical Chemistry RAMS, Moscow, Russia

16:40 – 16:55

PS1.3.07

Towards Single Cell Fingerprinting in Microfluidfic Device Format: Cell Manipulation, Protein Separation and Label-Free Detection Alexandra Ros, Bielefeld University, Bielefeld, Germany

15:00 – 16:55

PS1.4

STRUCTURAL PROTEOMICS / NANOTECHNOLOGY Chairs: Arne Skerra & Yoshinobu Baba

15:00 – 15:20

PS1.4.01

Strep-tag and Anticalins: Molecular Tools for Structural Proteome Research Arne Skerra, Technische Universität München, Freising, Germany

15:20 – 15:40

PS1.4.02

Protocol for NMR-Based Structural Proteomics Thomas Szyperski, State University of New York at Buffalo, Buffalo, NY, United States

15:40 – 16:00

PS1.4.03

3D Structures of Human Proteins: From Narrow Focus to Large-Scale Data Gathering and Back Udo Heinemann, Max-Delbrück-Centrum für Molekulare Medizin, Berlin, Germany

16:00 – 16:15

PS1.4.04

Structural Proteomics of Mycobacterium Tuberculosis: Structure-Based Research on Potential Targets for New Anti-TB Drugs Hans D. Bartunik, Max Planck Unit for Structural Molecular Biology, Hamburg, Germany

16:15 – 16:35

PS1.4.05

Nanobiotechnology in Proteomics Yoshinobu Baba, Nagoya University, Nagoya, and National Institute of Advanced Industrial Science and Technology, Takamatsu, Japan

ROOM: 5

HUPO 2005 • FINAL PROGRAM

31

DETAILED PROGRAM • MONDAY, AUGUST 29TH, 2005 16:35 – 16:55

PS1.4.06

17:00 – 17:30

Miniaturization Technology and Mass Spectrometry Coupling Frantisek Foret, Institute of Analytical Chemistry, Brno, Czech Republic COFFEE AND POSTER BREAK

17:30 – 19:25

PS1.5

CANCER PROTEOMICS II CHAIRS: Kazuyuki Nakamura & Carl Borrebaeck

17:30 – 17:50

PS1.5.01

Progress in Proteome Profiling of Hepatocellular Carcinoma Tissues from Patients Infected with Hepatitis C Virus and Its Possible Clinical Application Kazuyuki Nakamura, Yamaguchi University School of Medicine, Yamaguchi, Japan

17:50 – 18:10

PS1.5.02

From Gene Expression Profiling to Tissue Microarrays – A Way to Find Clinical Targets in Mantle Cell Lymphoma Carl Borrebaeck, Lund University, Lund, Sweden

18:10 – 18:25

PS1.5.03

Proteomic Identification of Oncogenic Chromosomal Translocation Partners Encoding Chimeric ALK Fusion Proteins Kojo Elenitoba-Johnson, University of Utah, Salt Lake City, UT, United States

18:25 – 18:40

PS1.5.04

Identification of Major Histocompatibility Complex (MHC) Class I Associated Tumor Peptides via NanoLC MALDI MS/MS Sandra Hofmann, J.W. Goethe University Frankfurt, Frankfurt am Main, Germany

18:40 – 18:55

PS1.5.05

Proteomic Mapping of Distinct Molecular Signatures at Luminal Endothelial Cell Surfaces in Organs and Solid Tumors for Imaging and Therapy Jan Schnitzer, Sidney Kimmel Cancer Center, San Diego, CA, United States

18:55 – 19:10

PS1.5.06

Identification of Serological Biomarkers of Cancer Using a Novel MultiDimensional Method to Analyze Serum from Mouse Models Nadeem Ali-Khan, The Wistar Institute, Philadelphia, PA, United States

32

HUPO 2005 • FINAL PROGRAM

ROOM: 14

DETAILED PROGRAM • MONDAY, AUGUST 29TH, 2005 19:10 – 19:25

PS1.5.07

Identifying Cancer Biomarkers Using 2D-DIGE M.J. O’Connor, KuDOS Pharmaceuticals, Cambridge, United Kingdom

17:30 – 19:20

PS1.6

ORGANELLAR PROTEOMICS Chairs: Leonard Foster & Hans-Peter Braun

17:30 – 17:50

PS1.6.01

A Mammalian Organellae Map by Protein Correlation Profiling Leonard Foster, University of British Columbia, Vancouver, BC, Canada

17:50 – 18:05

PS1.6.02

Proteomic Approach to Investigate the Supramolecular Structure of the Oxydative Phosphorylation System in Mitochondria Hans-Peter Braun, Universität Hannover, Hannover, Germany

18:05 – 18:20

PS1.6.03

Location Proteomics: Automated Determination of Subcellular Location Patterns by Fluorescence Microscopy Robert F. Murphy, Carnegie Mellon University, Pittsburgh, PA, United States

18:20 – 18:35

PS1.6.04

Identification of Novel Lysosomal Matrix Proteins Torben Lübke, Universität Göttingen, Göttingen, Germany

18:35 – 18:50

PS1.6.05

Proteomic Analysis of Liver Peroxisomes after Bezafibrate Treatment Using iTRAQ Quantification Markus Islinger, Universität Heidelberg, Heidelberg, Germany

18:50 – 19:05

PS1.6.06

Proteome and Phosphoproteome Analysis of the Human Mitotic Spindle Roman Körner, Max Planck Institute of Biochemistry, Martinsried, Germany

19:05 – 19:20

PS1.6.07

Using Functional Proteomics and Lipidomics for Defining the Molecular and Cellular Mechanisms of Aging Vladimir Titorenko, Concordia University, Montreal, QC, Canada

17:30 – 19:25

PS1.7

NEWS CORNER I Chairs: Rudolf Grimm & Reiner Westermeier

17:30 – 17:45

PS1.7.01

Protein Prefractionation: Passing Phase or Forward-Looking Approach? Hans-Rudolf Hoepker, GE Healthcare Bio-Sciences, Freiburg, Germany

17:45 – 18:00

PS1.7.02

High-Resolution Screening of Various Biomarker Compounds by Using a New HPLC-Chip MS Technology Rudolf Grimm, Agilent Technologies, Santa Clara, CA, United States

ROOM: 13

ROOM: 1

HUPO 2005 • FINAL PROGRAM

33

DETAILED PROGRAM • MONDAY, AUGUST 29TH, 2005 18:00 – 18:15

PS1.7.03

Peptide Mapping of Biofluids by Multidimensional LC/MALDI-TOF-MS with Integrated On-Line Sample Clean-Up Using Restricted Access Materials Egidijus Machtejevas, Johannes Gutenberg University, Mainz, Germany

18:15 – 18:25

PS1.7.04

Two-Dimensional Gel Electrophoresis/MALDI-MS Followed by iTRAQ Reagent Technology – A Powerful Tool in Toxicoproteomics for Identification and Prevalidation of Potential Early Biomarkers Michaela Kröger, Merck KGaA, Darmstadt, Germany

18:25 – 18:35

PS1.7.05

Biomarker Proteins in Diabetic and Normal Serum Samples Using Both Chromatographic and Preparative Electrophoretic Fractionation with 2D Gels Aran Paulus, Bio-Rad Laboratories, Hercules, CA, United States

18:35 – 18:45

PS1.7.06

Extending the Dynamic Range of Gel Based Proteomics for Biomarker Discovery Martin Schürenberg, Bruker Daltonik, Bremen, Germany

18:45 – 18:55

PS1.7.07

Improved Peptide Identification and Protein Coverage for Proteomic Samples Using Novel Alternative 2D-HPLC-MS/MS Approaches Petra Olivova, Waters Corporation, Milford, MA, United States

18:55 – 19:05

PS1.7.08

Absolute Quantitation of Proteins in Tissues by Protein Abundance Index and Isotope Dilution with Unlabeled Peptides Yasushi Ishihama, Eisai Co., Tsukuba, Japan

19:0 – 19:15

PS1.7.09

Nano-LC Fraction Analysis by Chip-Based Nanoelectrospray for Improved Glycopeptide Characterization Thomas Corso, Advion Biosciences, Ithaca, NY, United States

19:15 – 19:25

PS1.7.10

Unique Multivariate Approach to Biomarker Discovery Using New Technology for Analysis of Proteomics Data David Bramwell, Nonlinear Dynamics, Newcastle upon Tyne, United Kingdom

19:00 – 21:00

34

EUPA MEETING First GC meeting of EuPA

HUPO 2005 • FINAL PROGRAM

ROOM: 5

POSTER SESSION • MONDAY, AUGUST 29TH, 2005 POSTER SESSION ROOM:Y0 DISPLAY ALL DAY OFFICIAL VIEWINGS: 14:15 – 15:00

MEDICAL, CLINICAL, PHARMACEUTICAL AND DISEASE PROTEOMICS - CANCER PROTEOMICS MP001

Detection of Rare and Rapidly Degrading Proteins by Analysis of Their Degradation Products as MHC Peptides Arie Admon, Technion - Israel Institute of Technology, Haifa, Israel

MP002

Identification of Membrane Proteins as Biomarker Candidates in Colorectal Cancer Paula Álvarez-Chaver, University of Vigo, Vigo, Spain

MP003

Ovarian Tumor Classification and Biomarker Selection by Applying Multivariate Analysis on 2DDIGE Data Christian Andersson Ståhlberg, GE Healthcare, Uppsala, Sweden

MP004

Transcript Profiling of Microdissected Cell Populations Selected from Basal Cells in Normal Epidermis and Basal Cell Carcinoma Anna Asplund, Institute of Genetics and Pathology, Uppsala, Sweden

MP005

Characterisation of the Human "Mismatch Repairosome" by Proteomics Approaches Katja Bärenfaller, University of Zurich, Zurich, Switzerland

MP006

Proteins Differentially Expressed in Genomically Stable and Unstable Breast Adenocarcinomas Susanne Becker, Institute of Oncology & Pathology, Stockholm, Sweden

MP007

Screening Molecular Biomarkers Associated with Gastric Cancer by Proteomics Liu Bing-ya, Rui Jin Hospital, Shanghai Second Medical University, Shanghai, P.R China

MP008

Proteomic Profiling Using The Proteome Lab PF2D for the Discovery of Markers of Response to Novel Platinums in Glioma Oliver Bogler, U.T. M.D. Anderson Cancer Center, Houston, TX, United States

MP009

A Two-dimensional Electrophoresis Preliminary Approach to Human Hepatocarcinoma Differentiation Induced by PPAR-Agonists Patrizia Bottoni, Università Cattolica, Rome, Italy

MP010

Plasma Membrane Proteomes from Leukaemia Cell Lines Louise Bransgrove, University of Sydney, Sydney, Australia

MP011

Differential Proteomic Analysis of Human Endothelial Cells Treated with Vinblastine and Rapamycin Alone and in Combination Natascia Campostrini, University of Verona, Verona, Italy HUPO 2005 • FINAL PROGRAM

35

DETAILED PROGRAM • MONDAY, AUGUST 29TH, 2005 MP012

Identification of Tumor Associated Antigens of Surface Membrane Proteins in Colon Carcinoma Cells Luca Cannizzaro, San Raffaele Scientific Institute, Milano, Italy

MP013

The Epstein-Barr Virus Oncogene Product, Latent Membrane Protein 1, Regulates NM23-H1 at Transcriptional Level Yu-sun Chang, Institute of Basic Medical Sciences, Chang Gung University, Taoyuan, Taiwan

MP014

Proteomics Studies of Hepatitis B Virus-associated Hepatocellular Carcinoma by Two-dimensional Difference Gel Electrophoresis: More Accurate Qualitative and Quantitative Analysis Li Chen, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, P.R China

MP015

Novel Machines Remodel Chromatin and Recruit Transcription Factors to Control Cyclin A Transcription in B Cells Gerald Denis, Boston University School of Medicine, Boston, MA, United States

MP016

Proteome Analysis of Conditioned Medium from a Human Colon Carcinoma Cell Line Via 2D-PAGE and MALDI-TOF/TOF-MS Hanna Diehl, Medical Proteom-Center, Department of Internal Medicine (IMBL) Knappschaftskrankenhaus, Bochum, Germany

MP017

Analysis of Differential Protein Expression and Protein Modification in Nuclei if Prostate Cancer Cell Lines Versus Nuclei of Non-cancerous Cell Line Claudio Diema, German Cancer Research Center (DKFZ), Heidelberg, Germany

MP018

Proteomic Analysis of Human Breast Cancer Tissues by 2D-DIGE: Characterization of Proteins Associated with ErbB2 Receptor Overexpression in Metastatic Tumours M. Carmen Duran-Ruiz, Ludwig Institute-UCL, London, United Kingdom

MP019

Identification of Glycoproteins in Lung Adenocarcinoma Cell Surface Vitor Faca, Fred Hutchinson Cancer Research Center, Seattle, WA, United States

MP020

A Proteomic Analysis of Protein Expression Pattern of MCF-7 Cell Lines Transfected with the ZincFinger and Proline-rich Domain of Retinoblastoma-interacting Zinc-Finger Protein Annarita Farina, Second University of Naples, Caserta, Italy

MP021

Quantitative Proteomic Analysis of BRCA1-Deficient and Reconstituted HCC1937 Breast Cancer Cells: Evaluation of Sensitivity Profile to Mitotic Spindle-poisoning Drugs Marco Gaspari, University of Catanzaro, Catanzaro, Italy

MP022

Investigation of the Specificity of the LY294002 Inhibitor for PI3Ks and Other Novel Targets Using Chemical Proteomics Severine Gharbi, Ludwig Institute for Cancer Research, London, United Kingdom

36

HUPO 2005 • FINAL PROGRAM

POSTER SESSION • MONDAY, AUGUST 29TH, 2005 MP023

Analysis of Biomarkers for Cervical Cancer Natalia Govorukhina, University Groningen, Groningen, The Netherlands

MP024

Serum-Protein Alterations Associated with Pancreatic Cancer and Their Use for Sample Classification Brian B. Haab, Van Andel Research Institute, Grand Rapids, MI, United States

MP025

Proteomics as a Tool for Biomarker Discovery in Colon Cancer Research Daniel Haid, GE Healthcare, Amersham Biosciences AB, Uppsala, Sweden

MP026

Quantification of Membrane or Membrane-bound Proteins between Normal and Malignant Cells Isolated from the Same Patient with Primary Breast Cancer Mahbod Hajivandi, Invitrogen, Carlsbad, CA, United States

MP027

Differential Expression of Nuclear and Cytosolic Proteomes from Leukaemia Cell Lines Silke Henrich, University of Sydney, Sydney, Australia

MP028

Diagnosis of Testicular Cancer Using Proteomic Profiling Anders Holten Johnsen, Copenhagen University Hospital, Copenhagen, Denmark

MP029

Identification of Breast Cancer Metastasis and Chronic Myeloid Leukaemia Specific Cell Surface Proteins Piia- Riitta Karhemo, University of Helsinki, Helsinki, Finland Biomarkers Discovery: A Proteomics Approach for Brain Cancer Profiling Ashraf Khalil, Lund University, Lund, Sweden

MP030

MP031

Proteomic Approach for Tumor Marker Development for Personalized Medicine Tadashi Kondo, National Cancer Center Research Institute, Tokyo, Japan

MP032

Proteomic Profiling of Plasma from Colon Cancer Mouse Models Alexei Krasnoselsky, Fred Hutchison Cancer Research Center, Seattle, WA, United States

MP033

Proteomic Comparison between IGROV1, An Ovarian Cancer Cell Line Sensitive to Cisplatin, and Its Resistant Counterpart IGROV1-R10 Karen Le Moguen, Centre François Baclesse, Caen, France

MP034

MS Protein Profiles Discriminating between Relapses Versus Relapse-free Survival after Adjuvant Tamoxifen for Patients with a Primary ER and PgR Positive Breast Cancer Janne Lehtiö, Karolinska Institute, Stockholm, Sweden

MP035

Proteomic Analysis of Protein Expression in Prostate Cancer Helena Lexander, Karolinska Institute, Stockholm, Sweden

MP036

A Proteomic Investigation into a Human Gastric Tumor Cell Line, BGC823, Treated with Garlic Na Li, Beijing Genomics Institute, Chinese Academy of Sciences (CAS), Beijing, P.R. China

HUPO 2005 • FINAL PROGRAM

37

POSTER SESSION • MONDAY, AUGUST 29TH, 2005 MP037

Role of Runx3 in Colon-intestinal Tumorigenesis Anthony Chee-beng Lim, Institute of Molecular and Cell Biology, Singapore

MP038

Identification and Characterization of the Differentially Expressed Proteins In Human Gastric Carcinoma Kwang-huei Lin, Chang-gung University, Kwei-san, Taiwan

MP039

Proteomic and Glycomic Analyses of Serum and Ascitic Fluids in Relation to Colonic Tumor Progression in Inbred Mouse Model S.-Y. Lin, Biological Chemistry, Taipei, Taiwan

MP040

A Survey of Passage-dependent Secretory Proteomes to the Immortalized Cell Line of Human Lung Xiaomin Lou, Beijing Genomics Institute, Chinese Academy of Sciences (CAS), Beijing, P.R. China

MP041

Applicability of Protein Biomarkers Set to Distinguish Hepatocellular Carcinoma from Adjacent Non-tumor and Normal Liver Tissues John Luk, University of Hong Kong, Pokfulam, Hong Kong

MP042

Proteome Analysis of Whole-Cell Lysates of Human Glioblastoma and HeLA Cells during Passages Jayaprakash Madhamshetty, Lund University, Lund, Sweden

MP043

Differential Impact of Tumor Associated Fibroblasts and Their Mucosa-associated Counterparts on the Protein Profile of Gastric Cancer Cells Klaus Mayer, Ludwig-Maximilians-Universität, Munich, Germany

MP044

Two-dimensional Difference Gel Electrophoresis (DIGE) of a Bromodeoxyuridine-treated Human Lung Carcinoma Cell Line Andrew Dowd, Dublin City University, Dublin, Ireland

MP045

Quantitative Proteomics of Urokinase-type Plasminogen Activator Receptor (uPAR) Signaling in Ovarian Cancer Mark Molloy, Australian Proteome Analysis Facility, Sydney, Australia

MP046

Serum Amyloid A as Ovarian Cancer Biomarker Sergey Moshkovskiy, Institute of Biomedical Chemistry, Moscow, Russia

MP047

Identification and Characterisation of Putative Lymphoma Markers Using Protein Array Technology Derek Murphy, Royal College of Surgeons in Ireland, Dublin, Ireland

MP048

Detection of Potential Drug Resistant Markers in Lung Cancer Lisa Murphy, National Institute for Cellular Biotechnology, Dublin, Ireland

MP049

Breast Cancer Proteomics by 54 CM Daisy-Chain 2D-PAGE, Differential Radioactive Detection, Sample Pooling and Laser Capture Microdissection Hans Neubauer, University Women's Hospital Tübingen, Tübingen, Germany

38

HUPO 2005 • FINAL PROGRAM

POSTER SESSION • MONDAY, AUGUST 29TH, 2005 MP050

The "Omics" Analysis of Ultraviolet-A Exposed Mouse Melanoma Cells Reetta Nylund, STUK, Radiation and Nuclear Safety Authority, Helsinki, Finland

MP051

Proteomics Predicts Chemosensitivity to EGFR Tyrosine Kinase Inhibitor Gefitinib (Iressa, ZD1839) of Lung Adenocarcinoma Tetsuya Okano, Nippon Medical School, Tokyo, Japan

MP052

Differential Protein Expression Profiling by iTRAQ-2DLC-MS/MS Reveals a Pro-Metastatic Phenotype in TGF-_ -Induced Epithelial-Mesenchymal Transitions in Human Lung Cancer Cells Gilbert Omenn, University of Michigan, Ann Arbor, MI, United States

MP053

Proteomics Study of Proastate Cancer Among Malaysian Men Iekhsan Othman, University of Malaya, Kuala Lumpur, Malaysia

MP055

Proteome Analysis of Human Uveal Melanoma Cells by Two-Dimensional Gel Electrophoresis and Mass Spectrometry Maria Pardo, University of Oxford, Oxford, United Kingdom

MP056

Proteomic Identification of Tumor Antigens in Lung Cancer Sandra Pereira-Faca, Fred Hutchinson Cancer Research Center, Seattle, WA, United States

MP057

Cancer Biomarker Discovery: A Novel Approach to Obtain Increased Proteomic Coverage in Serum Profiles Using SELDI-TOF Maria Pernemalm, Karolinska Institute, Stockholm, Sweden

MP058

Comparative Proteomic Analysis of Chronic Myeloid Leukemia Patients in Chronic Phase Luciana Pizzatti, Universidade Federal Do Rio de Janeiro, Rio de Janeiro, Brazil

MP059

Treatment with the Histone Deacetylase Inhibitor MS-275 Induced Dose-dependent Changes in The Serum of Tumor Bearing Rats Analysed by Seldi-MS Oliver Politz, Schering AG, Berlin, Germany

MP060

Phosphorylation of Bcr-Abl Kinase and its Downstream Substrates in Response to STI571 Treatment in Human Chronic Myelioenous Leukemia Cells Marshall Pope, Invitrogen, Carlsbad, CA, United States

MP061

Cell Culture Model for Malignant Transformation - Differential and Quantitative Proteome Analysis Using 2D-PAGE and SILAC Stephanie Pütz, Rudolf Virchow Zentrum, Würzburg, Germany

MP062

Differention of Gastric Cancer Histological Subtypes Based on Proteome Analysis Uros Rajcevic, University of Ljubljana, Ljubljana, Slovenia

MP063

Proteome Analysis of Alkaline Protein Involved in Ki-ras Transformation Christian V. Recktenwald, University Halle, Halle, Germany

MP064

Proteomic Analysis of Clusterin Isoformsin Colorectal Cancer Ana M. Rodriguez-Piñeiro, Universidad de Vigo, Vigo, Spain HUPO 2005 • FINAL PROGRAM

39

POSTER SESSION • MONDAY, AUGUST 29TH, 2005 MP065

Development of a Combined MALDI-TOF and NanoLC-FTICR MS Method for the Identification of Carcinoma-related Proteins in Cerebrospinal Fluid Andreas Roempp, Justus Liebig University Giessen, Giessen, Germany

MP066

Protein Profiling of Imatinib-sensitive and Resistant Leukemic Cell Lines with ProteinChip Technology (SELDI) Julia Rosenhahn, Institute of Human Genetics and Anthropology, FSU Jena, Jena, Germany

MP067

Different Protein Levels of Subcellular Fractions Enriched in Mitochondria from Renal Cell Carcinoma Cecilia Sarto, Desio Hospital - University Milano Bicocca, Desio, Italy

MP068

Histone Deacetylase Inhibitor SAHA Arrest Cancer Cell Growth - A Proteomic Study Christian Scharf, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany

MP069

ICPL - Based Proteomics of Microdissected Renal Cell Carcinoma Samples Alexander Schmidt, Max Planck Institute for Biochemistry, Martinsried, Germany

MP070

New Biomarkers Revealed by Quantitative Differential Radioactive Analysis of Protein Expression in Human Prostate Cancers Gerhard Schwall, Proteosys AG, Mainz, Germany

MP071

Proteomic Analysis of Hepatocellular Carcinoma in HBX Transgenic Mice Je Kyung Seong, Seoul National University, Seoul, South Korea

MP072

Identification of Tumor Antigens by Serological Antibody Responses and Proteomic Approaches in Human Hepatocellular Carcinoma Jin-chuan Sheu, National Taiwan University Hospital, Taipei, Taiwan

MP073

Proper Sample Preparation Method for Discovery of Early Diagnostic Biomaker of Breast Cancer Tissues Hyuk Jai Shin, Seoul National University Hospital, Seoul, South Korea

MP074

Comprehensive Analysis of Human Lymphoblastoid Proteome Reveals Role of INHAT Complex in Response to DNA Double Strand Breaks Monique Slijper, Utrecht University, Utrecht, The Netherlands

MP075

Quantitative and Qualitative Multiplex Biomarker Profiling in Serum Using Multiwell Microarray Technology Jens Beator, Schleicher & Schuell BioScience GmbH – Whatmangroup, Dassel, Germany

MP076

Determination of Candidate Molecular Markers of the Pancreatic Cancer: Differential Proteome Analysis of 1000 Microdissected Cells Using DIGE Saturation Labelling Kai Stühler, Ruhr-University Bochum, Bochum, Germany

40

HUPO 2005 • FINAL PROGRAM

POSTER SESSION • MONDAY, AUGUST 29TH, 2005 MP077

Proteomic Signature of Soft-tissue Tumors Corresponding to Histological Classification and Grading Yoshiyuki Suehra, National Cancer Center Research Institute, Tokyo, Japan

MP078

Proteome Analysis of HBV-Related Hepatocellular Carcinoma by Two-Dimensional Difference Gel Electrophorresis (DIGE) Ying Jiang, Beijing Institute of Radiation Medicine, Beijing, P.R. China

MP079

Differential Expression of PI3K and PTEN Genes in Herceptin-Sensitive BT-474 Cells and Herceptin-Resistant Clones Kim Tan, Winston-Salem State University, Winston-Salem, NC, United States

MP080

Protein Expression in Human Hereditary and Sporadic Colorectal Cancer Andreas Unger, University of Schleswig- Holstein, Campus Lübeck, Lübeck, Germany

MP081

Analysis of Differencial Protein Expression in Cells Upon AFAP-110 Directed Activation CSRC Deanne Vincent, West Virginia University, Morgantown, WV, United States

MP082

Proteomic Profiling of T24 Bladder Carcinoma Cells Following Glutathione Depletion by Monoterpenes Timothy Vincent, West Virginia University, Morgantown, WV, United States

MP083

Identification of the Human Salivary Cystatin SN as a Target of the Tumour Suppressor SMAD4 in Colon Carcinoma Cells Martin W. Volmer, Ruhr-Universität Bochum, Bochum, Germany

MP084

Altered Proteomic Profiles of Prostate Neoplasm after Treatment with Traditional Chinese Medicines Inhibiting Cellular Proliferation Melanie White, Minomic, Frenchs Forest, Australia

MP085

Flavone Alters the Proteome in Colons of 1, 2-Dimethylhydrazine Treated C57BL/6J-Mice Isabel Winkelmann, Technical University of Munich, Freising, Germany

MP086

Proteomics for Autoantibodies React to Proteins Expressed in Hepatocellular Carcinoma Tissues Kuramitsu Yasuhiro, Yamaguchi University School of Medicine, Ube, Japan

MP087

Proteomic Study of Differentiation and Portal Vein Invasion of Hepatocellular Carcinoma by Laser Microdissection, Two-dimensional Difference Gel Electrophoresis and Bioinformatics Hideki Yokoo, Graduate School of Medicine, Hokkaido University, Sapporo, Japan

MP088

Isolation and Purification of a Novel Anticancer 60 K Daltons Protein from the Persian Gulf Sea Hare, Aplysia Dactylomela Keivan Zandi, Bushehr University of Medical Sciences, Bushehr, Iran

MP089

Comparative Subcellular Proteomic Analysis of Hepatocellular Carcinoma with Different Alpha Fetoprotein Expression Xiaohang Zhao, Cancer Institute & Hospital, Beijing, P.R. China HUPO 2005 • FINAL PROGRAM

41

POSTER SESSION • MONDAY, AUGUST 29TH, 2005 MP090

Protein Profiling in Colorectal Cancer Kaja Zimmermann, University of Schleswig- Holstein, Campus Lübeck, Lübeck, Germany

MEDICAL, CLINICAL, PHARMACEUTICAL AND DISEASE PROTEOMICS - CLINICAL BIOMARKER DISCOVERY MP091

A Proteomic Analysis of Serum Proteins Following BHV-1 Infection in Cattle Palok Aich, University of Saskatchewan, Saskatoon, SK, Canada

MP092

Identification of Urinary Protein Biomarkers in Acute Renal Failure John Arthur, Medical University of South Carolina, Charleston, SC, United States

MP093

Identification of Proteins Differentially Expressed by Circulating Human Monocytes in Acute Coronary Syndromes Maria G. Barderas, Fundacion Jimenez Diaz, Madrid, Spain

MP094

Standardization and Evaluation of Magnetic Bead-based Proteome Profiling with MALDI-TPF-MS for the Detection of New Biomarkers in Human Blood Sven Baumann, University Hospital Leipzig, Leipzig, Germany

MP095

Large Scale Tumor Analysis for Biomarker Discovery Sofia Bengtsson, Electrical Measurements, Lund, Sweden

MP096

Serological Proteome Analysis (SERPA) and Multiple Affinity Protein Profiling (MAPPING) to Discover Cancer Biomarkers Michel Caron, University Paris 13, Bobigny, France

MP097

Identification of Proteins by Mass Spectrometry on Laser Dissected Cells from Mouse Proximal Bronchial Epithelium Isabel Carvalho-Oliveira, Instituto Nacional de Saœde Dr. Ricardo Jorge, Lisbon, Portugal

MP098

High Resolution Urine Proteomic Profiling: 2D Comparative Analysis and Urinary Prostasin Mapping in Normotensive Individuals and Hypertensive Patients with Primary Aldosteronism Annalisa Castagna, University of Verona, Verona, Italy

MP099

Immune-Mediated Disorder Biomarkers in Sera of Patients Suffering from Blood-related Diseases Phan Van Chi, Institute of Biotechnology, Vietnamese Academy of Science and Technology, Cau Giay, Vietnam

MP100

Sub-cellular and Functional Proteomic Analysis of the Cellular Responses Induced by Helicobacter pylori Lu-Ping Chow, National Taiwan University, Taipei, Taiwan

MP101

Identification of Novel Biomarkers of Human Growth Hormone Administration by Serum Proteomic Profiling of Athletes Liping Chung, University of Sydney, Sydney, Australia

42

HUPO 2005 • FINAL PROGRAM

POSTER SESSION • MONDAY, AUGUST 29TH, 2005 MP102

Proteomic Analysis of the Mouse Lung Emphisema in Response to Cigarette Smoke Riccardo Cianti, University of Siena, Siena, Italy

MP103

Metabolic Syndrome Biomarker Discovery by Surface Enhanced Laser Desorption/Ionisation Timeof-Flight Mass Spectrometry Emma Cummins, Royal College of Surgeons in Ireland, Dublin, Ireland

MP104

A Proteomic Approach in the Study of Mandibuloacral Dysplasia Simona D'Aguanno, University Of Rome, Rome, Italy

MP105

Depletion of High Abundant Proteins Improves Proteomic Analysis of Plasma from Patients with Acute Coronary Syndrome Verónica M. Dardé, Fundacion Jimenez Diaz, Madrid, Spain

MP106

Proteomic Analysis of Tear Fluid Components Gustavo Antonio De Souza, Max Planck Institute of Biochemistry, Martinsried, Germany

MP107

Sera Mass Spectrometry Investigation in Multiple Sclerosis Affected Patients Piero Del Boccio, University of Chieti and Pescara, Chieti, Italy

MP108

Protein Profiling of Human Blood Platelets from Alzheimer’s Disease Patients Michael Diestinger, Surgical Research, Vienna, Austria

MP109

Biomarker Discovery in CSF of Depressive Patients Claudia Ditzen, Max Planck Institute of Psychiatry, Munich, Germany

MP110

Blood Collection: Effect of Preanalytic Conditions on Proteom Profiling Using MALDI-TOF Mass Spectrometry Patrick Ducoroy, I F R -100 Etablissement Francais du Sang Bourgogne Franche-Comté (EFS BFC), Dijon, France

MP111

Identification of Potential Biomarkers into the Cerebrospinal Fluid of Leber’s Disease by Proteomic Approach Giorgio Federici, University of Rome, Rome, Italy

MP112

Lack of Innate Immune Response during Down’s Syndrome Pregnancies Sophie Feldblum, Neurolab, Paris, France

MP113

Mass Spectrometric Protease Activity Profiling in Body Fluids - Biomarker Characterization and Therapy Target Identification for Rheumatoid Arthritis Michael Glocker, University of Rostock, Rostock, Germany

MP114

SELDI-TOF-MS Proteinchip Array Profiling of Tears from Dry-Eye Patients Franz Grus, University of Mainz, Mainz, Germany

HUPO 2005 • FINAL PROGRAM

43

POSTER SESSION • MONDAY, AUGUST 29TH, 2005 MP115

Identification of Differentially Expressed Proteins in Serums of Skin-irradiated Mice: Caracterisation of Potential Ionising Radiation Biomarkers Olivier Guipaud, Institute for Radiological Protection and Nuclear Safety, Fontenay Aux Roses, France

MP116

Prostate Cancer-associated Immunoreactivity Identified Using Arrays of Tumor-derived Proteins Brian B. Haab, Van Andel Research Institute, Grand Rapids, MI, United States

MP117

Diagnosis of Pancreatic Cancer by High-Resolution Mass Spectrometry Kazufumi Honda, National Cancer Center Research Institute, Tokyo, Japan

MP118

Proteomic Profiling of Experimental Autoimmune Encephalomyelitis: Quantitative and Phosphorylation Specific Protein Expression Changes in Different Mouse Models Archana Mary Jacob, Max Planck Institute of Psychiatry, Munich, Germany

MP119

Plasma Proteomics of Pancreatic Cancer by Multi-dimensional Liquid Chromatography and Twodimensional Gel Electrophoresis Tatsuhiko Kakisaka, National Cancer Center Research Institute, Tokyo, Japan

MP120

Identification of Glyoxalase-I as a Protein Marker in a Mouse Model of Extremes in Trait Anxiety Melanie Keßler, Max Planck Institute of Psychiatry, Munich, Germany

MP121

Profiling of Abnormally Expressed Proteins in Human Follicular Fluid from Recurrent Spontaneous Abortion (RSA) Patients M.-S. Kim, Cell and Gene Therapy Research Institute, Seoul, South Korea

MP122

Identification of Differentially Expressed Proteins in Polycystic Ovary Syndrome (PCOS) Patients Y.-S. Kim, Cell and Gene Therapy Research Institute, Seoul, South Korea

MP123

Screening and Quantification of Biomarkers for Neurodegenerative Disease Vesna Kostanjevecki, Innogenetics NV, Zwijnaarde, Belgium

MP124

Alzheimer’s Disease-specific Mass Signatures Identified by Carrier Protein-bound Proteomic Profiling Scott Kuzdzal, PerkinElmer Life & Analytical Sciences, Shelton, CT, United States

MP125

Comparative Analysis of the Serum Proteomes for Discovery of Biomarker of Hepatocellular Carcinoma Eun-young Lee, Yonsei Proteome Research Center, Yonsei University, Seoul, South Korea

MP126

Surrogate Endpoints in the Management of Acute Myeloid Leukemia Jinong Li, Johns Hopkins Medical Institutions, Baltimore, MD, United States

MP127

Proteomic Analysis of the Aging Related Proteins in Human Normal Colorectal Epithelial Tissue Ming Li, Cancer Research Institute, Central South University, Changsha, P.R. China

44

HUPO 2005 • FINAL PROGRAM

POSTER SESSION • MONDAY, AUGUST 29TH, 2005 MP129

Analysis of the Human CSF Proteome by LC-MALDI Tandem Mass Spectrometry Giuseppina Maccarrone, Max Planck Institute of Psychiatry, Munich, Germany

MP130

Biomarker Candidate Identification in Urine of RCC Patients by MALDI-TOF Based ClinProt Fulvio Magni, University Milano-Bicocca, Monza, Italy

MP131

Optimized and Integrated Identification Strategies for Peptidomics® Biomarker Discovery Christoph Menzel, Biovision Ag, Hannover, Germany

MP132

Urinary Proteome Analysis by Two-dimensional Electrophoresis: Optimized Conservation of Urine Samples Laurence Molina, Cnrs, Montpellier, France

MP133

Proteomic Analysis of Human Urine: Towards Finding Biomarker Candidates for Colorectal Cancer Un Na, Yonsei University, Seoul, South Korea

MP134

Proteomic Characterization of Acute Promyelocitic Leukemia Cell Lines, Sensitive and Resistant to Arsenic Trioxide Marzia Nuccetelli, University of Rome, Rome, Italy

MP135

Proteomic Analysis of Dedifferentiation-related Proteins in Normal Human Nasal Epithelial Cells Sae Jin Oh, Seoul National University, Seoul, South Korea

MP136

Differential Analysis of Mouse Brain Proteins Using Two Different Gel Systems Followed by Mass Spectrometry - the HUPO BPP Pilot Phase Nadine Palacios Bustamante, Ruhr University Bochum, Bochum, Germany

MP137

Differential Protein Profile of Prostasome Proteome in Normal and Neoplastic Cell Lines Daniele Perini, University of Siena, Siena, Italy

MP139

Identification of Glycosylated Human Serum Proteins Using Con-A Beads in Combination with MALDI-TOF/TOF Wolfgang Pusch, Bruker Daltonik GmbH, Bremen, Germany

MP140

Automated Profiling and Identification of Endogenous Peptidomic Markers in Human Plasma Tori Richmond, Thermo Electron Corporation, Cambridge, MA, United States

MP141

Identification of Brain Autoantigens as Candidate Biomarkers for Affective Disorders Eser Sayan-Ayata, Max Planck Institute of Psychiatry, Munich, Germany

MP142

Immuno-Secretomics: Serological Identification of Tumour-associated Antigens as Putative Serum Biomarkers Irmgard Schwarte-Waldhoff, Knappschaftskrankenhaus, Ruhr University Bochum, Bochum, Germany

MP143

Disease-associated Changes in the Microheterogeneity of Transthyretin Florian Schweigert, University of Potsdam, Potsdam-Rehbrücke, Germany HUPO 2005 • FINAL PROGRAM

45

POSTER SESSION • MONDAY, AUGUST 29TH, 2005 MP144

Metabolic Imaging Mass Spectrometry in Atherosclerotic Vessels Mas Sebastian, Fundación Jiménez Diaz, Madrid, Spain

MP145

Proteomics of Preeclampsia: An Analysis of Maternal Plasma Heather Shannon, University of Western Ontario, London, ON, Canada

MP146

Stratification and Pharmacodynamic Marker Discovery Using Blood Plasma Protein Expression Profiling Dmitri Sitnikov, Caprion Pharmaceuticals, St-Laurent, QC, Canada

