Identification of ovarian cancer associated genes using an integrated ...
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Identification of ovarian cancer associated genes using an integrated ...
CDC7; CHEK1; IGFBP7. 4.38. 0.000724521 0.00937227. 2. Escape growth suppressor. i.e. Insensitivity to growth inhibitor regulation of cell proliferation.
Identification of ovarian cancer associated genes using an integrated approach in a Boolean framework by Gaurav Kumar, Edmond J. Breen and Shoba Ranganathan Additional File 8: GATHER [71] GO biological process annotations of the differentially expressed genes associated with the cancer hallmarks
in Table 3.
Genes are annotated with GO terms using the GATHER enrichment method. B-factor (i.e. Bayes factor) quantifies the amount of evidence supporting the hypothesis that the annotation is associated with our genes. p-values and q-values are based on Fisher's exact test. Cancer Hallmark
GO Term Definition
GO Term-ID (GO-depth)
Genes
negative regulation of cell proliferation
GO:0008285 (6)
CDC7; CHEK1; IGFBP7
regulation of cell proliferation
GO:0042127 (5)
3. Active invasion and negative regulation of metastasis programmed cell death 4. Limitless replicative cell proliferation potential / Enable replicative immortality 5. Induces angiogenesis tissue regeneration 6. Resisting cell death anti-apoptosis 7. Genomic instability DNA damage checkpoint
GO:0043069 (6)
8. Deregulate cellular energetics
1. Sustain growth signal 2. Escape growth suppressor i.e. Insensitivity to growth inhibitor
