Oct 27, 2016 - in children with NNMD hospitalized with severe acute respiratory illness (SARI). Methods. Surveillance for patients with SARI was conducted at ...
ID WEEK 2016
versus 4.5 and 3.7 days, respectively; P < .001) and were more likely to have a severe outcome (absolute risk reduction = 2.3; 95% confidence interval [CI], 1.7–3.0) compared to children with no or other comorbidities. Furthermore, among children with NNMD, LOS was 26% longer when a pathogen was detected (95% CI, 16.7–35.6%; P < .001).
POSTER ABSTRACTS 134. Clinical Outcomes and Respiratory Virus Detections in Children With Neurologic/Neuromuscular Disorders Hospitalized for Acute Respiratory Infection, 2013–2015 Ashley Fowlkes, MPH1; Hannah Friedlander, MPH2; Sandra S. Chaves, MD, MSc1; Andrea Steffens, MPH1; Kathryn Como-Sabetti, MPH2; Dave Boxrud, MSc3; Sarah Bistodeau, BS4; Anna Strain, PhD4; Brett L. Whitaker, MS5; Ruth Lynfield, MD, FIDSA2; 1Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia; 2Minnesota Department of Health, St. Paul, Minnesota; 3Minnesota Department of Health, Minneapolis, Minnesota; 4Public Health Laboratory, Minnesota Department of Health, St. Paul, Minnesota; 5Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia Session: 46. Big Viruses in Little People (Pediatric Viral Diseases) Thursday, October 27, 2016: 12:30 PM Background. Children with neurologic/neuromuscular disorders (NNMD) may have impaired lung or muscle function, resulting in severe illness from respiratory viral infections. We describe clinical outcomes and respiratory pathogen detections in children with NNMD hospitalized with severe acute respiratory illness (SARI). Methods. Surveillance for patients with SARI was conducted at 3 hospitals in the Minneapolis/St. Paul metropolitan area. Respiratory specimens collected from SARI patients were tested for 22 respiratory pathogens by reverse transcriptase-polymerase chain reaction. Medical records were reviewed to collect demographic and clinical information. We compared severe outcomes (intensive care unit admission, mechanical ventilation, or death) and length of stay (LOS) by pathogen detection among 3 SARI patient groups: NNMD, other comorbidities, and no comorbidities. We used a multinomial logistic regression model to evaluate severe outcome and LOS by group and Poisson regression to evaluate LOS by pathogen detection among children with NNMD, adjusting for age. Results. From September 2013 to June 2015, 3128 children