MP147

Novel Allergy Biomarkers in Lymphocyte Plasma Membranes Cecilia Sundby Emanuelsson, Lund University, Lund, Sweden

MP148

Peptidomic Analysis of Breast Cancer Tissue Harald Tammen, Biovision Ag, Hannover, Germany

MP149

Identification and Characterization of Autoantibody-based Biomarkers Associated with Liver Cirrhosis and Cancer Tzu-ling Tseng, Industrial Technology Research Institute, Hsin Chu, Taiwan

MP150

Biomarker Investigations in Neurodegenerative Diseases Andrea Urbani, University of Chieti and Pescara, Chieti, Italy

MP151

Serum Profiling: The Analysis of Therapeutic Proteins and Diagnostic Markers for Lysosomal Storage Disorders by LC-MS Hans Vissers, Waters Corporation, Manchester, United Kingdom

MP153

Searching for Potential Oral Cancer Markers on the Basis of Cancer Cell-Secreted Proteomes Li-ping Weng, Chang Gung University, Kwei-Shan Tao-Yuan, Taiwan

MP154

Protein Profiling of Human Blood Platelets from Young and Aged Individuals Wolfgang Winkler, Surgical Research, Vienna, Austria

MP155

Cancer Cell-secreted Proteomes as a Basis for Searching Potential Tumor Markers Nasopharyngeal Carcinoma as a Model Chih Ching Wu, Graduate Institute of Basic Medical Sciences, Tao-yuan, Taiwan

MP156

A Preliminary Dataset of Cancer Cell-secreted Proteomes from Common Human Cancers Jau-song Yu, Graduate Institute of Basic Medical Sciences, Tao-yuan, Taiwan

MP157

Protein Profiling of Human Blood Platelets from Idiopathic Parkinson’s Disease Patients Maria Zellner, Surgical Research, Medical University of Vienna, Vienna, Austria

46

HUPO 2005 • FINAL PROGRAM

POSTER SESSION • MONDAY, AUGUST 29TH, 2005 MEDICAL, CLINICAL, PHARMACEUTICAL AND DISEASE PROTEOMICS – HEART & STROKE MP158

Identification of Brain Ischemia-Induced Changes in Protein Profiles by Quantitative Proteomics An Zhou, Legacy Research, Portland, OR, United States

MP159

Proteome Analysis of Secreted Proteins during Embryonal P19CLONE6 Cell Differentiation into Cardiac Myocytes Using 2-DE/MALDI-TOF Marion Blumenstein, University of Auckland, Auckland, New Zealand

MP160

Proteomic Analysis of Membrane Microdomains Derived from Both Failing and Non-failing Human Hearts Maura Brioschi, University of Milan and Monzino Cardiologic Center IRCCS, Milano, Italy

MP161

Characterization of Phosphorylated Proteins Associated with Ischemia / Reperfusion Injury in Rabbit Myocardium Stuart Cordwell, University of Sydney, Sydney, Australia

MP162

Differential Proteome Analysis of CRP-Activated Platelets Angel Garcia, University of Oxford, Oxford, United Kingdom

MP163

Subcellular Organelle Analyses of Protein Signatures in Genetic Dilated Cardiomyopathy Anthony Gramolini, University of Toronto, Toronto, ON, Canada

MP164

Influence of a Cardiovascular Disease Lifestyle Intervention on the Plasma Proteome Richard A. Katenhusen, Windber Reasearch Institute, Windber, PA, United States

MP165

Relation Between Different Apolipoprotein E Alleles and Paraoxonase-1 Activity in Early- and LateOnset Coronary Artery Disease (CAD) Shahnaz Khaghani, Tehran University of Medical Sciences, Tehran, Iran

MP166

Proteomic Analysis of Vascular Cells during Left Ventricular Hypertrophy Nari Kim, College of Medicine, Inje University, Busan, South Korea

MP167

Mutation of Methylenetetrahydrofolate Reductase Gene in CAD Haleh Masoudi, Tehran University of Medical Sciences, Tehran, Iran

MP168

Proteomic and Metabolomic Analysis of Atherosclerotic Aortas Derived from apoE-/- mice Manuel Mayr, St George’s, University of London, London, United Kingdom

MP169

Phosphorylation is a Major Regulator of the Proteolytic Activity of Cardiac 26S Proteasomes Peipei Ping, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States

MP170

Proteomic Analysis of Intact Mitochondrial Membrane Protein Complexes Containing ANT and VDAC: Implications for Mitochondrial Permeability Transition in Murine Heart Peipei Ping, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States

HUPO 2005 • FINAL PROGRAM

47

POSTER SESSION • MONDAY, AUGUST 29TH, 2005 MP171

Biochemical and Proteomic Characterization of the Murine Cardiac 26S Proteasome Peipei Ping, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States

MEDICAL, CLINICAL, PHARMACEUTICAL AND DISEASE PROTEOMICS – LIVER MP172

Search for HBsAg Associated Proteins in the Livers of HBV Transgenic Mice with Proteomic Analysis Chao Zhao, Shanghai Medical College, Fudan University, Shanghai, P.R. China

MP173

Changes in the Human Liver Proteome Induced by Transient Expression of Hepatitis Delta Virus RNA Celso Cunha, Institute of Hygiene and Tropical Medicine, Lisboa, Portugal

MP174

Proteome Analysis of Hepatocytes Terminal Differentiation Using the MMH in Vitro Model Tonino Alonzi, National Institute for Infectious Diseases, Rome, Italy

MP175

Protein Profilings in Mouse Liver Regeneration after Partial Hepatectomy Using iTRAQ Technology Sung-fang Chen, Industrial Technology Research Institute, Hsinchu, Taiwan

MP176

Proteome Analysis of Detergent-resistant Membrane Rafts from Human Liver Carcinoma HUH7 Cells Harboring Hepatitis C Virus Subgenomic Replicon Caiyun Fang, Fudan University, Shanghai, P.R China

MP177

SELDI-TOF-MS Profiling of Serum for Detection of Liver Cirrhosis and Hepatocellular Carcinoma in Chronic Hepatitis C Thomas Göbel, Klinik für Gastroenterologie, Hepatologie und Infektiologie, Düsseldorf, Germany

MP178

Changes in Hepatic Proteome during Fibrogenesis: DIGE (Difference in Gel Electrophoresis) Reveals New Proteins Like Selenium Binding Protein 2 in the Context of Fiborsis Corinna Henkel, University Hospital RWTH Aachen, Aachen, Germany

MP179

Disease Stage-specific Protein/Peptide in HCV-related Liver Cancer Takuya Katagiri, Molecular and Clinical BioInformatics Inc., Tsukuba, Japan

MP180

Proteomics as a Part of Systems Biology Digging for Membrane Proteins Elmar Langenfeld, Medizinisches Proteom Center, Bochum, Germany

MP182

Human Liver Proteome Changes Induced by the Hepatitis Delta Virus Sergio Mota, Institute of Hygiene and Tropical Medicine, Lisboa, Portugal

MP183

Identification of Cellular Factors Associated with the 3’-Nontranslated Region of the HCV Genome by RNA Affinity Capture and Mass Spectrometry Virendra Pandey, UMDNJ-New Jersey Medical School, Newark, NJ, United States

48

HUPO 2005 • FINAL PROGRAM

POSTER SESSION • MONDAY, AUGUST 29TH, 2005 MEDICAL, CLINICAL, PHARMACEUTICAL AND DISEASE PROTEOMICS – NEUROPROTEOMICS MP184

Diferential Protein Expression in Mouse Brain Regions Dijana Sagi, Charité - Universitätsmedizin Berlin, Berlin, Germany

MP186

Differentially Regulated Proteins in the Vitreous of Horses with Equine Recurrent Uveitis (ERU) and Eye Healthy Controls Frank Altmann, Institute of Animal Physiology, Munich, Germany

MP188

Identification of a Novel Panel of Cerebrospinal Fluid Biomarkers for Early Stage Alzheimer’s Disease Huw Davies, Ciphergen Biosystems Inc., Guildford, United Kingdom

MP189

Characterization of New Antigenic Targets by Sequential Analysis of the Self-Reactive IgG Response in Experimental Autoimmune Encephalomyelitis Mohamed El Behi, Center Hospitalier Régional Universitaire (CHRU) de Lille, Lille, France

MP190

Proteomic Characterization of the Non-human Primate Brain Willard Freeman, Penn State College of Medicine, Hershey, PA, United States

MP191

A New Proteomic Approach to Study the Heterogeneity of Amyloid Beta Species in Alzheimer's Disease Marie Gompel, Inserm U422, Lille, France

MP192

Differential Analysis of Phosphopeptides in Human Cerebrospinal Fluid Using Linear Ion Trap Mass Spectrometry in Pseudo Msn Scanning Mode Andreas Huhmer, Thermo Electron, San Jose, CA, United States

MP193

Combined Proteome and Transcriptome Analysis of Alterations in the Mouse Brain Caused by Huntington’s Disease Claus Hultschig, Max Planck Institute for Molecular Genetics, Berlin, Germany

MP194

Proteome Analysis of Human Brain with Alzheimer’s Disease and Diffuse Lewy Body Disease Takashi Ishii, Mcbi Inc, Tsukuba City, Japan

MP195

Diagnosis by Complex Autoantiboy-repertoires and Protein Profiles in Glaucoma Using Bio-chips Stephanie Joachim, University of Mainz, Mainz, Germany

MP196

Oxidation of Cerebrospinal Fluid Proteins in Aging and Alzheimer's Disease Minna A. Korolainen, University of Kuopio, Kuopio, Finland

MP197

Proteome Analysis of CRH Signal Transduction Pathways Helena Kronsbein, Max Planck Institute for Psychiatry, Munich, Germany

MP198

Alteration of GABA and Glutamatergic System in the Brain of the Niemann-pick Disease, Type C Mouse Bonghee Lee, Institute of Medical Science, College of Medicine, Cheju National University, Jeju, South Korea HUPO 2005 • FINAL PROGRAM

49

POSTER SESSION • MONDAY, AUGUST 29TH, 2005 MP199

Mapping the Proteome of Cultured Hippocampal Neurons and Profiling Changes Induced by BDNF Stimulation Bruno Manadas, Center for Neuroscience and Cell Biology, Coimbra, Portugal

MP200

Monoclonal Antibody Y1C7.A3 Probably Recognizes Titin in Neural, Muscle, and Other Nonmuscle Cells Aavo-Valdur Mikelsaar, University of Tartu, Tartu, Estonia

MP201

Identification of Binding Partners to Parkinson Disease Related Protein FKBP-12 Using Biacore 3000 and NANO-LC LTQ MS Anna Nilsson, Uppsala University, Uppsala, Sweden

MP202

Proteomic Studies of Fluoxetine Induced Neurogenesis in Female Rats Linda Paulson, The Arvid Carlsson Institute, Göteborg, Sweden

MP203

Differential Proteome Analysis of Brain from Alpha-Synuclein Mutant Mice Oliver Schmidt, Medical Proteom Center, Bochum, Germany

MP204

Morbus Alzheimer - Differential, Quantitative Proteome Analysis and Localisation of PostTranslational Modifications Thomas Schulenborg, Ruhr University Bochum, Bochum, Germany

MP205

High Resolution Mass Spectrometric Cleavage Site Elucidation of the Novel Serine Protease HtrA Involved in Amyloid Precursor Protein Processing Raluca Stefanescu, University of Konstanz, Konstanz, Germany

MP206

Far-Western Immunoblotting, 2-D Electrophoresis and MALDI-TOF MS Can Identify Prion Proteinbinding Proteins Andreas Stuke, German Primate Centre (DPZ), Göttingen, Germany

MP207

The Striatal Level of PEP-19 Is Reduced in the MPTP Mouse Model of Parkinson’s Disease Marcus Svensson, Lab for Medical and Biological Mass Spectrometry, Uppsala, Sweden

MP209

Comparative Proteomics Study of Cat Visual Cortex Development by Fluorescent 2-D DIGE and Mass Spectrometry Gert Van Den Bergh, Katholieke Universiteit Leuven, Leuven, Belgium

MP210

Identification of Neurotrypsin-Dependant Synaptic Changes by the Isotope-coded Affinity Tag (ICAT) Technology Pascal Walther, University of Zürich, Zürich, Switzerland

MP211

Clinical Neuroproteomics of Dementias: Current Status and Perspectives Jens Wiltfang, University of Erlangen, Erlangen, Germany Altered Endocytosis in Huntington's Disease Transgenic Mice Claus Zabel, Charite - University Medicine Berlin, Berlin, Germany

MP212

50

HUPO 2005 • FINAL PROGRAM

POSTER SESSION • MONDAY, AUGUST 29TH, 2005 MEDICAL, CLINICAL, PHARMACEUTICAL AND DISEASE PROTEOMICS – OBESITY & DIABETES MP213

DIGE Analyses Indicates Phenotypic Changes Between Glucose-responsive and Glucose Nonresponsive Min-6 Beta Cells Paul Dowling, Dublin City University, Dublin, Ireland

MP214

Proteomic Analysis of Strain-specific Liver Proteins in Inbred Mice Hye Sook Hwang, Seoul National University, Seoul, South Korea

MP215

Quantitative Profiles of Secreted Factors during Adipocyte Differentiation Irina Kratchmarova, University of Southern Denmark, Odense, Denmark

MP216

Identification and Characterization of DNA-binding Proteins Using Affinity Purification and Mass Spectrometry Ai-ping Lu, University of Southern Denmark, Odense, Denmark

MP217

Proteomic Analysis of Cytokine-induced Dysfunction and Death in Insulin-producing INS-1E Cells Lut Overbergh, Catholic University Leuven, Leuven, Belgium

MP218

Comparison of Insulin and IGF-1 Induced Signaling Cascades in 3T3-L1 Adipocytes by Mass Spectrometry-based Proteomics Cuiping Pan, Max Planck Institute of Biochemistry, Martinsried, Germany

MP219

A Fully Automated and Miniaturized Immunoassay for Insulin Quantification within a CD Microlaboratory Andrea Schmidt, Gyros Ab, Uppsala, Sweden

MEDICAL, CLINICAL, PHARMACEUTICAL AND DISEASE PROTEOMICS – PLASMA MP220

Drilling the Human Plasma Proteome: Novel Advancements in Fractionation and Separation Christoph Eckerskorn, BD, Martinsried, Germany

MP221

Human Serum Proteome Analysis by Protein 2D Chromatography System: Methodological Aspects Felix Elortza, CIC Biogune, Derio, Spain

MP222

Non-denaturating Multidimensional Separation of Serum Proteomes: Improved Method, Automatization and Applications Stefan Kreusch, Institut of Biochemistry, Jena, Germany

MP223

Characterization of Seleno-Glycoproteins in the Human Plasma of Seleno-Glycoproteins in the Human Plasma Antonios Kyriakopoulos, Hahn-Meitner-Institut, Berlin, Germany Proteomic Strategy for the Identification of Low Abundance Proteins and Investigation of Biomarker in Human Plasma Rong-Xia Li, Shanghai Institutes for Biological Sciences, Shanghai, P.R.. China

MP224

HUPO 2005 • FINAL PROGRAM

51

POSTER SESSION • MONDAY, AUGUST 29TH, 2005 MP225

Erythroid Membrane Proteomics Stefania Orru, Ceinge Biotecnologie Avanzate, Naples, Italy

MP226

The Proteomic Responses in Mouse Plasma to Sepsis Generated From CLP Model Yan Ren, Beijing Genomics Institute, Chinese Academy of Sciences (CAS), Beijing, P.R China

MP227

Comparison of Pretreatment Methods for Serum Profiling Using SELDI Proteinchip Technology Han Roelofsen, University Medical Centre Groningen, Groningen, The Netherlands

MP228

Baseline Serum Protein Profiles for 40 Normal Individuals and Pooled Subpopulations Using Optimized 2-DE Analysis Jennifer Van Eyk, Johns Hopkins University, Baltimore, MD, United States

MP229

Application of the Evidence® System to Quantify Cytokines in the Stanislas Cohort Sophie Visvikis-Siest, Inserm U525, Nancy, France

MP230

Development and Assessment of a High Abundant Human Plasma Protein Depletion Kit Using Monoclonal Antibodies against Native Serum Proteins Ning Yunshan, South Medical University, Guangzhou, P.R. China

MEDICAL, CLINICAL, PHARMACEUTICAL AND DISEASE PROTEOMICS - TARGET IDENTIFICATION AND VALIDATION MP231

Proteomic Analysis of Factors Released from P21-overexpressing Tumour Cells Currid Caroline, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland

MP232

Target Profiling Aiding the Drug Discovery Process Klaus Godl, GPC BIOTECH AG, Munich, Germany

MP233

LC-MALDI for Advanced Characterization of Complex Protein Samples Stephanie Hahner, Bruker Daltonik GmbH, Bremen, Germany

MP234

Proteomic Analysis of the Effects of Histone Deacetylase Inhibitor, Sodium Butyrate, on Chronic Myelogenous Leukemia-derived Cell Line K562 Kateina Kuzelová, Institute of Hematology and Blood Transfusion, Prague, Czech Republic

MP235

From Proteomics to K+ Channel Discovery in Rat Heart Mitochondria Youngsuk Lee, College of Medicine, Inje University, Busan, South Korea

MP236

Selective Targeting of Leishmania EF-alpha as a Novel Drug Target Based on Indel-Inferred Differences Devki Nandan, University of British Columbia, Vancouver, BC, Canada Identification of New Allergens to Baker's Asthma Tuula Nyman, Finnish Institute of Occupational Health, Helsinki, Finland

MP237

52

HUPO 2005 • FINAL PROGRAM

POSTER SESSION • MONDAY, AUGUST 29TH, 2005 MP238

Identification of Fatty Acid Binding Proteins as Markers Associated with the Initiation and/or Progression of Renal Cell Carcinoma Barbara Seliger, Martin Luther University Halle-Wittenberg, Halle, Germany

MP239

Identification and Validation of Low Abundant Components in Spliceosomal Protein Complexes by Predictive Multiple Reaction Monitoring Henning Urlaub, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany

MEDICAL, CLINICAL, PHARMACEUTICAL AND DISEASE PROTEOMICS - TOXICOLOGY MP240

Smoke and Follicular Damage: A Toxicoproteomics Approach Stefania Angelucci, Univesity of Chieti, Chieti, Italy

MP241

Proteomics Analysis of Rat Hepatic Endoplasmic Reticulum: Detoxification Machinery Alexander Bell, McGill University, Montreal, QC, Canada

MP242

Quantitative Proteomics of Maternal Plasma to Identify Biomarkers for Intrauterine Growth Restriction (IUGR) Madhulika B. Gupta, University Of Western Ontario, London, ON, Canada

MP243

Effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxins on Proteins Expression in HepG2 Cells Im Hosub, Korea University, Seoul, South Korea

MP244

Proteomic Analysis of the Response of Human Lung Cells to Uranium Veronique Malard, CEA, Bagnols-sur-Cèze Cedex, France

MP245

Role of Enzymes of the Antioxidave System(AOS) in the Rat's Liver in Adaptation to Interrupted Alcohol Treatment Dzmitry Miskevich, Institute of Biochemistry, Grodno, Belarus

MP246

Differental Expression Profiling of the Hepatic Proteome in a Rat Model of Dioxin Resistance Roberta Pastorelli, Istituto di Ricerche Farmacologiche, Milano, Italy

MP247

Particle-induced Proteome Changes in Epithelial Cell Line Taiyoun Rhim, Soonchunhyang University Hospital, Bucheon-si, South Korea

MP248

Quantitative Analysis of TCDD-induced Proteome Alterations in 5L Rat Hepatoma Cells Hakan Sarioglu, GSF-Forschungszentrum Für Gesundheit Und Umwelt, Neuherberg, Germany

MP249

Toxicoproteomic Biomarkers in Plasma Proteins of Rats Exposed to Formaldehyde Donggeun Sul, Korea University, Seoul, South Korea

HUPO 2005 • FINAL PROGRAM

53

POSTER SESSION • MONDAY, AUGUST 29TH, 2005 MP250

The Proteomic Alterations of T.tengcongensis Cultured at the Different Temperatures Jingqiang Wang, Beijing Genomics Institute, Chinese Academy of Sciences (CAS), Beijing, .R. China

MEDICAL, CLINICAL, PHARMACEUTICAL AND DISEASE PROTEOMICS – OTHER TISSUES MP251

Proteomic Analysis of Apical Microvillous Membranes of Syncitiothrophoblast Cells Reveals a High Degree of Similarity with Lipid Rafts Juan Pablo Albar, Centro Nacional de Biotecnología, Madrid, Spain

MP252

Expression Proteomics Analysis in E2F1-/- T Lymphocytes Mikel Azkargorta, University of the Basque Country, Bilbao, Spain

MP253

Human Epididymal Secretome and Proteome Jean Louis Dacheux, INRA, Nouzilly, France

MP254

Comparative Proteome Analysis to Study the Blood Platelet Storage Lesion Marie Duguay, University of British Columbia, Vancouver, BC, Canada

MP255

Analysis of Human Stored-platelet Proteome by 2D-DIGE David Engler, Texas Heart Institute, Houston, TX, United States

MP256

The Change of Tear Protein Pattern in Smokers and Contact Lens Wearers Ali Erfani, The University of Guilan, Rasht, Iran

MP257

A Preliminary Investigation of the Human Aortic Media Proteome Annarita Farina, Second University of Naples, Caserta, Italy

MP258

Comparative Proteomics Identified Nuclear Translocation of NFAT C1 in Ulcerative Colitis Sen-Yung Hsieh, Chang Gung Memorial Hospital, Tao Yuan, Taiwan

MP259

Proteomic Analysis of Dysferlin-Mediated Cell Membrane Repair Pathway Siok-yuen Kam, National Cancer Centre, Singapore, Singapore

MP260

The Influence of Hypothermia on Renin-Angiotensin-Aldosterone Axis in Rats Zargham Ostadi, Drug Applied Research Center, Tabriz, Iran

MP261

Large-Scale Proteomic Analysis of Human Seminal Plasma Bartosz Pilch, Max Planck Institute for Biochemistry, Martinsried, Germany

MP262

Purification and Characterization of Human Articular Chondrocyte Mitochondria for Proteomic Analysis C. Ruiz, C.H.U. Juan Canalejo, A Coruña, Spain

MP263

Proteomics of Murine Prostate Secretion Thomas Schwend, Karolinska Institute, Stockholm, Sweden

54

HUPO 2005 • FINAL PROGRAM

POSTER SESSION • MONDAY, AUGUST 29TH, 2005 MP264

Proteomic Analysis of in Vitro - Differentiating Cytotrophoblasts Leif Steil, Ernst-Moritz-Arndt Universität, Greifswald, Germany

MP265

Proteomic Study of Phenotypic Variability in a Murine Model of Osteogenesis Imperfecta Chiara Tani, University of Siena, Siena, Italy

MP266

Subproteomic Identification of New Metal-Protein Interactions in Human Antigen Presenting Cells (APC) Reveals a Potential Link to Metal-specific Immune Responses in Human Nickel Allergy Hermann- Josef Thierse, University of Freiburg and Max Planck Institute for Immunobiology, Mannheim, Germany

MP267

Proteomics of Human Sputum Ruddy Wattiez, University of Mons-Hainaut, Mons, Belgium

MP268

Human Salivary Proteome Weihong Yan, University of California at Los Angeles, Los Angeles, CA, United States

MP269

Proteome of Normal Human Kidney Glomerulus: Database, Differential Expression and 2-DE Profiling of Glomeruli Isolated from Biopsy Tissues Yutaka Yoshida, Niigata Graduate School of Medical and Dental Sciences, Niigata, Japan

MP270

Seminal Plasma Levels of 15-F2t -isoprostane, Malondialdehyde and Total Homocysteine in Normozoospermic and Asthenozoospermic Males Nosratollal Zarghami, Drug Applied Research Center, Tabriz, Iran

MEDICAL, CLINICAL, PHARMACEUTICAL AND DISEASE PROTEOMICS - OTHER MP271

Production of Nitric Oxide in j774, A1 Mouse Macrophages Cells Is Affected by Brucella Strains Dna Zahra Afraz, Tehran University, Tehran, Iran

MP272

Candidate Proteins Involved in the Trafficking Defect of f508del-CFTR: A Proteomic Approach Patricia Alves, Instituto Nacional de Saœde Dr. Ricardo Jorge, Lisbon, Portugal

MP273

Gmp Compliant Validation of Protein Quantification, 2D-PAGE Protein Separation and Protein Identification by Mass Spectrometry Katja Aschermann, Protagen AG, Dortmund, Germany

MP274

Identification of Proteins Characteristic of An Interleukin-23 Driven Pathogenic T-cell Population (Th IL-17) That Induces Autoimmune Inflammation Kristian Bak-Jensen, Dnax Research Inc., Palo Alto, CA, United States

MP275

Identification of Novel Neuronal Receptors in Human Sperm by Proteomic Analysis Jon Barbour, Ruhr University Bochum, Bochum, Germany

HUPO 2005 • FINAL PROGRAM

55

POSTER SESSION • MONDAY, AUGUST 29TH, 2005 MP276

Novel Assay Design for Parallel Detection of Auto-antibodies in Patient Serum Jens Beator, Schleicher & Schuell BioScience GmbH – Whatmangroup, Dassel, Germany

MP277

Functional Genomics of the Progeroid Syndrome Trichothiodystrophy Harm De Waard, Erasmusmc, Rotterdam, The Netherlands

MP278

Adical Oxidation of Peptide Leucin-enkephalin Monitored by Electrospray Tandem Mass Spectrometry M. Rosario Domingues, University of Aveiro, Aveiro, Portugal

MP279

Unravelling Endothelial Senescence by Using Differential Proteome Analysis Michael Eman, Utrecht University, Utrecht, The Netherlands

MP280

Assaying the Polyadenylationstateof SLBP mRNA in Mouse Oocytes and Early Embryos Parinaz Ghadam, Azzahra University, Tehran, Iran

MP281

Urinary Findings in 500 Patients with Organophosphorous Intoxication at 8 Years Duration from 1997-2004 in Khorramabad Hospitals of Iran Aref Hossinian Amiry, School of Medcine, Khoramabad, Iran

MP282

Differential Peptide Display of in Vivo Changes in Peptide Patterns of Rat Plasma Induced by Anticoagulation Therapy Marco Jost, Biovision Ag, Hannover, Germany

MP283

High-confidence Analysis of the Human Urinary Proteome Adachi Jun, Max Planck Institute for Biochemistry, Martinsried, Germany

MP284

Matricaria Urea Extract Exhibits Antinociceptive Activity in Male Rat Mojtaba Khaksarian, School of Medcine, Khoramabad, Iran

MP285

Identification of Adipose Differentiation-related Proteins Expressed in the Longissimus Dorsi Muscle Tissues of Korean Native Cattle Hong-gu Lee, Seoul National University, Seoul, South Korea

MP286

Spot Patterns of Lysed Mouse Macrophages: What Comes From Cell Culture Medium? Ingrid Miller, Institute for Medical Chemistry, Vienna, Austria

MP287

Oxidative Damage of Peptides: Identification of Protein-lipid Adducts Formed by Reactive Aldehydes Formed during Phospholipid Radical Reaction Ana Reis, University of Aveiro, Aveiro, Portugal

MP288

Proteomics of Macrophage: An Approach to Understand Lipopolysaccharide Challenged Inflammation Liu Suk Yin Karen, The University of Hong Kong, Hong Kong, P.R. China Statistical Analysis of Differential Proteome Expression Andreas Wattenberg, Protagen AG, Dortmund, Germany

MP289

56

HUPO 2005 • FINAL PROGRAM

POSTER SESSION • MONDAY, AUGUST 29TH, 2005 MP290

The Expanding Toolbox for Characterizing Human Salivary Proteome Yongming Xie, University of California, Los Angeles, CA, United States

07:00 - 08:00 IS4 – INDUSTRY SPONSORED SYMPOSIUM NONLINEAR DYNAMICS MODAS 2D/MS – THE FIRST FULLY INTEGRATED PROTEOMICS PLATFORM ROOM: 5 Chair: John Spreadbury, Group Sales & Marketing Director, CEO Nonlinear United States, Nonlinear Dynamics 07:00 – 07:10 Buffet Breakfast 07:10 - 07:30 Analysing Data across the Proteomics Workflow Professor Mark S. Baker, CEO, Australian Proteome Analysis Facility (APAF) 07:30 - 07:50 MODAS 2D/MS – The Integrated Platform for Proteomics Analysis Stephen David & Philippe Bogard, Strategic Marketing, Nonlinear Dynamics, United Kingdom 07:50 - 08:00 Questions and Further Discussion Prize draw - Attend HUPO 2006, Long Beach, California, United States (Your chance to win complimentary registration and hotel accommodation!)

08:30 – 10:30

PL2.1

HONORARY LECTURES "PIONEERS IN PROTEOMICS" Chairs: Angelika Görg & Matthias Mann

08:30 – 09:00

PL2.1.01

A Successful Thesis? Patrick O’Farrell, University of California-San Francisco, CA, United States

09:00 – 09:30

PL2.1.02

Clues to Composition and Conformation of Peptides and Proteins from Their Adduction Behaviour John Fenn, Virginia Commonwealth University, Richmond, VA, United States

09:30 – 10:00

PL2.1.03

MALDI Mass Spectrometry in Proteomics: Past, Present and Future Franz Hillenkamp, University of Münster, Münster, Germany

10:00 – 10:30

PL2.1.04

From Sequences to Knowledge, the Role of the Swiss-Prot Component of UniProt Amos Bairoch, Swiss Institute of Bioinformatics, Geneva, Switzerland

10:30 – 11:15

ROOM: 14

COFFEE AND POSTER BREAK

HUPO 2005 • FINAL PROGRAM

57

POSTER SESSION • MONDAY, AUGUST 29TH, 2005 11:15 – 12:30

PL2.2

PLENARY LECTURES: PROTEOMICS TECHNOLOGIES Chairs: Peter Roepstorff & Roman Zubarev

11:15 – 11:40

PL2.2.01

Driving Biological Discovery using Mass Spectrometry John Yates III, The Scripps Research Institute, La Jolla, CA, United States

11:40 – 12:05

PL2.2.02

2D Electrophoresis for Proteome Analysis Angelika Görg, Technische Universität München, Freising, Germany

12:05 – 12:30

PL2.2.03

Toward Error-Free Proteomics Roman Zubarev, Uppsala University, Uppsala, Sweden

ROOM: 14

12:45 – 14:15 IS5 - LUNCHEON INDUSTRY SPONSORED SYMPOSIUM BD BREAKING THROUGH HURDLES IN CLINICAL PROTEOMICS: NEW TECHNIQUES FOR PROTEIN COLLECTION & STABILIZATION, SEPARATION, AND PHOSPHORYLATION EVENT ANALYSIS ROOM: 1 Chair: Bruce C. Haywood, Business Development Leader, BD Diagnostics, Preanalytical Systems, Franklin Lakes, NJ, United States 12:45 – 12:55 Overview Bruce C. Haywood, Business Development Leader, BD Diagnostics, Preanalytical Systems, Franklin Lakes, NJ, United States 12:55 – 13:30 Novel Methods for Sample Collection, Stabilization, and High-Resolution Separation of Plasma Proteins Christoph Eckerskorn, Dr., PD, Vice President, Science & Technology Proteomics, BD Diagnostics, Im Innovationszentrum Biotechnologie, Martinsried, Germany 13:30 – 14:05 Signaling Network Analysis in Single Cells: Techniques and Clinical Applications Robert Balderas, Vice President, Research and Development, BD Biosciences, San Diego, CA, United States 14:05 – 14:15 Questions and Answers

58

HUPO 2005 • FINAL PROGRAM

POSTER SESSION • MONDAY, AUGUST 29TH, 2005 12:45 – 14:15 IS6 - THERMO ELECTRON CORPORATION LUNCHEON INDUSTRY - SPONSORED SYMPOSIUM Proteomicsn – Proven Solutions for Proteomics ROOM: 13 Chair: Michaela Scigelova, Thermo Electron Corporation 12:45 – 12:55 Welcome and Introduction Michaela Scigelova, Ph.D, Thermo Electron Corporation, Hemel Hempstead, United Kingdom 12:55 – 13:25 The Quest for Biomarkers of Human Brain Disorders Prof. Chris Turck, Ph.D, Dept. Proteomics, Max Planck Institute of Psychiatry, Martinsried, Germany 13:30 – 14:00 Protein Identification with Near Certainty on an LTQ-FT Prof. Matthias Mann, Ph.D, Director Center for Experiment Bio-Informatics (CEBI) University of Southern Denmark, Odense, Denmark and Max Planck Institute for Biochemistry, Martinsried, Germany 14:00 – 14:15 Discussion with Speakers 14:15 – 15:00

POSTER VIEWING PARALLEL SESSIONS

15:00 – 16:55

PS2.1

BIOINFORMATICS STANDARDS DATABASES Chairs: Rolf Apweiler & Ron Appel

ROOM: 14

15:00 – 15:20

PS2.1.01

Towards Standardized Capturing of Proteomics Data and Proteomics Repositories Rolf Apweiler, EMBL, European Bioinformatics Institute, Hinxton, United Kingdom

15:20 – 15:40

PS2.1.02

What’s in MS Spectra? What’s in Databases? Take the Best to Identify Active Proteins Ron Appel, Swiss Institute of Bioinformatics, Geneva, Switzerland

15:40 – 15:55

PS2.1.03

An Evaluation, Comparison and Accurate Benchmarking of Several Publicly-Available MS/MS Search Algorithms: Sensitivity and Specificity Analysis Eugene Kapp, Ludwig Institute for Cancer Research, Melbourne, Australia

HUPO 2005 • FINAL PROGRAM

59

DETAILED PROGRAM • TUESDAY, AUGUST 30TH 15:55 – 16:10

PS2.1.04

High-Performance Shotgun Proteomics Data Validation Using Experimental Parameters Manfred Heller, University of Bern, Bern, Switzerland

16:10 – 16:25

PS2.1.05

The Creation and Usage of a Human Protein Atlas Database Erik Björling, KTH – Royal Institute of Technology, Stockholm, Sweden

16:25 – 16:40

PS2.1.06

Reference Libraries of Peptide Mass Spectra Stephen Stein, National Institute of Standards and Technology, Gaithersburg, MD, United States

16:40 – 16:55

PS2.1.07

Bioinformatics at NIAID Biodefense Proteomics Administrative Resource Center P. McGarvey, Georgetown University Medical Center, Washington D.C., United States

15:00 – 16:55

PS2.2

PROTEOMIC METHODS I Chairs: Yoshiya Oda & Fred Regnier

15:00 – 15:20

PS2.2.01

Activity Based and Affinity Based Approaches Using Stable Isotope Labeling in Drug Discovery Yoshiya Oda, Eisai Co., Tsukuba, Ibaraki, Japan

15:20 – 15:40

PS2.2.02

Carbonylation of Protein during Oxidative Stress Fred Regnier, Purdue University, West Lafayette, IN, United States

15:40 – 15:55

PS2.2.03

Protein Quantification in Formalin Fixed Tissue Samples Karl-Friedrich Becker, Technische Universität München, Munich, Germany

15:55 – 16:10

PS2.2.04

DIGE as an Analytical Tool for Quantitative Multivariable DifferentialDisplay Proteomics David B. Friedman, Vanderbilt University School of Medicine, Nashville, TN, United States

16:10 – 16:25

PS2.2.05

Double Standards in Quantitative Proteomics: Direct Comparative Assessment of Difference Gel Electrophoresis and Metabolic Stable Labeling Annemieke Kolkmann, Utrecht University, Utrecht, The Netherlands

16:25 – 16:40

PS2.2.06

Multi-Dimensional Capillary Electrophoresis Separation Interfaced with Mass Spectrometry for Bioanalytical Drug Characterization Norberto Guzman, Johnson & Johnson, Raritan, NJ, United States

60

HUPO 2005 • FINAL PROGRAM

ROOM: 5

DETAILED PROGRAM • TUESDAY, AUGUST 30TH 16:40 – 16:55

PS2.2.07

Molecular Tools for the Detection and Enrichment of Protein Families in Functional Proteomics Norberto Sewald, Bielefeld University, Bielefeld, Germany

15:00 – 17:00

PS2.3

POST-TRANSLATIONAL MODIFICATIONS Chairs: Peter Roepstorff & Naoyuki Taniguchi

15:00 – 15:20

PS2.3.01

Modification Specific Proteomics, a Concept for Subproteomics Peter Roepstorff, University of Southern Denmark, Odense, Denmark

15:20 – 15:40

PS2.3.02

Role of Branching N-Glycans and the Functional Glycomics Naoyuki Taniguchi, Osaka University Graduate School of Medicine, Osaka, Japan

15:40 – 16:00

PS2.3.03

Quantitation of Post-Translational Modifications in Proteomics by Mass Spectrometry Ole Noerregaard Jensen, University of Southern Denmark, Odense, Denmark

16:00 – 16:15

PS2.3.04

Detection of Phosphopeptides from Complex Mixtures Using Titanium Oxide Pre-Columns and FT-ICR Mass Spectrometry Martijn Pinkse, Utrecht University, Utrecht, The Netherlands

16:15 – 16:30

PS2.3.05

Phosphorylation as a Regulatory Mechanism in the Spindle Assembly Checkpoint Arminja Kettenbach, Harvard Medical School, Boston, MA, United States

16:30 – 16:45

PS2.3.06

Revival of Negative Ion Electrospray Tandem Mass Spectrometry in Protein Phosphorylation Analysis Wolf Dieter Lehmann, German Cancer Research Center, Heidelberg, Germany

16:45 – 17:00

PS2.3.07

Peptoscope: Automatic Detection of Post-Translational Modifications Driving a Search Engine Frank Potthast, Uni/ETH Zürich, Zürich, Switzerland

15:00 – 16:55

PS2.4

CLINICAL PROTEOMICS II Chairs: Michael J. Dunn & Peipei Ping

15:00 – 15:20

PS2.4.01

Myocardial Ischemic Injury and Proteasome Function Peipei Ping, Geffen School of Medicine at UCLA, Los Angeles, CA, United States

