Apr 1, 2011 - interleukin 1 [IL-1 ], IL-1 receptor antagonist [IL-1Ra], IL-2, IL-2R, ... glucose-6-phosphate dehydrogenase (G6PD) deficiency, and sickle cell trait ...
INFECTION AND IMMUNITY, Nov. 2011, p. 4674–4680 0019-9567/11/$12.00 doi:10.1128/IAI.05161-11 Copyright © 2011, American Society for Microbiology. All Rights Reserved.
Vol. 79, No. 11
Identification of Inflammatory Biomarkers for Pediatric Malarial Anemia Severity Using Novel Statistical Methods䌤 John M. Ong’echa,1* Gregory C. Davenport,2 John M. Vulule,3 James B. Hittner,4 and Douglas J. Perkins1,2 University of New Mexico Laboratories of Parasitic and Viral Diseases, Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya1; Center for Global Health, Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico2; Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya3; and Department of Psychology, College of Charleston, Charleston, South Carolina4 Received 1 April 2011/Returned for modification 11 May 2011/Accepted 12 August 2011
Areas where Plasmodium falciparum transmission is holoendemic are characterized by high rates of pediatric severe malarial anemia (SMA) and associated mortality. Although the etiology of SMA is complex and multifactorial, perturbations in inflammatory mediator production play an important role in the pathogenic process. As such, the current study focused on identification of inflammatory biomarkers in children with malarial anemia. Febrile children (3 to 30 months of age) presenting at Siaya District Hospital in western Kenya underwent a complete clinical and hematological evaluation. Children with falciparum malaria and no additional identifiable anemia-promoting coinfections were stratified into three groups: uncomplicated malaria (hemoglobin [Hb] levels of >11.0 g/dl; n ⴝ 31), non-SMA (Hb levels of 6.0 to 10.9 g/dl; n ⴝ 37), and SMA (Hb levels of
