i iii iv iii v ii i iv ii v ii i iv ii iii vi iii iv iii v ii i iii iv iii v ii abcdef - PLOS

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Treatment of cells by ethidium bromide impairs complexes possessing mtDNA- encoded subunits. Q. Q. Q. I. IV. 1/2O2. H2O. NADH. NAD+. II. Succ. Fum. III. H+.
A

B A15

ϴ° sensitive element HN

O

rosamine O

N

CH3

II

Q III Q III IV Q

I

Fum Succ

MitoThermoYellow

Q

I

Fum Succ

The different targets of the respiratory chain inhibitors

Aa

IV Q

NADH

II

V

H2O 1/2O2

ATP

ADP Pi

Q III Q III IV Q Rot

F

H+

Overexpression of UCP1 results in oligomycin-resistant respiration

H+

H+

Q

Q III IV AOX Q II

H2O

V

H2O NADH 1/2O2 ADP ATP KCN Pi + NAD+ Pyr Pyr cyanohydrin COOH-CO-CH3 COOH-CNOH-CH3

Fum Succ

Overexpression of AOX results in propylgallate sensitive cyanide-resistant respiration

1/2O2

Oligo

I

E

PG

ADP Pi

ATP

D

NAD+

Fum Succ

H2O

NAD+

CH3

Treatment of cells by ethidium bromide impairs complexes possessing mtDNAencoded subunits

II II

V

½O2

NADH

C

Q

H+

NH 2

rhodamine 123

COOCH3

HN

H+

heat

I

H2O

1/2O2

NADH NAD+

III IV

III

V ATP ADP Pi

II Fum Succ

H+

I NADH NAD+

H+

Q

Q

UCP1

N

The mitochondrial respiratory chain concurrently generates ATP and heat

V H2O 1/2O2

H+ ATP

ADP Pi

Q