ROOM: 13

ROOM: 1

HUPO 2005 • FINAL PROGRAM

61

DETAILED PROGRAM • TUESDAY, AUGUST 30TH 15:20 – 15:40

PS2.4.02

Proteomics of the Transplanted Heart Michael J. Dunn, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland

15:40 – 15:55

PS2.4.03

Integrated Proteomic and Metabolomic Analysis Reveals Metabolic Remodeling in Human Persistent Atrial Fibrillation Ursula Mayr, St. George’s University of London, London, United Kingdom

15:55 – 16:10

PS2.4.04

Potential Rational Disease Biomarkers for Chronic Obstructive Pulmonary Disease (COPD) from Human Plasma Julia Bandow, Pfizer Inc., Ann Arbor, MI, United States

16:10 – 16:25

PS2.4.05

Characterization of the Multiple Sclerosis Cerebrospinal Fluid Proteome by Gel-Based and Gel-Free Proteomic Approaches Debora Dumont, Limburgs Universitair Centrum, Diepenbeek, Belgium

16:25 – 16:40

PS2.4.06

Quantitative Cellular Proteomics of Presynaptic Active Zone and Postsynaptic Density of Mouse Hippocampus – Effect of Morphine Treatment Rong Wang, Mount Sinai School of Medicine, New York, NY, United States

16:40 – 16:55

PS2.4.07

Vaccine Discovery and Proteomics Guido Grandi, Chiron Vaccines, Siena, Italy

17:00 – 17:30

COFFEE, SNACKS and POSTER BREAK

17:30 – 19:30

PS2.5

NEWS CORNER II Chair: Helmut E. Meyer

17:30 – 17:40

PS2.5.01

Mild Tissue Dissociation and Subcellular Fractionation Sample Preparation Tools, Facilitating Functional Investigations of Proteins Rob Hendricks, Merck KgaA, Darmstadt, Germany

17:40 – 17:50

PS2.5.02

Strategies for Selective Isolation and Identification of Proteins from Complex Clinical Samples by Magnetic Bead-Based MALDI-TOF/TOF Markus Kostrzewa, Bruker Daltonik, Bremen, Germany

17:50 – 18:00

PS2.5.03

Cost-Efficient and High Capacity Depletion of Abundant Serum Proteins Martina Palm, Affibody AB, Bromma, Sweden

18:00 – 18:10

PS2.5.04

Developments in TOF/TOF Technology Applied to Proteomics Martin Hornshaw, Applied Biosystems, Warrington, United Kingdom

62

HUPO 2005 • FINAL PROGRAM

ROOM: 14

DETAILED PROGRAM • TUESDAY, AUGUST 30TH 18:10 – 18:20

PS2.5.05

Dynamic Analysis of Nucleolar Proteome by i-PROT Technology Bing Xie, Agilix,Corporation, New Haven, CT, United States

18:20 – 18:30

PS2.5.06

Reversible Covalent Binding of the Fluorophore Epicoccone to Proteins Provides a Novel Approach to the Sensitive Quantification of Proteins Across a Wide Variety of Different Platforms Duncan Adam Veal, FLUOROtechnics, Sydney, Australia

18:30 – 18:40

PS2.5.07

EpiTags: A Scalable Approach for Building Binders and Assays to Study the Proteome John Tonkinson, Epitome Biosystems, Waltham, MA, United States

18:40 – 18:50

PS2.5.08

Array-Based Systems for High Information Protein Interaction Analysis in Proteomics Björn Persson, Biacore AB, Uppsala, Sweden

18:50 – 19:00

PS2.5.09

Discover Multiple Facets of the Innovative Phenyx Platform and Achieve Increased Confidence in Protein Identification Pierre-Alain Binz, Geneva Bioinformatics (GeneBio SA), Geneva, Switzerland

19:00 – 19:10

PS2.5.10

Integration of Databases, TRANSFAC, TRANSPATH and Proteome, Is the Comprehensive Resource to Study Protein Functions Alexander Kel, Biobase GmbH, Wolfenbüttel, Germany

19:10 – 19:20

PS2.5.11

Fourier Transform Mass Spectrometry Based Comparative Proteomics for Plasma Profiling Cloud Paweletz, Merck Research Laboratories, Rahway, NJ, United States

19:20 – 19:30

PS2.5.12

Protein Biomarkers for Inflammatory Disease Dissection Christine Labeur, Peakadilly, Zwijnaarde, Belgium

PS2.6

DOCTORS’ OFFICE I: Two-Dimensional Electrophoresis & DIGE Chairs: Thierry Rabilloud, CEA-INSERM, Grenoble, France Reiner Westermeier, GE Healthcare, Freiburg, Germany David Friedman, Vanderbilt University, Nashville, TN, United States Walter Weiss, Technische Universität München, Freising, Germany

17:30 – 19:30

ROOM: 1

HUPO 2005 • FINAL PROGRAM

63

DETAILED PROGRAM • TUESDAY, AUGUST 30TH 17:30 – 19:30

PS2.7

DOCTORS’ OFFICE II: Mass Spectrometry Chairs: Peter Roepstorff, University of Southern Denmark, Odense, Denmark Karin Hjernœ, University of Southern Denmark, Odense, Denmark Ole Noerregaard Jensen, University of Southern Denmark, Odense, Denmark Martin Røssel Larsen, University of Southern Denmark, Odense, Denmark

ROOM: 13

17.30 – 19.30

PS2.8

DOCTORS’ OFFICE III: Bioinformatics Chairs: Ron Appel, Swiss Institute of Bioinformatics, Geneva, Switzerland Henning Hermjakob, European Bioinformatics Institute, Hinxton, United Kingdom Pierre-Alain Binz, Geneva Bioinformatics, Geneva, Switzerland Frederique Lisacek, Swiss Institute of Bioinformatics, Geneva, Switzerland

ROOM: 5

POSTER SESSION ROOM:B0 DISPLAY ALL DAY OFFICIAL VIEWINGS: 14:15 – 15:00 NEWS CORNER TP001 TP002

Isolation of Intact Mitochondria from Tissue Peter Bell, Pierce Biotechnology, Inc., Rockford, IL, United States Biotinylation and Isolation of Cell Surface Proteins for Western Blot Analysis Margaret Benton, Pierce Biotechnology, Inc., Rockford, IL, United States

TP003

Detection and Quantification of Proteins Using a Novel Fluorescent Dye Tom Berkelman, Bio-Rad Laboratories, Hercules, CA, United States

TP004

High Recovery Liquid Chromatographic Methods for Protein Fractionation Barry Boyes, Agilent Technologies Inc., Wilmington, DE, United States

TP005

An ISO9001 Industrialized Platform for Yeast Two-hybrid Screening Vincent Collura, Hybrigenics SA, Paris, France

TP006

Biomarker Validation Using Proteuslims™ - The Proteomics Lab Information and Scientific Data Management System James DeGreef, Genologics Life Sciences Software Inc., Victoria, BC, Canada

TP007

IgY-Immunoaffinity Separation and Detection: Divide and Conquer the Proteome Xiangming Fang, Genway Biotech Inc., San Diego, CA, United States

64

HUPO 2005 • FINAL PROGRAM

POSTER SESSION • TUESDAY, AUGUST 30TH TP008

A Device to Ease Rapid in Gel Digestion Bernhard Granvogl, Ludwig-Maximilians-University, Munich, Germany

TP009

Rapid Screening of pI Separated Protein Samples from a MicroRotofor Using the Experion Automated Electrophoresis Andrew Cohen, Bio-Rad Laboratories, Hercules, CA, United States

TP010

Free Liquid IEF Pre-fractionation in the MicroRotofor™: Improved 2-D Resolution of Low Abundance Proteins in Microscale Sample Volumes Andrew Cohen, Bio-Rad Laboratories, Hercules, CA, United States

TP011

Monitoring the Expression, Purification and Processing of GST-tagged Proteins with Bio-Rad’s Experion Automated Electrophoresis System Aran Paulus, Bio-Rad Laboratories Inc., Hercules, CA, United States

TP012

Biomarker Discovery and Validation in One Step: Combination of High Throughput Monoclonal Antibody (MAB) and Mass Spectrometry Technologies William Hempel, Biosystems International, Evry, France

TP013

First Functional Protein Microarrays for Multiplexed Investigation of Cancer Mechanisms Henry Hepburne-Scott, Procognia Ltd., Maidenhead, United Kingdom

TP014

Quatitative Immunodetection Using Infrared Technology Muna Krings, Li-Cor Biosciences GmbH, Bad Homburg, Germany

TP015

MPEP MALDI Chips for High Sensitivity and Throughput Peptide Analysis by MALDI-TOF MS Michael Lutz, Sunyx, Cologne, Germany

TP016

Reproducible Sample Complexity Reduction for 2D Gel and MALDI based Biomarker Discovery Chris Lynch, PerkinElmer, Shelton, CT, United States

TP017

Protein Production in a Wheat Germ Cell-Free Translation System Bernd Buchberger, Roche Diagnostics GmbH, Penzberg, Germany

TP018

ECL Plex - Fluorescent Multiplex Western Blotting Eva Malmport, GE Healthcare, Uppsala, Sweden

TP019

Selective Labeling of Cell Surface Proteins Rita Marouga, GE Healthcare, Uppsala, Sweden

TP020

Human Histone Isoform Profiling Using the ZOOM® Benchtop Proteomics System Gavin Meredith, Invitrogen Corp, Carlsbad, CA, United States

TP021

Genomic Antibodies™: Directly from DNA to Antibodies Lawrence Motyka, Strategic Diagnostics Inc., Newark, DE, United States

HUPO 2005 • FINAL PROGRAM

65

POSTER SESSION • TUESDAY, AUGUST 30TH TP022

Maximising Reproducibility and Improving the Resolution of Target Proteins with Automated Gradient Gel Casting for 2D Electrophoresis Robert Mount, NextGen Sciences Ltd, Cambridgeshire, United Kingdom

TP023

Software Solutions for the Analysis of Heterogeneity by Analytical Ultracentrifugation Stefan Overkamp, Beckman Coulter GmbH, Krefeld, Germany

TP023

2D-PAGE Based Proteomics and Protein Analysis Thomas Pohl, Wita GmbH, Teltow, Germany

TP025

Isoelectric Focusing in Serial Immobilized pH Gradient Gels to Improve Protein Separation in Proteomic Analysis Slobodan Poznanovic, ProteoSys AG, Mainz, Germany

TP026

An Automated Approach to Top-down Biomarker Analysis Barkovich Robert, Thermo Electron Corporation, San Jose, CA, United States

TP027

Differential Protein Binding to the Enchant Albumin Depletion Kit Column as a Result of Altering Buffer Composition Roberto Rodriguez, Pall Corp., Ann Arbor, MI, United States

TP028

New Fluorescence Dyes for Protein Gel Stains Alex Rück, Fluka GmbH, Buchs, Switzerland

TP029

Automated Electrophoresis by Slotgels Hartmut Schlichting, Viametrixx GmbH, Gilching, Germany

TP030

Integrated Resource for Functional Proteomics Data Johannes Schuchhardt, Microdiscovery GmbH, Berlin, Germany Quantitation of Amyloid Beta Peptides with MALDI-TOF-MS Gerold Schwarz, Waters Corporation, Almere, The Netherlands

TP031

TP032

Functional Validation of RNAi Knockdown at the Protein Level, via Sequential Quantitative Proteomics Techniques Graham Scott, Sigma-Aldrich Corporation, Saint Louis, MS, United States

TP033

Codelink™ Polymer Slides for Multiplex Protein Array Applications Pritesh Shah, GE Healthcare Bio-Sciences, Piscataway, NJ, United States

TP034

Simultaneous Qualitative and Quantitative Analysis of the E. coli Proteome: A Sweet Tale Jeffrey Silva, Waters Corporation, Milford, MA, United States

TP035

Top-down Versus. Bottom-up Proteomics Approaches of Human Platelet Proteins Using Monolithic PS-DVB Capillary Columns in a Multidimensional LC/MS Set-up Evert-jan Sneekes, LC Packings – Dionex, Amsterdam, The Netherlands

66

HUPO 2005 • FINAL PROGRAM

POSTER SESSION • TUESDAY, AUGUST 30TH TP036

A New Chip Technology for Identification of Biomarkers Kenji Tanaka, Protosera Inc., Kobe, Japan

TP037

A Compliant Solution for Monitoring Proteins Using a Lab-on-a-Chip Instrument Marc Valer, Agilent Technologies, Waldbronn, Germany

TP038

Protein Assays by a High Performance Blotless Nano Western System David Voehringer, Cell Biosciences, Palo Alto, CA, United States

TP039

Protein Quantification by the SELDI-TOF-MS-based Protein Chip® System Andreas Wiesner, Ciphergen Biosystems GmbH, Göttingen, Germany

TP040

TILLING®: High Throughput Functional Genomics Heike Wohlgemuth, LI-COR Biosciences GmbH, Bad Homburg, Germany

TP041

Analysis of Human Serum after Albumin and IGG Depletion with Vivapure Anti-HSA/IGG Kit Robert Zeidler, Vivascience AG, Hannover, Germany

TP042

Rapid and Accurate Protein Sizing, Quantitation and Analysis Using the Experion Automated Electrophoresis System and the Experion PRO260 Analysis Kit Mary Grace Brubacher, Bio-Rad Laboratories, Hercules, CA, United States

POST-TRANSLATIONAL MODIFICATIONS- GLYCOSYLATION AND GLYCOPROTEOMICS TP043

The Potential Implication of O-GlcNAc in the Protection of Fast Muscle against Atrophy Induced by Hindlimb Unloading Caroline Cieniewski-Bernard, Laboratoire de Glycobiologie Structurale et Fonctionnelle, Villeneuve D'Ascq, France

TP044

Carbohydrate Sequencing Database: CABOSDB Norihiro Kikuchi, Mitsui Knowlegde Industry Co., Tokyo, Japan

TP045

Identification and Quantification of N-Linked Glycoproteins Using Immobilized Aminophenylboronic Acid, Multiplex Isobaric Tagging, and Mass Spectrometry Young Hwan Kim, Korea Basic Science Institute, Taejeon, South Korea

TP046

Glycoproteomic Analysis Based on Multiple Enzymes Printing Technology Satoshi Kimura, Shimadzu Corporation, Kyoto, Japan

TP047

Glycoproteomic Analyses of Hepatitis B Virus Infected Hepatoma Cells Akihiro Kondo, Osaka University, Suita, Japan

TP048

Fucosylated Haptoglobin Is a Novel Marker for Pancreatic Cancer: A Detailed Analysis on the Oligosaccharide Structure and a Possible Mechanism for Fucosylation Eiji Miyoshi, Osaka University Graduate School of Medicine, Suita, Japan

HUPO 2005 • FINAL PROGRAM

67

POSTER SESSION • TUESDAY, AUGUST 30TH TP049

Capillary Electrophoresis: Electrospray Mass Spectrometry for Rapid and Sensitive Analysis of NGlycans as 9-Fluorenylmethyl Derivatives Miyako Nakano, Osaka University Graduate School of Medicine, Suita, Japan

TP050

Titanium Dioxide, A Promising Approach for GPI-anchored Peptide Enrichment Miren Josu Omaetxebarria, University of Southern Denmark, Odense, Denmark

TP051

ASC_GKY_FLUO: A New Reagent for the Selective Characterization of Glycoproteins Clément Roux, Université des Sciences et Technologies de Lille, Villeneuve d'Ascq, France

TP052

Approaches to the Mucin-Type O-Glycoproteome of Drosophila Melanogaster S2 Cells Udo Roth, ZMMK Universität Kölm, Cologne, Germany

TP053

Development of Pattern Recognition Methods Using Lectin Map for Identification of Oligosaccharide Structures Yoriko Takahashi, Mitsui Knowledge Industry Co., Ltd., Nakano-ku, Japan

TP054

Characterisation of Glycoproteins and N-Glycans of Recombinant Human Erythropoietin by Liquid Chromatography and Mass Spectrometry Nick Tomczyk, Waters Corporation, Almere, The Netherlands

TP055

Characterization of Site-Specific Glycans of Large Glycoproteins, Fibronectin and Apolipoprotein B100, Using a Method of Hydrophilic Affinity Isolation of Glycopeptides and MALDI Mass Spectrometry Yoshinao Wada, Osaka MCHRI, Izumi, Japan

POST-TRANSLATIONAL MODIFICATIONS - PHOSPHORYLATION AND PHOSPHOPROTEOMICS TP056

Analysis of Protein Phosphorylation in Halobacterium Salinarum Michalis Aivaliotis, Max Planck Institute of Biochemistry, Martinsried, Germany

TP057

Analysis of Ser/Thr Phosphorylation by MALDI Mass Spectrometry Giorgio Arrigoni, Lund University, Lund, Sweden

TP058

A Novel Combined Genetic and Proteomic Approach to Identify PI3kgamma-Dependent Phosphorylated Proteins Laura Barberis, University of Torino, Torino, Italy

TP059

Phosphoprotein Modulated by SEL1L Induced Expression in MCF-7 Human Mammary Carcinoma Cell Line Luca Bini, University of Siena, Siena, Italy

TP060

Mass Spectrometry Mapping and Quantitation of Stimulation-dependent Phosphorylation of EGF Receptor by Stable Isotope Labeling Elisabetta Boeri Erba, University of Southern Denmark, Odense, Denmark

68

HUPO 2005 • FINAL PROGRAM

POSTER SESSION • TUESDAY, AUGUST 30TH TP061

SELDI-MS and SELDI-MS/MS Analysis of Phosphopeptides Specifically Enriched on GA(III)-IMAC Arrays Ralf Bogumil, Ciphergen Biosystems GmbH, Reutlingen, Germany

TP062

Quantitation of Protein Phosphorylation Using Stable Isotope Dimethyl Labeling Coupled with Immobilized Metal Affinity Chromatography (IMAC) and Mass Spectrometry Shu-hui Chen, National Cheng Kung University, Tainan, Taiwan

TP063

Identification of New in Vivo Phosphorylation Sites of EBV-LMP1 by Mass Spectrometry Lang-ming Chi, Chang Gung University, Kwei-sha, Taiwan

TP064

A Strategy for Phosphoproteomics That Integrates Various Gel- and MS-based Techniques Tom Colby, Max Planck Institut für Züchtungsforschung, Cologne, Germany

TP065

IMAC for Phosphoproteins Anna Dubrovska, Ludwig Institute for Cancer Research, Uppsala, Sweden

TP066

Neural Network and Mass Spectrometry for Identification of Protein Kinase A and B Substrates Involved in Apoptosis Steen Gammeltoft, Glostrup Hospital, Glostrup, Denmark

TP067

High Sensitivity Chemiluminescent Detection and Quantitation of Phosphoproteins after Western Blotting from 1D and 2D-Gels: Analysis of 2D-Spot Patterns of Proteins from Bacillus Subtilis Peter Jackson, Perkinelmer Life and Analytical Sciences, Beaconsfield, United Kingdom

TP068

The Human Cerebrospinal Fluid Phosphoproteome Nikolaus Kolb, Max Planck Institute of Psychiatry, Munich, Germany

TP069

Protein and Proteome Phosphorylation Stoichiometry Determined by µLC-ICP-MS and Imaging Laser Ablation ICP-MS Ralf Krueger, German Cancer Research Center, Heidelberg, Germany

TP070

Investigation of Tyrosine Phosphorylation Triggered by Lps Stimulation in Drosophila Immune Cells Olga Loseva, Stockholm University, Stockholm, Sweden

TP071

Insulin Dependent Tyrosine-Phosphorylated IRS-1 Characterized with CAPLCc-Q-TOF Mass Sectrometry Xiao-Ming Lu, Massachusetts General Hospital, Shriners Burns Hospital, Harvard Medical School, Boston, MA, United States

TP072

Quantitative Phosphoproteomics Applied to the Epidermal Growth Factor Receptor Pathway Jesper V. Olsen, University of Southern Denmark, Odense, Denmark

TP073

Differentiation of Phosphorylated and Sulfated Peptides Using a Novel API-QTOF Technology Matthias Pelzing, Bruker Daltonik GmbH, Bremen, Germany

HUPO 2005 • FINAL PROGRAM

69

POSTER SESSION • TUESDAY, AUGUST 30TH TP074

Investigation of Differential Phosphoproteome Expression in Rat Primary Neurons Following Amyloid-beta Peptide Treatment Roberto Raggiaschi, Siena Biotech Spa, Siena, Italy

TP075

Analysis of Phosphorylated Membrane Proteins in Human Hepatocytes Gorden Redlich, Ruhr University Bochum, Bochum, Germany

TP076

A Proteomic Approach for Phosphoprotein Profiling Sarah Sanglier, CNRS - Université Louis Pasteur, Strasbourg, France

TP077

Modulation of TCTP Oligomerization through PLK-dependent Phosphorylation Barbara Valsasina, Nerviano Medical Sciences, Nerviano, Italy

TP078

Detection of Novel Tyrosine Phosphorylated Proteins in Macrophages by Proteomic Analysis Robin Wait, Imperial College London, London, United Kingdom

TP079

Comparing the Tandem Mass Spectra of Phosphorylated Peptides Acquired by Using Different Type of Mass Spectrometer Jinglan Wang, Beijing Institute of Radiation Medicine, Beijing, P.R. China

POST-TRANSLATIONAL MODIFICATIONS - OTHER TP080

Protein Nitration in Amyotrophic Lateral Sclerosis: Possible Multifunctional Role in the Pathogenesis Valentina Bonetto, Dulbecco Telethon Institute, Milano, Italy

TP081

Mass Spectrometry-Based Strategies for Identification of Reversibly Oxidized Endogenous Protein Tyrosine Phosphatases in Cancer Cells Y.Y. Chen, Core Facilities for Proteomics Research, Academica Sinica, Taiwan, Taipei, Taiwan

TP082

Analysis of Farnesylation of Drosophila Visual Ggamma-Subunit by Mass-Spectrometry Armin Huber, University of Karlsruhe, Karlsruhe, Germany

TP083

Histone Modifications-Complex Patterns of Development and Disease Axel Imhof, Protein Analysis Unit, Munich, Germany

TP084

Polyubiquitin Conjugates as Molecular Lead Structures for Ubiquitin-Proteasome Proteomics: Synthesis, Structures and Biochemical Properties Jieun Jung, University of Konstanz, Konstanz, Germany

TP085

Disulphide Bond Mapping of Transmembrane Activator and CAML Interactor (TACI) CRD1 Jennie Lill, Genentech Inc., South San Francisco, CA, United States

TP086

ASC_OX_BIOT: A New Reagent for the Specific Isolation of Oxidized Proteins Souhila Oudir, Université des Sciences et Technologies de Lille, Villeneuve d'Ascq, France

70

HUPO 2005 • FINAL PROGRAM

POSTER SESSION • TUESDAY, AUGUST 30TH TP087

Analysis of Protein Arginine Methylation by Mass Spectrometry: Kinetics and Sequence Preferences of PRMT1 and PRMT3 Steffen Pahlich, Universität Zürich, Zürich, Switzerland

TP088

Principles and Application of a New Method for C-terminal Sequence Analysis of Proteins Kjell Sergeant, University of Ghent, Ghent, Belgium

TP089

HMGA'S Post-translational Modifications (PMTS): Is There Any Link with the Process of Neoplastic Transformation? Riccardo Sgarra, University of Trieste, Trieste, Italy

TP090

FFE as a Multifunctional Separation for Isolating Isoforms of Protein Species Robert Wildgruber, BD, Martinsried, Germany

PROTEOMICS TECHNOLOGIES - 2D ELECTROPHORESIS TP091

Proteome Response of Suaeda aegyptiaca, a Halophyte, to Different Salt Levels Hossein Askari, Agricultural Biotechnology Research Institute of Iran, Karaj, Iran

TP092

Significant Improvements in Two-dimensional Gel Electrophoresis (2DE) of HIV-1 and SIV Using Large-Format Bis-Tris SDS-PAGE Gels: Towards HIV Proteomics Graham David, Johns Hopkins School of Medicine, Baltimore, MD, United States

TP093

A Comparison of 2-Dimensional Electrophoesis Imaging Analysis Tools Ola Forsström-Olsson, Ludesi, Lund, Sweden

TP094

Formulation's Optimization of a Fluorescent Ruthenium Complex for In-gel Staining Electrophoresis Anne-Gaëlle Fournial, Université Scientifique et Technologique de Lille-CNRS, Villeneuve D'Ascq, France

TP095

Impact of 6-Pyruvoyl Tetrahydropterin Synthase Knockout on Protein Profiles of Mouse Liver Georg Golderer, Innsbruck Medical University, Innsbruck, Austria

TP096

Multivariate Analysis of 2-D Electrophoresis Protein Patterns- Practical Approaches Harald Grove, Norwegian Food Research Institute, Aas, Norway

TP097

A Proteomic Approach to Analyze Drought-responsive Proteins in Wheat Mature Seed Mohsen Hajheidari, Agricultural Biotechnology Research Institute of Iran, Karaj, Iran

TP098

High Resolution Differential Membrane Protein Analysis of Scarce Samples: Analysis of T Cell Membrane Proteins Stefan Helling, Ruhr University Bochum, Bochum, Germany

TP099

A Supervised Learning Approach Classifies 2D Gel Spots Ernst Henle, Bioimagene, San Mateo, CA, United States

HUPO 2005 • FINAL PROGRAM

71

POSTER SESSION • TUESDAY, AUGUST 30TH TP100

Enrichment of Basic and Low-Abundance Rat Brain Proteins via Ion Exchange Spin Columns Prior to 2-D Gel Analysis Julie Hey, Bio-Rad Laboratories, Hercules, CA, United States

TP101

Proteome Response of Salt Tolerant and Susceptible Durum Wheat to Salt Stress Rahele Karimi, Agricultural Biotechnology Research Institute of Iran, Karaj, Iran

TP102

Reduction and Alkylation of Proteins for Two-dimensional Gel Electrophoresis József Klem, University of Szeged, Szeged, Hungary

TP103

Temperature during Isoelectric Focusing in a Ceramic Versus in a Polymeric Manifold Kjell Larsson, GE Healthcare, Uppsala, Sweden

TP104

Establishment of High-resolution Two-dimensional Reference Maps Using 2D-DIGE Technique of Sheep and Buffalo Milk Fat Globules Silvia Matteoni, University of Siena, Siena, Italy

TP105

Detergent and Sonication Free Nuclear Protein Fractionation of Wi 38 Cells: An Essential Step Prior to Efficient 2D DIGE Analysis Gabriel Mazzucchelli, University of Liège, Liège, Belgium

TP106

Development of New Gel Technologies for the Separation of Hydrophobic Proteins Bouchra Mezgueldi, Université des Sciences et Technologies de Lille, Villeneuve d'Ascq, France

TP107

Proteomer: A Novel Software Application for Management of Proteomic 2DE-Gel Data - II Application Grit Nebrich, Institut für Humangenetik, Berlin, Germany

TP108

Selection of Protein Expression Signatures by Interfacing Pathophysiology and Proteomics Technology in Smokers and Never-Smokers Amelie Plymoth, Respiratory Medicine and Allergology, Lund, Sweden

TP109

Muscle Protein Expression Changes during Extremely High Altitude Exposure by DIGE Approach Marilena Ripamonti, National Research Council, Milano, Italy

TP110

One Sample, One-piece Large Gel: Further Development of Large Gel 2-DE for the Analysis of Microdissected Cells Using DIGE Saturation Labeling Barbara Sitek, Ruhr University Bochum, Bochum, Germany

TP111

DIGE Protein Labeling: How Low Can You Go? Kathleen Sonck, K.U. Leuven, Leuven, Belgium

TP112

Statistical Methods for the Analysis of 2D-GE Data Michael Tribanek, Ruhr University Bochum, Bochum, Germany

72

HUPO 2005 • FINAL PROGRAM

POSTER SESSION • TUESDAY, AUGUST 30TH TP113

Protein Extraction from Woody Plants: Chaotrope and Detergent Optimization Cristina Maria Valcu Technische Universität Mÿnchen, Freising, Germany

TP114

Proteomer: A Novel Software Application for Management of Proteomic 2DE-Gel Data - I Technical Overview Maik A. Wacker, Charite - Universitätsmedizin Berlin, Berlin, Germany

PROTEOMICS TECHNOLOGIES - MASS SPECTROMETRY TECHNOLOGY TP115

Comparison of Different SELDI Proteinchip Arrays for Proteomic Profiling of Urine Gloria A. Llamas, University Medical Centre Groningen, Groningen, The Netherlands

TP116

Use of Adsorbed and Immobilized Trypsin in Protein Digestion Gunes Barka, Sunchrom GmbH, Friedrichsdorf, Germany

TP117

MALDI Imaging of Zebrafish Sections Soeren-oliver Deininger, Bruker Daltonik GmbH, Bremen, Germany

TP118

On-membrane Direct MALDI-TOF Ms Identification of Proteins Detected by Western Blotting and Lectin Blotting Masaru Furuta, Shimadzu Corporation, Kyoto, Japan

TP119

Sample Preparation for Mass Spectrometry Using Magnetic Bead Technology David Gillooly, Invitrogen Corporation, Oslo, Norway

TP120

An Integrated Approach for Intact Protein Analysis and Protein Identification by LC/MS for Complex Biological Samples Veronika Glukhova, Fred Hutchinson Cancer Research Center, Seattle, WA, United States

TP121

Improving the Confidence of Protein Identification by Combining MALDI-MS and -MS/MS Data Karin Hjernoe, University of Southern Denmark, Odense, Denmark Rapid and High Quality Peptide Mapping Using Silica Nano-monoliths in On- and Off-line Capillary LC-ESI- and LC-MALDI-MS/MS Karl Holschuh, Merck KGaA, Darmstadt, Germany

TP122

TP123

Microwave-assisted Chemical Digestion: A Promising Technique for Rapid Protein Identification Lin Hua, Genome Institute of Singapore, Singapore

TP124

A Novel High-speed Duty Cycle of Ion Traps for a More Detailed Analysis of Protein Mixtures Arnd Ingendoh, Bruker Daltonik GmbH, Bremen, Germany

TP125

Proteomic Analysis Based on pH Elution and Integrated Multiple Dimensional Liquid Chromatography Coupled to Mass Spectrometry Dai Jie, Shanghai Institutes for Biological Sciences, Shanghai, P.R. China

HUPO 2005 • FINAL PROGRAM

73

POSTER SESSION • TUESDAY, AUGUST 30TH TP126

Dynamic MALDI Targets Mohammed Kajjout, Université des Sciences et Technologies de Lille, Villeneuve d'Ascq, France

TP127

Multiplexed Screening for Posttranslational Modifications by Tandem Mass Spectrometry Juergen Kast, University of British Columbia, Vancouver, BC, Canada

TP128

MassPective: A Graphical Tool to Validate Posttranslational Modification Identification from Tandem Mass Spectra Sangtae Kim, Korea Military Academy, Seoul, South Korea

TP129

Polymeric Microfluidic Devices for Proteomic Analysis Daniel Knapp, Medical University of South Carolina, Charleston, SC, United States

TP130

New Developments in Direct Analysis by MALDI Mass Spectrometry for the Study of Ovarian Cancer Remi Lemaire, Université des Sciences et Technologie de Lille, Villeneuve d'Ascq, France

TP131

Combining Novel Fragmentation and Front End Enrichment Techniques for Highly Increased Sensitivity and Selectivity of Phosphopeptide Detection Markus Lubeck, Bruker Daltonik GmbH, Bremen, Germany

TP132

Nano-ESI-IT, AP-MALDI-IT, MALDI-IT/RTOF and MALDI TOF/curved Field RTOF MS for de Novo Sequencing of the Elucitator of Type I Allergy in Elderberry (Sambucus nigra) Martina Marchetti, Vienna University of Technology, Vienna, Austria

TP133

Novel Biochip Platform for High-throughput MALDI MASS Spectrometry of Peptides Michael Mariani, Australian Proteome Analysis Facility, and Department of Chemistry & Biomolecular, Macquarie University, Sydney. Australia

TP134

Identification of Glomerular Proteins Involved in a Renal Disease by MALDI High Energy CID (TOF/RTOF) and Atmospheric Pressure MALDI Low Energy CID (3D IT) Corina Mayrhofer, Medical University of Vienna, Vienna, Austria

TP135

Improved Protein Identification Using a Microfluidic Chip-based System Christine Miller, Agilent Technologies, Santa Clara, CA, United States

TP136

Enhanced Dynamic Range and Improved Mass Accuracy for Proteomics Analysis Using a Hybrid Linear Ion Trap: FTICR Mass Spectrometer Thomas Moehring, Thermo Electron Corporation, Bremen, Germany

TP137

Immunochemistry with Direct Mass Spectrometric Detection Alexis Nazabal, Swiss Federal Institute of Technology-ETHZ, Zürich, Switzerland

TP138

Comparative Analysis of Ovarian Cancer Plasma Proteome Using SELDI-TOF MS and FTICR MS with Different Ionization Methods Evgeny Nikolaev, Research Institute of Biomedical Chemistry Rams, Moscow, Russia

74

HUPO 2005 • FINAL PROGRAM

POSTER SESSION • TUESDAY, AUGUST 30TH TP139

Long Term Archiving of Proteomic Samples on Disposable Prespotted MALDI Targets Martin Schürenberg, Bruker Daltonik GmbH, Bremen, Germany

TP140

Analysis of Post-translationally Modified Peptides and Proteins by High Resolution Electron Capture Dissociation (ECD) FTICR-MS Kerstin Strupat, Thermo Electron Corporation, Bremen, Germany

TP141

Simplified 2D LC-MS/MS Method for Proteomic Analysis Lester Taylor, Thermo Electron, San Jose, CA, United States

TP142

Automation of In-gel Digestion and MALDI Spotting of Two-dimensional Electrophoresis Separated Rat Liver Proteins Kareen Tenz, Federal Institute of Risk Assessment, Berlin, Germany

TP143

Evaluation of Solvent-free MALDI-MS for the Analysis of Proteins via the Mini-ball Mill Approach Sarah Trimpin, Oregon State University, Corvallis, OR, United States

TP144

Complementary Analysis of Human CSF Proteins by Nano LC MALDI and ESI/MS/MS Rosa Viner, Thermo Electron, San Jose, CA, United States

TP145

Strategies for Generating Sequence Information from High Mass Peptides/Low Mass Proteins Using Novel Tandem TOF Technology and iTRAQTM Reagent Chemistry Matthew Willetts, Applied Biosystems, Framingham, MA, United States

TP146

Mesoporous Material as MALDI-Matrix and Enzyme-reactor for Proteomics Pengyuan Yang, Fudan University, Shanghai, P.R China

TP147

An Automated Top-down LC/MSn Approach for Identification and Characterization Of Unknown Yeast Proteins Vlad Zabrouskov, Thermo Electron, San Jose, CA, United States

PROTEOMICS TECHNOLOGIES - MASS SPECTROMETRY BASED QUANTITATIVE PROTEOMICS TP148

Quantitative Analysis of Cytochrome P450 Isozymes by Means of Unique Isozyme-specific Tryptic Peptides: A Proteomic Approach Combining Mass Spectrometry and Immunochemistry Michail Alterman, University of Kansas, Lawrence, KS, United States

TP149

Prerequisites to Accuracy in Absolute Protein Quantification by Mass Spectrometry Christian Arsene, Physikalisch- Technische Bundesanstalt, Braunschweig, Germany

TP150

Identification of Statistically Relevant Protein Differences of Normal and Tumor Brain Tissue Using 2D-DIGE and LC-ESI-MS/MS G. Reid Asbury, GE Healthcare, Piscataway, NJ, United States

TP151

Differential Peptide Pattern Analysis and Interactive 3D Visualization for Multiple LC/MS Datasets Jörg Bernhardt, University of Greifswald, Greifswald, Germany HUPO 2005 • FINAL PROGRAM

75

POSTER SESSION • TUESDAY, AUGUST 30TH TP152

A Novel Approach for Protein Expression Profiling of Mouse Prostate Sanjeev Bhardwaj, Applied Biosystems Inc., Framingham, MA, United States

TP153

In Vitro Stable Isotope Labeling on Methionine Residues for Mass Spectrometry-based Quantitative Proteomics: No More Reactions Have to be Applied to the Samples Kun-yi Chien, Chang Gung University, Kwei-Shan Tao-Yuan, Taiwan

TP154

ICPL, Quantitative High Throughput Monitoring of Proteins for Functional Analysis of Natural Compounds (MONACO) Cornelia Ciosto, Max Planck Institute of Biochemistry, Martinsried, Germany

TP155

Study of Relative Turnover of Proteins from Glioblastoma Cells Using Differential Arginine Labelling Annika Dahl, Clinical Neuroscience, Göteborg, Sweden

TP156

Endometrial Cancer Marker Discovery Using Differentially Labeled Clinical Samples Leroi Desouza, York University, Toronto, ON, Canada

TP157

Differential Expression Analysis of E.coli Proteins Using a New Software for Relative Quantification of LC-MS Data John Flensburg, GE Healthcare, Amersham Biosciences, Uppsala, Sweden

TP158

Quantitative Profiling of the Phosphotransferase System in Escherichia coli Gudrun Franke, Ruhr University Bochum, Bochum, Germany

TP159

Study of the Function of the THAP Proteins by Differential Proteomics Anne Gonzalez De Peredo, CNRS, Toulouse, France

TP160

Advances in Biomarker Discovery on a Novel Tandem Time-of-Flight Mass Spectrometer Dominic Gostick, Applied Biosystems, Framingham, MA, United States

TP161

Absolute Quantification of Myoglobin Content in Blood Serum Using HPLC/MS through Automatic Bioinformatics Analysis Eva Lange, Fu Berlin, Berlin, Germany

TP162

Stable Isotope Labeling of Arabidopsis Thaliana Cells and Quantitative Proteomics by Mass Spectrometry Albrecht Gruhler, University of Southern Denmark, Odense, Denmark

TP163

N-terminal Protein Sulfonation: Combining Protein Identification and Quantitation Elisabeth Guillaume, Nestlé Research Center, Lausanne, Switzerland

TP164

1D-Zoomer: Integrated Software to Manage MALDI-TOF PMF and ESI-MS/MS Parallel Probe Processing Semen Gusev, Research Institute of Biomedical Chemistry RAMS, Moscow, Russia

76

HUPO 2005 • FINAL PROGRAM

POSTER SESSION • TUESDAY, AUGUST 30TH TP165

Isotope-coded Protein Labelling (ICPL)-Applications: Comparison of Direct LC-MALDI-MS/(MS) with SDS-PAGE-LC-MALDI-MS/(MS) and 2D-PAGE-LC-MALDI-MS/(MS) Thomas M. Halder, Toplab, Martinsried, Germany

TP166

Evaluation of the Protein Sequence Tags (qPST™) Approach for Quantitative Differential Proteomic Analyses of Complex Biological Samples Christian Hamon, Proteome Sciences R & D, Frankfurt am Main, Germany

TP167

Charge-directed Fragmentation of Non-tryptic Peptides Maria Jansson, Electrical Measurements, Lund, Sweden

TP168

2-Dimensional Gel Electrophoresis Versus Quantitative Protein Sequence Tags (qPST™) A Comparative Proteomic Study in Yeast Richard Joubert, Proteome Sciences R&D GmbH & Co. KG, Frankfurt am Main, Germany

TP169

Identification and Relative Quantitation of Plasma Proteome Using LT-FT/MS Combined with Stable Isotope Tags and 1DE Separation Jin Young Kim, Korea Basic Science Institute, Daejeon, South Korea

TP170

Quantitative Proteomics of Fruit Fly Development by Metabolic Labeling Jeroen Krijgsveld, Utrecht University, Utrecht, The Netherlands

TP171

Quantitative Analysis of Peptides and Proteins Using Deuterated N-Naphthyliodoacetamide by Stable Isotope Differential Mass Spectrometry Sadamu Kurono, Iberica Co., Ltd., Kurume-Shi, Japan

TP172

Quantitative and Qualitative Analysis of Tubulin Isoforms by Mass Spectrometry Christian Larroque, Inserm, Montpellier, France

TP173

Analysis of Low Mass Ions in Peptide Fragmentation Spectra with a Linear Ion Trap Ken Miller, Thermo Electron, San Jose, CA, United States

TP174

Isobaric Tagging of Intact Protein for Identification and Quantitation Marjorie Minkoff, Applied Biosystems, Framingham, MA, United States

TP177

Quantitative Shotgun Proteomics Using 18O Labeling and Linear Ion Trap Mass Spectrometry Antonio Ramos-Fernandez, Centro de Biologia Molecular Severo Ochoa, Cantoblanco, Spain

TP178

New Isotopic Labeling Approach for Quantitative Protein Analysis by LC-MALDI-TOF/TOF Uwe Rapp, Bruker Daltonik GmbH, Bremen, Germany

TP179

The Use of ITRAQ Labeling and Multidimensional Chromatography LC-MS Strategies for a Quantitative Analyses of the Heat Shock Responsive Soluble Proteome of a Wild Type and a Thermal Tolerant Mutant of Synechocystis (PCC 6803) William Simon, University of Durham, Durham, United Kingdom

HUPO 2005 • FINAL PROGRAM

77

POSTER SESSION • TUESDAY, AUGUST 30TH TP181

Heterogeneity of Human 20S Proteasome Complexes: A Quantitative Proteomic Study Using 2D Gels and ICAT™ Labeling Sandrine Uttenweiler, IPBS/CNRS, Toulouse, France

TP182

Fractional Synthesis Rates of Proteins from 13c-labeled Mouse Liver Determined by MALDI-TOF MS and Analysis of Relative Isotopologue Abundances Using Average Masses Josef A. Vogt, Universität Ulm, Ulm, Germany

TP183

PIQS - Parent Ion Quantitation Scanning Asa Wahlander, Electrical Measurements, Lund, Sweden

TP184

Isotope-coded Protein Tagging for Comparative Proteome Analysis by Mass Spectrometry Bettina Warscheid, Ruhr University Bochum, Bochum, Germany

TP185

Evaluating Workflows for Protein Quantification of Serum and Plasma Using Stable Isotope Labeling, MDLC, and a New Solid Support Cysteine Capture Technique Lynn Zieske, Applied Biosystems, Foster City, CA, United States

PROTEOMICS TECHNOLOGIES - NANOTECHNOLOGY/ PROTEIN ARRAYS TP186

Multiple Spotting Technology: Performing Multiplex Assays on a Single Microarray Philipp Angenendt, German Cancer Research Center, Heidelberg, Germany

TP187

AFM and Optical Biosensor Nanotechnology in Revelation of Protein Complexes Yury Ivanov, Research Institute of Biomedical Chemistry RAMS, Moscow, Russia

TP188

Development of Protein Chips for Analysis by Ellipsometry Mark Johnson, Victoria University of Wellington, Wellington, New Zealand

TP189

The Use of Protein Microarrays for the Validation of Phage Display Antibody Selections within the German NGFN Initiative Antibody Factory Zoltán Konthur, Max Planck Institute for Molecular Genetics, Berlin, Germany Development of Quantitative Protein Detection Arrays Ulrike Korf, DKFZ, Heidelberg, Germany

TP190

TP191

Quantitative MHC Expression Profiling Using Reverse Phase Protein Microarrays Stefan Kramer, Natural and Medical Sciences Institute, Reutlingen, Germany

TP192

Combined Protein/Antibody Microarrays for Investigation of Bacterial Meningitis Jürgen Kreutzberger, Max Planck Institute for Molecular Genetics, Berlin, Germany

TP193

Very High Sensitivity Micron Scale Microfabricated Nano-ESI Tips Compatible with Standard Analytical Chromatography Fittings Séverine Le Gac, Université des Sciences et Technologies de Lille, Villeneuve, d'Ascq, France

78

HUPO 2005 • FINAL PROGRAM

POSTER SESSION • TUESDAY, AUGUST 30TH TP194

Implementation of Protein Microarrays for the Validation of Early Detection and Progression Markers in Colorectal Cancer Juan Madoz – Gurpide, CNIO Spanish National Cancer Centre, Madrid, Spain

TP195

A Novel Protein-Chip for Analysis of Protein-Protein Interaction Using DLC Plate Mitsuyoshi Ohba, Toyo Kohan Co., Chiyoda-Ku, Japan

TP196

Mass Spectrometry Identification of Interaction between Beta-Amyloid Peptide and Its Inhibitor LFFPD Eliandre Olivieira, Science Park of Barcelona - University of Barcelona, Barcelona, Spain

TP197

Peptide Based Proteomics Using Array Technology Stefan Pabst, The University of Tübingen, Reutlingen, Germany

TP198

Isolation of Highly Specific Antibodies for Use in Sandwich Antibody Microarray Analyses René Rübenhagen, German Research Center for Biotechnology, Braunschweig, Germany

TP199

A Protein Interaction Array in Quantitative Characterization of SCFV Antibodies Using a Peptide Panel Approach Markus F. Templin, NMI Natural and Medical Sciences Institute at The University of Tübingen, Reutlingen, Germany

TP200

Identification of Small Molecule Protease Inhibitors Using a Microarray Based PNA Detection System Hugo Urbina, Genomics Institute of The Novartis Research Foundation, San Diego, CA, United States

TP201

Simultaneous Quantification of Carcinoembryonic Antigen (CEA), Alpha Fetoprotein (AFP), and Hepatitis B Surface Antigen (HBSAG) in Human Serum Using Suspension Array Technology Chen Wei, Guangzhou Antibody Research Center, Guangzhou, P.R. China

TP202

Fabrication of a Protein Array Using Microcontact Printing and Its Electrochemical Detection Danke Xu, Beijing Institute of Radiation Medicine, Beijing, P.R. China Protein Profiling and Phosphorylation in Breast Cancer Cells with Antibody Microarrays Garabet Yeretssian, University of Nantes, Nantes, France

TP203

PROTEOMICS TECHNOLOGIES - PROTEIN CHEMISTRY TP204

Enrichment and Identification of Cysteine-containing Peptides from Tryptic Digests of Performic Oxidized Proteins by Strong Cation Exchange Lc and Maldi-TOF/TOF MS Yun Cai, Beijing Institute of Radiation Medicine, Beijing, P.R. China

TP205

Combination of Chemical Cross-Linking and FT-MS for the Structural Characterization of Rat CD69 Molecule Petr Pompach, Academy of Science of Czech Republic, Prague, Czech Republic

TP206

High-Throughput Method for N-Terminal Sequencing of Proteins by Using Post Source Decay of MALDI Mass Spectrometry Eiji Ando, Shimadzu Corporation, Kyoto, Japan HUPO 2005 • FINAL PROGRAM

79

POSTER SESSION • TUESDAY, AUGUST 30TH TP207

The Thermal Aggregation Process of Lentil Seedling Amine Oxidase S. Zahra Moosavi-nejad, Alzahra University, Tehran, Iran

TP208

Improved On-line Electrochemical Cleavage of Proteins: An Instrumental Alternative to Enzymatic Digestion Hjalmar Permentier, University of Groningen, Groningen, The Netherlands

PROTEOMICS TECHNOLOGIES - PROTEIN PREFRACTIONATION TECHNOLOGIES TP209

Pores Formation in Cell Membranes by Saponins as a Rapid Method of Soluble Proteins Released Nicolas Cellier, University of Liège, Liège, Belgium

TP210

Comparative Analysis of Control and Breast Cancer Sera Using a New Multi-dimensional Separation Strategy Haiying Chen, Agilent Technologies Inc., Wilmington, DE, United States

TP211

Multicompartment Electrolyzer with New Acrylamide-Agarose Copolymer Membranes: Fractionation of Milk Marina Cretich, Consiglio Nazionale Delle Ricerche, Milano, Italy

TP212

A Map of the Rat Liver Proteome Giuseppe Gazzana, Fraunhofer Gesellschaft, Hannover, Germany

TP213

Affinity-based Tagging of Kinases with Reversible Inhibitors Miriam Hagenstein, University of Bielefeld, Bielefeld, Germany

TP214

Abundant Protein Depletion Coupled with Multidimensional Fractionation of the Human Plasma Proteome Karsten Hendriks, Beckman Coulter GmbH, Krefeld, Germany

TP215

Deciphering Complex Protemes Using Liquid and Gel Phase Prefractionation Approaches Alexander Ivanov, Harvard School of Public Health, Boston, MA, United States

TP216

A Novel Device for Discovering Extremely Low Abundant Protein Biomarkers in Human Serum Giman Jung, Toray Industries Inc., Kamakura, Japan

TP218

Multidimensional Fractionation and Analysis of Rat Liver Microsomal Proteins Using Two Dimensional Liquid Sepraration and Tandem Mass Spectrometry Hyoung-Joo Lee, Yonsei Proteome Research Center & Biomedical Proteome Research Center, Seoul, South Korea

TP219

Purification of Polyclonal Antibody against Human T-lymphocytes (ATG) by Ion-exchange Chromatography Jafar Majidi, Drug Applied Research Center, Tabriz, Iran

80

HUPO 2005 • FINAL PROGRAM

POSTER SESSION • TUESDAY, AUGUST 30TH TP220

Analysis of a HeLa Cell Proteasome Fraction by a Combination of Off-gel Isoelectric Focusing and HPLC Chip/MS Friedrich Mandel, Agilent Technologies, Waldbronn, Germany

TP221

A Novel Approach towards Differential Proteomics with Multidimensional Intact Protein Prefractionation of Brain Samples Katrin Marcus, Ruhr University Bochum, Bochum, Germany

TP222

A New Multidimensional Liquid Chromatography Technique That Allows to Enrich Small Proteins and Peptides from Albumin and IGG-depleted Body Fluid Samples Uwe Michelsen, Merck KgaA, Darmstadt, Germany

TP223

A Novel, Combinatorial Ligand Library Approach Used to Address Protein Dynamic Range Detection Challenges of Human Serum Ron Orlando, University of Georgia, Athens, GA, United States

TP224

Enhanced Reproducibility and Predictability in Serum Proteomics Achieved by Off-Gel Isoelectric Focussing of Tryptic Peptides Tobias Preckel, Agilent Technologies, Waldbronn, Germany

TP225

Separation of Functionally Active Wild Type Enzyme and Point Mutants Using Free Flow Electrophoresis Hunghiang Quek, BD Diagnostics, Franklin Lakes, NJ, United States

TP226

Comparing Chromatography Columns for the Separation and ESI LC-MS/MS Analysis of Peptide Mixtures Ulrike Schweiger-Hufnagel, Bruker Daltonik GmbH, Bremen, Germany

TP227

Affinity Chromatograpy and Solution Isoelectric Focusing for Albumin Removal in Cerebrospinal Fluid Prior to 2-D Gel Electrophoresis Carina Sihlbom, Göteborg University, Göteborg, Sweden

TP228

Enrichment of Galectin-3 in Thyroid Papillary Carcinoma Using Microscale Solution-Phase Isoelectric Focusing and LC/MS/MS Chantragan Srisomsap, Chulabhorn Research Institute, Bangkok, Thailand

TP229

Towards the Identification of Membrane Proteins Implicated in the Blood-Brain Barrier Mechanisms Caroline Tokarski, University of Artois, Lens, France

TP230

Off-line 2D LC Approaches for the Analysis of Intact Proteins Followed by Proteolytic Digestion And LC/MS/MS Analysis Robert Van Ling, Lc Packings – Dionex, Amsterdam, The Netherlands

TP231

Free-flow Isoelectric Focusing for Separation of Both Cytosolic and Membrane Associated Human Proteins Gerhard Weber, BD, Martinsried, Germany HUPO 2005 • FINAL PROGRAM

81

POSTER SESSION • TUESDAY, AUGUST 30TH TP232

Sample Prefractionation with Sephadex IEF for Enrichment of Low Abundance Proteins and Improvement of Maldi-MS Spectra Walter Weiss, Technical University of Munich, Freising, Germany

TP233

Alternative Approach to Protein Separation by HPLC Yury Zelechonok, Sielc Technologies Inc., Chicago, IL, United States

TP234

New Strategy of Multidimensional Chromatography and Electrophoresis Coupling to Mass Spectrometry for Proteomic Analysis Xiangmin Zhang, Fudan University, Shanghai, P.R China

PROTEOMICS TECHNOLOGIES - OTHER TP235

Strategies to Investigate the Membrane Proteome of Halobacterium Salinarum Birgit Bisle, Max Planck Institute of Biochemistry, Martinsried, Germany

TP236

Synthetic Peptide Studies on the Substrate Specificity Preferences of Severe Acute Respiratory Syndrome Coronavirus 3C-Like Protease via a Mass Spectrometry Approach Ling Hon Matthew Chu, The Chinese University of Hong Kong, Hong Kong, P.R. China

TP237

Novel Monolithic Polymer Based Capillary Columns with Trapped Metallic Nanoparticles for Proteomics Application Francois Dupire, Université des Sciences et Technologies de Lille, Villeneuve d'Ascq, France

TP238

Combining 2-Dimensional Liquid Chromatography with Whole Mass MALDI for a Powerful 3Dimensional Proteomic Analysis Steven Elliott, Johns Hopkins University, Baltimore, MD, United States

TP239

Nano LC-MALDI: Development of the Technique and Its Application in Proteomic Research Johan Gobom, Max Planck Institute for Molecular Genetics, Berlin, Germany

TP240

Metalloprotein Profile (Metallomics) in Pine Nuts (Pinus pinea) by Size-exclusion-LC-ICP-MS José Luis Gómez-Ariza, Universidad de Huelva, Huelva, Spain

TP241

Identification and Characterization of Seleno-peptides in Selenium Enrich Yeast Using Cofradic Technology and Linear Ion Trap Mass Spectrometry Daniel Lopez-Ferrer, Centro de Biologia Molecular Severo Ochoa- CSIC, Cantoblanco, Spain

TP242

A Proteomic Study of Calcium Binding Proteins Teck Yew Low, Genome Institute of Singapore, Singapore

TP243

Novel Diazirinyl Photophor for Isoelectrofocusing Hashimoto Makoto, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan

82

HUPO 2005 • FINAL PROGRAM

POSTER SESSION • TUESDAY, AUGUST 30TH TP244

Selective Labelling of Plasmamembrane Proteins of Jurkat T-cells Using Cydye DIGE Fluor Minimal Dyes Caroline May, Ruhr University Bochum, Bochum, Germany

TP245

Mass Spectrometric Analysis of Membrane Proteins after Digestion with Unspecific Enzymes Björn Meyer, J. W. Goethe University Frankfurt, Frankfurt, Germany

TP246

A Comparison of Sample Preparation Methods for the Analysis of Intact Proteins by MALDI-MS Matthew Openshaw, Shimadzu Biotech, Manchester, United Kingdom

TP247

Kingfisher 96, A Novel Tool for High Throughput Protein Applications Maija Partanen, Thermo Electron Corporation, Vantaa, Finland

TP248

Gene Finding: Using Peptide PI, Accurate Mass, and MS/MS Spectra to Search Genomic Sequences Joel Sevinsky, Research Triangle Institute, RTP, NC, United States

TP249

High Throughput LC/MS/MS Analysis of Protein Digests Using a Parallel Monolithic (PS-DVB) µColumn Switching Set-up Remco Swart, LC Packings – Dionex, Amsterdam, The Netherlands

TP250

Protein Separation Using Electroosmotic Flow Induced by Dynamic SDS-coated Plastic Microchips Mari Tabuchi, The University of Tokushima, Toksuhima, Japan

TP251

Protein Analysis by 3-D Geometry Gel Electrophoresis Robert Ventzki, European Molecular Biology Laboratory, Heidelberg, Germany

TP252

Top-down Proteomics of the Human Salivary Proteome Julian Whitelegge, University of California at Los Angeles, Los Angeles, CA, United States

BIOINFORMATICS TP253 TP254

Generation Knowledge by Retrieving Information Web System J. Alberto Medina-Aunon, Centro Nacional de Biotecnologia, Madrid, Spain Towards a Comprehensive Catalog of Gene-disease and Gene-Drug Relationships in Cancer Kaj Albermann, Biomax Informatics AG, Martinsried, Germany

TP255

Classifying High Quality Unassigned Tandem Mass Spectra for Improved Protein Identification Christian E.H. Beaudrie, McGill University, Montreal, QC, Canada

TP256

ASC_ME: A New Engine for Peptide Mass Fingerprinting Directly from Mass Spectrum without Mass List Extraction Jean-Charles Boisson, Université des Sciences et Technologie de Lille, Villeneuve d'Ascq, France

TP257

Analysis of Peptide Counting for Protein Quantification Brian Carrillo, McGill University, Montreal, QC, Canada HUPO 2005 • FINAL PROGRAM

83

POSTER SESSION • TUESDAY, AUGUST 30TH TP258

MISPECIES: Automatic Generation of User Defined Databases for Use in Mass Spectrometry Searches Agnes Debril, Minomic Pty Ltd., Frenchs Forest, Australia

TP259

Visualizing Protein-protein Interactions Involved in Poly(ADP-ribose) Metabolism Arnaud Droit, Laval University, Sainte-Foy, QC, Canada

TP260

Swepep: A Database Designed For Neuropeptides and Mass Spectrometry Maria Falth, Uppsala University, Uppsala, Sweden

TP261

Allergen-specific Molecular Features: A Bioinformatic Approach Ruta Furmonaviciene, The University of Nottingham, Nottingham, United Kingdom

TP262

Proteios - Proteomic Data Storage and Sharing Jari Häkkinen, Lund University, Lund, Sweden

TP263

E-mitochondria Research for Systems Biology and Proteomics Jin Han, College of Medicine, Inje University, Busan, South Korea

TP264

Software Framework for Comparison of Quantitative Proteomics and DNA Microarray Data Sergii Ivakhno, Institute of Molecular Biology and Genetics, Kiev, Ukraine

TP265

UNIPROTKB/SWISS-PROT and the Human Proteomics Initiative Silvia Jimenez, Swiss Institute of Bioinformatics, Geneva, Switzerland

TP266

Validation of Proteomic Data from Liquid Chromatography/Tandem Mass Spectrometry Using Probability Score-based Elution Correlation of Peptide Assignments Takao Kawakami, Tokyo Medical University, Tokyo, Japan

TP267

A Statistical Framework for Identifying Protein Complexes Thomas Kreitler, Max Planck Institute for Molecular Genetics, Berlin, Germany

TP268

RALPH: Rapid Annotation for Large Protein Lists By MeSH Min-Seok Kwon, Yonsei Proteome Research Center & Biomedical Proteome Research Center, Seoul, South Korea

TP269

OPENMS - A Generic Open Source Framework for Chromatography/MS-based Proteomics Eva Lange, FU Berlin, Berlin, Germany

TP270

Peak Detection of SELDI Measurements for Identifying Protein Biomarkers Janne Lehtiö, Karolinska Institute, Stockholm, Sweden

TP271

The Strategies, Standards and Platforms for Large Scale Data Management of Hlpp Expression Profiling Project Jianqi Li, Beijing Institute of Radiation Medicine, Beijing, P.R China

84

HUPO 2005 • FINAL PROGRAM

POSTER SESSION • TUESDAY, AUGUST 30TH TP272

Integrated Management of Dataflow within the Proteomic Projects Andrey Lisitsa, Research Institute of Biomedical Chemistry RAMS, Moscow, Russia

TP273

SPLASH: Systematic Proteomics Laboratory Analysis and Storage Hub Siaw Ling Lo, National University of Singapore, Singapore

TP274

The Biomarker Sieve: A Computational Framework for Label-free Ms-based Proteomic Biomarker Discovery Askenazi Manor, Thermo Electron Corporation, Cambridge, MA, United States

TP275

A Web System to Depict a Set of Identified Proteins within an in-Silico 2D Array J. Alberto Medina-Aunon, Centro Nacional de Biotecnología, CSIC, Madrid, Spain

TP276

Creation and Interconnection of Distributed Proteomic Databases: The MAKE2d-DB Ii Tool, an Example Applied To 2-DE Datasets Khaled Mostaguir, Swiss Institute of Bioinformatics, Geneva, Switzerland

TP277

Non-Redundant Protein Sets with High Quality Annotation Derived from Uniprot and the International Protein Index Sandra Orchard, Embl-ebi, Cambridge, United Kingdom

TP278

Optimizing Search Conditions for the Mass-fingerprint-based Identification of Proteins Elena Ossipova, Swedish University of Agricultural Sciences, Uppsala, Sweden

TP279

Development of Protein Data Validation Method Using Reversed Protein Database and Molecular Weight Information in Proteome Analysis Gun Wook Park, Korea Basic Science Institute, Daejeon, South Korea

TP280

PHproteomicDB: A Tool for 2-DE Gel Data Management on Web Sites Arnaud Bruneel, Hôpital Saint-Antoine, Paris, France

TP281

INTEGR8, A Resource for Proteomic and Genomic Data Manuela Pruess, EMBL-Ebi, Cambridge, United Kingdom

TP282

Transfog: Translational and Functional Oncogenomics Antony Quinn, European Bioinformatics Institute, Cambridge, United Kingdom

TP283

Peakardt.FindPairs - Automated Quantitative Evaluation of Stable Isotope-coded Peptide Mass Spectra Kai A. Reidegeld, Ruhr University Bochum, Bochum, Germany

TP284

Differential Network Analysis of Clinical Proteomics Data Using Keymolnet Hiromi Sato, Institute of Medicinal Molecular Design Inc., Tokyo, Japan

TP285

MS/MS Background Noise Filtering: A First Step towards Robust Sequence-similarity Identifications Vineeth Surendranath, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany

HUPO 2005 • FINAL PROGRAM

85

POSTER SESSION • TUESDAY, AUGUST 30TH TP286

Bioinformatics Solutions for Proteomics Herbert Thiele, Bruker Daltonik GmbH, Bremen, Germany

TP287

Peptide Isoelectric Point Filtering of Tandem Mass Spectrometry Search Data Nkemdilim Uwaje, Max Planck Institute of Psychiatry, Munich, Germany

TP288

MSight: An LC-MS Image Analysis Software Daniel Walther, Swiss Institute of Bioinformatics, Geneva University Hospital, Geneva, Switzerland

TP289

A Peptide Candidate Selection Support Vector Machine for Ms-based Peptide Identification Bobbie-Jo Webb-Robertson, Pacific Northwest National Laboratory, Richland, WA, United States

TP290

From Analysis to Prediction of Human Protein Interaction Sara Zanivan, University of Turin, Candiolo, Italy

TP291

Data Evaluation and Integration of HUPO Liver Proteome Project Yunping Zhu, Beijing Institute of Radiation Medicine, Beijing, P.R. China

TP292

An Integrated Strategy for Functional Analysis in Large-scale Proteomic Research by Gene Ontology Yunping Zhu, Beijing Institute of Radiation Medicine, Beijing, P.R. China

07:00 – 08:00 IS7 - INDUSTRY SPONSORED SYMPOSIUM AGILENT TECHNOLOGIES LATEST TRENDS IN PROTEOMICS ROOM: 5 Chair: Dr. Rudolf Grimm, Agilent Technologies, Santa Clara, CA, United States 07:00 – 07:05 Introduction Breakfast Dr. Rudolf Grimm, Agilent Technologies, Santa Clara, CA, United States 07:05 – 07:35 Quantitative Proteomics: Current Technologies and New Directions Professor Ruedi Aebersold, ETH Zurich Switzerland, Institute for Systems Biology, Seattle, WA, United States 07:35 – 07:55 Recent Technology Advances and Latest Trends to Enhance Proteomics Research Dr. Friedrich Mandel, Agilent Technologies, Waldbronn, Germany 07:55 – 08:00 Closing Remarks Dr. Rudolf Grimm, Agilent Technologies, Santa Clara, CA, United States

86

HUPO 2005 • FINAL PROGRAM

DETAILED PROGRAM • WEDNESDAY, AUGUST 31ST 08:30 – 10:20

PL3.1

PLENARY LECTURES: SUBPROTEOMES Chairs: Ruedi Aebersold & Richard Simpson

08:30 – 09:00

PL3.1.01

Proteomics of the Early Secretory Pathway John J.M. Bergeron, McGill University, Montreal, QC, Canada

09:00 – 09:30

PL3.1.02

Cell Fate Decisions Revealed by Quantitative Phosphoproteomics Matthias Mann, Max Planck Institute of Biochemistry, Martinsried, Germany

09:30 – 09:55

PL3.1.03

Combined Fractional Diagonal Chromatography (COFRADIC): A MultiPurpose Tool for Peptide-Centric Proteomics Joel Vandekerckhove, University of Gent, Gent, Belgium

09:55 – 10:20

PL3.1.04

Quantitative Proteomics by Metabolic Stable Isotope Labeling and Mass Spectrometry Albert Heck, Utrecht University, Utrecht, The Netherlands

10:20 – 10:50

ROOM: 14

COFFEE AND POSTER BREAK

10:50 – 12:40

PL3.2

PLENARY LECTURES: MODEL ORGANISMS Chairs: John J. M. Bergeron & Joel Vandekerckhove

10:50 – 11:20

PL3.2.01

Analysis of the Budding Yeast Proteome Erin K. O’Shea, Howard Hughes Medical Institute, San Francisco, CA, United States

11:20 – 11:50

PL3.2.02

Towards a Comprehensive Understanding of Bacterial Physiology by Proteomics Michael Hecker, University of Greifswald, Greifswald, Germany

11:50 – 12:15

PL3.2.03

Deciphering Membrane Proteomes in the Model Plant Arabidopsis thaliana Helene Barbier-Brygoo, CNRS, Gif-sur-Yvette Cedex, France

12:15 – 12:40

PL3.2.04

A Novel Cell Signaling Pathway in Arabidopsis Revealed by Proteomics Anthony Slabas, University of Durham, Durham, United Kingdom

ROOM: 14

12:45 – 14:15 IS8 - LUNCHEON INDUSTRY SPONSORED SYMPOSUM GE HEALTHCARE ROOM: Hall 14 12:45 – 13:00 Introduction Dr. Joakim Rodin, V.P. Development, GE Healthcare HUPO 2005 • FINAL PROGRAM

87

DETAILED PROGRAM • WEDNESDAY, AUGUST 31ST 13:00 – 13:20 2-D DIGE as an Analytical Tool for Quantitative Multivariable Differential Display Proteomics Dr. David Friedman, Research Assistant Professor of Biochemistry Associate Director, Proteomics Laboratory Mass Spectrometry Research Center Vanderbilt University 13:20 – 13:40 Peptidomics and Parkinson’s Disease Dr. Per Andren, Laboratory for Biological and Medical Mass Spectrometry Uppsala University 13:40 – 14:00 Expanding the Potential of proteomic Analysis using DeCyderTM EDA Dr. Mark O’Connor, KuDOS Pharmaceuticals Ltd. 14:00 – 14:15 Questions & Answers - Closing Remarks Dr. Joakim Rodin, V.P. Development, GE Healthcare

12:45 – 14:15 IS9 WATERS CORPORATION A NOVEL METHODOLOGY THAT ENABLES MORE THAN LABEL FREE QUANTITATION ROOM: 13 12:45 – 13:05 Welcome and Lunch 13:05 – 13:35 An Introduction to the Waters Protein Expression System® 13:35 – 14:05 Applications of the Waters Protein Expression System® 14:05 – 14:15 Discussion 14:15 – 15:00

POSTER SESSION

15:00 – 17:00

15:00 – 15:30

88

PARALLEL SESSIONS PS3.1

HUPO INITIATIVES I Chairs: John J. M. Bergeron & Laura Beretta

PS3.1.01

HUPO Human Liver Proteome Project Fuchu He, Beijing Institute of Radiation Medicine, Beijing, P.R. China

HUPO 2005 • FINAL PROGRAM

ROOM: 14

DETAILED PROGRAM • WEDNESDAY, AUGUST 31ST 15:30 – 16:00

PS3.1.02

HUPO Plasma Proteome Project Gilbert Omenn, University of Michigan, Ann Arbor, MI, United States

16:00 – 16:30

PS3.1.03

HUPO Brain Proteome Project Helmut E. Meyer, Ruhr University Bochum, Bochum, Germany

16:30 – 16:45

PS3.1.04

Quantitative Proteomics of Membrane Proteins for Studying Brain and Its Diseases Jacek Roman Wisniewski, Protana Inc., Toronto, ON, Canada

16:45 – 17:00

PS3.1.05

Identification of Hepatocellular Carcinoma-Associated Serum Glycoproteins by Lectin Affinity Purification and 2D Gel Analysis Irene L. Ang, Chinese University of Hong Kong, Hong Kong, P.R. China

15:00 – 16:55

PS3.2

CLINICAL PROTEOMICS III & TOXICOLOGY Chairs: Luca Bini & Gerd Schmitz

15:00 – 15:20

PS3.2.01

Proteomic Approach to Define Multivariate Protein Markers in Lung Diseases Luca Bini, University of Siena, Siena, Italy

15.20 – 15.40

PS3.2.02

Plasma Proteomics – Challenges and Windows of Opportunities Gerd Schmitz, University of Regensburg, Germany

15:40 – 15:55

PS3.2.03

A Proteomic Approach to Human Muscle Plascity and Function: From Physiology to Pathology Cecilia Gelfi, National Research Council, Segrate, Italy

15:55 – 16:10

PS3.2.04

Proteome Analysis of the Red Blood Cell: What More Can Be Learned? Erica M. Pasini, Biomedical Primate Research Center, Rijswijk, The Netherlands

16:10 – 16:25

PS3.2.05

Overexpression of Angiopoietin-like Protein 4 Alters the Protein Expression Profiles of the Liver Tissue in DB/DB Diabetic Mice Yu Wang, University of Hong Kong, Hong Kong, P.R. China

16:25 – 16:40

PS3.2.06

Identification and Purification of Sperm Surface Proteins Related to Sperm Maturation Clémence Belleannée, INRA, Nouzilly, France

16:40 – 16:55

PS3.2.07

Proteomics in Predictive Toxicology Herbert Platsch, BASF, Ludwigshafen, Germany

15:00 - 16:45

PS3.3

PROTEOMIC METHODS II Chairs: Joel Vandekerckhove & David Fenyö

ROOM: 1

ROOM: 5

HUPO 2005 • FINAL PROGRAM

89

DETAILED PROGRAM • WEDNESDAY, AUGUST 31ST 15:00 – 15:15

PS3.3.01

ICPL, a Technique for Comprehensive and Quantitative Proteome Analysis Friedrich Lottspeich, Max Planck Institute of Biochemistry, Martinsried, Germany

15:15 – 15:30

PS3.3.02

Non-Labeling Liquid Chromatography-Mass Spectrometry-Based Quantitative Proteomics Xiao-jun Li, Institute for Systems Biology, Seattle, WA, United States

15:30 – 15:45

PS3.3.03

Comparison of Time-Course and Steady-State Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC) to Investigate the Function and Dynamics of a Large Multi-Protein Complex Jens S. Andersen, University of Southern Denmark, Odense, Denmark

15:45 – 16:00

PS3.3.04

Fluorous Proteomics: Enrichment and Analysis of Peptide Subsets Using Fluorous Affinity Tags and Mass Spectrometry Eric Peters, Genomics Institute of the Novartis Research Foundation, San Diego, CA, United States

16:00 – 16:15

PS3.3.05

New Approaches to Full Characterization of Cancer Biomarkers at the Trace Level – Epidermal Growth Factor Receptor Shiaw-Lin Wu, Northeastern University, Boston, MA, United States

16:15 – 16:30

PS3.3.06

2-Dimensional-Image-Converted Analysis of Nano-Flow Liquid Chromatography and Mass Spectrometry Masaya Ono, National Cancer Research Institute, Tokyo, Japan

16:30 – 16:45

PS3.3.07

Predicting the Success Rate of Proteome Analysis by Modeling Protein Abundance Distributions and Experimental Designs David Fenyö, Rockefeller University, New York, NY, United States

15:00 – 17:00

PS3.4

MICROBIAL AND OTHER NON-MAMMALIAN PROTEOMES Chairs: Michael Hecker & Alfred Nordheim

15:00 – 15:15

PS3.4.01

Proteomic Identification of Proteins Associated with Biofilm Growth of the Pathogen Staphylococcus aureus Alfred Nordhein, University of Tübingen, Tübingen, Germany

15:15 – 15:30

PS3.4.02

Mining Quorum Sensing Regulated Proteins – Role of Bacterial Cell Communication in Global Gene Regulation as Assessed by Proteomics Kathrin Riedel, Institute of Plant Biology, University of Zürich, Zürich, Switzerland

15:30 – 15:45

PS3.4.03

Syntrophic Microbes Examined With Virtual and Classical 2-D Gels Rachel Loo, University of California – Los Angeles, Los Angeles, CA, United States

90

HUPO 2005 • FINAL PROGRAM

ROOM: 13

DETAILED PROGRAM • WEDNESDAY, AUGUST 31ST 15:45 – 16:00

PS3.4.04

Proteomic Profiling of Bacterial Strains Vadim Govorun, Research Institute for Physico-Chemical Medicine, Moscow, Russia

16:00 – 16:15

PS3.4.05

Monitoring the Dynamic of Transcription and Translation within the Time Course of Recombinant E. coli Cultivations Karin Dürrschmid, University of Natural Resources and Applied Life Sciences, Vienna, Austria

16:15 – 16:30

PS3.4.06

Proteome Analysis of Corynebacterium glutamicum Ansgar Poetsch, Ruhr University Bochum, Bochum, Germany

16:30 – 16:45

PS3.4.07

Proteomic Analysis of the Membrane Proteins in Alkalimonas amylolytica Bo Meng, Beijing Genomics Institute, CAS, Beijing, P.R. China

16:45 – 17:00

PS3.4.08

FLYCAT – Towards a Drosophila Database Erich Brunner, University of Zürich, Zürich, Switzerland

17:00 – 17:30

COFFEE AND POSTER BREAK

17:30 – 19:30

PARALLEL SESSIONS PS3.5

HUPO INITIATIVES II Chairs: Richard J. Simpson & Gilbert Omenn

ROOM: 14

17:30 – 17:45

PS3.5.01

Quantitation and Resolution of Proteins in Complex Specimens Matthias Mann, Max Planck Institute of Biochemistry, Martinsried, Germany

17:45 – 18:00

PS3.5.02

Priority Proteins from Each Initiative for HUPO Antibodies Production Mathias Uhlen, Royal Institute of Technology (KTH), Stockholm, Sweden

18:00 – 18:15

PS3.5.03

Organ-Based Additional Proteomes and Annotation Peipei Ping, Geffen School of Medicine at UCLA, Los Angeles, CA, Unites States

18:15 – 18:30

PS3.5.04

Bioinformatics Annotations and Cross-Comparisons of Proteomics Findings in Plasma, Liver and Brain Rolf Apweiler, EMBL European Bioinformatics Institute, Hinxton, United Kingdom

18:30 – 18:45

PS3.5.05

High Throughput Analysis of Plasma Proteins Ruedi Aebersold, Swiss Federal Institute of Technology ETH, Zürich, Switzerland

HUPO 2005 • FINAL PROGRAM

91

DETAILED PROGRAM • WEDNESDAY, AUGUST 31ST 18:45 – 19:00

PS3.5.06

Feasibility of Clinical Proteomics Denis Hochstrasser, Geneva University Hospital, Geneva, Switzerland

19:00 – 19:15

PS3.5.07

Proteomics of Protein Biomarkers for Liver Diseases Laura Beretta, Fred Hutchinson Cancer Research Center, Seattle, WA, United States

19:15 – 19:30

General Discussion

17:30 – 19:25

PS3.6

CLINICAL BIOMARKER DISCOVERY Chairs: Steven Pennington & Hubert Hondermarck

17:30 – 17:50

PS3.6.01

Discovery, Validation and Quantification of Potential Biomarkers and Therapeutic Targets Steven Pennington, Conway Institute for Biomolecular and Biomedica l Research, University College Dublin, Dublin, Ireland

17:50 – 18:10

PS3.6.02

Proteomics of Breast Cancer for Signal Pathway Profiling and Target Discovery Hubert Hondermarck, INSERM, University of Sciences and Technologies, Lille, France

18:10 – 18:25

PS3.6.03

The Multi-Dimensional µLC-MALDI-MS Differential Peptide Profiling System for Identification of Cancer Biomarker Kazuhiko Uchida, Graduate School of Comprehensive Human Sciences, Tsukuba, Japan

18:25 – 18:40

PS3.6.04

Biomarker Discovery in Human Cerebral Spinal Fluid for Neurodegenerative Diseases Catherine Pan, University of Washington, Seattle, WA, United States

18:40 – 18:55

PS3.6.05

Focused Mass Specrometric Proteomics for Discovery of Novel Diagnostic Targets in Biofluids Niels Heegaard, Statens Serum Institut, Copenhagen, Denmark

18:55 – 19:10

PS3.6.06

Discovery of Biomarkers in Type 2 Diabetes Urine: Potential for a Non-Invasive Early Diagnostic Brad Walsh, Minomic Pty Ltd., Harbord, Australia

19:10 – 19:25

PS3.6.07

Developing Peptide MRM-Based Assays for Cardiovascular Biomarker Proteins in Plasma Using a Hybrid Triple Quadrupole Linear Ion Trap Mass Spectrometer Christie Hunter, Applied Biosystems, Foster City, CA, United States

92

HUPO 2005 • FINAL PROGRAM

ROOM: 1

DETAILED PROGRAM • WEDNESDAY, AUGUST 31ST 17:30 – 19:30

PS3.7

FUNCTIONAL PROTEOMICS Chairs: Bernard Küster & Daniel Figeys

ROOM: 13

17:30 – 17:45

PS3.7.01

A Proteomic Screen for Host Cell Proteins Interacting with Tyrosine Phosphorylated Bacterial Effectors Matthias Selbach, Max Planck Institute of Biochemistry, Martinsried, Germany

17:45 – 18:00

PS3.7.02

Analysis of Protein Kinases by Chemical Proteomics Henrik Daub, Max Planck Institute of Biochemistry, Martinsried, Germany

18:00 – 18:15

PS3.7.03

Cell Cycle Dynamics of Chromatin Proteome in Xenopus Egg Extract Guennadi Khoudoli, University of Dundee, Dundee, United Kingdom

18:15 – 18:30

PS3.7.04

Targeted Proteomic and Structural Analysis of 14-3-3sigma, a p53 Effector Commonly Silenced in Cancer Heiko Hermeking, Max Planck Institute of Biochemistry, Martinsried, Germany

18:30 – 18:45

PS3.7.05

Systematic Analysis of Uncharacterized Protein Complexes from Saccharomyces cerevisiae Kevin Breitkreuz, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada

18:45 – 19:00

PS3.7.06

Mapping Protein-Protein and Protein-DNA Interactions Daniel Figeys, University of Ottawa, Ottawa, ON, Canada

19:00 – 19:15

PS3.7.07

Functional Knockouts of Specific Protein Interactions Mark Fear, Institute for Child Health Research, Perth, Australia

19:15 - 19:30

PS3.7.08

Proteomic Mapping of Dynamic Protein-Protein Interactions in Mammalian Cells Miriam Barrios-Rodiles, Samuel Lunenfeld Research Institute, Toronto, ON, Canada

17:30 – 19:30

PS3.8

PLANT PROTEOMES AND METABOLOMES Chairs: Jesus Jorrin Novo & Lothar Willmitzer

17:30 – 17:50

PS3.8.01

Integrative Analysis of the Metabolome and Transcriptome Lothar Willmitzer, Max Planck Institut für Molekulare Pflanzenphysiologie, Potsdam-Golm, Germany

ROOM: 5

HUPO 2005 • FINAL PROGRAM

93

DETAILED PROGRAM • WEDNESDAY, AUGUST 31ST 17:50 – 18:10

PS3.8.02

Proteomics of Plant Responses to Biotic Stresses: Progress, Problems and Challenges Jesus Jorrin Novo, University of Córdoba, Córdoba, Spain Using Proteomics Approaches to Help the Rice Genome Annotation Jun Wang, Beijing Genomics Institute, Beijing, P.R. China

18:10 – 18:25

PS3.8.03

18:25 – 18:40

PS3.8.04

Hiding Behind Hydrophobicity – Transmembrane Segments in Mass Spectrometry Lutz Eichacker, Ludwig Maximilians Universität München, Munich, Germany

18:40 – 18:55

PS3.8.05

Membrane Proteomics of Arbuscular Mycorrhiza Elaine Dumas-Gaudot, INRA, Dijon, France

18:55 – 19:10

PS3.8.06

Tracing Altered Metabolic States in the Thylakoid Membrane Holger Seelert, Darmstadt University of Technology, Darmstadt, Germany

19:10 – 19:25

PS3.8.07

Extracellular Matrix Proteome of Chickpea (Cicer arietinum) Illustrates Pathway Abundance, Novel Protein Functions and Evolutionary Perspect Niranjan Chakraborty, National Centre for Plant Research, New Delhi, India

POSTER SESSION ROOM:BO DISPLAY ALL DAY OFFICIAL VIEWINGS: 14:15 – 15:00

FUNCTIONAL PROTEOMICS - CELL SIGNALING WP001

A Differential Proteomic Approach to Study Stimulus Induced Plasticity of Olfactory Receptors in Mice Jenny Adler, Ruhr University Bochum, Bochum, Germany

WP002

Identification of Highly Expressed Proteins by IL-3 Stimulation in Lymphocytes K.-H. Baek, Cell and Gene Therapy Research Institute, Seoul, South Korea

WP003

Analysis of Light-depensent Dynamics of Protein Complexes in the Retina Monika Beer, GSF-National Research Center for Environment and Health, Munich, Germany

WP004

Mapping of the Rat Natural Killer Cell Membrane Microdomain Karel Bezouska, Charles University Prague, Prague, Czech Republic

94

HUPO 2005 • FINAL PROGRAM

POSTER SESSION • WEDNESDAY, AUGUST 31ST WP005

Quantitative Proteomics of EGF and PDGF Signaling Networks Reveals Controlling Mechanism of Mesenchymal Stem Cell Differentiation Blagoy Blagoev, University of Southern Denmark, Odense, Denmark

WP006

Impaired Functionality of Mutated CDC48P in the ER-associated Protein Degradation Pathway Triggers Mitochondria-mediated Cell Death Ralf Braun, G. S. F. - National Research Center of Environment and Health, Neuherberg, Germany

WP007

Signal Through 4-1BB Ligand Inhibits Osteoclastogenesis by Increasing Interferon-Beta in Bone Marrow-derived Macrophages H.S. Choi, University of Ulsan, Ulsan, South Korea

WP008

Deorphanization of Membrane Receptors Involved in Leukocyte Trafficking David Communi, Free University of Brussels, Brussels, Belgium

WP009

Proteomic Study of TGFβ Signal Transduction Paolo Conrotto, Ludwig Institute for Cancer Research, Uppsala, Sweden

WP010

Temporal Analysis of Insulin Induced Changes in the Tyrosine-Phosphoproteom of Brown Adipocytes Marcus Krueger, University of Southern Denmark, Odense, Denmark

WP011

Investigation of the Influence of Calpain on Membrane Ruffling René Lametsch, The Royal Veterinary and Agricultural University, Frederiksberg C, Denmark

WP012

Phosphoproteomics of Angiopoietin Signalling in Lymphatic Endothelial Cells Victoria P. K. H. Nguyen, University of Toronto, Toronto, ON, Canada

WP013

Identification of New Apoptosis Regulators by Differential, Multidimensional Proteome Analysis Combined with High Throughput RNA Interference Thomas Rudel, Max Planck Institute for Infection Biology, Berlin, Germany

WP014

Growth-related Oncogene (GRO) Is Produced in Human Breast Cancer Cells and Regulated by Syk Protein-Tyrosine Kinase Neil Sidell, Emory University School of Medicine, Atlanta, GA, United States

WP015

Identification of NPM-ALK-interacting Proteins Involved in the Transformation of Anaplastic Lymphomas Claudia Voena, University of Turin, Turin, Italy

WP016

Optimized Sample Preparation Tools for the Analysis of Oncological Relevant Signal Transduction Pathways Joerg von Hagen, Merck KGaA, Darmstadt, Germany

WP017

Analysis of Human Proteins Regulated by Stimulation with Muramyl Dipeptide Dieter Weichart, Max Planck Institute for Molecular Genetics, Berlin, Germany

HUPO 2005 • FINAL PROGRAM

95

POSTER SESSION • WEDNESDAY, AUGUST 31ST WP018

Proteomics of TGF Beta Signaling in "Normal" Human Breast Epithelial Cells Hanna Woksepp, Ludwig Institute for Cancer Research, Uppsala, Sweden

WP019

Comparative Proteomics Analysis of Rat Mesangial Cell Apoptosis Induced by Lovastatin Jiang Xiao-Sheng, Shanghai Institutes for Biological Science, Shanghai, P.R. China

WP020

Quantitative Proteomic Analysis of Proteins in Membrane Lipid Microdomains Isolated from 3T3L1 Preadipocytes with or without Caveolae Hu Zhou, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, P.R. China

FUNCTIONAL PROTEOMICS - PROTEIN-PROTEIN INTERACTIONS AND NETWORKS WP021

A GPCR Interactome: A Comprehensive Membrane Protein Interaction Map of Human G-proteincoupled Receptors Using the Membrane-Based Yeast Two-Hybrid Approach Lukas Bürkle, University of Zürich, Zürich, Switzerland

WP022

Study on Expression and Activity Identification of Recombinant LG4-5 Domain of Laminin alpha4 Chain Liu Chang, Jilin University, Changchun, P.R. China

WP023

SGT1 Interacting Proteins in Drosophila Melanogaster Ana Varela Coelho, ITQB- Instituto de Tecnologia Quimica e Biológica, Oeiras, Portugal

WP024

Use of Marimastat Conjugates for the Analysis of Proteome and Interactome of Metalloproteinases Magalie Collet, Bielfeld University, Bielefeld, Germany

WP025

Proteomics of Soluble Fragment and Full Lenght E-cadherin for Deciphering Invasion Mechanisms in Breast Cancer Cells Laurent Dollé, Laboratory of Experimental Cancerology, Ghent, Belgium

WP026

Microfluidic Analysis of Antibodies in a Compact Disc Format Cecilia Eriksson, Molecular Biotechnology, Stockholm, Sweden

WP027

Detection of Protein - Protein - Interactions by Proteinchip Technology Niko Escher, Institute of Human Genetics and Anthropology, Jena, Germany

WP028

Proteomic Analysis of Hepatitis C Virus Interacting Proteins Using Tandem Affinity Purification and Mass Spectrometry Gian Maria Fimia, National Institute for Infectious Diseases, Rome, Italy

WP029

Development of a Biochip-based Approach for the Genome-Wide Mapping of Interactions between Protein Domains and Peptide Ligands Ronald Frank, GBF, Braunschweig, Germany

96

HUPO 2005 • FINAL PROGRAM

POSTER SESSION • WEDNESDAY, AUGUST 31ST WP030

Isolation and Molecular Analysis of a Transcription Factor for Placenta-specific Expression of the Bovine CYP19 Gene Rainer Fürbaß, Research Institute for the Biology of Farm Animals, Dummerstorf, Germany

WP031

Development of a New Tandem Affinity Purification (TAP) Strategy for Isolation of Protein Complexes Involved in Cell Signalling out of Mammalian Cell Culture Christian Johannes Gloeckner, GSF National Research Centre, Neuherberg, Germany

WP032

Microscale Peptide Synthesis for Protein Interaction Experiments Stefan Hanke, Max Planck Institute for Biochemistry, Martinsried, Germany

WP033

Biomolecular Interaction Analysis as a General Tool for Functional Proteomics Friedrich Herberg, Kassel University, Kassel, Germany

WP034

Cloning and Expression of Apoptin Fusion Geneand the Effects on Apoptosis of Tumor Cells Hao Junyuan, Jilin University, Changchun, P.R China

WP035

IntAct - an Open Source Framework for Molecular Interactions Samuel Kerrien, EMBL-EBI, Cambridge, United Kingdom

WP036

Comparative Analysis of PDZ Domains Binding Modalities Elena Landi, University of Pisa, Pisa, Italy

WP037

Mammalian Proliferating Cell Nuclear Antigen May Function as a Double Homotrimer Complex Hoyun Lee, Northeastern Ontarion Regional Cancer Centre, Sudbury, ON, Canada

WP038

Deciphering Stem Cell Differentiation Program Using Proteomics and Bioinformatics Tools Michal Linial, The Hebrew University of Jerusalem, Jerusalem, Israel

WP039

Reverse Engineering of Cell Cycle-specific Protein Networks from 2D-PAGE Data Petr Lokhov, Research Institute of Biomedical Chemistry RAMS, Moscow, Russia

WP040

Analysis of Human Plasma Proteins under Non-Denaturing Conditions Takashi Manabe, Ehime University, Matsuyama, Japan

WP041

Molecular and Functional Characterization of Multiprotein Complexes Interacting with Serotonin 5HT2 and 5-HT4 Receptors Philippe Marin, Cnrs Umr5203, Montpellier, France

WP042

The Regulation Mechanism of the Eukaryotic Translation Initiation Factor 4E in Drosophila Melanogaster Maria Monti, Ceinge Biotecnologie Avanzate, Naples, Italy

WP043

Proteomic Approach to Identify PEX3P Interacting Proteins in Saccharomyces Cerevisiae Silke Oeljeklaus, Ruhr University Bochum, Bochum, Germany

HUPO 2005 • FINAL PROGRAM

97

POSTER SESSION • WEDNESDAY, AUGUST 31ST WP044

The Calcium-sensing Receptor (CASR) Dimerizes in the Endoplasmic Reticulum: Biochemical and Biophysical Characterization of CASR Mutants Retained Intracellularly Svetlana Pidasheva, McGill University, Montreal, QC, Canada

WP045

Uncovering the Structure of Protein-Protein Interaction Networks Natasa Przulj, University of Toronto, Toronto, ON, Canada

WP046

Identification and Characterisation of Cellular Proteins Associated to the Epstein-Barr Virus-encod ed Nuclear Antigen 5 (EBNA 5) Ulla Rüetschi, Institute for Laboratory Medicine, Göteborg, Sweden

WP047

Self Assembling Protein Microarrays for Mapping Protein-Protein Interactions among 1300 Breast Cancer Related Proteins Daniel Schiwek, Institute of Proteomics, Cambridge, MA, United States

WP049

Tandem Affinity Purification to Study Cdk/Cyclin Complexes in Arabidopsis Thaliana Hilde Stals, Ghent University, Zwijnaarde, Belgium

WP050

Systematic Identification of Human Protein-Protein Interactions Using Protein Arrays Martin Stroedicke, Max-Delbrück-Centrum für Molekulare Medizin, Berlin, Germany

WP051

TET-KRAB Mediated Gene Expression Enables the Identification of Proteins Functionally Associated with TIF-1BETA Protein Complexes Hans-Juergen Thiesen, University of Rostock, Rostock, Germany

WP052

A Proteomic Approach to Understand the Anti-invasive and Pro-apoptotic Effect of Xanthohumol in Human Breast Cancer Cells Barbara Vanhoecke, Laboratory of Experimental Cancerology, Ghent, Belgium

WP053

Proteins of the Epidermal Differentiation Complex (EDC) Are Differentially Expressed in CD4+CD25+ Regulatory T Cells Thomas Wiebringhaus, University of Applied Science of Gelsenkirchen, Recklinghausen, Germany

WP054

The Studies of P15INK4B Tumor Suppressor in Chicken Ai Yongxing, Jilin University, Changchun, P.R. China

WP055

Identification of Ubiquitin Interacting Proteins in A549 Cells with the Multidimensional Protein Identification Technique Following an Ubiquitin Affinity Chromatography Yung Joon Yoo, Gwangju Institute of Science and Technology, Gwangju, South Korea

WP056

Protein Function in the Evolution of Yeast Protein Interaction Network Yunping Zhu, Beijing Institute of Radiation Medicine, Beijing, P.R. China

WP057

Entropic Trapping of Globular Proteins Gleb Zilberstein, Traps Ltd, Rehovot, Israel

98

HUPO 2005 • FINAL PROGRAM

POSTER SESSION • WEDNESDAY, AUGUST 31ST HUPO INITIATIVES - LIVER WP058

Age Peculiarity in Regulation of Liver Aldehyde Reductase Activity by Free Radical Oxidation Products Vadim Davydov, Institution of Children and Adolescent Health Care Ams of Ukraine, Kharkov, Ukraine

WP059

Detection and Identification of New Tumor Markers in Human Hepatocellular Carcinomas Evelyn Zeindl-Eberhart, Ludwig-Maximilians-University, Munich, Germany Comparative Proteomic Analysis of Rat Liver Fibrogenic Cells of Different Origins Nelly Bosselut, Hopital St-Antoine, Paris, France

WP060

WP061

Proteomic Roadmap of Mouse Liver Development from Embryo to Adult John Luk, The University of Hong Kong, Hong Kong, P.R. China

WP062

Mapping of Human Liver Proteins by DIGE Asier Galan, One Way Liver Genomics, Derio, Spain

WP063

Generation and Characterization of Hybridoma Cell Lines against Human Liver Cytosolic Proteins by Using Fractionated Proteins as Immunogens Jian-en Gao, Beijing Proteomics Research Center, Beijing, P.R. China

WP064

Subcellular Preparation and Evaluation of Mouse Liver Ying Jiang, Beijing Institute of Radiation Medicine, Beijing, P.R. China

WP065

Comparative Analysis of 2D Blue Native Gel Profiles of Rat Liver Mitochondria Proteins during Liver Regenration Ying Jiang, Beijing Institute of Radiation Medicine, Beijing, P.R. China

WP066

Protein Expression Profile for Differentiating among Hepatocellular Carcinoma Cell Lines, Tumor Tissues, Adjacent Non-tumor Liver, and Normal Liver Terence C.W. Poon, The Chinese University of Hong Kong, Hong Kong, P.R. China

WP067

Complexity Reduction Techniques in Liver Proteomics Konstantin Yarygin, Research Institute of Biomedical Chemistry RAMS, Moscow, Russia

WP068

3-D Schemes for Establishing the Proteome Reference Map of Human Liver Wantao Ying, Beijing Institute of Radiation Medicine, Beijing, P.R. China

HUPO INITIATIVES - ANTIBODIES WP069

A High Throughput Approach for Bioinformatic Design and Cloning of Protein Epitope Sequence Tags Suitable for Antibody Generation Cristina Al-Khalili Szigyarto, Royal Institute of Technology, Stockholm, Sweden

HUPO 2005 • FINAL PROGRAM

99

DETAILED PROGRAM • WEDNESDAY, AUGUST 31ST WP070

Cell-TMA; A Method Creating an Artificial Tissue of Cells for Use in a High Throughput TMA Setting Ann-Catrin Andersson, Uppsala University, Uppsala, Sweden

WP071

Real-time RT-PCR of Protein Epitope Signature Tags Caroline Asplund, Royal Institute of Technology, Stockholm, Sweden

WP072

Inhibition of Angiogenesis by a Novel Neutralizing Antibody Hao Chen, Beijing Institute of Radiation Medicine, Beijing, P.R. China

WP073

Rapid and Efficient Production of Mouse Antibodies Specific for Human Membrane Receptors and "Difficult to Express" Proteins by Optimized Genetic Immunization Methods Joe Chiba, Tokyo University of Science, Noda, Japan

WP074

Preparation and Characterization of Monoclonal Antibodies against LSECtin Molecule Xuemei Du, Beijing Institute of Radiation Medicine, Beijing, P.R. China

WP075

Improved Phage Display Systems for the German Ngfn Proteome Antibody Initiative Stefan Dübel, Technical University of Braunschweig, Braunschweig, Germany

WP076

Generation and Characterization of Antibodies against CXCR3-B NH2 Terminus Yuan Gao, Beijing Institute of Radiation Medicine, Beijing, P.R. China

WP077

IGG Purity Assay Using a New High Resolution SDS Gel Dietmar Hansen, Beckman Coulter, Krefeld, Germany

WP078

Identification of Protein Antigens by Biopanning of T7 Phage Display Library Xiang He, Beijing Institute of Radiation Medicine, Beijing, P.R. China

WP079

Mapping the Human Proteome Using Tissue Micro Arrays Caroline Kampf, Uppsala University, Uppsala, Sweden

WP080

An Alternative Strategy for High Throughput Generation and Characterization of Monoclonal Antibodies against Human Plasma Proteins Using Fractionated Native Proteins as Immunogens Ming Li, South Medical University, Guangzhou, P.R. China

WP081

Selection of Antigenic Protein Fragments for Antibody-Based Proteomics Mats Lindskog, Institution of Biotechnology, Stockholm, Sweden

WP082

High Throughput Antibody Generation and Validation for Antibody Proteomics Jenny Ottosson, Royal Institute of Technology, Stockholm, Sweden

WP083

Mono-specific Antibodies: Validation Based on Immunohistochemistry on Tissue Microarrays Linda Paavilainen, Uppsala University, Uppsala, Sweden

WP084

Expression of Three Unrelated Proteins in Mycoplasma Infected Cell Lines Sara Strömberg, Uppsala University, Uppsala, Sweden

100

HUPO 2005 • FINAL PROGRAM

POSTER SESSION • WEDNESDAY, AUGUST 31ST WP085

Preparation, Characterization, and Application of Monoclonal Antibodies against Human Liver Mitochondrial Enzymes Qi-hong Sun, Beijing Institute of Radiation Medicine, Beijing, P.R. China

WP086

Novel Flow Cytometry-based Method for Analysis of Protein Production in Escherichia coli Hanna Tegel, Royal Institute of Technology, Stockholm, Sweden

WP087

Multiplex Immunization Strategies for Generation of Monospecific Antibodies in Proteomics Research Henrik Wernérus, Royal Institute of Technology, Stockholm, Sweden

HUPO INITIATIVES - BRAIN WP088

Comparative Transcriptome and Proteome Analysis of Mouse Models for Human Neurodegenerative Diseases Johannes Beckers, GSF - National Research Center, Neuherberg, Germany

WP089

Proteomegrid: High-throughput Image Analysis for Proteomics Andrew Dowsey, Imperial College London, London, United Kingdom

WP090

HUPO Brain Proteome Project: The Pilot Studies - Evaluation of 2D-DIGE, ICAT and LC-MS-MS in Neuroproteomics Thomas Fröhlich, Gene Center - University of Munich, Munich, Germany

WP091

HUPO Brain Proteome Project: The Pilot Studies - Proteomic Profiling of Human Temporal Lobe from Biopsy and Autopsy Specimen Ji Jianguo, Peking University, Beijing, P.R. China

WP092

HUPO Brain Proteome Project: The Pilot Studies Helmut E. Meyer, Ruhr University Bochum, Bochum, Germany

WP093

HUPO Brain Proteome Project: The Pilot Studies: Characterization of Brain Biopsy and Autopsy Samples by Gel-based and Gel-free Proteomic Approaches Jean-Paul Noben, Limburgs Universitair Centrum, Diepenbeek, Belgium

WP094

HUPO Brain Proteome Project: The Pilot Studies - Identification of Human Brain Proteome by Multidimensional Separations Coupled with Mass Spectrometer Young Mok Park, Korea Basic Science Institute, Daejeon, South Korea

WP095

Differential 4-Dimensional Separation of Brain Proteins in an Alzheimer disease Maise Model Gabriella Armin, Bio-Rad Laboratories, Hercules, CA, United States

WP096

Plasma Membrane Proteomics in the Rat Brain Jens Schindler, University of Kaiserslautern, Kaiserslautern, Germany

HUPO 2005 • FINAL PROGRAM

101

POSTER SESSION • WEDNESDAY, AUGUST 31ST WP097

Exploring Molecular Networks Directly in the Cell Walter Schubert, Institute of Medical Neurobiology, Molecular Pattern Recognition Research Group, Magdeburg, Germany

WP098

ITRAQ Labeling in Conjunction with 2D-LC and Tandem-MS to Study the Proteome and Dynamics of Excitatory Synapses in the Brain Jianru Stahl-zeng, Applied Biosystems, Darmstadt, Germany

WP099

The HUPO Brain Proteome Project Pilot Studies - Data Reprocessing and Further Analyses Christian Stephan, Ruhr University, Bochum, Bochum, Germany

WP100

The German Human Brain Proteome Project within the National Genome Research Network Andre Van Hall, Ruhr University Bochum, Bochum, Germany

HUPO INITIATIVES - GLYCOPROTEOMICS WP101

Simulation of Characteristic Fragment Patterns on MS/MS Spectra of Complex Type of N-linked Oligosaccharide Isomers Akihiko Kameyama, National Institute of Advanced Industrial Science and Technology, Tsukuba, Japan

WP102

Glycoproteomic Analysis Based on Multiple Enzymes Printing Technology Satoshi Kimura, Shimadzu Corporation, Kyoto, Japan

WP103

Sialylated Apolipoprotein E Increased in Human Hepatocellular Carcinoma Kazuyuki Nakamura, Yamaguchi University School of Medicine, Yamaguchi, Japan

WP104

Effects of Dendrostellera Lessertii on Hepatocarcinoma Alkaline Phosphatase Azin Nowrouzi, University of Tehran, Tehran, Iran

WP106

HGPI Pilot Study on the Analytical Method of Glycans Yoshino Wada, Osaka MCHRI, Izumi, Japan

HUPO INITIATIVES – NEW TECHNOLOGIES WP107

Quantitative Analysis of Proteomic Mixtures by Intact Protein LC/MS Scott Berger, Waters Corporation, Milford, MA, United States

WP108

Detection of Immunoglobulin by Piezoelectric Quartz Crystal Microarray Immunosensor Yao Chunyan, Southwest Hospital of the Third Military Medical University, Chongqing, P.R. China

WP109

Immoblilized pH Gradient Isoelectric Focusing for Biofluid Proteome Analysis Jonathan Bundy, Research Triangle Institute, RTP, NC, United States

102

HUPO 2005 • FINAL PROGRAM

POSTER SESSION • WEDNESDAY, AUGUST 31ST WP110

Protein Profiling in Endometrial Cancer Johanna Lahmann, University of Schleswig- Holstein, Campus Lÿbeck, Lÿbeck, Sweden

WP111

Flow Cytometry Analysis of Adhesion and Inflammation Molecules in Activated Lymphocytes, Monocytes and Granulocytes Daniel Lambert, Inserm U525, Nancy, France

WP112

Automated Control of the Electron Microscopy Proteomic Organellar Preparation Robot Karishma Punwani, McGill University, Montreal, QC, Canada

WP113

Novell Protein Separation Array Sergej Repnikov, Siberian Proteomics Center, Novosibirsk, Russia

WP114

Detailed MALDI-MS/MS Analysis of Gel Spots: Results Comparable to LC-MS in a Fraction of the Time, without the Need for LC Separation Michaela Scigelova, Thermo Electron, Hemel Hempstead, United Kingdom

WP115

Protein Ontology: Seamless Protein Data Integration A. S. Sidhu, University of Technology Sydney, Broadway, Australia

WP116

Experimental Research of Detecting the Plasma Fibrinogen and Coagulation Factor; Using Piezoelectric Quartz Crystal Blood Coagulation Sensors Fu Weiling, The Third Military Medical University, Chongqing, P.R. China

HUPO INITIATIVES – PLASMA WP117

Plasma Proteome Analysis Using Double Affinity Enrichment Oliver Bernhard, Ludwig Institute for Cancer Research, Parkville, Australia

WP118

New Insights into Proteomics of Human Haptoglobin Arnaud Bruneel, Hôpital Saint-Antoine, Paris, France

WP119

Preanalytical Variability of the Plasma Proteome Craig Gelfand, BD Diagnostics, Franklin Lakes, NJ, United States

WP120

Molecular Diagnosis of Hemoglobin Disorders in Azad Jammu and Kashmir, Pakistan Zahid Mahmood, University of Agriculture, Faisalabad, Pakistan

WP121

Intrinsic Preanalytical Variability of Serum Samples Is Evidenced in Peptide MALDI MS Spectra Patrick O'Mullan, BD Diagnostics, Franklin Lakes, NJ, United States

WP122

Novel Immunoaffinity Depletion Technology Removes Twenty High Abundance Proteins from Human Plasma to Better Visualize Low Abundance Proteins Mark Schuchard, Sigma-Aldrich, St. Louis, MS, United States

HUPO 2005 • FINAL PROGRAM

103

POSTER SESSION • WEDNESDAY, AUGUST 31ST WP123

Preanalytical Variability and the Stability of Human Plasma Proteins: Mass Spectrometry Changes Post Blood Collection J. Yi, BD Diagnostics, Franklin Lakes, NJ, United States

HUPO INITIATIVES – STANDARDS WP124

Toward a Cancer - Free Serum Standard through Electrospray Mass Spectrometry and Bioinformatics Gilberto B. Domont, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil

WP125

Report on the HUPO-PSI Mass Spectrometry Data Standards Randall Julian, Indigo Biosystems, Inc., Indianapolis, IN, United States

WP126

The Pride Project: Enabling You to Deliver Your Data to the World Lennart Martens, University of Ghent, Ghent, Belgium

MODEL ORGANISMS - MICROBIAL PROTEOMES WP127

Purification and Characterization of Endoglucanase from Neurospora Sitophila Muhammad Javaid Asad, University of Agriculture, Faisalabad, Pakistan

WP128

Antioxidant Status, Alpha - Amylase Production, Growth and Survival in Hemoglobin Bearing Escherichia Coli Exposed to Hypochlorous Acid Suleyman Aydin, Firat University, School of Medicine, Elazig, Turkey A Proteome Approach for Characterisation of Bacterial Resistance to Hop Ionophores in Lactobacillus Brevis Jürgen Behr, Technische Universität München, Freising, Germany

WP129

WP130

Two Dimensional Electrophoresis Analysis of Mycobacterium Avium Sub. Paratuberculosis Luigi Bonizzi, University of Milan, Milan, Italy

WP131

Proteomic Analysis of Iron and Sulfur Oxidizing Acidithiobacillus Ferrooxidans Using Immobilized pH Gradients and Mass Spectrometry Pavel Bouchal, Masaryk University Brno, Brno, Czech Republic

WP132

Towards the Proteome of Burkholderia Cenocepacia H111: Setting Up a 2-DE Reference Map Maria Paula Carranza, University of Zürich, Zürich, Switzerland

WP133

Significant Changes Are Induced in the Helicobacter Pylori Proteome by Environmental Growth Conditions Phillip Cash, University of Aberdeen, Aberdeen, United Kingdom

WP134

Effect of Nitric Oxide Treatment on Proteome of Escherichia Coli Cells Eleonora Cesareo, Università di Roma Tor Vergata, Roma, Italy

104

HUPO 2005 • FINAL PROGRAM

POSTER SESSION • WEDNESDAY, AUGUST 31ST WP135

Serological Proteome Analysis of B. Anthracis Theodor Chitlaru, Israel Institute for Biological Research, Ness-Zionna, Israel

WP136

Functional Approaches into the Elucidation of Cyanobacterial Positive Phototaxis Jong-soon Choi, Korea Basic Science Institute, Daejeon, South Korea

WP137

Proteomic Analysis of Membrane Proteins of Bacillus Subtilis Annette Dreisbach, Medical School, Greifswald, Germany

WP138

Proteomics Reveals 9 Different Proteins Shared Between Nocardia Africana (SD769) and Eubacteria Mogahid Mohammed El Hassan, Sudan University of Science and Technology, Khartoum, Sudan

WP139

Comparative Proteome Analysis of Planctonic and Biofilm-associated Cells of Pseudomonas Aeruginosa Using 2D-DIGE Katharina Fund, Forschungszentrum Karlsruhe, Eggenstein, Germany

WP140

The Encountering between Candida Albicans and Macrophages: What Is Going on? Concha Gil, Facultad de Framacia, Universidad Complutense, Madrid, Spain

WP141

YaiM and YeiG Genes Encode Two Close Related Carboxylesterases Involved in Escherichia Coli Formaldehyde Resistance Claudio F Gonzalez, Universtity of Toronto, Toronto, ON, Canada

WP142

The Effect of Carbon and Nitrogen Limitation on the Yeast Proteome Studied by Metabolic Stable Isotope Labeling and Mass Spectrometry Albert Heck, Utrecht University, Utrecht, The Netherlands

WP143

A Novel Strategy to Identify Surface Proteins in Whole Yeast Cells María Luisa Hernáez, Universidad Complutense De Madrid, Madrid, Spain

WP144

Diffential Proteomics of Environmental Bacteria Peter Hufnagel, Bruker Daltonics, Bremen, Germany

WP145

Analysis of Aromatic Catabolic Pathways in Pseudomonas putida KT 2440 by Combined Proteomic Approach: 2-DE/MS and ICAT Analysis Seung Il Kim, Korea Basic Science Institute, Daejeon, South Korea

WP146

Identification of the Cytosolic Protein Inventory and Quantitative Analysis under Different Physiological States on Natronomonas Pharaonis Kosta Konstantinidis, Max Planck Institute of Biochemistry, Munich, Germany

WP147

A Proteome Reference Map for Gluconacetobacter Diazotrophicus PAL5 Leticia, L. M. Lery, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

WP148

Proteome Analysis of C. Glutamicum: Strategies for the Detection/ Identification of Alkaline and Low Abundance Proteins Carsten Lück, Technical University of Munich, Freising, Germany HUPO 2005 • FINAL PROGRAM

105

POSTER SESSION • WEDNESDAY, AUGUST 31ST WP149

Comparative Proteome Analyses of Virulent and Attenuated Mycobacterial Strains Jens Mattow, Max Planck Institute for Infection Biology, Berlin, Germany

WP150

Physiological Responses of Acinetobacter Radioresistens S13 to Aromatic Molecules Detected by Proteomics and Glycoproteomics Roberto Mazzoli, University of Torino, Torino, Italy Proteomics Studies on D.radiodurans: Investigating Radiation Resistance Elena Micossi, European Synchrotron Radiation Facility, Grenoble, France

WP151

WP152

The Proteome of Mycobacterium Leprae Ana G.C. Neves-Ferreira, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil

WP153

Ribosomal Proteins as Candidate Gate-keepers of Differential mRNA Translation Karin Pachler, University of Salzburg, Salzburg, Austria

WP154

Investigating Changes in Proteome of Escherichia Coli Cells during Different Phases of Growth Alessandra Primavera, Università di Roma Tor Vergata, Roma, Italy

WP155

The Elucidation of the Mechanism of Expression in E. coli of an Archaeal Interrupted Gene by a Proteomic Approach Pietro Pucci, University of Naples, Naples, Italy

WP156

Physiological Proteomics with Anaerobic Aromatic-degrading "Aromatoleum" SP. Strain EbN1 Ralf Rabus, Max Planck Institute for Marine Microbiology, Bremen, Germany

WP157

Highly Phosphorylated Bacterial Proteins Ran Rosen, Tel Aviv University, Tel Aviv, Israel

WP158

A Study of Allelic Variation in Merozoite Surface Protein 1 in Plasmodium Falciparum in Iran, Using Molecular Techniques Ashraf Shabani, Faculty Of Science, Tehran, Iran

WP159

Effects of Neutral and Acidic Oligosaccharides on Invasion, Viability, and Protein Expression of Enteroinvasive Escherichia Coli Andrea Spory, University of Würzburg, Würzburg, Germany

WP160

Exploring Fungal Spore Proteins by Mass Spectrometry Miroslav Sulc, Institute of Microbiology, Prague, Czech Republic

WP161

Analysis of the Cytosolic Proteome of Halobacterium Salinarum - Genome Annotation and Differential Expression Andreas Tebbe, Max Planck Institute of Biochemistry, Martinsried, Germany

WP162

A Proteomic Analysis of the Phosphate Stimulon in Vibrio Cholerae O1 Reveals Functions Involved in Adaptation, Survival and Pathogenesis Wanda, M. A. Von Kruger, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

106

HUPO 2005 • FINAL PROGRAM

POSTER SESSION • WEDNESDAY, AUGUST 31ST WP163

Proteome Analysis of C. Glutamicum Wild-Type Strains and Mutants Overproducing L-Lysine Florian Weiland, Technical University of Munich, Freising, Germany

WP164

The Differential Proteome of Denitrifying Strain EbN1 during Growth with Aromatic Compounds Lars Wöhlbrand, Max Planck Institute for Marine Microbiology, Bremen, Germany

WP165

Burkholderia Pseudomallei Intracellular Proteome Reference Map Identified by Two-Dimensional Gel Electrophoresis and Mass Spectrometry Patompon Wongtrakoongate, Mahidol University, Bangkok, Thailand

WP166

A Proteomic Study of Manganese Regulation of Gene Expression in Neisseria Gonorrhoeae Hsing-Ju Wu, Academia Sinica, Taipei, Taiwan

WP167

E. Coli Haloacid Dehalogenase-like Hydrolases: A Large Family of Promiscuous Phosphatases Alexander Yakunin, University of Toronto, Toronto, ON, Canada

WP168

Epitome Study on Protein Antigen of Helicobacter Pylori Li Yan, South Medical University, Guangzhou, P.R. China

MODEL ORGANISMS - OTHER NON-MAMMALIAN PROTEOMES WP169

Protein Abundance Versus. Identification by Mass Spectrometry: The Yeast Proteome Case Lyris Martins Franco De Godoy, Center for Experimental Bioinformatics - University of Southern Denmark, Odense, Denmark

WP170

Differential Proteomic Analysis of the Human Pathogen Trichomonas Vaginalis Jose Batista De Jesus, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil

WP171

Proteomic Analysis of Embryonic Stem Cell-derived Cardiomyocytes and Neonatal Mouse Cardiomyocytes Saman Hosseinkhani, Tarbiat Modarres University, Tehran, Iran

WP172

Identification of Protein Markers Separating Chloroquine Resistant and Sensitive Strains of Plasmodium Falciparum by SELDI-Profiling Sasa Koncarevic, University Giessen, Giessen, Germany

WP173

Functional Proteomics in Zebrafish Vinzenz Link, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany

WP174

TIR2 Positional Candidate Genes Analysis Joseph Nganga, International Livestock Research Institutte and Jomo Kenyatta University, Nairobi, Kenya

WP175

Proteomic Analysis of Dictyostelium Discoideum Udo Roth, Medical Faculty, University of Cologne, Cologne, Germany

HUPO 2005 • FINAL PROGRAM

107

POSTER SESSION • WEDNESDAY, AUGUST 31ST WP176

Proteomic Profiling of the Protozoan Parasite Leishmania Major LV 39 Developmental Stages Utilising 2-D Electrophoresis Elizabeth Sage, Institute of Psychiatry, London, United Kingdom

WP177

Homology-driven Proteomics in Insects and Plants by Automated LC-MS/MS de Novo Sequencing and MS BLAST Searches Patrice Waridel, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany

WP178

Proteomic Characterization of Mouse Liver GOLGI/ENDOSOME (G/E) Fractions Eric Winstall, Université Laval, Quebec, QC, Canada

MODEL ORGANISMS – PLANT PROTEOMES WP179

Tuber Borchii Vittad. Mycelial Hyphae: Protein Expression Profile and Protein Identification Laura Bianchi, University of Siena, Siena, Italy

WP180

Proteomic Strategy for Investigatigation of Cytokinin Action in Arabidopsis Thaliana Gabriela Bohmova, Masaryk University Brno, Brno, Czech Republic Two-Dimensional Gel Electrophoresis and Subsequent Protein Identification via MALDI-MS/MS: A Successful Approach to Unravel the Abiotic Stress Responses in a Non-model Organism (Musa Spp.) Sebastien Carpentier, Kuleuven, Leuven, Belgium

WP181

WP182

Out on a Limb - Forging a New Trail in Forest Research with Proteomics Sunita G Chowrira, University of British Columbia, Vancouver, BC, Canada

WP183

A Comparative Proteomics Approach to Identifying Salt and Drought Tolerance Genes in Plants Ghasem Hosseini Salekdeh, Agricultural Biotechnology Research Institute of Iran, Karaj, Iran

WP184

Rearangement in the Chromatin Parts Under Influence of Non-Thermal Electromagnetic Radiation Liya Minasbekyan, Yerevan State University, Yerevan, Armenia

WP185

Proteome Analysis of Cold Stress Response in Arabidopsis Thaliana: A Quantitative Proteomic Study Using Shotgun Technology Mark Ritchie, Waters Corporation, Manchester, United Kingdom

WP186

Variations in Peroxidase Due To Environment Change Reyhaneh Sariri, The University Of Guilan, Rasht, Iran

WP187

Characterization of Regulatory Genes in the Secondary Meristem of Populus by in Situ Protein Localization Fredrik Sterky, Royal Institute of Technology, Stockholm, Sweden

WP188

Proteome Analysis of Barley Seeds Katja Witzel, IPK Gatersleben, Gatersleben, Germany

108

HUPO 2005 • FINAL PROGRAM

POSTER SESSION • WEDNESDAY, AUGUST 31ST WP189

Effects of Copper (Cu2+) on Chlorophyll, Proline, Protein and Abscisic Acid Level of Sunflower (Helianthus Annuus L.) Seedlings Fikriye Zengin K, Firat University, Elazig, Turkey

WP190

The Proteomic Comparison of the Rice with and without the Transformation of Genomic DNAs from Echinochloa Crusgalli Caifeng Zhao, Beijing Genomics Institute, Chinese Academy of Sciences (CAS), Beijing, P.R. China

ORGANELLAR PROTEOMICS WP191

Comprehensive Analysis of Tissue and Organelle Selective Expression Patterns: An Integrated Proteomics, Bioinformatics and Genomics Analysis Thomas Kislinger, University of Toronto, Toronto, ON, Canada

WP192

Golgi Apparatus and Copi Vesicles in the Secretory Pathway - An Organellar Proteomics Approach Catherine Au, McGill University, Montreal, QC, Canada

WP193

A Lysosome-associated Arf-family Protein Identified by Lysosomal Proteomics Rick Bagshaw, The Hospital for Sick Children, Toronto, ON, Canada

WP194

Different Approaches for the Characterisation of the Synaptic Vesicle Proteome. Comparison of 1D and 2D Page Followed by Mass Spectrometry (MALDI-TOF; NANO-LC ESI MS/MS) Tobias Beckhaus, Johann Wolfgang Goethe-University, Frankfurt, Germany

WP195

Analysis of the Synaptic Vesicle Proteome Using SDS-Page and Nano-Liquid Chromatography/Tandem Mass Spectrometry (Nano-LC/MS/MS) Jacqueline Burré, Johann Wolfgang Goethe-University, Frankfurt, Germany Analysis of Insoluble Nuclear Proteins Using Isoelectrofocussing and Enzyme-catalyzed O-18 Labeling Catherine Fenselau, University of Maryland, College Park, MD, United States

WP196

WP197

Proteomics Analysis of the Early Secretory Pathway Annalyn Gilchrist, McGill University, Montreal, QC, Canada

WP199

Comprehensive Protein Profiling on the Human and Mouse Embryonic Stem Cells Hui-chu Hsieh, Industrial Technology Research Institute, Hsin Chu, Taiwan

WP200

Changes in the Mitochondrial Proteome of Chlamydomonas Reinhardtii during Adaptation to Iron Deficiency Renuka Jain, Umeå Plant Science Center, Umeå, Sweden

WP201

Nuclear Fractionation Strategies for the Proteomic Analysis of Tissue Samples Stefan Kienle, Proteome Sciences R&D, Frankfurt, Germany

WP202

Free-flow Isotachophoresis - A New, Efficient Method for Organelle Separation Heribert Mohr, Universität Heidelberg, Heidelberg, Germany

HUPO 2005 • FINAL PROGRAM

109

POSTER SESSION • WEDNESDAY, AUGUST 31ST WP203

Analyzing the Platelet Membrane Reveals Several New Proteins Albert Sickmann, Protein Mass Spectrometry, Würzburg, Germany

WP204

Subcellular Proteomics of Neuromelanin Granules Isolated from the Human Brain Florian Tribl, Clinic and Polyclinic for Psychiatry and Psychotherapy, Würzburg, Germany

WP205

A Proteomics Approach to Analyze Paracitophorous Phagolysosomes Isolated from Vero Cell Lines Infected with Coxiella Burnetii Phase II Georgios Tsiotis, University Crete, Heraklion, Greece

WP206

Identification of Novel Centrosomal Proteins in Dictyostelium Discoideum Yvonne Wagner, University Würzburg, Würzburg, Germany

WP207

Subcellular Proteome of Mouse Liver: The Investigation by Combined Proteomics Approaches Victor Zgoda, Research Institute of Biomedical Chemistry RAMS, Moscow, Russia

WP208

Differential Analysis of Mitochondria by Free Flow Electrophoresis Hans Zischka, GSF -National Research Centre for Environment and Health, Munich, Germany

PROTEOMICS IN BIOTECHNOLOGY WP209

Purification of Polygalacturonase Enzyme from Strain F58 of Fusarium Oxysporum Behrang Alani, Drug Applied Research Center, Tabriz, Iran

WP210

Proteomic Approach for the Establishment of Substantial Equivalence of aTransgenic CRY1AB Expressing Rice with Its Traditional Counterpart: Cultivar Tarom Molaii Behzad Ghareyazie, Agricultural Biotechnology Research Institute of Iran, Karaj, Iran

WP211

Differential Proteomic and Phosphoproteomic Analysis of Meiotic Maturation of Oocytes Petr Halada, Institute of Microbiology, Prague, Czech Republic

WP212

Meta-Proteomics, A New Way to Explore Microbial Function in Natural Environments Jinjun Kan, University of Maryland Biotechnology Institute, Baltimore, MD, United States

WP213

Identification of Growth Factors by Functional Selection on Combinatorial Libraries of Affinity Ligands Julia Lathrop, American Red Cross, Rockville, MD, United States

WP214

A Shot Gun Approach to Identify Proteins Acetylation by LC-MS Jining Liu, Genome Institute of Singapore, Singapore

WP215

Proximity Ligation - A Method that Converts Proteins into Dna-tags Edith Schallmeiner, Uppsala University, Uppsala, Sweden

WP216

Fully Integrated Chip for 2D Protein Separation (IEF+MW) Alexander Suvorov, Protein Fleet Ltd., Herzliya, Israel

110

HUPO 2005 • FINAL PROGRAM

POSTER SESSION • WEDNESDAY, AUGUST 31ST WP217 WP218

A Completely Automated Cell-Preatment Unit for Proteomics Mari Tabuchi, The University of Tokushima, Toksuhima, Japan Classification of Microorganisms Contained in EM (Effective Microorganims) Based on Automated MALDI-TOF MS Fingerprinting and Pattern Recognition Software Herbert Thiele, Bruker Daltonik GmbH, Bremen, Germany

WP219

Omicslink Open Reading Frame Expression Clones of Humam Genes (a Platform for Systems Biology and Reverse Proteomics) Shuwei Yang, Genecopoeia Inc., Germantown, MD, United States

WP220

Subcloning and Expression of Human Alpha-fetoprotein Gene in Pichia Pastotris Yeast Nosratollal Zarghami, Drug Applied Research Center, Tabriz, Iran

STRUCTURAL PROTEOMICS WP221 WP222

Interaction of Kinetochore Proteins with Tubulin Gonçalo Da Costa, Instituto de Tecnologia Química e Biológica, Lisboa, Portugal Proteomic Investigations Suggest Conformational Equilibria Cause Charge Heterogeneity of 2DE Gel Separated Wool Intermediate Filament Proteins Louise Paton, Canesis Network Ltd, Christchurch, New Zealand

WP223

Proteomic Data Evaluation of Caseins from Milk and Mammary Gland Paola Roncada, Istituto Sperimentale Italiano Lazzaro Spallanzani, Milano, Italy

WP224

HIV-1 Co-receptor CXCR4: Structural Mapping in the Mammalian Cellular Context Julie P. Wong, University of British Columbia, Vancouver, BC, Canada

OTHER WP225

Clustering of Mass Spectra Assist Identification of Strawberry Proteins and Allergen Isoforms Rikard Alm, Chemical Instituition, Lund, Sweden

WP226

Embryo-induced Alterations in the Proteome of Bovine Endometrium Frank Berendt, Gene Center, LMU, Munich, Germany

WP227

Proteome Changes in Bovine Muscle during Slaughter Kristin Hollung, Matforsk, Aas, Norway

WP228

Sociomics: Locating and Analysing Proteomics Networks on the Worldwide Web Ruth McNally, Cardiff University, Cardiff, United Kingdom

WP229

The Anatomy of Salt Stress in Desulfovibrio Vulgaris Hildenborough Aindrila Mukhopadhyay, Lawrence Berkeley National Laboratory, Berkeley, CA, United States

HUPO 2005 • FINAL PROGRAM

111

POSTER SESSION • WEDNESDAY, AUGUST 31ST WP230

US National Heart Lung and Blood Institute Proteomics Initiative Margaret Schachte, Medical University of South Carolina, Charleston, SC, United States

WP231

Proteome Analysis of Carcass of Hanwoo (Korean Brown Cattle) by Two Dimensional Electrophoresis and MALDI-TOF Kang-seok Seo, National Livestock Research Institution, Cheonan, South Korea

WP232

Fructosamine-3-Kinase-related-protein - An Enzyme in Search of a Function Benjamin Szwergold, Dartmouth Medical School, Hanover, NH, United States

WP233

High Troughput Immunohistochemistry in Tissue Proteomics Kenneth Wester, Uppsala University, Uppsala, Sweden

20:00 – 23:00 CONGRESS DINNER (see page 12) Thursday, September 1st 08:30 – 10:00

PL4.1

PLENARY LECTURES: INTERACTION PROTEOMICS Chairs: Erin O’Shea & Ole Noerregaard Jensen

08:30 – 09:00

PL4.1.01

The EU Interaction Proteome Project Franz Ulrich Hartl, Max-Planck Institute of Biochemistry, Martinsried, Germany

09:00 – 09:30

PL4.1.02

Funtional and Chemical Proteomics for Drug Discovery Bernard Küster, Cell Zome, Heidelberg, Germany

09:30 – 10:00

PL4.1.03

Regulation of the Raf Signaling Pathway by Protein Interactions Walter Kolch, Beatson Institute for Cancer Research, Glasgow, United Kingdom

10:00 – 10:30 10:30 – 12:15

COFFEE BREAK PL4.2

ROUND TABLE: EUROPEAN AND INTERNATIONAL COLLABORATION IN PROTEOMIC RESEARCH Allison Abbott, Moderator, Science Journalist, Nature, Munich, Germany Erika Mann, Member of European Parliament, Brussels, Belgium John Fenn, Nobel Prize Laureate, Richmond, VA, United States Matthias Mann, Max Planck Institute of Biochemistry, Martinsried, Germany Hanno Langen, Roche Center for Medical Genomics, Basel, Switzerland

112

ROOM: 1

HUPO 2005 • FINAL PROGRAM

ROOM: 1

DETAILED PROGRAM • THURSDAY, SEPTEMBER 1ST 12:15 – 13:30 IS10 - LUNCHEON INDUSTRY SPONSORED SYMPOSIUM APPLIED BIOSYSTEMS INNOVATIVE SOLUTIONS FOR PROTEIN BIOMARKER DISCOVERY AND VALIDATION ROOM: 5 Chair: Volker Kruft, Manager Application Support Proteomics, Applied Biosystems, Darmstadt, Germany 12:15 – 12:40 Introducing the 4800 MALDI TOF/TOFTM Analyzer – the Most Direct Path to Definitive Protein Identification and Quantitation Matthew Willetts, Senior Specialist Technical Marketing Proteomics, Applied Biosystems, Framingham, United States Volker Kruft, Manager Application Support Proteomics, Applied Biosystems, Darmstadt, Germany 12:50 – 13:20 New Developments in LC/MS for Protein Biomarker Discovery and Validation Dominic Gostick, Director, 4800 and QSTAR Product Lines, Applied Biosystems, Framingham, United States Christof Lenz, Senior Specialist Mass Spectrometry Protein, Applied Biosystems, Darmstadt, Germany 13:20 – 13:30 Summary & Conclusions 13:30 – 15:00 PL4.3 PLENARY LECTURES: SYSTEMS BIOLOGY ROOM: 1 CHAIRS: Alber Heck & Bernard Küster 13:30 – 14:00 PL4.3.01 Proteomics as a Genomic Science Ruedi Aebersold, Swiss Federal Institute of Technology ETH, Zürich, Switzerland 14:00 – 14:30 PL4.3.02 Integration of Experimental Data on Gene Expression and Protein-Protein Interaction with Predicted Functional Associations Soren Brunak, Technical University of Denmark, Lyngby, Denmark 14:30 – 15:00 PL4.3.03 SmartCell: A Cell Network Simulation Program Luis Serrano, EMBL Heidelberg, Germany

HUPO 2005 • FINAL PROGRAM

113

DETAILED PROGRAM • THURSDAY, SEPTEMBER 1ST 15:00 – 15:30 PL4.4 CLOSING CEREMONY Poster Awards and HUPO Distinguished Awards ROOM: 1 15:30 – 16:00 PL4.5 CLOSING LECTURE ROOM: 1 PL4.5.01 Equalizer Beads: The Quest for a "Democratic Proteome" Pier-Giorgio Righetti, University of Verona, Verona, Italy

114

HUPO 2005 • FINAL PROGRAM

PRESENTER INDEX Abbott, A. . . . . . . . . . . . . . . .PL4.2

Asbury, G. R. . . . . . . . . . . . .TP150

Bengtsson, S. . . . . . . . . . .MP095

Adler, J. . . . . . . . . . . . . . . .WP001

Aschermann, K. . . . . . . . . .MP273

Benton, M. . . . . . . . . . . . . .TP002

Admon, A. . . . . . . . . . . . . .MP001

Askari, H. . . . . . . . . . . . . . .TP091

Berendt, F. . . . . . . . . . . . . .WP226

Aebersold, R. . . . . .IS3, IS7, PL3.1, PS3.5.05, PL4.3.01

Asplund, A. . . . . . . . . . . . .MP004

Beretta, L. . . . . . .PS3.1, PS3.5.07

Asplund, C. . . . . . . . . . . . .WP071

Berger, S. . . . . . . . . . . . . . .WP107

Au, C. . . . . . . . . . . . . . . . . .WP192 Aydin, S. . . . . . . . . . . . . . .WP128

Bergeron, J. J. M. . . . . . .PL1.1.02, PL3.1.01, PL3.2, PS3.1

Azkargorta, M. . . . . . . . . . .MP252

Berkelman, T. . . . . . . . .IS1, TP003

Baba, Y. . . . . . . . .PS1.4, PS1.4.05

Bernhard, O. . . . . . . . . . . .WP117

Baek, K. . . . . . . . . . . . . . . .WP002

Bernhardt, J. . . . . . . . . . . . .TP151

Bagshaw, R. . . . . . . . . . . .WP193

Bezouska, K. . . . . . . . . . . .WP004

Bairoch, A. . . . . . . . . . . .PL2.1.04

Bhardwaj, S. . . . . . . . . . . . .TP152

Balderas, R. . . . . . . . . . . . . . . .IS5

Bianchi, L. . . . . . . . . . . . . .WP179

Bak-Jensen, K. . . . . . . . . .MP274

Bing-ya, L. . . . . . . . . . . . . .MP007

Baker, M.S. . . . . . . . . . . . . . . .IS4

Bini, L. . . .PS3.2, PS3.2.01, TP059

Bandera, C. . . . . . . . . . . .PS1.1.07

Binz, P. . .EP1.07, PS2.5.09, PS2.8

Bandow, J. . . . . . . . . . . .PS2.4.04

Bisle, B. . . . . . . . . . . . . . . . .TP235

Barberis, L. . . . . . . . . . . . . .TP058

Björling, E. . . . . . . . . . . .PS2.1.05

Barbier-Brygoo, H. . . . . .PL3.2.03

Blagoev, B. . . . . . . . . . . . . .WP005

Barbour, J. . . . . . . . . . . . . .MP275

Blumenstein, M. . . . . . . . .MP159

Barderas, M. G. . . . . . . . . .MP093

Boeri Erba, E. . . . . . . . . . . .TP060

Bärenfaller, K. . . . . . . . . . .MP005

Bogard, P. . . . . . . . . . . . . . . . .IS4

Barka, G. . . . . . . . . . . . . . . .TP116

Bogler, O. . . . . . . . . . . . . . .MP008

Barrios-Rodiles, M. . . . .PS3.7.08

Bogumil, R. . . . . . . . . . . . . .TP061

Bartunik, H. D. . . . . . . . .PS1.4.04

Bohmova, G. . . . . . . . . . . .WP180

Baumann, S. . . . . . . . . . . .MP094

Boissan, M. . . . . . . . . . . .PS1.2.04

Beator, J. . . . . . . . .MP075, MP276

Boisson, J. . . . . . . . . . . . . .TP256

Beaudrie, C. E. . . . . . . . . . .TP255

Bonetto, V. . . . . . . . . . . . . . .TP080

Becker, K. . . . . . . . . . . . .PS2.2.03

Bonizzi, L. . . . . . . . . . . . . .WP130

Apweiler, R. . . . .PS2.1, PS2.1.01, PS3.5.04

Becker, S. . . . . . . . . . . . . .MP006

Bork, P. . . . . . . . . . . . . . .PL1.2.02

Beckers, J. . . . . . . . . . . . .WP088

Borrebaeck, C. . . .PS1.5, PS1.5.02

Archakov, A. . . . . .PS1.3, PS1.3.06

Beckhaus, T. . . . . . . . . . . .WP194

Bosselut, N. . . . . . . . . . . . .WP060

Armin, G. . . . . . . . . . . . . . .WP095

Beer, M. . . . . . . . . . . . . . . .WP003

Bottoni, P. . . . . . . . . . . . . .MP009

Arrigoni, G. . . . . . . . . . . . . .TP057

Behr, J. . . . . . . . . . . . . . . .WP129

Bouchal, P. . . . . . . . . . . . . .WP131

Arsene, C. . . . . . . . . . . . . . .TP149

Bell, A. . . . . . . . . . . . . . . . .MP241

Boyes, B. . . . . . . . . . . . . . . .TP004

Arthur, J. . . . . . . . . . . . . . .MP092

Bell, P. . . . . . . . . . . . . . . . . .TP001

Bramwell, D. . . . . . . . . . .PS1.7.10

Asad, M. J. . . . . . . . . . . . .WP127

Belleannée, C. . . . . . . . .PS3.2.06

Bransgrove, L. . . . . . . . . . .MP010

Afraz, Z. . . . . . . . . . . . . . . .MP271 Aich, P. . . . . . . . . . . . . . . . .MP091 Aivaliotis, M. . . . . . . . . . . . .TP056 Al-Khalili Szigyarto, C. . . . .WP069 Alani, B. . . . . . . . . . . . . . . .WP209 Albar, J. P. . . . . . . . . . . . . .MP251 Albrecht, W. . . . . . . . . . . . . . . .IS2 Albermann, K. . . . . . . . . . . .TP254 Ali-Khan, N. . . . . . . . . . .PS1.5.06 Alm, R. . . . . . . . . . . . . . . . .WP225 Alonzi, T. . . . . . . . . . . . . . .MP174 Alterman, M. . . . . . . . . . . . .TP148 Altmann, F. . . . . . . . . . . . . .MP186 Alvarez-Chaver, P. . . . . . . .MP002 Alves, P. . . . . . . . . . . . . . . .MP272 Andersen, J. S. . . . . . . . .PS3.3.03 Andersson, A. . . . . . . . . . .WP070 Andersson Ståhlberg, C. . .MP003 Ando, E. . . . . . . . . . . . . . . .TP206 Andren, P. E. . . . . . . . .EP1.03, IS8 Ang, I. L. . . . . . . . . . . . . .PS3.1.05 Angelucci, S. . . . . . . . . . . .MP240 Angenendt, P. . . . . . . . . . . .TP186 Appel, R. . . . . . . . .EP1.06, PS2.1, PS2.1.02, PS2.8

X

HUPO 2005 • FINAL PROGRAM

PRESENTER INDEX Braun, H. . . . . . . .PS1.6, PS1.6.02

Chiba, J. . . . . . . . . . . . . . .WP073

Davydov, V. . . . . . . . . . . . .WP058

Braun, R. . . . . . . . . . . . . . .WP006

Chien, K. . . . . . . . . . . . . . . .TP153

De Godoy, L. M. F. . . . . . . .WP169

Breitkreuz, K. . . . . . . . . .PS3.7.05

Chitlaru, T. . . . . . . . . . . . . .WP135

De Jesus, J. B. . . . . . . . . . .WP170

Brill, L. . . . . . . . . . . . . . .PS1.1.06

Choi, H. . . . . . . . . . . . . . . .WP007

De Souza, G. A. . . . . . . . . .MP106

Brioschi, M. . . . . . . . . . . . .MP160

Choi, J. . . . . . . . . . . . . . . .WP136

De Waard, H. . . . . . . . . . . .MP277

Brubacher, M. G. . . . . . . . . .TP042

Chow, L. . . . . . . . . . . . . . . .MP100

Debril, A. . . . . . . . . . . . . . . .TP258

Brunak, S. . . . . . . . . . . . .PL4.3.02

Chowrira, S. G. . . . . . . . . .WP182

DeGreef, J. . . . . . . . . . . . . .TP006

Bruneel, A. . . . . . . .TP280, WP118

Christopherson, R. . . . . .PS1.1.03

Deininger, S. . . . . . . . . . . . .TP117

Brunner, E. . . . . . . . . . . .PS3.4.08

Chu, L. H. M. . . . . . . . . . . . .TP236

Del Boccio, P. . . . . . . . . . . .MP107

Buchberger, B. . . . . . . . . . .TP017

Chung, L. . . . . . . . . . . . . . .MP101

Denis, G. . . . . . . . . . . . . . .MP015

Bundy, J. . . . . . . . . . . . . . .WP109

Chung, M. C. M. . .PS1.1, PS1.1.02

Desouza, L. . . . . . . . . . . . . .TP156

Bürkle, L. . . . . . . . . . . . . . .WP021

Chunyan , Y. . . . . . . . . . . . .WP108

Diehl, H. . . . . . . . . . . . . . . .MP016

Burré, J. . . . . . . . . . . . . . . .WP195

Cianti, R. . . . . . . . . . . . . . .MP102

Diema, C. . . . . . . . . . . . . . .MP017

Cai, Y. . . . . . . . . . . . . . . . . .TP204

Cieniewski-Bernard, C. . . . .TP043

Diestinger, M. . . . . . . . . . .MP108

Campostrini, N. . . . . . . . . .MP011

Ciosto, C. . . . . . . . . . . . . . .TP154

Ditzen, C. . . . . . . . . . . . . . .MP109

Cannizzaro, L. . . . . . . . . . .MP012

Coelho, A. V. . . . . . . . . . . . .WP023

Dollé, L. . . . . . . . . . . . . . . .WP025

Caroline, C. . . . . . . . . . . . .MP231

Cohen, A. . . . . . . . . .TP009, TP010

Domingues, M. R. . . . . . . .MP278

Caron, M. . . . . . . . . . . . . . .MP096

Colby, T. . . . . . . . . . . . . . . .TP064

Domont, G. B. . . . . . . . . . .WP124

Carpentier, S. . . . . . . . . . . .WP181

Collet, M. . . . . . . . . . . . . . .WP024

Dowd, A. . . . . . . . . . . . . . .MP044

Carranza, M. P. . . . . . . . . .WP132

Collura, V. . . . . . . . . . . . . . .TP005

Dowling, P. . . . . . . . . . . . . .MP213

Carrillo, B. . . . . . . . . . . . . . .TP257

Communi, D. . . . . . . . . . . .WP008

Dowsey, A. . . . . . . . . . . . . .WP089

Carvalho-oliveira, I. . . . . . .MP097

Conrotto, P. . . . . . . . . . . . .WP009

Dreisbach, A. . . . . . . . . . . .WP137

Cash, P. . . . . . . . . . . . . . . .WP133

Cordwell, S. . . . . . . . . . . . .MP161

Droit, A. . . . . . . . . . . . . . . . .TP259

Castagna, A. . . . . . . . . . . .MP098

Corso, T. . . . . . . . . . . . . .PS1.7.09

Du, X. . . . . . . . . . . . . . . . . .WP074

Cellier, N. . . . . . . . . . . . . . .TP209

Cren-Olivé, C. . . . . . . . . .PS1.2.07

Dübel, S. . . . . . . . . . . . . . .WP075

Cesareo, E. . . . . . . . . . . . .WP134

Cretich, M. . . . . . . . . . . . . .TP211

Dubrovska, A. . . . . . . . . . . .TP065

Chakraborty, N. . . . . . . . .PS3.8.07

Cummins, E. . . . . . . . . . . .MP103

Ducoroy, P. . . . . . . . . . . . . .MP110

Chang, L. . . . . . . . . . . . . . .WP022

Cunha, C. . . . . . . . . . . . . . .MP173

Duguay, M. . . . . . . . . . . . . .MP254

Chang, Y. . . . . . . . . . . . . . .MP013

D'Aguanno, S. . . . . . . . . . .MP104

Dumas-Gaudot, E. . . . . .PS3.8.05

Chen, H. . . . . . . . . . . . . . . .TP210

Da Costa, G. . . . . . . . . . . . .WP221

Dumont, D. . . . . . . . . . . .PS2.4.05

Chen, H. . . . . . . . . . . . . . . .WP072

Dacheux, J. L. . . . . . . . . . .MP253

Dunn, M. J. . . . . .PS2.4, PS2.4.02

Chen, L. . . . . . . . . . . . . . . .MP014

Dahl, A. . . . . . . . . . . . . . . . .TP155

Dupire, F. . . . . . . . . . . . . . . .TP237

Chen, S.H. . . . . . . . . . . . . . .TP062

Dardé, V. M. . . . . . . . . . . . .MP105

Duran-Ruiz, M. C. . . . . . . .MP018

Chen, S.F. . . . . . . . . . . . . . .MP175

Daub, H. . . . . . . . . . . . . .PS3.7.02

Dürrschmid, K. . . . . . . . .PS3.4.05

Chen, Y.Y. . . . . . . . . . . . . . .TP081

David, G. . . . . . . . . . . . . . . .TP092

Eckerskorn, C. . . . . . . . . . .MP220

Chi, L. . . . . . . . . . . . . . . . . .TP063

David, S. . . . . . . . . . . . . . . . . .IS4

Eichacker, L. . . . . . . . . . .PS3.8.04

Chi, P. V. . . . . . . . . . . . . . . .MP099

Davies, H. . . . . . . . . . . . . .MP188

Eicherskorn, C. . . . . . . . . . . . .IS5

122

HUPO 2005 • FINAL PROGRAM

PRESENTER INDEX El Behi, M. . . . . . . . . . . . . .MP189

Galan, A. . . . . . . . . . . . . . .WP062

Grus, F. . . . . . . . . . . . . . . . .MP114

El Hassan, M. M. . . . . . . . .WP138

Gammeltoft, S. . . . . . . . . . .TP066

Guillaume, E. . . . . . . . . . . .TP163

Elenitoba-Johnson, K. . .PS1.5.03

Gao, J. . . . . . . . . . . . . . . . .WP063

Guipaud, O. . . . . . . . . . . . .MP115

Elliott, S. . . . . . . . . . . . . . . .TP238

Gao, Y. . . . . . . . . . . . . . . . .WP076

Gupta, M. B. . . . . . . . . . . . .MP242

Elortza, F. . . . . . . . . . . . . . .MP221

Garcia, A. . . . . . . . . . . . . . .MP162

Gusev, S. . . . . . . . . . . . . . . .TP164

Eman, M. . . . . . . . . . . . . . .MP279

Gaspari, M. . . . . . . . . . . . .MP021

Guzman, N. . . . . . . . . . . .PS2.2.06

Engler, D. . . . . . . . . . . . . . .MP255

Gazzana, G. . . . . . . . . . . . . .TP212

Haab, B. B. . . . . . .MP024, MP116

Erfani, A. . . . . . . . . . . . . . .MP256

Gelfand, C. . . . . . . . . . . . . .WP119

Hagenstein, M. . . . . . . . . . .TP213

Eriksson, C. . . . . . . . . . . . .WP026

Gelfi, C. . . . . . . . . . . . . . .PS3.2.03

Hahner, S. . . . . . . . . . . . . .MP233

Escher, N. . . . . . . . . . . . . .WP027

Ghadam, P. . . . . . . . . . . . . .MP280

Haid, D. . . . . . . . . . . . . . . .MP025

Faca, V. . . . . . . . . . . . . . . .MP019

Gharbi, S. . . . . . . . . . . . . . .MP022

Hajheidari, M. . . . . . . . . . . .TP097

Falth, M. . . . . . . . . . . . . . . .TP260

Ghareyazie, B. . . . . . . . . . .WP210

Hajivandi, M. . . . . . . . . . . .MP026

Fang, C. . . . . . . . . . . . . . . .MP176

Gil, C. . . . . . . . . . . . . . . . . .WP140

Häkkinen, J. . . . . . . . . . . . .TP262

Fang, X. . . . . . . . . . . . . . . .TP007

Gilchrist, A. . . . . . . . . . . . .WP197

Halada, P. . . . . . . . . . . . . . .WP211

Farina, A. . . . . . . .MP020, MP257

Gillooly, D. . . . . . . . . . . . . . .TP119

Halder, T. M. . . . . . . . . . . . .TP165

Fear, M. . . . . . . . . . . . . .PS3.7.07

Glocker, M. . . . . . . . . . . . . .MP113

Hamon, C. . . . . . . . . . . . . . .TP166

Federici, G. . . . . . . . . . . . .MP111

Gloeckner, C. J. . . . . . . . . .WP031

Han, J. . . . . . . . . . . . . . . . .TP263

Feldblum, S. . . . . . . . . . . .MP112

Glukhova, V. . . . . . . . . . . . .TP120

Hanash, S. . . . . . . . . . . .PL1.1.05

Fenn, J. . . . . . . . .PL2.1.02, PL4.2

Göbel, T. . . . . . . . . . . . . . . .MP177

Hanke, S. . . . . . . . . . . . . . .WP032

Fenselau, C. . . . . . . . . . . . .WP196

Gobom, J. . . . . . . . . . . . . . .TP239

Hansen, D. . . . . . . . . . . . . .WP077

Fenyö, D. . . . . . . .PS3.3, PS3.3.07

Godl, K. . . . . . . . . . . . . . . .MP232

Hartl, F. U. . . . . . . . . . . . .PL4.1.01

Figeys, D. . . . . . . .PS3.7, PS3.7.06

Golderer, G. . . . . . . . . . . . . .TP095

Haywood, B. C. . . . . . . . . . . . .IS5

Fimia, G. M. . . . . . . . . . . . .WP028

Gómez-Ariza, J. L. . . . . . . .TP240

He, F. . . . . . . . . . . . . . . . .PS3.1.01

Flensburg, J. . . . . . . . . . . . .TP157

Gompel, M. . . . . . . . . . . . .MP191

He, X. . . . . . . . . . . . . . . . . .WP078

Foret, F. . . . . . . . . . . . . .PS1.4.06

Gonzalez, C. F. . . . . . . . . . .WP141

Heck, A. . .PL3.1.04, PL4.3, WP142

Forsström-Olsson, O. . . . . .TP093

Gonzalez De Peredo, A. . . .TP159

Hecker, M. . . . . . .PL3.2.02, PS3.4

Foster, L. . . . . . . .PS1.6, PS1.6.01

Görg, A. . . . . . . . .PL1.1.03, PL1.2, PL2.1, PL2.2.02

Heegaard, N. . . . . . . . . .PS3.6.05

Fournial, A. . . . . . . . . . . . . .TP094 Frank, R. . . . . . . . . . . . . . .WP029 Franke, G. . . . . . . . . . . . . . .TP158 Freeman, W. . . . . . . . . . . . .MP190 Friedman, D. .PS2.2.04, PS2.6, IS8 Fröhlich, T. . . . . . . . . . . . . .WP090 Fund, K. . . . . . . . . . . . . . . .WP139 Fürbaß, R. . . . . . . . . . . . . .WP030 Furmonaviciene, R. . . . . . . .TP261 Furuta, M. . . . . . . . . . . . . . .TP118

Gostick, D. . . . . . . . . .TP160, IS10 Govorukhina, N. . . . . . . . . .MP023 Govorun, V. . . . . . . . . . . .PS3.4.04 Gramolini, A. . . . . . . . . . . .MP163 Grandi, G. . . . . . . . . . . . .PS2.4.07 Granvogl, B. . . . . . . . . . . . .TP008 Grimm, R. . . .PS1.7, PS1.7.02, IS7 Grove, H. . . . . . . . . . . . . . . .TP096 Gruhler, A. . . . . . . . . . . . . . .TP162

Heinemann, U. . . . . . . . .PS1.4.03 Heller, M. . . . . . . . . . . . .PS2.1.04 Helling, S. . . . . . . . . . . . . . .TP098 Hempel, W. . . . . . . . . . . . . .TP012 Hendriks, K. . . . . . . . . . . . .TP214 Hendriks, R. . . . . . . . . . .PS2.5.01 Henkel, C. . . . . . . . . . . . . .MP178 Henle, E. . . . . . . . . . . . . . . .TP099 Henrich, S. . . . . . . . . . . . . .MP027 Hepburne-Scott, H. . . . . . . .TP013 HUPO 2005 • FINAL PROGRAM

123

PRESENTER INDEX Herberg, F. . . . . . . . . . . . . .WP033

Ivakhno, S. . . . . . . . . . . . . .TP264

Katenhusen, R. A. . . . . . . .MP164

Herick, K. . . . . . . . . . . . . . . . . .IS3

Ivanov, A. . . . . . . . . . . . . . .TP215

Kawakami, T. . . . . . . . . . . .TP266

Hermeking, H. . . . . . . . .PS3.7.04

Ivanov, Y. . . . . . . . . . . . . . . .TP187

Kel, A. . . . . . . . . . . . . . . .PS2.5.10

Hermjakob, H. . . . . .EP1.07, PS2.8

Jackson, P. . . . . . . . . . . . . .TP067

Kerrien, S. . . . . . . . . . . . . .WP035

Hernáez, M. L. . . . . . . . . . .WP143

Jacob, A. M. . . . . . . . . . . . .MP118

Kersten, B. . . . . . . . . . . .PS1.3.05

Herrmann, W. A. . . . . . . .PL1.1.01

Jain, R. . . . . . . . . . . . . . . .WP200

Keßler, M. . . . . . . . . . . . . .MP120

Hey, J. . . . . . . . . . . . . . . . . .TP100

Jansson, M. . . . . . . . . . . . .TP167

Kettenbach, A. . . . . . . . .PS2.3.05

Hillenkamp, F. . . . . . . . . .PL2.1.03

Jensen, O. N. . . . . .EP1.05, PL4.1, PS2.3.03, PS2.7

Khaghani, S. . . . . . . . . . . .MP165

Hjernoe, K. . . . . . . . . . . . .EP1.04, PS2.7, TP121

Ji, H. . . . . . . . . . . . . . . . .PS1.1.04

Hochstrasser, D. . . . . . . .PL1.2.01, PS3.5.06

Jiang, Y. . . . . . . . . . . . . . .MP078, WP064, WP065

Khoudoli, G. . . . . . . . . . .PS3.7.03

Hoepker, H. R. . . . .EP1.03, EP1.02

Jianguo, J. . . . . . . . . . . . . .WP091

Kienle, S. . . . . . . . . . . . . . .WP201

Hofmann, S. . . . . . . . . . .PS1.5.04

Jie, D. . . . . . . . . . . . . . . . . .TP125

Kikuchi, N. . . . . . . . . . . . . .TP044

Hollung, K. . . . . . . . . . . . . .WP227

Jimenez, S. . . . . . . . . . . . . .TP265

Kim, J. Y. . . . . . . . . . . . . . . .TP169

Holschuh, K. . . . . . . . . . . . .TP122

Joachim, S. . . . . . . . . . . . .MP195

Kim, M. . . . . . . . . . . . . . . .MP121

Honda, K. . . . . . . . . . . . . . .MP117

Johnsen, A. H. . . . . . . . . . .MP028

Kim, N. . . . . . . . . . . . . . . . .MP166

Hondermarck, H. .PS3.6, PS3.6.02

Johnson, M. . . . . . . . . . . . .TP188

Kim, S. . . . . . . . . . . . . . . . .TP128

Höpker, H. . . . . . . . . . . . .PS1.7.01

Joos, O. T. . . . . . . . . . . . .PS1.3.04

Kim, S. I. . . . . . . . . . . . . . .WP145

Hornshaw, M. . . . . . . . . .PS2.5.04

Jorrin Novo, J. . . .PS3.8, PS3.8.02

Kim, Y. . . . . . . . . . . . . . . . .MP122

Hosseini Salekdeh, G. . . . .WP183

Jost, M. . . . . . . . . . . . . . . .MP282

Kim, Y. H. . . . . . . . . . . . . . .TP045

Hosseinkhani, S. . . . . . . . .WP171

Joubert, R. . . . . . . . . . . . . .TP168

Kimura, S. . . . . . . .TP046, WP102

Hossinian Amiry, A. . . . . . .MP281

Julian, R. . . . . . . . . . . . . . .WP125

Kislinger, T. . . . . . . . . . . . .WP191

Hosub, I. . . . . . . . . . . . . . .MP243

Jun, A. . . . . . . . . . . . . . . . .MP283

Klem, J. . . . . . . . . . . . . . . .TP102

Hsieh, H. . . . . . . . . . . . . . .WP199

Jung, G. . . . . . . . . . . . . . . .TP216

Knapp, D. . . . . . . . . . . . . . .TP129

Hsieh, S. . . . . . . . . . . . . . .MP258

Jung, J. . . . . . . . . . . . . . . . .TP084

Kolb, N. . . . . . . . . . . . . . . . .TP068

Hua, L. . . . . . . . . . . . . . . . .TP123

Junyuan, H. . . . . . . . . . . . .WP034

Kolch, W. . . . . . . . . . . . . .PL4.1.03

Huber, A. . . . . . . . . . . . . . . .TP082

Kajjout, M. . . . . . . . . . . . . .TP126

Kolkman, A. . . . . . . . . . .PS2.2.05

Hufnagel, P. . . . . . . . . . . . .WP144

Kakisaka, T. . . . . . . . . . . . .MP119

Koncarevic, S. . . . . . . . . . .WP172

Huhmer, A. . . . . . . . . . . . . .MP192

Kam, S. . . . . . . . . . . . . . . .MP259

Kondo, A. . . . . . . . . . . . . . .TP047

Hultschig, C. . . . . . . . . . . .MP193

Kameyama, A. . . . . . . . . . .WP101

Kondo, T. . . . . . . . . . . . . . .MP031

Hunter, C. . . . . . . . . . . . .PS3.6.07

Kampf, C. . . . . . . . . . . . . . .WP079

Konstantinidis, K. . . . . . . .WP146

Hwang, H. S. . . . . . . . . . . .MP214

Kan, J. . . . . . . . . . . . . . . . .WP212

Konthur, Z. . . . . . . . . . . . . .TP189

Imhof, A. . . . . . . . . . . . . . . .TP083

Kapp, E. . . . . . . . . . . . . .PS2.1.03

Korf, U. . . . . . . . . . . . . . . . .TP190

Ingendoh, A. . . . . . . . . . . . .TP124

Karhemo, P. R. . . . . . . . . . .MP029

Körner, R. . . . . . . . . . . . .PS1.6.06

Ishihama, Y. . . . . . . . . . .PS1.7.08

Karimi, R. . . . . . . . . . . . . . .TP101

Korolainen, M. A. . . . . . . . .MP196

Ishii, T. . . . . . . . . . . . . . . . .MP194

Kast, J. . . . . . . . . . . . . . . . .TP127

Kostanjevecki, V. . . . . . . . .MP123

Islinger, M. . . . . . . . . . . .PS1.6.05

Katagiri, T. . . . . . . . . . . . . .MP179

Kostrzewa, M. . . . . . . . .PS2.5.02

124

HUPO 2005 • FINAL PROGRAM

Khaksarian, M. . . . . . . . . .MP284 Khalil, A. . . . . . . . . . . . . . .MP030

PRESENTER INDEX Kramer, S. . . . . . . . . . . . . . .TP191

Lee, H. . . . . . . . . . . . . . . . .WP037

Lübke, T. . . . . . . . . . . . . .PS1.6.04

Krasnoselsky, A. . . . . . . . .MP032

Lee, H. J. . . . . . . . . . . . . . . .TP218

Lück, C. . . . . . . . . . . . . . . .WP148

Kratchmarova, I. . . . . . . . .MP215

Lee, Y. . . . . . . . . . . . . . . . .MP235

Luk, J. . . . . . . . . . .MP041, WP061

Kreitler, T. . . . . . . . . . . . . . .TP267

Lehmann, W. D. . . . . . . .PS2.3.06

Lutz, M. . . . . . . . . . . . . . . . .TP015

Kreusch, S. . . . . . . . . . . . .MP222

Lehtiö, J. . . . . . . . .MP034, TP270

Lynch, C. . . . . . . . . . . . . . . .TP016

Kreutzberger, J. . . . . . . . . .TP192

Lemaire, R. . . . . . . . . . . . . .TP130

Maccarrone, G. . . . . . . . . .MP129

Krijgsveld, J. . . . . . . . . . . . .TP170

Lenz, C. . . . . . . . . . . . . . . . . .IS10

Macek, B. . . . . . . . . . . . . .EP1.06

Krings, M. . . . . . . . . . . . . . .TP014

Lery, L. L. M. . . . . . . . . . . .WP147

Macht, M. . . . . . . . . . . . . . . . .IS2

Kröger, M. . . . . . . . . . . . .PS1.7.04

Lexander, H. . . . . . . . . . . . .MP035

Machtejevas, E. . . . . . . .PS1.7.03

Kronsbein, H. . . . . . . . . . . .MP197

Li, J. . . . . . . . . . . . . . . . . . .TP271

Madhamshetty, J. . . . . . . .MP042

Krueger, M. . . . . . . . . . . . .WP010

Li, J. . . . . . . . . . . . . . . . . . .MP126

Madoz - Gurpide, J. . . . . . .TP194

Krueger, R. . . . . . . . . . . . . .TP069

Li, M. . . . . . . . . . . . . . . . . .WP080

Magni, F. . . . . . . . . . . . . . .MP130

Kruft, V. . . . . . . . . . . . . . . . . .IS10

Li, M. . . . . . . . . . . . . . . . . .MP127

Mahmood, Z. . . . . . . . . . . .WP120

Kurono, S. . . . . . . . . . . . . . .TP171

Li, N. . . . . . . . . . . . . . . . . .MP036

Majidi, J. . . . . . . . . . . . . . . .TP219

Küster, B. . .PL4.1.02, PL4.3, PS3.7

Li, R. X. . . . . . . . . . . . . . . .MP224

Makoto, H. . . . . . . . . . . . . .TP243

Kuzdzal, S. . . . . . . . . . . . . .MP124

Li, X. J. . . . . . . . . . . . . . .PS3.3.02

Malard, V. . . . . . . . . . . . . . .MP244

Kuzelová, K. . . . . . . . . . . . .MP234

Lill, J. . . . . . . . . . . . . . . . . .TP085

Malmport, E. . . . . . . . . . . . .TP018

Kwon, M. . . . . . . . . . . . . . .TP268

Lim, A. C. . . . . . . . . . . . . . .MP037

Manabe, T. . . . . . . . . . . . . .WP040

Kyriakopoulos, A. . . . . . . . .MP223

Lin, K. . . . . . . . . . . . . . . . .MP038

Manadas, B. . . . . . . . . . . . .MP199

Labeur, C. . . . . . . . . . . . .PS2.5.12

Lin, S. . . . . . . . . . . . . . . . .MP039

Mandel, F. . . . . . . . . . .TP220, IS7

Lahmann, J. . . . . . . . . . . . .WP110

Lindskog, M. . . . . . . . . . . .WP081

Mann, E. . . . . . . . . . . . . . . .PL4.2

Llamas, G. A. . . . . . . . . . . .TP115

Linial, M. . . . . . . . . . . . . . .WP038

Lambert, D. . . . . . . . . . . . .WP111

Link, V. . . . . . . . . . . . . . . . .WP173

Mann, M. . . . . . . .PL1.1.03, PL1.2, PL2.1, IS.6, PL3.1.02, PS3.5.01, PL4.2

Lametsch, R. . . . . . . . . . . .WP011

Lisacek, F. . . . . . . . . . . . . . .PS2.8

Manor, A. . . . . . . . . . . . . . .TP274

Landi, E. . . . . . . . . . . . . . .WP036

Lisitsa, A. . . . . . . . . . . . . . .TP272

Marchetti, M. . . . . . . . . . . .TP132

Lange, E. . . . . . . . . .TP161, TP269

Liu, J. . . . . . . . . . . . . . . . . .WP214

Marcus, K. . . . . . . . . . . . . .TP221

Langen, H. . . . . . . . . . . . . . .PL4.2

Lo , S. L. . . . . . . . . . . . . . . .TP273

Mariani, M. . . . . . . . . . . . . .TP133

Langenfeld, E. . . . . . . . . . .MP180

Lokhov, P. . . . . . . . . . . . . . .WP039

Marin, P. . . . . . . . . . . . . . .WP041

Larroque, C. . . . . . . . . . . . .TP172

Loo, R. . . . . . . . . . . . . . .PS3.4.03

Marouga, R. . . . . . . . . . . . .TP019

Larsen, M. R. . . . . .EP1.04, PS2.7

Lopez-ferrer, D. . . . . . . . . . .TP241

Martens, L. . . . . . . . . . . . .WP126

Larsson, K. . . . . . . . . . . . . .TP103

Loseva, O. . . . . . . . . . . . . . .TP070

Masoudi, H. . . . . . . . . . . . .MP167

Lathrop, J. . . . . . . . . . . . . .WP213

Lottspeich, F. . . . . . . . . .PS3.3.01

Matteoni, S. . . . . . . . . . . . .TP104

Le Gac, S. . . . . . . . . . . . . . .TP193

Lou, X. . . . . . . . . . . . . . . . .MP040

Mattow, J. . . . . . . . . . . . . .WP149

Le Moguen, K. . . . . . . . . . .MP033

Low, T. Y. . . . . . . . . . . . . . . .TP242

May, C. . . . . . . . . . . . . . . . .TP244

Lee, B. . . . . . . . . . . . . . . . .MP198

Lu, A. . . . . . . . . . . . . . . . . .MP216

Mayer, K. . . . . . . . . . . . . . .MP043

Lee, E. Y. . . . . . . . . . . . . . .MP125

Lu, X. . . . . . . . . . . . . . . . . .TP071

Mayr, M. . . . . . . . . . . . . . . .MP168

Lee, H. G. . . . . . . . . . . . . . .MP285

Lubeck, M. . . . . . . . . . . . . .TP131

Mayr, U. . . . . . . . . . . . . .PS2.4.03 HUPO 2005 • FINAL PROGRAM

125

PRESENTER INDEX Mayrhofer, C. . . . . . . . . . . .TP134

Murphy, R. . . . . . . . . . . .PS1.6.03

Orchard, S. . . . . . . . . . . . . .TP277

Mazzoli, R. . . . . . . . . . . . . .WP150

Na, U. . . . . . . . . . . . . . . . . .MP133

Orlando, R. . . . . . . . . . . . . .TP223

Mazzucchelli, G. . . . . . . . . .TP105

Nakamura, K. . . . . . . . . . . .PS1.5, PS1.5.01, WP103

Orru, S. . . . . . . . . . . . . . . .MP225

McGarvey, P. . . . . . . . . . .PS2.1.07 McNally, R. . . . . . . . . . . . .WP228 Medina-Aunon, J. A. . . . . .TP253, TP275

Nakano, M. . . . . . . . . . . . . .TP049 Nandan, D. . . . . . . . . . . . . .MP236 Nazabal, A. . . . . . . . . . . . . .TP137

Meng, B. . . . . . . . . . . . . .PS3.4.07

Nebrich , G. . . . . . . . . . . . . .TP107

Menzel, C. . . . . . . . . . . . . .MP131

Neubauer, H. . . . . . . . . . . .MP049

Meredith, G. . . . . . . . . . . . .TP020

Neves-Ferreira, A. G. . . . . .WP152

Meyer, B. . . . . . . . . . . . . . . .TP245

Nganga, J. . . . . . . . . . . . . .WP174

Meyer, H. E. . . . . . . . . . . . .PS2.5, PS3.1.03, WP092

Nguyen, V. . . . . . . . . . . . . .WP012

Mezgueldi, B. . . . . . . . . . . .TP106 Michelsen, U. . . . . . . . . . . .TP222 Micossi, E. . . . . . . . . . . . . .WP151 Mikelsaar, A. . . . . . . . . . . .MP200 Miller, C. . . . . . . . . . . . . . . .TP135 Miller, I. . . . . . . . . . . . . . . .MP286 Miller, K. . . . . . . . . . . . . . . .TP173 Minasbekyan, L. . . . . . . . .WP184 Minkoff, M. . . . . . . . . . . . . .TP174 Miskevich, D. . . . . . . . . . . .MP245 Miyoshi, E. . . . . . . . . . . . . .TP048 Moehring, T. . . . . . . . . . . . .TP136 Mohr, H. . . . . . . . . . . . . . . .WP202 Molina, L. . . . . . . . . . . . . . .MP132 Molloy, M. . . . . . . . . . . . . .MP045 Monti, M. . . . . . . . . . . . . . .WP042 Moosavi-nejad, S. Z. . . . . . .TP207 Moshkovskiy, S. . . . . . . . . .MP046 Mostaguir, K. . . . . . . . . . . .TP276 Mota, S. . . . . . . . . . . . . . . .MP182 Motyka, L. . . . . . . . . . . . . . .TP021 Mount, R. . . . . . . . . . . . . . .TP022

Nikolaev, E. . . . . . . . . . . . . .TP138 Nilsson, A. . . . . . . . . . . . . .MP201 Nilsson, P. . . . . . . . . . . . .PS1.3.03 Noben, J. . . . . . . . . . . . . . .WP093 Nordheim, A. . . . .PS3.4, PS3.4.01 Nowrouzi, A. . . . . . . . . . . .WP104 Nuccetelli, M. . . . . . . . . . .MP134 Nylund, R. . . . . . . . . . . . . .MP050 Nyman, T. . . . . . . . . . . . . . .MP237 O'Connor, M. . . . . . .PS1.5.07, IS8 O'Farrell, P. . . . . . . . . . . .PL2.1.01 O'Mullan, P. . . . . . . . . . . . .WP121 O'Shea, E. K. . . . .PL3.2.01, PL4.1 Oda, Y. . . . . . . . . .PS2.2, PS2.2.01 Oeljeklaus, S. . . . . . . . . . .WP043 Oh, S. J. . . . . . . . . . . . . . . .MP135 Ohba, M. . . . . . . . . . . . . . . .TP195 Okano, T. . . . . . . . . . . . . . .MP051 Olivieira, E. . . . . . . . . . . . . .TP196 Olivova, P. . . . . . . . . . . . .PS1.7.07 Olsen, J. V. . . . . . . . . . . . . .TP072 Omaetxebarria, M. J. . . . . .TP050

Ossipova, E. . . . . . . . . . . . .TP278 Ostadi, Z. . . . . . . . . . . . . . .MP260 Othman, I. . . . . . . . . . . . . .MP053 Ottosson, J. . . . . . . . . . . . .WP082 Oudir, S. . . . . . . . . . . . . . . .TP086 Overbergh, L. . . . . . . . . . . .MP217 Overkamp, S. . . . . . . . . . . .TP023 Paavilainen, L. . . . . . . . . . .WP083 Pabst, S. . . . . . . . . . . . . . . .TP197 Pachler, K. . . . . . . . . . . . . .WP153 Pahlich, S. . . . . . . . . . . . . . .TP087 Paik, Y. . . . . . . . . .PS1.2, PS1.2.01 Palacios Bustamante, N. . .MP136 Palm, M. . . . . . . . . . . . . .PS2.5.03 Pan, C. . . . . . . . . . . . . . .PS3.6.04 Pan, C. . . . . . . . . . . . . . . . .MP218 Pandey, V. . . . . . . . . . . . . .MP183 Pardo, M. . . . . . . . . . . . . . .MP055 Park, G. W. . . . . . . . . . . . . .TP279 Park, Y. M. . . . . . . . . . . . . .WP094 Partanen, M. . . . . . . . . . . . .TP247 Pasini, E. M. . . . . . . . . . .PS3.2.04 Pastorelli, R. . . . . . . . . . . .MP246 Paton, L. . . . . . . . . . . . . . .WP222 Paulson, L. . . . . . . . . . . . . .MP202 Paulus, A. . . .IS1, PS1.7.05, TP011 Paweletz, C. . . . . . . . . . .PS2.5.11 Pelzing, M. . . . . . . . . . . . . .TP073 Pennington, S. . . .PS3.6, PS3.6.01 Pereira-Faca, S. . . . . . . . . .MP056 Perini, D. . . . . . . . . . . . . . .MP137

Mukhopadhyay, A. . . . . . . .WP229

Omenn, G. . . . . . . . . . . . . .MP052, PS3.1.02, PS3.5

Permentier, H. . . . . . . . . . . .TP208

Murphy, D. . . . . . . . . . . . . .MP047

Ono, M. . . . . . . . . . . . . . .PS3.3.06

Pernemalm, M. . . . . . . . . .MP057

Murphy, L. . . . . . . . . . . . . .MP048

Openshaw, M. . . . . . . . . . . .TP246

Persson, B. . . . . . . . . . . .PS2.5.08

126

HUPO 2005 • FINAL PROGRAM

PRESENTER INDEX Peters, E. . . . . . . . . . . . .PS3.3.04

Recktenwald, C. V. . . . . . . .MP063

Sariri, R. . . . . . . . . . . . . . .WP186

Pidasheva, S. . . . . . . . . . . .WP044

Redlich, G. . . . . . . . . . . . . .TP075

Sarto, C. . . . . . . . . . . . . . . .MP067

Pilch, B. . . . . . . . . . . . . . . .MP261

Regnier, F. . . . . . .PS2.2, PS2.2.02

Sato, H. . . . . . . . . . . . . . . . .TP284

Ping, P. . .MP169, MP170, MP171, PS2.4, PS2.4.01, PS3.5.03

Reidegeld, K. A. . . . . . . . . .TP283

Sayan-Ayata, E. . . . . . . . . .MP141

Reis, A. . . . . . . . . . . . . . . .MP287

Schachte, M. . . . . . . . . . . .WP230

Ren, Y. . . . . . . . . . . . . . . . .MP226

Schallmeiner, E. . . . . . . . . .WP215

Repnikov, S. . . . . . . . . . . . .WP113

Scharf, C. . . . . . . . . . . . . . .MP068

Rhim, T. . . . . . . . . . . . . . . .MP247

Schenk, S. . . . . . . . . . . .PS1.2.06

Richmond, T. . . . . . . . . . . .MP140

Schindler, J. . . . . . . . . . . . .WP096

Riedel, K. . . . . . . . . . . . .PS3.4.02

Schiwek, D. . . . . . . . . . . . .WP047

Righetti, P. . . . . . . . . . . . .PL4.5.01

Schlichting, H. . . . . . . . . . .TP029

Ripamonti, M. . . . . . . . . . . .TP109

Schmidt, A. . . . . . . . . . . . .MP069

Ritchie, M. . . . . . . . . . . . . .WP185

Schmidt, A. . . . . . . . . . . . .MP219

Robert, B. . . . . . . . . . . . . . .TP026

Schmidt, O. . . . . . . . . . . . .MP203

Rodin, J. . . . . . . . . . . . . . . . . . .IS8

Schmitz, G. . . . . .PS3.2, PS3.2.02

Rodriguez, R. . . . . . . . . . . .TP027

Schnitzer, J. . . . . . . . . . .PS1.5.05

Rodríguez-Piñeiro, A. M. . .MP064

Schubert, W. . . . . . . . . . . .WP097

Roelofsen, H. . . . . . . . . . . .MP227

Schuchard, M. . . . . . . . . . .WP122

Roempp, A. . . . . . . . . . . . .MP065

Schuchhardt, J. . . . . . . . . .TP030

Roepstorff, P. . . . . .EP1.04, PL2.2, PS2.3, PS2.3.01, PS2.7

Schuerenberg, M. . . . . .PS1.7.06, TP139

Pruess, M. . . . . . . . . . . . . .TP281

Roncada, P. . . . . . . . . . . . .WP223

Schwall, G. . . . . . . . . . . . . .MP070

Przulj, N. . . . . . . . . . . . . . .WP045

Ros, A. . . . . . . . . . . . . . .PS1.3.07

Schwarte-Waldhoff, I. . . . .MP142

Pucci, P. . . . . . . . . . . . . . . .WP155

Rosen, R. . . . . . . . . . . . . . .WP157

Schwarz, G. . . . . . . . . . . . .TP031

Punwani, K. . . . . . . . . . . . .WP112

Rosenhahn, J. . . . . . . . . . .MP066

Schweiger-Hufnagel, U. . . .TP226

Pusch, W. . . . . . . . . . . . . . .MP139

Roth, U. . . . . . . . . .TP052, WP175

Schweigert, F. . . . . . . . . . .MP143

Pütz, S. . . . . . . . . . . . . . . .MP061

Roux, C. . . . . . . . . . . . . . . .TP051

Schwend, T. . . . . . . . . . . . .MP263

Qian, X. . . . . . . . . . . . . . .PS1.2.03

Rübenhagen, R. . . . . . . . . .TP198

Scigelova, M. . . . . . . .IS6, WP114

Quek, H. . . . . . . . . . . . . . . .TP225

Rück, A. . . . . . . . . . . . . . . .TP028

Scott, G. . . . . . . . . . . . . . . .TP032

Quinn, A. . . . . . . . . . . . . . . .TP282

Rudel, T. . . . . . . . . . . . . . . .WP013

Sebastian, M. . . . . . . . . . .MP144

Rabilloud, T. . . . . . . . . . . . . .PS2.6

Rüetschi, U. . . . . . . . . . . . .WP046

Seelert, H. . . . . . . . . . . .PS3.8.06

Rabus, R. . . . . . . . . . . . . . .WP156

Ruiz, C. . . . . . . . . . . . . . . .MP262

Selbach, M. . . . . . . . . . .PS3.7.01

Raggiaschi, R. . . . . . . . . . .TP074

Sage, E. . . . . . . . . . . . . . . .WP176

Seliger, B. . . . . . . . . . . . . .MP238

Rajcevic, U. . . . . . . . . . . . .MP062

Sagi, D. . . . . . . . . . . . . . . .MP184

Seo, K. . . . . . . . . . . . . . . . .WP231

Ramos-Fernandez, A. . . . . .TP177

Sanglier, S. . . . . . . . . . . . . .TP076

Seong, J. K. . . . . . . . . . . . .MP071

Rapp, U. . . . . . . . . . . . .IS2, TP178

Sarioglu, H. . . . . . . . . . . . .MP248

Sergeant, K. . . . . . . . . . . . .TP088

Pinkse, M. . . . . . . . . . . . .PS2.3.04 Pisano, M. . . . . . . . . . . . . . . . .IS3 Pizzatti, L. . . . . . . . . . . . . .MP058 Platsch, H. . . . . . . . . . . .PS3.2.07 Plymoth, A. . . . . . . . . . . . . .TP108 Poetsch, A. . . . . . . . . . . .PS3.4.06 Pohl, T. . . . . . . . . . . . . . . . .TP024 Politz, O. . . . . . . . . . . . . . .MP059 Pompach, P. . . . . . . . . . . . .TP205 Ponten, F. . . . . . . . . . . . .PS1.3.01 Poon, T. C. . . . . . . . . . . . . .WP066 Pope, M. . . . . . . . . . . . . . .MP060 Posch, A. . . . . . . . . . . . . . . . . .IS1 Potthast, F. . . . . . . . . . . .PS2.3.07 Poznanovic, S. . . . . . . . . . .TP025 Preckel, T. . . . . . . . . . . . . . .TP224 Primavera, A. . . . . . . . . . . .WP154

Schulenborg, T. . . . . . . . . .MP204

HUPO 2005 • FINAL PROGRAM

127

PRESENTER INDEX Serrano, L. . . . . . . . . . . .PL4.3.03

Strömberg, S. . . . . . . . . . .WP084

Trimpin, S. . . . . . . . . . . . . .TP143

Sevinsky, J. . . . . . . . . . . . . .TP248

Strupat, K. . . . . . . . . . . . . .TP140

Tseng, T. . . . . . . . . . . . . . .MP149

Sewald, N. . . . . . . . . . . .PS2.2.07

Stühler, K. . . . . . . . . . . . . .MP076

Tsiotis, G. . . . . . . . . . . . . .WP205

Sgarra, R. . . . . . . . . . . . . . .TP089

Stuke, A. . . . . . . . . . . . . . .MP206

Turck, C. . . . . . . . . . . . . . . . . . .IS6

Shabani, A. . . . . . . . . . . . .WP158

Suehra, Y. . . . . . . . . . . . . . .MP077

Uchida, K. . . . . . . . . . . . .PS3.6.03

Shah, P. . . . . . . . . . . . . . . . .TP033

Suk Yin Karen, L. . . . . . . . .MP288

Shannon, H. . . . . . . . . . . . .MP145

Sul, D. . . . . . . . . . . . . . . . .MP249

Uhlen, M. . . . . . .PL1.2.04, PS1.3, PS3.5.02

Sheu, J. . . . . . . . . . . . . . . .MP072

Sulc, M. . . . . . . . . . . . . . . .WP160

Shin, H. J. . . . . . . . . . . . . .MP073

Sun, Q. . . . . . . . . . . . . . . . .WP085

Sickmann, A. . . . . . . . . . . .WP203

Sundby Emanuelsson, C. . .MP147

Sidell, N. . . . . . . . . . . . . . .WP014

Surendranath, V. . . . . . . . . .TP285

Sidhu, A. S. . . . . . . . . . . . .WP115

Suvorov, A. . . . . . . . . . . . . .WP216

Sihlbom, C. . . . . . . . . . . . . .TP227

Svensson, M. . . . . . . . . . . .MP207

Silva, J. . . . . . . . . . . . . . . . .TP034

Swart, R. . . . . . . . . . . . . . . .TP249

Simon, W. . . . . . . . . . . . . . .TP179

Szwergold, B. . . . . . . . . . .WP232

Simpson, R. J. . . . . .PL3.1, PS1.1, PS1.1.01, PS3.5

Szyperski, T. . . . . . . . . . .PS1.4.02

Sitek, B. . . . . . . . . . . . . . . .TP110 Sitnikov, D. . . . . . . . . . . . . .MP146 Skerra, A. . . . . . . .PS1.4, PS1.4.01 Slabas, T. . . . . . . . . . . . .PL3.2.04 Slijper, M. . . . . . . . . . . . . .MP074 Sneekes, E. . . . . . . . . . . . . .TP035 Sonck, K. . . . . . . . . . . . . . .TP111 Souchelnytskyi, S. . . . . .PS1.1.05 Speicher, D. . . . . .PS1.2, PS1.2.05 Spory, A. . . . . . . . . . . . . . .WP159 Spreadbury, J. . . . . . . . . . . . . .IS4 Srisomsap, C. . . . . . . . . . . .TP228 Stahl-zeng, J. . . . . . . . . . .WP098 Stals, H. . . . . . . . . . . . . . . .WP049 Stefanescu, R. . . . . . . . . . .MP205 Steil, L. . . . . . . . . . . . . . . .MP264 Stein, S. . . . . . . . . . . . . .PS2.1.06 Stephan, C. . . . . . . . . . . . .WP099 Sterky, F. . . . . . . . . . . . . . .WP187 Stroedicke, M. . . . . . . . . . .WP050

128

HUPO 2005 • FINAL PROGRAM

Tabuchi, M. . . . . . .TP250, WP217 Takahashi, Y. . . . . . . . . . . . .TP053 Tammen, H. . . . . . . . . . . . .MP148 Tan, K. . . . . . . . . . . . . . . . .MP079 Tanaka, K. . . . . . . . . . . . . . .TP036

Unger, A. . . . . . . . . . . . . . .MP080 Urbani, A. . . . . . . . . . . . . . .MP150 Urbina, H. . . . . . . . . . . . . . .TP200 Urlaub, H. . . . . . . . . . . . . . .MP239 Uttenweiler, S. . . . . . . . . . .TP181 Uwaje, N. . . . . . . . . . . . . . .TP287 Valcu, C. M. . . . . . . . . . . . .TP113 Valer, M. . . . . . . . . . . . . . . .TP037 Valsasina, B. . . . . . . . . . . . .TP077 Van Den Bergh, G. . . . . . . .MP209 Van Eyk, J. . . . . . . . . . . . . .MP228 Van Hall, A. . . . . . . . . . . . .WP100 Van Ling, R. . . . . . . . . . . . .TP230 van Oostrum, J. . . . . . . .PL1.2.03

Tani, C. . . . . . . . . . . . . . . . .MP265

Vandekerckhove, J. . . . .PL3.1.03, PL3.2, PS3.3

Taniguchi, N. . . . .PS2.3, PS2.3.02

Vanhoecke, B. . . . . . . . . . .WP052

Taylor, L. . . . . . . . . . . . . . . .TP141

Veal, D. A. . . . . . . . . . . . .PS2.5.06

Tebbe, A. . . . . . . . . . . . . . .WP161

Ventzki, R. . . . . . . . . . . . . .TP251

Tegel, H. . . . . . . . . . . . . . .WP086

Vincent, D. . . . . . . . . . . . . .MP081

Templin, M. F. . . . . . . . . . . .TP199

Vincent, T. . . . . . . . . . . . . .MP082

Tenz, K. . . . . . . . . . . . . . . . .TP142

Viner, R. . . . . . . . . . . . . . . .TP144

Thiele, H. . . . . . . . .TP286, WP218

Vissers, H. . . . . . . . . . . . . .MP151

Thierse, H. J. . . . . . . . . . . .MP266

Visvikis-Siest, S. . . . . . . . .MP229

Thiesen, H. . . . . . . . . . . . .WP051

Voehringer, D. . . . . . . . . . . .TP038

Titorenko, V. . . . . . . . . . .PS1.6.07

Voena, C. . . . . . . . . . . . . . .WP015

Tokarski, C. . . . . . . . . . . . . .TP229

Vogt, J. A. . . . . . . . . . . . . . .TP182

Tomczyk, N. . . . . . . . . . . . .TP054

Volmer, M. W. . . . . . . . . . . .MP083

Tonkinson, J. . . . . . . . . .PS2.5.07

von Hagen, J. . . . . . . . . . .WP016

Tribanek, M. . . . . . . . . . . . .TP112

Von Kruger, W. M. A. . . . . .WP162

Tribl, F. . . . . . . . . . . . . . . . .WP204

Wacker, M. A. . . . . . . . . . . .TP114

PRESENTER INDEX Wada, Y. . . . . . . . . .TP055, WP106

Winkelmann, I. . . . . . . . . . .MP085

Zandi, K. . . . . . . . . . . . . . .MP088

Wagner, Y. . . . . . . . . . . . . .WP206

Winkler, W. . . . . . . . . . . . . .MP154

Zanivan, S. . . . . . . . . . . . . .TP290

Wahlander, A. . . . . . . . . . . .TP183

Winnacker, E. . . . . . . . . .PL1.1.04

Zarghami, N. . . . . .MP270, WP220

Wait, R. . . . . . . . . . . . . . . . .TP078

Winstall, E. . . . . . . . . . . . .WP178

Zeidler, R. . . . . . . . . . . . . . .TP041

Walsh, B. . . . . . . . . . . . .PS3.6.06

Wisniewski, J. R. . . . . . .PS3.1.04

Zeindl-Eberhart, E. . . . . . .WP059

Walther, D. . . . . . . . . . . . . .TP288

Witzel, K. . . . . . . . . . . . . . .WP188

Zelechonok, Y. . . . . . . . . . . .TP233

Walther, P. . . . . . . . . . . . . .MP210

Wöhlbrand, L. . . . . . . . . . .WP164

Zellner, M. . . . . . . . . . . . . .MP157

Wang, J. . . . . . . . . . . . . . . .TP079

Wohlgemuth, H. . . . . . . . . .TP040

Zeng, R. . . . . . . . . . . . . .PS1.2.02

Wang, J. . . . . . . . . . . . . . . .MP250

Woksepp, H. . . . . . . . . . . .WP018

Zengin K, F. . . . . . . . . . . . .WP189

Wang, J. . . . . . . . . . . . . .PS3.8.03

Wong, J. . . . . . . . . . . . . . . .WP224

Zgoda, V. . . . . . . . . . . . . . .WP207

Wang, R. . . . . . . . . . . . . .PS2.4.06

Wongtrakoongate, P. . . . . .WP165

Zhang, X. . . . . . . . . . . . . . .TP234

Wang, Y. . . . . . . . . . . . . .PS3.2.05

Wu, C. C. . . . . . . . . . . . . . .MP155

Zhao, C. . . . . . . . . . . . . . . .WP190

Waridel, P. . . . . . . . . . . . . .WP177

Wu, H. . . . . . . . . . . . . . . . .WP166

Zhao, C. . . . . . . . . . . . . . . .MP172

Warscheid, B. . . . . . . . . . . .TP184

Wu, S. . . . . . . . . . . . . . . .PS3.3.05

Zhao, X. . . . . . . . . . . . . . . .MP089

Wattenberg, A. . . . . . . . . . .MP289

Xiao-Sheng, J. . . . . . . . . . .WP019

Zhou, A. . . . . . . . . . . . . . . .MP158

Wattiez, R. . . . . . . . . . . . . .MP267

Xie, B. . . . . . . . . . . . . . . .PS2.5.05

Zhou, H. . . . . . . . . . . . . . . .WP020

Webb-Robertson, B. . . . . . .TP289

Xie, Y. . . . . . . . . . . . . . . . . .MP290

Zhu, Y. . . . .TP291, TP292, WP056

Weber, G. . . . . . . . . . . . . . .TP231

Xu, D. . . . . . . . . . . . . . . . . .TP202

Zieske, L. . . . . . . . . . . . . . .TP185

Wei, C. . . . . . . . . . . . . . . . .TP201

Yakunin, A. . . . . . . . . . . . . .WP167

Zilberstein, G. . . . . . . . . . .WP057

Weichart, D. . . . . . . . . . . . .WP017

Yan, L. . . . . . . . . . . . . . . . .WP168

Zimmermann, K. . . . . . . . .MP090

Weiland, F. . . . . . . . . . . . . .WP163

Yan, W. . . . . . . . . . . . . . . . .MP268

Zischka, H. . . . . . . . . . . . .WP208

Weiling, F. . . . . . . . . . . . . .WP116

Yang, P. . . . . . . . . . . . . . . . .TP146

Zubarev, R. . . . . . .PL2.2, PL2.2.03

Weiss, W. . . . . . . . . .PS2.6, TP232

Yang, S. . . . . . . . . . . . . . . .WP219

Weng, L. . . . . . . . . . . . . . . .MP153

Yarygin, K. . . . . . . . . . . . . .WP067

Wernérus, H. . . . . . . . . . . .WP087

Yasuhiro, K. . . . . . . . . . . . .MP086

Wester, K. . . . . . . . . . . . . .WP233

Yates, J. . . . . . . . . . . . . .PL2.2.01

Westermeier, R. . . . . . . . .EP1.01, PS1.7, PS2.6

Yeretssian, G. . . . . . . . . . . .TP203

White, M. . . . . . . . . . . . . . .MP084 Whitelegge, J. . . . . . . . . . . .TP252 Wiebringhaus, T. . . . . . . . .WP053 Wiesner, A. . . . . . . . . . . . . .TP039 Wildgruber, R. . . . . . . . . . . .TP090 Willetts, M. . . . . . . . . .TP145, IS10 Willmitzer, L. . . . .PS3.8, PS3.8.01 Wiltfang, J. . . . . . . . . . . . .MP211 Wingren, C. . . . . . . . . . . .PS1.3.02

Yi, J. . . . . . . . . . . . . . . . . . .WP123 Ying, W. . . . . . . . . . . . . . . .WP068 Yokoo, H. . . . . . . . . . . . . . .MP087 Yongxing, A. . . . . . . . . . . . .WP054 Yoo, Y. J. . . . . . . . . . . . . . .WP055 Yoshida, Y. . . . . . . . . . . . . .MP269 Yu, J. . . . . . . . . . . . . . . . . .MP156 Yunshan, N. . . . . . . . . . . . .MP230 Zabel, C. . . . . . . . . . . . . . .MP212 Zabrouskov, V. . . . . . . . . . . .TP147 HUPO 2005 • FINAL PROGRAM

129

EXHIBIT DIRECTORY

LIST OF EXHIBITORS IN ALPHABETICAL ORDER EXHIBITOR Advion Bio Sciences Agilent Technologies Antibodies by Design, a Division of MorphoSys Applied Biosystems Association of Biomolecular Resource Facilities (ABRF) BD Beckman Coulter GmbH Biacore AB Bio-Rad Laboratories BIOBASE GmbH BioGenes GmbH BioGrafx Scientific & Medical Images Biomax Informatics AG Bruker Daltonics Ciphergen Biosystems Inc. Dionex Corporation European Bioinformatics Institute GE Healthcare (formerly Amersham Biosciences) GeneData Geneva BioInformatics GeneBio S.A. Genologics Life Sciences Software Genomic Solutions Ltd. Human Proteome Organisation (HUPO) / HUPO 2006 IBA BioTAGnology INTAVIS AG Invitrogen JPT Peptide Technologies LI-COR Biosciences Matrix Science Merck Biosciences Millipore Molecular & Cellular Proteomics (MCP) NextGen Sciences Ltd Nonlinear Dynamics Pall Life Sciences Perbio Science Deutschland GmbH PerkinElmer Life and Analytical Sciences Protagen AG Protana Proteome Factory AG Proxeon QIAGEN Roche Diagnostics GmbH

BOOTH # 226 307 620 306 109 200 318 405 400 107 221 218 127 406 507 407 516 201 316 207 518 521 119/117 123 517 504 216 215 101 314 514 214 409 417 219 103 500 206 616 222 608 404 419

HUPO 2005 • FINAL PROGRAM

131

LIST OF EXHIBITORS IN ALPHABETICAL ORDER EXHIBITOR Rosetta Biosoftware Science / AAAS SERVA Electrophoresis GmbH Shimadzu Biotech Sigma Aldrich SunChrom GmbH SuNyx GmbH Syngene Technische Universität München (TUM) Thermo Electron Corporation (GmbH) Thermo Electron Corporation (Oy) Vivascience AG Waters Corp. Whatman Schleicher & Schuell Wiley-VCH Verlag GmbH & co. KGaA WITA GmbH

132

HUPO 2005 • FINAL PROGRAM

BOOTH # 600 604 509 508 501 304 610 519 115 301 305 505 401 205 224 618

LIST OF EXHIBITORS IN NUMMERICAL ORDER BOOTH #

EXHIBITOR

101 103 107 109 115 117/1179 123 127 200 201 205 206 207 214 215 216 218 219 221 222 224 226 301 304 305 306 307 314 316 318 400 401 404 405 406 407 409 415 419 500 501 504 505

Matrix Science Perbio Science Deutschland GmbH BIOBASE GmbH Association of Biomolecular Resource Facilities (ABRF) Technische Universität München (TUM) Human Proteome Organisation (HUPO) / HUPO 2006 IBA BioTAGnology Biomax Informatics AG BD GE Healthcare (formerly Amersham Biosciences) Whatman Schleicher & Schuell Protagen AG Geneva BioInformatics GeneBio S.A. Molecular & Cellular Proteomics (MCP) LI-COR Biosciences JPT Peptide Technologies BioGrafx Scientific & Medical Images Pall Life Sciences BioGenes GmbH Proteome Factory AG Wiley-VCH Verlag GmbH & co. KGaA Advion Bio Sciences Thermo Electron Corporation (GmbH) SunChrom GmbH Thermo Electron Corporation (Oy) Applied Biosystems Agilent Technologies Merck Biosciences GeneData Beckman Coulter GmbH Bio-Rad Laboratories Waters Corp. QIAGEN Biacore AB Bruker Daltonics Dionex Corporation NextGen Sciences Ltd Nonlinear Dynamics Roche Diagnostics GmbH PerkinElmer Life and Analytical Sciences Sigma Aldrich Invitrogen Vivascience AG

HUPO 2005 • FINAL PROGRAM

133

LIST OF EXHIBITORS IN NUMMERICAL ORDER BOOTH # 507 508 509 514 516 517 518 519 521 600 604 608 610 616 618 620

134

EXHIBITOR Ciphergen Biosystems Inc. Shimadzu Biotech SERVA Electrophoresis GmbH Millipore European Bioinformatics Institute INTAVIS AG Genologics Life Sciences Software Syngene Genomic Solutions Ltd. Rosetta Biosoftware Science / AAAS Proxeon SuNyx GmbH Protana WITA GmbH Antibodies by Design, a Division of MorphoSys

HUPO 2005 • FINAL PROGRAM

EXHIBIT FLOOR PLAN

Internationales Congress Center München, Messe München GmbH (ICM) Hall B0

3m 2m 226

127

224

125

222

2m 123 3m

Poster Service Counter 2m

3m 2m 221

117

3m

318 219

115 214 2m

620

518

419

Internet Café

216 3m

2m 521

4m

4m

119 218 3m 3m

Coffee Stations & Concession Stand

3m

217

2m 215

316

4m

314

2m

6m

3m

519 618

3m

517 616

516 417

514

3m

3m

3m 3m

4m

3m

3m 4m

5m

3m

207 3m

4m

3m

103 101 3m

7m

200 4m

6m

6m

205

307

306 304

3m 305

301 6m

4m

610

507

608

505

604

501

600

407 404

5m

201

3m

3m

3m

5m

509 508

406

3m 3m

409

400 4m

405

504

401

500

4m

3m

4m 3m

3m

Coffee Stations

Coffee Stations

5m

206

3m

4m

2m 109 3m 107 3m

3m

3m

Entrance from Foyer of Conference Center

= 88 Poster Boards (352 posters) = high tables

HUPO 2005 • FINAL PROGRAM

135

EXHIBIT DIRECTORY ADVION BIOSCIENCES, INC. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .226 Contact: Ms. Amy Boardman 15 Catherwood Road Ithaca, NY 14850 USA Telephone: +1-607-266-0665 Fax: +1-607-266-0749 E-Mail: [email protected]

AGILENT TECHNOLOGIES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .307 Contact: Dr. Odilo Müller Hewlett-Packard-Str.8 Waldbronn, 76337 Germany Telephone: +49-(0)800-603-1000 Fax: +49-(0)6995-307-919 E-Mail: [email protected] Agilent Technologies is a leading supplier of life science technologies, providing solutions for gene expression, proteomics and informatics that optimize sensitivity and workflow productivity. Key products include: whole genome and custom microarrays, scanners; HPLC, LC/MS/MS and HPLC-Chip/MS; ion trap and TOF mass spectrometers; lab-on-a-chip products; reagents; and data analysis software.

ANTIBODIES BY DESIGN, A DIVISION OF ORPHOSYS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .620 Contact: Sandra Rengsberger Lena-Christ-Str. 48 Martinsried / Planegg, 82152 Germany Telephone: +49-(0)89-899-27-305 Fax: +49-(0)89-899-27-5305 E-Mail: [email protected] Antibodies by Design delivers custom monoclonal antibodies in just 8 weeks — and charges only on delivery! These highaffinity recombinant antibodies are selected from a library of over 15 billion antibody specificities. The company also offers over 4000 catalog antibodies and ISO-certified antibody manufacturing services at its Biogenesis division.

APPLIED BIOSYSTEMS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .306 Contact: Nicole Wagner Frankfurter Strasse 129 B Darmstadt, 64293 Germany Telephone: +49-(0)6151-96-70-0 Fax: +49-(0)6151-96-70-5599 E-Mail: [email protected] Applied Biosystems/MDS SCIEX, the leading provider of Mass Spectrometry to life science researchers, offers innovative solutions for protein biomarker discovery and validation. BIOiTRAQ™ systems and the new 4800 MALDI TOF/TOF™ Analyzer provide high sensitivity and high confidence biomarker identification and quantitation, and novel iTRAQ™ reagents enable multiplexed experiments.

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EXHIBIT DIRECTORY ASSOCIATION OF BIOMOLECULAR RESOURCE FACILITIES (ABRF) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .109 Contact: Miquela Ortiz 2019 Galisteo St., Bldg. I-1 Santa Fe, NM, 87505 USA Telephone: +1-505-983-8102 Fax: +1-505-989-1073 E-Mail: [email protected] ABRF is an association comprised of scientists working in resource and research biotechnology laboratories. Members represent government, academic, research and industry core laboratories. The annual conference highlights emerging biotechnology in a range of forums including lectures, research group presentations, poster sessions, workshops and exhibits. For more information visit www.abrf.org

BD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .200 Contact: Bruce Haywood 1 Becton Drive Frankline Lakes, NJ, 07417 USA Telephone: +1-201-847-5343 Fax: +1-201-847-4851 E-Mail: [email protected] BD is a medical technology company that serves healthcare institutions, life science researchers, clinical laboratories, industry, and the general public. BD manufactures and sells a broad range of medical supplies, devices, laboratory equipment, and diagnostic products. For the fiscal year ended September 30, 2004, BD reported total revenues of $4.935 billion.

BECKMAN COULTER GMBH . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .318 Contact: Dietmar Hansen / Uwe König Europark Fichtenhain B13 Krefeld, 47807 Germany Telephone: +49-(0)2151-333-724 Fax: +49-(0)2151-333-631 E-Mail: [email protected] Beckman Coulter is a supplier of Systems for Proteomics and Quality Control of Antibodies. PF2D fractionates Proteins with a Differential Display, PA800 is designed to characterize Proteins and is best suitable for Quality Control of IgG. It works with SDS Gelelektropheresis, Isoelectric Focussing and Carbohydrate Labeling and Analysis Kits. For the depletion of high abundant Proteins different IgY Systems are available.

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EXHIBIT DIRECTORY BIACORE AB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .405 Contact: Helena Nilshans/Florian Koelle Rapsgatan 7 Uppsala, 754 50 Sweden Telephone: +46-18-67-57-00 Fax: +46-18-150-110 E-Mail: [email protected] Biacore supplies analytical systems that improve productivity of research and development in the life science and pharmaceutical markets. Unique data on protein interactions give insights into protein functionality, the role of proteins in normal and diseased states, and the influence of potential drug candidates. For more information visit www.biacore.com

BIO-RAD LABORATORIES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .400 Contact: Gabriella Armin 2000 Alfred Nobel Drive Hercules, CA, 94547 USA Telephone: +1-510-741-6678 Fax: +1-510-741-4113 E-Mail: [email protected] Bio-Rad Brings You Products and Advice You Can Depend On. Expert 2D advice and products from sample prep through image analysis make Bio-Rad your resource for comparative expression proteomics. Visit us at www.expressionproteomics.com for the latest products launched at HUPO, as well as our complete set of online support functions.

BIOBASE GMBH . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .107 Contact: Susanne Thiele, Sr. Manager Sales and Marketing Halchtersche Str. 33 Wolfenbüttel, Lower Saxony, 38304 Germany Telephone: +49-(0)5331-85-84-25 Fax: +49-(0)5331-85-84-71 E-Mail: [email protected] BIOBASE (www.biobase-international.com) develops and distributes molecular biological databases for industrial and academic applications. BIOBASE’s product portfolio includes TRANSFAC®, TRANSPATH®, BRENDA® and the Proteome Bioknowledge Library®, internationally acclaimed, manually curated molecular biological databases. So far, over 70 biotechnological and pharmaceutical companies and over 350 academic institutes are satisfied customers of the company.

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EXHIBIT DIRECTORY BIOGENES GMBH . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .221 Contact: Dagmar Schwertner Koepenicker Strasse 325 Berlin, D-12555 Germany Telephone: +49-(0)30-6576-2396 Fax: +49-(0)30-6576-2397 E-Mail: [email protected] BioGenes provides certified customised services: - Development and production of monoclonal antibodies - Production of polyclonal antibodies in different species - Development, validation and production of immunoassays. BioGenes has experience for many years. Complete development of monoclonal antibodies can be performed with very small amount of antigen within 3-4 months.

BIOGRAFX SCIENTIFIC & MEDICAL IMAGES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .218 Contact: Kenneth Eward 7799 East Welter Rd. Ovid, MI, 48866 USA Telephone: +1-989-834-9825 Fax: +1-989-834-6221 E-Mail: [email protected] BioGrafx is the science illustration studio of Kenneth Eward. Trained in physiology & cellular biophysics, Eward specializes in high-impact biomedical and technical artwork for print, web and broadcast media.

BIOMAX INFORMATICS AG . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .127 Contact: Dr. Philipp Krubasik Lochhamer Str.9 Martinsried / 82152 Germany Telephone: + 49 89 895574 Fax: + 49 89 895574 E-Mail: [email protected]

BRUKER DALTONICS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .406 Contact: Anne Kropp Fahrenheitstrasse 4 Bremen, 28359 Germany Telephone: +49-(0)421-2205-433 Fax: +49-(0)421-2205-104 E-Mail [email protected] Bruker Daltonics is a leading developer and provider of innovative life science tools based on mass spectrometry. With MALDI-TOF, ESI-Ion Trap LC/MS, ESI-TOF MS and FTMS instruments, we supply solutions for proteomics (PROTEINEER and PROTEINEER-LC), metabolomics (METABOLIC PROFILER), clinical proteomics (CLINPROT), genomics (GENOLINK) and general chemical analysis. HUPO 2005 • FINAL PROGRAM

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EXHIBIT DIRECTORY CIPHERGEN BIOSYSTEMS INC. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .507 Contact: Steve Cleverly 6611 Dumbarton Circle Fremont, CA, 94555 USA Telephone: +44-1483-409-974 Fax: +44-1252-642-180 E-Mail [email protected] SELDI ProteinChip® Systems perform are designed for the Pattern TrackTM process of biomarker discovery to assay. Biomarkers with high predictive value are discovered, validated and identified in disease, drug development, toxicity and theranostic studies, before being developed into powerful chromatographic or antibody based assays. Please visit us at www.ciphergen.com

DIONEX CORPORATION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .407 Contact: 1228 Titan Way Sunnyvale, CA, 94085 USA Telephone: +1-408-737-0700 Fax: +1-408-730-9403 Website: www.dionex.com LC Packings/Dionex is the leader in protein and amino acid separations. The offering includes the Nano and Capillary LC systems (UltiMate™ 3000) and the Probot Microfraction collector for high-sensitivity LC/MS analysis of peptides and proteins. The Nano and Capillary Monolithic columns offer unique resolution and separation speed in proteome analysis.

EUROPEAN BIOINFORMATICS INSTITUTE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .516 Contact: Janet Copeland EMBL Outstation Hinxton, The Wellcome Trust Genome Campus Cambridge, Hinxton, CB10 1SD UK Telephone: +44-1223-492-510 Fax: +44-1223-494-487 E-Mail: [email protected] The EBI maintains and provides unrestricted access to core molecular databases including EMBL-bank, Ensembl, UniProt, ArrayExpress, MSD (ePDB), InterPro, IntAct and Reactome, as well as many bioinformatics tools. EBI provides an excellent environment for bioinformatics research, has developed unique ways of supporting its users, and offers advanced training in bioinformatics.

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EXHIBIT DIRECTORY GE HEALTHCARE (FORMERLY AMERSHAM BIOSCIENCES) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .201 Contact: Tom Naven Pollards Wood, Nightingales Lane Chalfont St Giles, Buckinghamshire, HP8 4SP UK Telephone: +44-7799-582-034 Fax: +44-1494-498-235 E-Mail: [email protected] GE Healthcare provides transformational medical technologies that will shape a new age of patient care with expertise ranging from medical imaging to systems for drug discovery and disease research. Products and applications for proteomics research include 2-D DIGE, 2-D and 1-D electrophoresis, liquid chromatography workflows and systems for high throughput protein purification. www.amershambiosciences.com/proteomics

GENEDATA Contact:

Telephone: Fax: E-Mail:

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .316 Dr. Melanie Markmann Lena-Christ-Str. 50 Martinsried, 82152 Germany +49-(0)89-89511-0214 +49-(0)89-89511-0215 [email protected]

Genedata Expressionist® provides one computational solution for investigating proteome, metabolome, and transcriptome data for drug development. Compatible with 2D-PAGE, MS, and microarray platforms, Expressionist spans the workflow from experiment planning to decision support. Key applications include biomarker identification and validation, bioactive molecule evaluation, and patient group stratification for clinical trials.

GENEVA BIOINFORMATICS GENEBIO SA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .207 Contact: Mr. Andrew Smith (Marketing Manager) 25 avenue de Champel Genève, 1206 Switzerland Telephone: +41-702-9900 Fax: +41-22-702-9999 E-Mail [email protected] GeneBio is a multifaceted bioinformatics company situated at the heart of the Lake Geneva Region, one of the world’s major proteomics centres of excellence. Based on expertise in the proteomics and bioinformatics fields, GeneBio offers original educational and knowledge-discovery solutions that help clients shape heterogeneous information into relevant biological knowledge.

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EXHIBIT DIRECTORY GENOLOGICS LIFE SCIENCES SOFTWARE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .518 Contact: Christine Eastgaard 4464 Markham Street, Suite 2302 Victoria, BC, V8Z 7X8 Canada Telephone: +1-250-483-7011 ext. 3300 Fax: +1-250-483-7777 E-Mail: [email protected] GenoLogics’ ProteusLIMSTM solution assists life science laboratories to manage, integrate and analyze vast volumes of scientific and lab data. Serving Proteomics and Systems Biology research labs, ProteusLIMS automates the lab workflow and provides data integration and analytical tools that aid labs in their research, scientific discovery and biomarker validation.

GENOMIC SOLUTIONS LTD. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .521 Contact: Mark Eddy Genomic Solutions Ltd, Unit 8, Blackstone Road Huntingdon, Cambridgeshire, PE29 6EF UK Telephone: +44-1480-426719 Fax: +44-1480-426767 E-Mail: [email protected] Genomic Solutions provides automated systems to Life Science researchers involved in HTS, Genomic and Proteomic applications. The Investigator Proteomic systems provide a complete solution for Proteomic researchers using electrophoresis and MDLC to separate their proteins - protein spot picking robot, digestion platforms and MS protein identification and management tools.

HUMAN PROTEOME ORGANISATION (HUPO) / HUPO 2006 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .117/119 Contact: Elizabeth Cooper 740 Dr Penfield, Suite 6206 Montreal, QC, H3A 1A4 Canada Telephone: +1-514 398 1531 Fax: +1-514 398 2036 E-Mail [email protected] HUPO defines and promotes proteomics through international cooperation and collaborations by fostering the development of new technologies, techniques and training to better understand human disease. www.HUPO.org

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EXHIBIT DIRECTORY IBA BIOTAGNOLOGY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .123 Contact: Alois Schneiderbauer Rudolf-Wissell-Str. 28 Göttingen, D-37079 Germany Telephone: +49-551 50672-0 Fax: +49-551-50672-181 E-Mail: [email protected] IBA GmbH, a German "BioTAGnology" company", is one of the foremost providers of expression cloning and protein purification technologies, such as the Strep-tag® and double-tag technology. Also offered are Magnet Assisted Transfection Reagents, nucleic acid specialties (e.g. LNA license; dsRNA for gene silencing), as well as contract manufacturing of e.g. proteins under (pre-) GMP

INTAVIS AG . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .517 Contact: Heinrich Gausepohl, PhD Nattermannallee 1 Cologne, 50829 Germany Telephone: +49-(0)22150-2946-80 Fax: +49-(0)22150-2946-89 E-Mail: [email protected] INTAVIS automates complex procedures in peptide synthesis, proteomics and functional genomics. Our AutoSpot is a unique instrument for synthesis of peptide arrays on membranes. The MultiPep is a powerful multiple peptide synthesizer. Our DigestPro MS fully automates protein digestion and MALDI sample preparation. The InsituPro VS performs in situ detection.

INVITROGEN . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .504 Contact: Alan Livingston Inchinnan Business Park 3 Fountain Drive Paisley, Scotland, PA4 9RF UK Telephone: +44-(0)141-814-6100 Fax: +44-(0)141-814-6260 E-Mail: [email protected] Invitrogen provides technologies for disease research, drug discovery, and commercial bio-production for the Life Science community. Our own research and development efforts are focused on breakthrough innovation in all major areas of biological discovery including proteomics-placing Invitrogen's products in nearly every major laboratory in the world. For more information about Invitrogen, visit our web site at www.invitrogen.com

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EXHIBIT DIRECTORY JPT PEPTIDE TECHNOLOGIES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .216 Contact: Dr. Wenschuh Invalidenstr. 130 Berlin, 10115 Germany Telephone: +49-(0)3097-8930 Fax: +49-(0)3097-893299 E-Mail: [email protected] JPT Peptide Technologies is the leader of innovative peptide-based tools for biomedical reaserch. Our PepSpotTM and PepStarTM platforms enable flexible and highly economical production of peptide arrays for mapping of protein/protein interactions. With SPOTTM tens-of-thousands individual peptides are accessible at lowest costs. JPT developed a comprehensive tool box for profiling kinases, phosphatases and proteases using substrate collections on chips and in microtiterplates.

LI-COR BIOSCIENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .215 Contact: Dr. Heike Wohlgemuth Siemensstr. 25A Bad Homburg, 61352 Germany Telephone: +49-(0)6172-17177-71 Fax: +49-(0)6172-17177-99 E-Mail: [email protected] LI-COR® Biosciences are specialists in infrared fluorescence technology. The Odyssey® Infrared Imaging System delivers superior quantitative 2-target Westerns and features direct detection for applications such as cell-based assays, protein arrays, EMSAs, section/in vivo imaging. The 4300 Analyzer is the instrument of choice for DNA Sequencing, Microsatellites, AFLP®, TILLING & Ecotilling.

MATRIX SCIENCE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .101 Contact: David Creasy 8 Wyndham Place London, W1H 1PP UK Telephone: +44-(0)20-7723-2142 Fax: +44-(0)20-7725-9360 E-Mail: [email protected] Take the guesswork out of protein identification. Mascot is fast, flexible and integrates all the proven strategies for protein identification using mass spectrometry data. Mascot Distiller provides cross-platform browsing and processing of raw mass spectrometry data. Mascot Integra is a complete solution for proteomics workflow automation and data mining.

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EXHIBIT DIRECTORY MERCK BIOSCIENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .314 Contact: Mrs. Katrin Frank Ober der Roeth Bad Soden, D-65824 Germany Telephone: +49-(0)6151-72-7573 Fax: +49-(0)6151-72-917573 E-Mail: [email protected] Merck KGaA through its affiliated companies Merck Biosciences / EMD Biosciences offers sample preparation kits for proteomics which cover the whole workflow, from fractionated protein extraction and abundant protein removal to concentrating and digestion of proteins and finally selective capture of phosphorylated peptides ready for mass spectrometry analysis.

MILLIPORE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .514 Contact: Samuel Urbain / Susanne Schaaf 39 Route Industrielle De La Hardt Molsheim, 67120 France Telephone: +33-39046-9300 Fax: +33-39046-9193 E-Mail: [email protected] / [email protected] From Amicon centrifugal filters to ZipTip pipette tips, there's a Millipore device to purify just about any protein sample - Protein Concentration and Desalting - Western Blotting/Protein Sequencing - Albumin Depletion - In-Gel Digestion - Mass Spec Sample Prep - Clarification & Sterile Filtration - Ultrapure Water for Molecular Biology

MOLECULAR & CELLULAR PROTEOMICS (MCP) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .214 Contact: Barbara Gordon 9650 Rockville Pike Bethesda, MD, 20814 USA Telephone: +1-301-634-7145 Fax: +1-301-634-7126 E-Mail [email protected] Learn why Molecular & Cellular Proteomics (MCP) has earned the highest impact factor of any peer-reviewed journal in proteomics, and why MCP ranks in the top 100 among all 5,968 biology/medical journals indexed by the ISI Journal Citation Reports, 2004 Edition. Learn more at Booth # 214 or www.mcponline.org

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EXHIBIT DIRECTORY NEXTGEN SCIENCES LTD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .409 Contact: Lorna Watson Building 56 Alconbury North Airfield Huntingdon, Cambridgeshire, PE28 4DA UK Telephone: +44-(0)1480-410-850 Fax: +44-(0)1480-410-858 E-Mail: [email protected]

NextGen Sciences is a leading provider of technologies and reagents for molecular biology and protein research. The company’s advanced products automate and simplify complex research techniques, saving time and resources, improving results and accelerating discovery. NONLINEAR DYNAMICS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .417 Contact: John Spreadbury (Group Sales & Marketing Director CEO Nonlinear USA) Cuthbert House, All Saints Newcastle upon Tyne, Tyne & Wear, NE1 2ET UK Telephone: +44-(0)191-230-2121 Fax: +44-(0)191-230-2131 E-Mail: [email protected] Nonlinear Dynamics is a leading developer of bioinformatics solutions. The Company offers a wide-range of analysis and data-mining software products for the proteomics community. Recent innovations include a fully integrated solution to analyse 2D and MS data, and a novel technology which offers a unique multivariate approach to biomarker discovery.

PALL LIFE SCIENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .219 Contact: Kara Cannon 2200 Northern Blvd. East Hills, NY, 11548 USA Telephone: +1-516-484-5400 Pall Life Sciences is a leading supplier of products for small to large scale purifications and separations. Products include: Enchant Kits for protein purification; AcroPrep multiwell filterplates for high throughput separation and Biosepra chromatography sorbents for a multitude of protein fractionation applications.

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EXHIBIT DIRECTORY PERBIO SCIENCE DEUTSCHLAND GMBH . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .103 Contact: Malinka Bral Adenauerallee 113 Bonn, 53113 Germany Telephone: +32-5385-7432 Fax: +32-5385-7430 E-Mail: [email protected] Our work at Perbio Science: To advance life science by creating and producing first-quality products and services to further the work of life science professionals.

Our brands: Pierce - protein research to isolate, purify, characterize, label, modify and detect proteins. Endogen – for cytokine research needs HyClone – Premium serum and media Dharmacon - RNA Interference

PERKINELMER LIFE AND ANALYTICAL SCIENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .500 Contact: 710 Bridgeport Ave. Shelton, CT, 06484 USA Telephone: +1-203-925-4602 int. / 800-762-4000 nat. Fax: +1-203-944-4914 PerkinElmer serves a number of growing industries and markets including the environmental, pharmaceutical, chemical, petrochemical, semiconductor, academic research, biotechnology, and clinical screening segments. Our total applicationdriven laboratory solutions help our customers speed drug discovery, enhance research productivity, meet strict regulatory requirements, improve time-to-market, and increase manufacturing efficiencies.

PROTAGEN AG . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .206 Contact: Dr. Matthias Kalbas Otto Hahn Str. 15 Dortmund, NRW, 44227 Germany Telephone: +49-(0)231-9742-6300 Fax: +49-(0)231-9742-6301 E-Mail: [email protected] Protagen AG offers products and services in protein analysis (under GMP as well), proteome studies, protein biochips and BIO-IT. The new UNIchip® AV-400 is designed for the validation of antibodies and the definition of new autoimmune markers. The UNIchip® AV-VAR includes additionally custom-generated content defined by the client.

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EXHIBIT DIRECTORY PROTANA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .616 Contact: Tim Blacker 251 Attwell Dr Toronto, ON, M9W 7H4 Canada Telephone: +1-416-644-5100 Fax: +1-416-644-5111 E-Mail: [email protected] Protana is a proteomic services company with expertise in the analysis of proteins via mass spectrometry. Protana’s capabilities include: - Protein analysis services, from gel bands to differential protein analysis - A comprehensive biomarker discovery platform - Proprietary mass spectrometry-based, small molecule screening platform For more information, please visit www.protana.com

PROTEOME FACTORY AG . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .222 Contact: Dr. Christian Scheler, CEO Dorotheenstr. 94 Berlin, D-10117 Germany Telephone: +49-(0)700 PROTEOME / 700-7768-3663 Fax: +49-(0)700 PROTEOME / 700-7768-3663 E-Mail: [email protected] WWW.PROTEOMEFACTORY.COM PRODUCTS: robots, kits, software for proteomics: Spot picker spotXpress, denovo sequencing software PF-Sequit; MeCat & breakable PAGE kits (coming soon). SERVICES: proteomics, protein and PTM identification & characterization, 2DE (upto 60x30cm), MDnanoLCMSMS, Edman, free-flow electrophoresis; TECHNOLOGIES: Metal Coded Affinity Tags (MeCAT) for proteomics and absolute protein quantification.

PROXEON . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .608 Contact: Ole Vorm Staermosegaardsvej 6 Odense, DK-5230 Denmark Telephone: +45-2633-2323 Fax: +45-6557-2301 E-Mail: [email protected] Proxeon develops and markets innovative hardware and software products for use in the analysis of proteins. Based in Odense, Denmark, Proxeon supplies its products world-wide, and has well over one thousand customers in the pharmaceutical and biotechnological industry as well as the academic research sector.

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EXHIBIT DIRECTORY QIAGEN . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .404 Contact: Olivier Taby, PhD 3 Avenue du Canada LP 809 Courtaboeuf Cedex, 91974 France Telephone: +33-160-920-920 Fax: +33-160-920-925 E-Mail: [email protected] QIAGEN is the world’s leading provider of innovative technologies for separating, purifying, and handling nucleic acids and proteins. QIAGEN offers a comprehensive range of integrated kits and reagents, as well as complete automation systems, and provides custom design and synthesis of siRNA for gene silencing.

ROCHE DIAGNOSTICS GMBH . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .419 Contact: Mrs. Claudia Möller Sandhoferstrasse 116 Mannheim, D-68298 Germany Telephone: +49-(0)621-759-1317 Fax: +49-(0)621-759-8830 E-Mail: [email protected] Roche Applied Science provides reagents and systems for life-science research. Our products for transfection, gene-knockdown, protein-expression, protein protection and analysis help you achieve optimal results in proteomics research. FuGENE 6 Transfection Reagent and Complete Protease Inhibitor Cocktails Tablets are used in thousands of laboratories for transfection and protease inhibition.

ROSETTA BIOSOFTWARE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .600 Contact: Scott DePriest 401 Terry Avenue N Seattle, WA, 98109 USA Telephone: +1-206-926-1220 Fax: +1-206-926-1299 E-Mail: [email protected] Rosetta Biosoftware develops informatics solutions and provides services that enable research organizations to efficiently and effectively conduct life-saving discoveries and develop drugs. Our mission is to be the premier provider of enterprisescale software solutions to empower research that improves the quality of human life.

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EXHIBIT DIRECTORY SCIENCE / AAAS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .604 Contact: Wendy Sturley Bateman House, 82-88 Hills Road Cambridge, CB2 1LQ UK Telephone: +44-(0)1223-326-500 Fax: +44-(0)1223-326-535 E-Mail: [email protected] Science magazine is published by the AAAS, the world’s largest general scientific society. Founded in 1880 by Thomas Edison, Science ranks as the world’s leading scientific journal, with over 125,000 subscribers. Since its founding in 1848, AAAS has become the world’s largest multidisciplinary society and the leading international voice for the advancement of science.

SERVA ELECTROPHORESIS GMBH . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .509 Contact: Dr. Juergen Dreher Carl-Benz-Straße 7 Heidelberg, BW, 69115 Germany Telephone: +49-(0)6221-13840-24 Fax: +49-(0)6221-13840-54 E-Mail [email protected] For quantification of proteins by mass spectrometry SERVA Electrophoresis GmbH offers the new ICPLTM-Kit. It’s a unique technology for isotope labelling of protein samples to be analysed, e.g., to measure differential expression of one protein in two different cell states. For more information please visit us at our booth (#509).

SHIMADZU BIOTECH . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .508 Contact: Dr. Martin Resch 6-10 Albert Hahn Strasse Duisburg, D-47269 Germany Telephone: +49-(0)203-7687-445 Fax: +49-(0)203-766-625 E-Mail: [email protected] Shimadzu Biotech brings together diverse technologies to provide a total solution to the protein research work flow and to drug discovery. Our technology platforms include the award winning chemical inkjet printer, automated systems for gel processing and mass spectrometry for MALDI and LC including IT-TOF systems.

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EXHIBIT DIRECTORY SIGMA ALDRICH . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .501 Contact: Michael Hadjisavis 3050 Spruce St. St. Louis, MO, 63103 USA Telephone: 1-800-521-8956 Fax: 1-800-325-5052 E-Mail: [email protected] Sigma-Aldrich serves proteomic research through novel products and technologies enabling protein isolation, detection, identification and quantification. Sigma’s products form an integrated system covering the areas of Expression Profiling, Recombinant Protein Expression, Interaction Profiling, Sample Preparation, Mass Spectrometry and Post-translational Modification where individual pieces function cohesively offering continuity and superior performance.

SUNCHROM GMBH . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .304 Contact: Dr. G. Barka Max-Planck-Str. 22 Friedrichsdorf, D-61381 Germany Telephone: +49-(0)6172-953-350 Fax: +49-(0)6172-953-399 E-Mail: [email protected] SunChrom offers instruments and all necessary consumables for analytical, micro and nano HPLC. The latest innovations are the smallest MALDI spotter with unique features; sample preparation pipette tips prior to micro/nano HPLC; CE and CEC. These SPE tips can be delivered with 10 different materials incl. immobilized enzymes for in situ digestion of proteins.

SUNYX GMBH . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .610 Contact: Dr. Michael Lutz Stolbergerstr. 370 Köln, NRW, D-50933 Germany Telephone: +49-(0)221-485 2460 Fax: +49-(0)221-485 2479 E-Mail: [email protected] With the MPep and MProt Chips, SuNyx provides innovative bioanalytical solutions with these novel ready-to-use, disposable sample plates for MALDI MS analysis. Both chips feature up to 100-fold higher sensitivity compared to currently applied tools. Both peptide and protein analyses are also possible at maximum throughput and greatly enhanced reproducibility.

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EXHIBIT DIRECTORY SYNGENE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .519 Contact: Laura Sullivan Beacon House, Nuffield Road Cambridge, CB4 1TF UK Telephone: +44-(0)1223-727-123 Fax: +44-(0)1223-727-101 E-Mail: [email protected] Syngene is a leading-edge software development company specialising in Genomics and Proteomics. On stand will be the recently launched Dymension 2DGE software. Dymension overturns the accepted conventions of 2D gel electrophoresis analysis. Warping, spot detection and spot matching – tasks that once took hours - can now be performed within seconds.

TECHNISCHE UNIVERSITÄT MÜNCHEN (TUM) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .115 Contact: Dieter Heinrichsen, M.A (Presse & Kommunikation) Arcisstrasse 19/1 Munich, D-80290 Germany Telephone: +49-(0)89-289-22779 Fax: +49-(0)89-289-23388 E-Mail [email protected] The TECHNISCHE UNIVERSITÄT MÜNCHEN is ranked foremost among German universities and holds a unique position in Europe in terms of the choice of fields it offers. With 480 professors and 8.500 total staff, the TUM covers all areas of the natural and engineering sciences, along with medicine and life sciences.

THERMO ELECTRON CORPORATION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .301/305 Contact: Thermo Electron Corporation GmbH Susanne Tobin Hanna-Kunath-Str. 11 Bremen, 28199 Germany Telephone: +49-(0)421-5493-325 Fax: +49-(0)421-5493-426 E-Mail: [email protected] Contact:

Telephone: Fax: E-Mail:

Thermo Electron Corporation (OY) Tuula Jernström Ratastie 2 Vantaa, 01620 Finland +358-9-3291-0461 +358-9-3291-0415 [email protected]

About Thermo Electron Corporation Thermo Electron Corporation is the world leader in analytical instruments inside and outside the lab, helping our customers to make the world a healthier, cleaner and safer place. Thermo also provides, scientific equipment, services, software solutions, drug discovery, clinical, environmental and on-line manufacturing processes. Visit www.thermo.com

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EXHIBIT DIRECTORY VIVASCIENCE AG . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .505 Contact: Stephanie Wagner Feodor-Lynen-Str. 21 Hannover, 30625 Germany Telephone: +49-(0)511-524 875-11 Fax: +49-(0)511-524 875-19 E-Mail: [email protected] Vivascience develops solutions for protein purification and analysis offering device formats for filtration, ultrafiltration, protein purification, and cell culture. Vivascience is a wholly owned subsidiary of Sartorius AG and has access to the Group’s technology platform and core expertise, allowing integrated process solutions from laboratory scale to process scale applications.

WATERS CORP . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .401 Contact: Dr. Matt Kennedy Transistorstraat 18 Almere, 1322 CE The Netherlands Telephone: +31-36-540-6000 Fax: +31-36-540-6001 E-Mail: [email protected] Waters Corporation is dedicated to leveraging life science research from biomarker discovery through advanced therapy development to the facilitation of novel molecular diagnostics. Our integrated systems are the product of more than 30 years of commitment to excellence in mass spectrometry, separations science and informatics.

WHATMAN SCHLEICHER & SCHUELL . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .205 Contact: Barbara Knipper Hahnestr. 3 Dassel, 37586 Germany Telephone: +49-(0)5561-791-556 Fax: +49-(0)5561-791-591 E-Mail: [email protected] Nitrocellulose-coated FAST® Slides are the leading surface for protein microarrays. They are used e.g. for abundance profiling of serum cancer biomarkers, quantitative multiplex assays of cytokines and diagnostic antigen assays. FAST Slides are available in different formats including a system for integrating protein microarrays with automated liquid handling.

WITA GMBH . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .224 Contact: Roland Hess Boschstr. 12 Weinheim, 69469 Germany Telephone: +49 (0) 6201-606197 Fax: +49 (0) 6201-606100 E-Mail: [email protected]

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EXHIBIT DIRECTORY WITA GMBH . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .618 Contact: Dr. Hanns-Rüdiger Graack Warthestr. 21 Teltow, D-14513 Germany Telephone: +49-(0)3328-39490 Fax: +49-(0)3328-394949 E-Mail: [email protected] WITA provides exclusively the high-resolution NEPHGE two-dimensional gel-electrophoresis (Klose system) as system provider (equipment, chemicals, training, after sales service) as well as contract research service all over the world.

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s/ m te 6. ys 30 os d Bi an d st lie at pp IEX tA C ee S M DS M

Discover biomarkers.

Amount

Co nt r Co ol 1 nt ro l2

M ar ke M r re p ar ke lica rr t ep e 1 lic at e 2

Identify and quantitate protein biomarkers with confidence.

114 115 116 117 m/z

Multiplex Biomarker Results with iTRAQ™ Reagents

From discovery to validation, total system solutions from Applied Biosystems/MDS SCIEX make your protein biomarker research faster, easier, and more productive. Our innovative technologies for protein identification and relative and absolute quantitation provide rapid, accurate results from your most complex samples. In fact, using powerful new workflows and innovative BIOiTRAQ™ systems, you can confidently identify putative biomarkers and accurately quantitate them, all within a single experiment. To learn more, visit http://info.appliedbiosystems.com/biomarkers

BIOiTRAQ™ TT System

BIOiTRAQ™ QT System

BIOiTRAQ™ QS System

For Research Use Only. Not for use in diagnostic procedures. Applied Biosystems is a registered trademark and AB (Design), Applera, and BIOiTRAQ are trademarks of Applera Corporation or its subsidiaries in the US and/or certain other countries. MDS and SCIEX are registered trademarks of MDS Inc. © 2005 Applied Biosystems. All rights reserved.

SPONSOR ACKNOWLEDGEMENT The HUPO 4th Annual World Congress would like to thank the following sponsors for their generous support: ELITE SPONSOR GE Healthcare

PREMIER SPONSORS Applied Biosystems

BD- LoRes

Thermo Electron Corporation

CORPORATE SPONSORS Agilent Technologies NonLinear Dynamics

Bio-Rad Laboratories Sigma-Aldrich

Bruker Daltonics Waters Corporation

OTHER Invitrogen

Novartis

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